| OXR1 maintains the retromer to delay brain aging under dietary restriction. | OXR1 maintains the retromer to delay brain aging under dietary restriction.
Wilson KA, Bar S, Dammer EB, Carrera EM, Hodge BA, Hilsabeck TAU, Bons J, Brownridge GW 3rd, Beck JN, Rose J, Granath-Panelo M, Nelson CS, Qi G, Gerencser AA, Lan J, Afenjar A, Chawla G, Brem RB, Campeau PM, Bellen HJ, Schilling B, Seyfried NT, Ellerby LM, Kapahi P., Free PMC Article | 01/26/2024 |
| A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial-temporal regulation of histone arginine methylation in neurodevelopment. | A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial-temporal regulation of histone arginine methylation in neurodevelopment.
Lin X, Wang W, Yang M, Damseh N, de Sousa MML, Jacob F, Lång A, Kristiansen E, Pannone M, Kissova M, Almaas R, Kuśnierczyk A, Siller R, Shahrour M, Al-Ashhab M, Abu-Libdeh B, Tang W, Slupphaug G, Elpeleg O, Bøe SO, Eide L, Sullivan GJ, Rinholm JE, Song H, Ming GL, van Loon B, Edvardson S, Ye J, Bjørås M., Free PMC Article | 10/13/2023 |
| A novel recessive mutation in OXR1 is identified in patient with hearing loss recapitulated by the knockdown zebrafish. | A novel recessive mutation in OXR1 is identified in patient with hearing loss recapitulated by the knockdown zebrafish.
Li Y, Ning G, Kang B, Zhu J, Wang XY, Wang Q, Cai T., Free PMC Article | 06/15/2023 |
| MiR-616 promotes the progression of pancreatic carcinoma by targeting OXR1. | MiR-616 promotes the progression of pancreatic carcinoma by targeting OXR1.
Zhou Y, Meng P, Tang B, Ke Z, Liu L, Chen Y, Zhu F. | 08/7/2021 |
| Oxidation resistance 1 prevents genome instability through maintenance of G2/M arrest in gamma-ray-irradiated cells. | Oxidation resistance 1 prevents genome instability through maintenance of G2/M arrest in gamma-ray-irradiated cells.
Matsui A, Kobayashi J, Kanno SI, Hashiguchi K, Miyaji M, Yoshikawa Y, Yasui A, Zhang-Akiyama QM., Free PMC Article | 10/10/2020 |
| Over-expression of Oxr1 was able to delay neuromuscular abnormalities in the hSOD1G93A amyotrophic lateral sclerosis mouse model. | Neuronal over-expression of Oxr1 is protective against ALS-associated mutant TDP-43 mislocalisation in motor neurons and neuromuscular defects in vivo.
Williamson MG, Finelli MJ, Sleigh JN, Reddington A, Gordon D, Talbot K, Davies KE, Oliver PL., Free PMC Article | 05/30/2020 |
| Loss of OXR1 is Associated with an Autosomal-Recessive Neurological Disease with Cerebellar Atrophy and Lysosomal Dysfunction. | Loss of Oxidation Resistance 1, OXR1, Is Associated with an Autosomal-Recessive Neurological Disease with Cerebellar Atrophy and Lysosomal Dysfunction.
Wang J, Rousseau J, Kim E, Ehresmann S, Cheng YT, Duraine L, Zuo Z, Park YJ, Li-Kroeger D, Bi W, Wong LJ, Rosenfeld J, Gleeson J, Faqeih E, Alkuraya FS, Wierenga KJ, Chen J, Afenjar A, Nava C, Doummar D, Keren B, Juusola J, Grompe M, Bellen HJ, Campeau PM., Free PMC Article | 04/4/2020 |
| Low OXR1 expression is associated with the development of esophageal squamous cell carcinoma. | MicroRNA-373 promotes the development of esophageal squamous cell carcinoma by targeting LATS2 and OXR1.
Wang L, Wang L, Chang W, Li Y, Wang L. | 12/21/2019 |
| findings provide new insights into the mechanism by which senescent cells are highly resistant to oxidative stress and suggest that OXR1 is a novel senolytic target that can be further exploited for the development of new senolytic agents | Oxidation resistance 1 is a novel senolytic target.
Zhang X, Zhang S, Liu X, Wang Y, Chang J, Zhang X, Mackintosh SG, Tackett AJ, He Y, Lv D, Laberge RM, Campisi J, Wang J, Zheng G, Zhou D., Free PMC Article | 10/12/2019 |
| The results of the present study indicated that sevoflurane exerts its neurotoxic effect by regulating the hsamiR302e/OXR1 axis. Therefore, the manipulation of the hsamiR302e/OXR1 pathway will be useful for preventing sevofluraneinduced neurotoxicity. | Sevoflurane‑induced neurotoxicity is driven by OXR1 post‑transcriptional downregulation involving hsa‑miR‑302e.
Yang L, Shen Q, Xia Y, Lei X, Peng J. | 02/16/2019 |
| OXR1 may act as a sensor of cellular oxidative stress to regulate the transcriptional networks required to detoxify reactive oxygen species and modulate cell cycle and apoptosis. | Transcriptome analysis of human OXR1 depleted cells reveals its role in regulating the p53 signaling pathway.
Yang M, Lin X, Rowe A, Rognes T, Eide L, Bjørås M., Free PMC Article | 10/22/2016 |
| Oxr1 serves as a potential therapeutic target for ALS and other neurodegenerative disorders characterized by TDP-43 or FUS pathology. | Oxr1 improves pathogenic cellular features of ALS-associated FUS and TDP-43 mutations.
Finelli MJ, Liu KX, Wu Y, Oliver PL, Davies KE., Free PMC Article | 02/6/2016 |
| OXR1 upregulates the expression of antioxidant genes via the p21 signaling pathway to suppress hydrogen peroxide-induced oxidative stress and maintain mtDNA integrity. | Human OXR1 maintains mitochondrial DNA integrity and counteracts hydrogen peroxide-induced oxidative stress by regulating antioxidant pathways involving p21.
Yang M, Luna L, Sørbø JG, Alseth I, Johansen RF, Backe PH, Danbolt NC, Eide L, Bjørås M. | 08/15/2015 |
| The protein segment encoded by exon 8 plays an important role in the anti-oxidative function of the human OXR1 protein. | Structural/functional analysis of the human OXR1 protein: identification of exon 8 as the anti-oxidant encoding function.
Murphy KC, Volkert MR., Free PMC Article | 01/12/2013 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ., Free PMC Article | 12/5/2010 |
| human OXR1 is capable of reducing the DNA damaging effects of reactive oxygen species when expressed in bacteria, indicating the protein has an activity that can contribute to oxidation resistance. | The OXR domain defines a conserved family of eukaryotic oxidation resistance proteins.
Durand M, Kolpak A, Farrell T, Elliott NA, Shao W, Brown M, Volkert MR., Free PMC Article | 01/21/2010 |
| Data show that human and yeast oxidation resistance 1 (OXR1) genes are induced by heat and oxidative stress and that their proteins localize to the mitochondria and function to protect against oxidative damage. | Stress induction and mitochondrial localization of Oxr1 proteins in yeast and humans.
Elliott NA, Volkert MR., Free PMC Article | 01/21/2010 |