| PIWIL2 restrains the progression of thyroid cancer via interaction with miR-146a-3p. | PIWIL2 restrains the progression of thyroid cancer via interaction with miR-146a-3p.
Lu X, Zhu Q, Du H, Gu M, Li X., Free PMC Article | 08/31/2023 |
| A homozygous PIWIL2 frameshift variant affects the formation and maintenance of human-induced pluripotent stem cell-derived spermatogonial stem cells and causes Sertoli cell-only syndrome. | A homozygous PIWIL2 frameshift variant affects the formation and maintenance of human-induced pluripotent stem cell-derived spermatogonial stem cells and causes Sertoli cell-only syndrome.
Wang X, Li Z, Qu M, Xiong C, Li H., Free PMC Article | 10/15/2022 |
| Multiple transcriptome analysis of Piwil2-induced cancer stem cells, including piRNAs, mRNAs and miRNAs reveals the mechanism of tumorigenesis and development. | Multiple transcriptome analysis of Piwil2-induced cancer stem cells, including piRNAs, mRNAs and miRNAs reveals the mechanism of tumorigenesis and development.
Tan X, Mi T, Zhang Z, Jin L, Wang Z, Wu X, Wang J, Li M, Zhanghuang C, He D. | 07/16/2022 |
| Lower Spermatozoal PIWI-LIKE 1 and 2 Transcript Levels Are Significantly Associated with Higher Fertilization Rates in IVF. | Lower Spermatozoal PIWI-LIKE 1 and 2 Transcript Levels Are Significantly Associated with Higher Fertilization Rates in IVF.
Giebler M, Greither T, Handke D, Seliger G, Behre HM., Free PMC Article | 01/15/2022 |
| P-element Induced WImpy protein-like RNA-mediated gene silencing 2 regulates tumor cell progression, apoptosis, and metastasis in oral squamous cell carcinoma. | P-element Induced WImpy protein-like RNA-mediated gene silencing 2 regulates tumor cell progression, apoptosis, and metastasis in oral squamous cell carcinoma.
Zhou S, Yang S, Li F, Hou J, Chang H., Free PMC Article | 11/22/2021 |
| CBP-mediated Wnt3a/beta-catenin signaling promotes cervical oncogenesis initiated by Piwil2. | CBP-mediated Wnt3a/β-catenin signaling promotes cervical oncogenesis initiated by Piwil2.
Feng D, Yan K, Liang H, Liang J, Wang W, Yu H, Zhou Y, Zhao W, Dong Z, Ling B., Free PMC Article | 10/9/2021 |
| PIWIL2 may serve as a prognostic predictor in cancers: A systematic review and meta-analysis. | PIWIL2 may serve as a prognostic predictor in cancers: A systematic review and meta-analysis.
Hu W, Sun X, Ye T, Feng S, Ruan Q, Xi M, Zhou X, Li M, Ye Z, Cheng X, Xie W. | 09/11/2021 |
| Structural basis for RNA 3'-end recognition by the PIWIL2 PAZ domain. | Structural basis for RNA 3'-end recognition by the PIWIL2 PAZ domain.
Li Q, Dong A, Zhu Z, Zhang J, Li Y, Xu C. | 07/10/2021 |
| PIWIL-2 and piRNAs are regularly expressed in epithelia of the skin and their expression is related to differentiation. | PIWIL-2 and piRNAs are regularly expressed in epithelia of the skin and their expression is related to differentiation.
Pammer J, Rossiter H, Bilban M, Eckhart L, Buchberger M, Monschein L, Mildner M., Free PMC Article | 06/19/2021 |
| Generation of an iPSC line (HUSTi002-A) from fibroblasts of a patient with Sertoli cell-only syndrome carrying c.731_732delAT in PIWIL2 gene. | Generation of an iPSC line (HUSTi002-A) from fibroblasts of a patient with Sertoli cell-only syndrome carrying c.731_732delAT in PIWIL2 gene.
Wang X, Xie S, Li Z, Ye Z, Gu X, Zhou L, Li H. | 12/5/2020 |
| By up-regulating CTNNB1 and CCND1, PIWIL2 can promote cell cycle and proliferation in tumor cells. | PIWIL2 stabilizes β-catenin to promote cell cycle and proliferation in tumor cells.
Qiu B, Zeng J, Zhao X, Huang L, Ma T, Zhu Y, Liu M, Tao D, Liu Y, Lu Y, Ma Y. | 07/11/2020 |
| PIWIL2 interacts with HDAC3 and promotes the stability and phosphorylation of HDAC3. PIWIL2 can play a role in HDAC3-mediated epigenetic regulation on cancer cell proliferation and apoptosis. | PIWIL2 suppresses Siah2-mediated degradation of HDAC3 and facilitates CK2α-mediated HDAC3 phosphorylation.
Zhang Y, Zheng X, Tan H, Lu Y, Tao D, Liu Y, Ma Y., Free PMC Article | 03/28/2020 |
| Findings showed that PIWIL2 can predict effectively OSCC prognosis and OL with a high risk of OSCC development and substantiate the deduction that cancer stem(-like) cells in oral cancer have the ability to reconstitute the heterogeneity of the bulk tumor and contribute to poor outcome and immunosuppression. | Expression of PIWIL2 in oral cancer and leukoplakia: Prognostic implications and insights from tumors.
Wang S, Li F, Fan H, Xu J, Hu Z. | 03/28/2020 |
| Piwi-like 1 and -2 positivity are associated with clinico-pathological factors and survival. Both Piwi-like proteins are suggested as biomarkers for MIBC patients. | Piwi-like 1 and -2 protein expression levels are prognostic factors for muscle invasive urothelial bladder cancer patients.
Eckstein M, Jung R, Weigelt K, Sikic D, Stöhr R, Geppert C, Agaimy A, Lieb V, Hartmann A, Wullich B, Wach S, Taubert H., Free PMC Article | 10/19/2019 |
| Our results showed that HILI suppresses microtubule polymerization and promotes cell proliferation, migration and invasion via TBCB for the first time, revealing a novel mechanism for HILI in tumorigenesis. | HILI destabilizes microtubules by suppressing phosphorylation and Gigaxonin-mediated degradation of TBCB.
Tan H, Liao H, Zhao L, Lu Y, Jiang S, Tao D, Liu Y, Ma Y., Free PMC Article | 07/27/2019 |
| Data show that piR-FTH1 (ferritin heavy chain 1) knocks down the Fth1 mRNA via the HIWI2 and HILI mediated mechanism. | A piRNA utilizes HILI and HIWI2 mediated pathway to down-regulate ferritin heavy chain 1 mRNA in human somatic cells.
Balaratnam S, West N, Basu S., Free PMC Article | 07/13/2019 |
| PIWILIKE 1 and PIWILIKE 2 mRNA expression exhibited a significant association with impaired sperm characteristics and may be a useful candidate for the evaluation of the impact of PIWILIKE 1-4 mRNA expression on male infertility. | Altered PIWI-LIKE 1 and PIWI-LIKE 2 mRNA expression in ejaculated spermatozoa of men with impaired sperm characteristics.
Giebler M, Greither T, Müller L, Mösinger C, Behre HM., Free PMC Article | 06/15/2019 |
| n vitro experiments demonstrated a possible role of the PIWIL2/HILI short isoform in repressing TEs, which could provide a growth advantage for testicular germ cell tumors through securing their genome integrity. | Assessment of piRNA biogenesis and function in testicular germ cell tumors and their precursor germ cell neoplasia in situ.
Gainetdinov IV, Skvortsova YV, Kondratieva SA, Klimov A, Tryakin AA, Azhikina TL., Free PMC Article | 08/18/2018 |
| A statistically significantly higher level of PIWIL1 and PIWIL2 was found in IDC compared to mastopathy samples (p</=0.0001). Increased expression of PIWIL1 was correlated with increased PIWIL2 expression in breast cancer tissue. | Aberrant Expression of PIWIL1 and PIWIL2 and Their Clinical Significance in Ductal Breast Carcinoma.
Litwin M, Szczepańska-Buda A, Michałowska D, Grzegrzółka J, Piotrowska A, Gomułkiewicz A, Wojnar A, Dzięgiel P, Witkiewicz W. | 05/12/2018 |
| this study shows that an unusual intragenic promoter of PIWIL2 contributes to aberrant activation of oncogenic PL2L60 | An unusual intragenic promoter of PIWIL2 contributes to aberrant activation of oncogenic PL2L60.
Liu SS, Liu N, Liu MY, Sun L, Xia WY, Lu HM, Fu YJ, Yang GL, Bo JJ, Liu XX, Feng H, Wu H, Li LF, Gao JX., Free PMC Article | 04/21/2018 |
| High expression of PIWIL2 is associated with glioma. | High expression of PIWIL2 promotes tumor cell proliferation, migration and predicts a poor prognosis in glioma.
Li J, Xu L, Bao Z, Xu P, Chang H, Wu J, Bei Y, Xia L, Wu P, Cui G. | 04/7/2018 |
| Protein expression levels of PIWIL2 was significantly up-regulated in both papillary and micropapillary thyroid cancers (p<0.01). Moreover, consistent with protein expression levels, mRNA expression levels of PIWIL2 was elevated in both papillary and micropapillary thyroid cancer tissues. | Differential expression of PIWIL2 in papillary thyroid cancers.
Erdogdu IH, Yumrutas O, Ozgur Cevik M, Bozgeyik I, Erdogdu M, Inan HM, Bagis H. | 03/24/2018 |
| Results revealed that Piwil2 exhibits 100% positive expression in the cell nucleus, with the intensity higher than in the cytoplasm. Along with nuclear location of PIWIL4, PIWIL2 expression is associated with worse prognosis of hepatocellular carcinoma. | Co-expression of Piwil2/Piwil4 in nucleus indicates poor prognosis of hepatocellular carcinoma.
Zeng G, Zhang D, Liu X, Kang Q, Fu Y, Tang B, Guo W, Zhang Y, Wei G, He D., Free PMC Article | 02/24/2018 |
| this study demonstrates that Piwil2, reactivated by the human papillomavirus oncoproteins E6 and E7, plays an essential role in the transformation of cervical epithelial cells to tumor-initiating cells via epigenetics-based cell reprogramming | Piwil2 is reactivated by HPV oncoproteins and initiates cell reprogramming via epigenetic regulation during cervical cancer tumorigenesis.
Feng D, Yan K, Zhou Y, Liang H, Liang J, Zhao W, Dong Z, Ling B., Free PMC Article | 02/24/2018 |
| Data show that the PIWIL2 protein transfected fibroblast cells grew into tumorous masses within 5 weeks of subcutaneous injection into adult nude mice. | Piwil2-transfected human fibroblasts are cancer stem cell-like and genetically unstable.
Zhang D, Wu X, Liu X, Cai C, Zeng G, Rohozinski J, Zhang Y, Wei G, He D., Free PMC Article | 08/12/2017 |