| TCAB1 prevents nucleolar accumulation of the telomerase RNA to facilitate telomerase assembly. | TCAB1 prevents nucleolar accumulation of the telomerase RNA to facilitate telomerase assembly.
Klump BM, Perez GI, Patrick EM, Adams-Boone K, Cohen SB, Han L, Yu K, Schmidt JC., Free PMC Article | 10/11/2023 |
| Differential effects of WRAP53 transcript variants on non-small cell lung cancer cell behaviors. | Differential effects of WRAP53 transcript variants on non-small cell lung cancer cell behaviors.
Zhu Y, Sun W, Jiang X, Bai R, Luo Y, Gao Y, Li S, Huang Z, Gong Y, Xie C., Free PMC Article | 02/4/2023 |
| Next-generation sequencing errors due to genetic variation in WRAP53 encoding TCAB1 on chromosome 17. | Next-generation sequencing errors due to genetic variation in WRAP53 encoding TCAB1 on chromosome 17.
Savage SA, Jones K, Teshome K, Lori A, McReynolds LJ, Niewisch MR., Free PMC Article | 12/24/2022 |
| [Effect of WRAP53 beta Targeted Co-Inhibitory Pathways Based on Comprehensive Bioinformatics Analysis in Treating Squamous Cell Carcinoma of the Head and Neck]. | [Effect of WRAP53 β Targeted Co-Inhibitory Pathways Based on Comprehensive Bioinformatics Analysis in Treating Squamous Cell Carcinoma of the Head and Neck].
Yao YF, Liu W, Zhou ML, Qiu TL, Wang K., Free PMC Article | 06/11/2022 |
| Nuclear WRAP53 promotes neuronal survival and functional recovery after stroke. | Nuclear WRAP53 promotes neuronal survival and functional recovery after stroke.
Sánchez-Morán I, Rodríguez C, Lapresa R, Agulla J, Sobrino T, Castillo J, Bolaños JP, Almeida A., Free PMC Article | 04/23/2022 |
| Biallelic mutations in WRAP53 result in dysfunctional telomeres, Cajal bodies and DNA repair, thereby causing Hoyeraal-Hreidarsson syndrome. | Biallelic mutations in WRAP53 result in dysfunctional telomeres, Cajal bodies and DNA repair, thereby causing Hoyeraal-Hreidarsson syndrome.
Bergstrand S, Böhm S, Malmgren H, Norberg A, Sundin M, Nordgren A, Farnebo M., Free PMC Article | 04/3/2021 |
| analyze a haplotype comprising four SNPs, including rs1042522, rs17878362, rs2287499, and rs2287498, which are located at 5' regions of the TP53 and WRAP53 genes as molecular prognostic and predictive biomarkers for breast cancer. | Haplotype and linkage disequilibrium of TP53-WRAP53 locus in Iranian-Azeri women with breast cancer.
Pouladi N, Abdolahi S, Farajzadeh D, Hosseinpour Feizi MA., Free PMC Article | 03/14/2020 |
| These findings reveal that WDR79 is a novel UHRF1 regulator by maintaining UHRF1 stability. | WDR79 mediates the proliferation of non-small cell lung cancer cells by regulating the stability of UHRF1.
Chen J, Sheng X, Ma H, Tang Z, Yang C, Cao L, Sun Y, Deng T, Feng P, Hu B, Wei D, Liu J, Xiong W, Ye M., Free PMC Article | 10/26/2019 |
| we suggest that TDP-43 and WDR79 have separate roles in determining Cajal bodies (CBs) localization of subsets of C/D and H/ACA scaRNAs. | TDP-43 regulates site-specific 2'-O-methylation of U1 and U2 snRNAs via controlling the Cajal body localization of a subset of C/D scaRNAs.
Izumikawa K, Nobe Y, Ishikawa H, Yamauchi Y, Taoka M, Sato K, Nakayama H, Simpson RJ, Isobe T, Takahashi N., Free PMC Article | 10/19/2019 |
| Data show that up-regulated expression of telomerase Cajal body protein 1 (TCAB1), induced by Epstein-Barr virus (EBV) in the development of nasopharyngeal carcinoma (NPC), is involved in stimulating telomerase activity and regulating the DNA damage response. | Epstein-Barr virus-induced up-regulation of TCAB1 is involved in the DNA damage response in nasopharyngeal carcinoma.
Wang K, Ge Y, Ni C, Cui B, Du J, Zhang B, Hu X, Chen J, Xiao L, Sun C, Li Y., Free PMC Article | 01/12/2019 |
| a unique homozygous WRAP53 mutation site underlies the development of dyskeratosis congenita in a Chinese Han family | A unique homozygous WRAP53 Arg298Trp mutation underlies dyskeratosis congenita in a Chinese Han family.
Shao Y, Feng S, Huang J, Huo J, You Y, Zheng Y., Free PMC Article | 12/22/2018 |
| Wrap53 is likely a potential oncogene or possesses oncogenic activity in colorectal cancer, promoting colorectal tumorigenesis. | Oncogenic Activity of Wrap53 in Human Colorectal Cancer In Vitro and in Nude Mouse Xenografts.
Zhu Y, Ding L, Chen BF, Song JG, Yao YS., Free PMC Article | 12/22/2018 |
| The results collectively suggest that WDR79 and SMN play evolutionarily conserved cooperative functions in the nervous system and suggest that WDR79/TCAB1 may have the potential to modify SMA pathogenesis. | WDR79/TCAB1 plays a conserved role in the control of locomotion and ameliorates phenotypic defects in SMA models.
Di Giorgio ML, Esposito A, Maccallini P, Micheli E, Bavasso F, Gallotta I, Vernì F, Feiguin F, Cacchione S, McCabe BD, Di Schiavi E, Raffa GD. | 04/21/2018 |
| in response to DNA damage the Cajal body protein WRAP53beta is phosphorylated by ATM and that this phosphorylation is important for the recruitment of WRAP53beta to DNA lesions, its interaction with gammaH2AX, subsequent localization of the downstream repair factor 53BP1 to DNA breaks, as well as for HR and NHEJ repair. | Phosphorylation of the Cajal body protein WRAP53β by ATM promotes its involvement in the DNA damage response.
Coucoravas C, Dhanjal S, Henriksson S, Böhm S, Farnebo M., Free PMC Article | 04/7/2018 |
| The present findings indicate that WRAP53beta and RNF8 are rate-limiting factors in the repair of DNA double-strand breaks and raise the possibility that upregulation of WRAP53beta may contribute to genomic stability in and survival of cancer cells. | Overexpression of the scaffold WD40 protein WRAP53β enhances the repair of and cell survival from DNA double-strand breaks.
Rassoolzadeh H, Böhm S, Hedström E, Gad H, Helleday T, Henriksson S, Farnebo M., Free PMC Article | 10/28/2017 |
| WDR79 colocalized and interacted with USP7 in the nucleus of non-small cell lung cancer cells. This event, in turn, reduced the ubiquitination of Mdm2 and p53, thereby increasing the stability and extending the half-life of the two proteins. | WDR79 promotes the proliferation of non-small cell lung cancer cells via USP7-mediated regulation of the Mdm2-p53 pathway.
Sun Y, Cao L, Sheng X, Chen J, Zhou Y, Yang C, Deng T, Ma H, Feng P, Liu J, Tan W, Ye M., Free PMC Article | 04/29/2017 |
| The depletion of WRAP53 inhibits the proliferation of lung-adenocarcinoma A549 and SPC-A-1 cells via G1/S cell-cycle arrest. Several proteins interacting with WRAP53 were identified through co-immunoprecipitation and liquid chromatography/mass spectrometry. | Clinical, cellular, and bioinformatic analyses reveal involvement of WRAP53 overexpression in carcinogenesis of lung adenocarcinoma.
Yuan XS, Cao LX, Hu YJ, Bao FC, Wang ZT, Cao JL, Yuan P, Lv W, Hu J. | 04/8/2017 |
| we analyzed the association between the WRAP53 gene rs2287499 C>G polymorphism and risk of cancer using five case-control studies.In the overall analysis, no significant association between rs2287499 and risk of cancer was found. | Association between the WRAP53 gene rs2287499 C>G polymorphism and cancer risk: A meta-analysis.
Cao HY, Wang S, Zhang ZY, Lou JY. | 03/25/2017 |
| The interaction of MDC1 with RNF8, but not with ATM requires WRAP53beta, suggesting that WRAP53beta facilitates the former interaction without altering phosphorylation of MDC1 by ATM. | The proximity ligation assay reveals that at DNA double-strand breaks WRAP53β associates with γH2AX and controls interactions between RNF8 and MDC1.
Rassoolzadeh H, Coucoravas C, Farnebo M., Free PMC Article | 10/1/2016 |
| Moreover, our current observations identify the nuclear levels of WRAP53beta as a promising biomarker for the survival of patients with ovarian cancer. | Downregulation of the cancer susceptibility protein WRAP53β in epithelial ovarian cancer leads to defective DNA repair and poor clinical outcome.
Hedström E, Pederiva C, Farnebo J, Nodin B, Jirström K, Brennan DJ, Farnebo M., Free PMC Article | 07/16/2016 |
| the sub-cellular localization of the WRAP53 protein has a significant impact on breast cancer survival. | The Sub-Cellular Localization of WRAP53 Has Prognostic Impact in Breast Cancer.
Silwal-Pandit L, Russnes H, Borgen E, Skarpeteig V, Moen Vollan HK, Schlichting E, Kåresen R, Naume B, Børresen-Dale AL, Farnebo M, Langerød A., Free PMC Article | 06/11/2016 |
| This study showed that UCA1 and WRAP53 upregulation may serve as novel serum biomarkers for hepatocellular carcinoma diagnosis and prognosis. | Investigation of long noncoding RNAs expression profile as potential serum biomarkers in patients with hepatocellular carcinoma.
Kamel MM, Matboli M, Sallam M, Montasser IF, Saad AS, El-Tawdi AHF. | 06/4/2016 |
| WRAP53 is associated with development and progression of esophageal squamous cell carcinoma | Overexpression of WRAP53 is associated with development and progression of esophageal squamous cell carcinoma.
Rao X, Huang D, Sui X, Liu G, Song X, Xie J, Huang D., Free PMC Article | 01/16/2016 |
| Decreasing the expression of WRAP53 using RNA interference technique can enhance the radiosensitivity. | Regulatory effects of WRAP53 on radiosensitivity of laryngeal squamous cell carcinoma cells.
Qiu H, Zhao DY, Yuan LM, Zhang G, Xie CH. | 12/26/2015 |
| The telomerase holoenzyme Cajal body-associated protein, TCAB1, was released from telomerase RNA in mitotic cells coincident with TCAB1 delocalization from Cajal bodies. | Dynamics of Human Telomerase Holoenzyme Assembly and Subunit Exchange across the Cell Cycle.
Vogan JM, Collins K., Free PMC Article | 12/12/2015 |