| PPP2CA Inhibition Promotes Ferroptosis Sensitivity Through AMPK/SCD1 Pathway in Colorectal Cancer. | PPP2CA Inhibition Promotes Ferroptosis Sensitivity Through AMPK/SCD1 Pathway in Colorectal Cancer.
Liang X, Zhang H, Shang W, Wang M, Li J, Zhao Y, Fang C. | 06/18/2024 |
| PP2Ac Deficiency Enhances Tumor Immunogenicity by Activating STING-Type I Interferon Signaling in Glioblastoma. | PP2Ac Deficiency Enhances Tumor Immunogenicity by Activating STING-Type I Interferon Signaling in Glioblastoma.
Mondal I, Das O, Sun R, Gao J, Yu B, Diaz A, Behnan J, Dubey A, Meng Z, Eskandar E, Xu B, Lu RO, Ho WS., Free PMC Article | 09/29/2023 |
| The Pivotal Role of Protein Phosphatase 2A (PP2A) in Brain Tumors. | The Pivotal Role of Protein Phosphatase 2A (PP2A) in Brain Tumors.
Cucinotta L, Filippone A, Casili G, Lanza M, Bova V, Capra AP, Giuffrida R, Colarossi C, Sciacca D, Paterniti I, Cuzzocrea S, Campolo M, Esposito E., Free PMC Article | 01/11/2023 |
| Liver PP2A-Calpha Protects From Parenteral Nutrition-associated Hepatic Steatosis. | Liver PP2A-Cα Protects From Parenteral Nutrition-associated Hepatic Steatosis.
Maitiabula G, Tian F, Wang P, Zhang L, Gao X, Wan S, Sun H, Yang J, Zhang Y, Gao T, Xue B, Li C, Li J, Wang X., Free PMC Article | 09/3/2022 |
| The miR-345-3p/PPP2CA signaling axis promotes proliferation and invasion of breast cancer cells. | The miR-345-3p/PPP2CA signaling axis promotes proliferation and invasion of breast cancer cells.
Zeng Q, Jin F, Qian H, Chen H, Wang Y, Zhang D, Wei Y, Chen T, Guo B, Chai C., Free PMC Article | 05/14/2022 |
| PP2A Catalytic Subunit alpha promotes fibroblast activation and kidney fibrosis via ERK pathway. | PP2A Catalytic Subunit α promotes fibroblast activation and kidney fibrosis via ERK pathway.
Lu Q, Tan M, Hou Q, Wang M, Dai C. | 04/9/2022 |
| Protein phosphatase 2A in the healthy and failing heart: New insights and therapeutic opportunities. | Protein phosphatase 2A in the healthy and failing heart: New insights and therapeutic opportunities.
Sergienko NM, Donner DG, Delbridge LMD, McMullen JR, Weeks KL. | 04/9/2022 |
| Evolutionary crossroads of cell signaling: PP1 and PP2A substrate sites in intrinsically disordered regions. | Evolutionary crossroads of cell signaling: PP1 and PP2A substrate sites in intrinsically disordered regions.
Hoermann B, Köhn M., Free PMC Article | 02/5/2022 |
| Programmed cell death 10 promotes metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma via PP2Ac-mediated YAP activation. | Programmed cell death 10 promotes metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma via PP2Ac-mediated YAP activation.
Sun B, Zhong FJ, Xu C, Li YM, Zhao YR, Cao MM, Yang LY., Free PMC Article | 01/29/2022 |
| PP-1beta and PP-2Aalpha modulate cAMP response element-binding protein (CREB) functions in aging control and stress response through de-regulation of alphaB-crystallin gene and p300-p53 signaling axis. | PP-1β and PP-2Aα modulate cAMP response element-binding protein (CREB) functions in aging control and stress response through de-regulation of αB-crystallin gene and p300-p53 signaling axis.
Wang L, Zhang L, Gong XD, Fu JL, Gan YW, Hou M, Nie Q, Xiang JW, Xiao Y, Wang Y, Zheng SY, Yang L, Chen H, Xiang MQ, Liu Y, Li DW., Free PMC Article | 01/29/2022 |
| SIK2 represses AKT/GSK3beta/beta-catenin signaling and suppresses gastric cancer by inhibiting autophagic degradation of protein phosphatases. | SIK2 represses AKT/GSK3β/β-catenin signaling and suppresses gastric cancer by inhibiting autophagic degradation of protein phosphatases.
Dai XM, Zhang YH, Lin XH, Huang XX, Zhang Y, Xue CR, Chen WN, Ye JX, Lin XJ, Lin X., Free PMC Article | 11/22/2021 |
| Quantitative kinase and phosphatase profiling reveal that CDK1 phosphorylates PP2Ac to promote mitotic entry. | Quantitative kinase and phosphatase profiling reveal that CDK1 phosphorylates PP2Ac to promote mitotic entry.
Nasa I, Cressey LE, Kruse T, Hertz EPT, Gui J, Graves LM, Nilsson J, Kettenbach AN., Free PMC Article | 10/30/2021 |
| Mechanisms of Systolic Cardiac Dysfunction in PP2A, PP5 and PP2AxPP5 Double Transgenic Mice. | Mechanisms of Systolic Cardiac Dysfunction in PP2A, PP5 and PP2AxPP5 Double Transgenic Mice.
Dörner MF, Boknik P, Köpp F, Buchwalow IB, Neumann J, Gergs U., Free PMC Article | 10/30/2021 |
| Inhibiting PP2Acalpha Promotes the Malignant Phenotype of Gastric Cancer Cells through the ATM/METTL3 Axis. | Inhibiting PP2Acα Promotes the Malignant Phenotype of Gastric Cancer Cells through the ATM/METTL3 Axis.
Cheng Z, Gao S, Liang X, Lian C, Chen J, Fang C., Free PMC Article | 10/23/2021 |
| High-glucose-induced apoptosis, ROS production and pro-inflammatory response in cardiomyocytes is attenuated by metformin treatment via PP2A activation. | High-glucose-induced apoptosis, ROS production and pro-inflammatory response in cardiomyocytes is attenuated by metformin treatment via PP2A activation.
Cheng G, Li L. | 08/14/2021 |
| Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination. | Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination.
Huang KL, Jee D, Stein CB, Elrod ND, Henriques T, Mascibroda LG, Baillat D, Russell WK, Adelman K, Wagner EJ., Free PMC Article | 10/31/2020 |
| Antibodies recognizing the C terminus of PP2A catalytic subunit are unsuitable for evaluating PP2A activity and holoenzyme composition. | Antibodies recognizing the C terminus of PP2A catalytic subunit are unsuitable for evaluating PP2A activity and holoenzyme composition.
Frohner IE, Mudrak I, Kronlachner S, Schüchner S, Ogris E. | 10/24/2020 |
| Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A. | Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A.
Hoermann B, Kokot T, Helm D, Heinzlmeir S, Chojnacki JE, Schubert T, Ludwig C, Berteotti A, Kurzawa N, Kuster B, Savitski MM, Köhn M., Free PMC Article | 09/19/2020 |
| AKT Regulates Mitotic Progression of Mammalian Cells by Phosphorylating MASTL, Leading to Protein Phosphatase 2A Inactivation. | AKT Regulates Mitotic Progression of Mammalian Cells by Phosphorylating MASTL, Leading to Protein Phosphatase 2A Inactivation.
Reshi I, Nisa MU, Farooq U, Gillani SQ, Bhat SA, Sarwar Z, Nabi N, Fazili KM, Andrabi S., Free PMC Article | 08/15/2020 |
| PP2A is involved in apoptotic induction of hepatocytes after brain death by specific suppression of Akt. | PP2Ac upregulates PI3K-Akt signaling and induces hepatocyte apoptosis in liver donor after brain death.
Xiong Y, Lan J, Huang K, Zhang Y, Zheng L, Wang Y, Ye Q., Free PMC Article | 08/12/2020 |
| High PP2A expression is associated with diffuse intrinsic pontine gliomas. | DECIPHER pooled shRNA library screen identifies PP2A and FGFR signaling as potential therapeutic targets for diffuse intrinsic pontine gliomas.
Schramm K, Iskar M, Statz B, Jäger N, Haag D, Słabicki M, Pfister SM, Zapatka M, Gronych J, Jones DTW, Lichter P., Free PMC Article | 08/12/2020 |
| Hydrogen peroxide (H2O2) inhibits protein phosphatase 2 A activity during mitosis. | Inhibition of PP2A activity by H(2)O(2) during mitosis disrupts nuclear envelope reassembly and alters nuclear shape.
Ahn JH, Cho MG, Sohn S, Lee JH., Free PMC Article | 06/27/2020 |
| These results suggest that miR-650/PPP2CA axis could be modulated to interfere with motile ability of thyroid carcinoma cells | miR-650 promotes motility of anaplastic thyroid cancer cells by targeting PPP2CA.
Orlandella FM, Mariniello RM, Iervolino PLC, Imperlini E, Mandola A, Verde A, De Stefano AE, Pane K, Franzese M, Esposito S, Basolo F, Orrù S, Salvatore G. | 06/6/2020 |
| Ca2+-activated Cl- channels encoded by the Tmem16a gene are regulated by calmodulin-dependent protein kinase II (CaMKII) and protein phosphatases 1 (PP1) and 2A (PP2A). | Molecular mechanism of TMEM16A regulation: role of CaMKII and PP1/PP2A.
Ayon RJ, Hawn MB, Aoun J, Wiwchar M, Forrest AS, Cunningham F, Singer CA, Valencik ML, Greenwood IA, Leblanc N., Free PMC Article | 04/11/2020 |
| These data demonstrate that LB-100 is a catalytic inhibitor of both PP2AC and PPP5C and suggest that the observed antitumor activity might be due to an additive effect achieved by suppressing both PP2A and PPP5C. | The Antitumor Drug LB-100 Is a Catalytic Inhibitor of Protein Phosphatase 2A (PPP2CA) and 5 (PPP5C) Coordinating with the Active-Site Catalytic Metals in PPP5C.
D'Arcy BM, Swingle MR, Papke CM, Abney KA, Bouska ES, Prakash A, Honkanen RE., Free PMC Article | 03/14/2020 |