| PRMT6 facilitates EZH2 protein stability by inhibiting TRAF6-mediated ubiquitination degradation to promote glioblastoma cell invasion and migration. | PRMT6 facilitates EZH2 protein stability by inhibiting TRAF6-mediated ubiquitination degradation to promote glioblastoma cell invasion and migration.
Wang J, Shen S, You J, Wang Z, Li Y, Chen Y, Tuo Y, Chen D, Yu H, Zhang J, Wang F, Pang X, Xiao Z, Lan Q, Wang Y., Free PMC Article | 08/23/2024 |
| PRMT6 Promotes the Immune Evasion of Gastric Cancer by Upregulating ANXA1. | PRMT6 Promotes the Immune Evasion of Gastric Cancer by Upregulating ANXA1.
Xu L, Zhang F, Yu B, Jia S, Fan S. | 06/14/2024 |
| PRMT6 methylation of STAT3 regulates tumor metastasis in breast cancer. | PRMT6 methylation of STAT3 regulates tumor metastasis in breast cancer.
Chen Q, Hu Q, Chen Y, Shen N, Zhang N, Li A, Li L, Li J., Free PMC Article | 10/11/2023 |
| PRMT6-CDC20 facilitates glioblastoma progression via the degradation of CDKN1B. | PRMT6-CDC20 facilitates glioblastoma progression via the degradation of CDKN1B.
Wang J, Xiao Z, Li P, Wu C, Li Y, Wang Q, Chen Y, Zhou H, Li Z, Wang Z, Lan Q, Wang Y., Free PMC Article | 04/7/2023 |
| MiR-141-3p promotes malignant progression in prostate cancer through AlkB homolog 5-mediated m[6]A modification of protein arginine methyltransferase 6. | MiR-141-3p promotes malignant progression in prostate cancer through AlkB homolog 5-mediated m(6)A modification of protein arginine methyltransferase 6.
Li X, Liu B, Wang S, Li J, Ge X. | 02/24/2023 |
| PRMT6 functionally associates with PRMT5 to promote colorectal cancer progression through epigenetically repressing the expression of CDKN2B and CCNG1. | PRMT6 functionally associates with PRMT5 to promote colorectal cancer progression through epigenetically repressing the expression of CDKN2B and CCNG1.
Chen Y, Liang W, Du J, Ma J, Liang R, Tao M. | 01/14/2023 |
| Arginine Methylation of Integrin Alpha-4 Prevents Fibrosis Development in Alcohol-Associated Liver Disease. | Arginine Methylation of Integrin Alpha-4 Prevents Fibrosis Development in Alcohol-Associated Liver Disease.
Schonfeld M, Villar MT, Artigues A, Weinman SA, Tikhanovich I., Free PMC Article | 12/31/2022 |
| Huntingtin-mediated axonal transport requires arginine methylation by PRMT6. | Huntingtin-mediated axonal transport requires arginine methylation by PRMT6.
Migazzi A, Scaramuzzino C, Anderson EN, Tripathy D, Hernández IH, Grant RA, Roccuzzo M, Tosatto L, Virlogeux A, Zuccato C, Caricasole A, Ratovitski T, Ross CA, Pandey UB, Lucas JJ, Saudou F, Pennuto M, Basso M., Free PMC Article | 02/19/2022 |
| Systematic investigation of PRMT6 substrate recognition reveals broad specificity with a preference for an RG motif or basic and bulky residues. | Systematic investigation of PRMT6 substrate recognition reveals broad specificity with a preference for an RG motif or basic and bulky residues.
Hamey JJ, Rakow S, Bouchard C, Senst JM, Kolb P, Bauer UM, Wilkins MR, Hart-Smith G. | 10/16/2021 |
| PRMT6 deficiency induces autophagy in hostile microenvironments of hepatocellular carcinoma tumors by regulating BAG5-associated HSC70 stability. | PRMT6 deficiency induces autophagy in hostile microenvironments of hepatocellular carcinoma tumors by regulating BAG5-associated HSC70 stability.
Che N, Ng KY, Wong TL, Tong M, Kau PW, Chan LH, Lee TK, Huen MS, Yun JP, Ma S. | 08/7/2021 |
| PRMT6 serves an oncogenic role in lung adenocarcinoma via regulating p18. | PRMT6 serves an oncogenic role in lung adenocarcinoma via regulating p18.
Tang J, Meng Q, Shi R, Xu Y., Free PMC Article | 05/1/2021 |
| CRAF Methylation by PRMT6 Regulates Aerobic Glycolysis-Driven Hepatocarcinogenesis via ERK-Dependent PKM2 Nuclear Relocalization and Activation. | CRAF Methylation by PRMT6 Regulates Aerobic Glycolysis-Driven Hepatocarcinogenesis via ERK-Dependent PKM2 Nuclear Relocalization and Activation.
Wong TL, Ng KY, Tan KV, Chan LH, Zhou L, Che N, Hoo RLC, Lee TK, Richard S, Lo CM, Man K, Khong PL, Ma S. | 04/17/2021 |
| PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells. | PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells.
Huang T, Yang Y, Song X, Wan X, Wu B, Sastry N, Horbinski CM, Zeng C, Tiek D, Goenka A, Liu F, Brennan CW, Kessler JA, Stupp R, Nakano I, Sulman EP, Nishikawa R, James CD, Zhang W, Xu W, Hu B, Cheng SY., Free PMC Article | 04/3/2021 |
| SCF-FBXO24 regulates cell proliferation by mediating ubiquitination and degradation of PRMT6. | SCF-FBXO24 regulates cell proliferation by mediating ubiquitination and degradation of PRMT6.
Chen W, Gao D, Xie L, Wang A, Zhao H, Guo C, Sun Y, Nie Y, Hong A, Xiong S. | 02/27/2021 |
| PRMT6 Promotes Lung Tumor Progression via the Alternate Activation of Tumor-Associated Macrophages. | PRMT6 Promotes Lung Tumor Progression via the Alternate Activation of Tumor-Associated Macrophages.
Avasarala S, Wu PY, Khan SQ, Yanlin S, Van Scoyk M, Bao J, Di Lorenzo A, David O, Bedford MT, Gupta V, Winn RA, Bikkavilli RK., Free PMC Article | 11/21/2020 |
| PRMT6 promotes endometrial cancer via AKT/mTOR signaling and indicates poor prognosis. | PRMT6 promotes endometrial cancer via AKT/mTOR signaling and indicates poor prognosis.
Jiang N, Li QL, Pan W, Li J, Zhang MF, Cao T, Su SG, Shen H. | 10/31/2020 |
| asymmetric dimethylation at Arg2 on histone H3 (H3R2me2a) by protein arginine methyltransferase 6 (PRMT6) recruits the chromosomal passenger complex to chromosome arms and facilitates histone H3S10 phosphorylation by Aurora B for chromosome condensation. | PRMT6-mediated H3R2me2a guides Aurora B to chromosome arms for proper chromosome segregation.
Kim S, Kim NH, Park JE, Hwang JW, Myung N, Hwang KT, Kim YA, Jang CY, Kim YK., Free PMC Article | 04/18/2020 |
| we found that a small molecule inhibitor of the arginine methyltransferases CARM1 and PRMT6 was able to increase, in a gene specific manner, the number of active alleles/cell before and after hormonal stimulation, suggesting that mechanisms do indeed exist to modulate hormone receptor responses at the single cell and allele level. | Estrogen-induced transcription at individual alleles is independent of receptor level and active conformation but can be modulated by coactivators activity.
Stossi F, Dandekar RD, Mancini MG, Gu G, Fuqua SAW, Nardone A, De Angelis C, Fu X, Schiff R, Bedford MT, Xu W, Johansson HE, Stephan CC, Mancini MA., Free PMC Article | 04/4/2020 |
| Loss of PRMT6 Causes Hepatocellular Carcinoma. | PRMT6 Regulates RAS/RAF Binding and MEK/ERK-Mediated Cancer Stemness Activities in Hepatocellular Carcinoma through CRAF Methylation.
Chan LH, Zhou L, Ng KY, Wong TL, Lee TK, Sharma R, Loong JH, Ching YP, Yuan YF, Xie D, Lo CM, Man K, Artegiani B, Clevers H, Yan HH, Leung SY, Richard S, Guan XY, Huen MSY, Ma S. | 12/14/2019 |
| H3R2me2as is a strong prognostic indicator of gastric cancer (GC) patients, and PRMT6-overexpressing GC cells may acquire invasiveness through direct transcriptional inhibition of PCDH7 by increasing H3R2me2as level. | Asymmetric dimethylation at histone H3 arginine 2 by PRMT6 in gastric cancer progression.
Okuno K, Akiyama Y, Shimada S, Nakagawa M, Tanioka T, Inokuchi M, Yamaoka S, Kojima K, Tanaka S. | 11/9/2019 |
| Loss of PPARalpha from the intestine promotes colon carcinogenesis by increasing DNMT1/PRMT6-mediated DNA methylation. | Intestinal PPARα Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
Luo Y, Xie C, Brocker CN, Fan J, Wu X, Feng L, Wang Q, Zhao J, Lu D, Tandon M, Cam M, Krausz KW, Liu W, Gonzalez FJ., Free PMC Article | 09/28/2019 |
| Our data reveal that PRMT6 plays a role in the control of erythroid/megakaryocytic differentiation and open up the possibility that manipulation of PRMT6 activity could facilitate enhanced erythropoiesis for therapeutic use. | Protein arginine methyltransferase 6 controls erythroid gene expression and differentiation of human CD34(+) progenitor cells.
Herkt SC, Kuvardina ON, Herglotz J, Schneider L, Meyer A, Pommerenke C, Salinas-Riester G, Seifried E, Bonig H, Lausen J., Free PMC Article | 07/27/2019 |
| PRMT6 is physically associated with PTEN, promotes asymmetrical dimethylation of PTEN, and regulates the PI3K-AKT cascade through PTEN R159 methylation. | PTEN arginine methylation by PRMT6 suppresses PI3K-AKT signaling and modulates pre-mRNA splicing.
Feng J, Dang Y, Zhang W, Zhao X, Zhang C, Hou Z, Jin Y, McNutt MA, Marks AR, Yin Y., Free PMC Article | 05/25/2019 |
| This study indicated that the hypomethylation of PRMT6 promoter could be a novel diagnostic biomarker for colorectal cancer. | Significant association of PRMT6 hypomethylation with colorectal cancer.
Pan R, Yu H, Dai J, Zhou C, Ying X, Zhong J, Zhao J, Zhang Y, Wu B, Mao Y, Wu D, Ying J, Duan S., Free PMC Article | 12/22/2018 |
| PRMT6 negatively regulates DNA methylation in cancer. PRMT6 overexpression impairs chromatin association of UHRF1, an accessory factor of DNMT1, resulting in passive DNA demethylation. | The Arginine Methyltransferase PRMT6 Regulates DNA Methylation and Contributes to Global DNA Hypomethylation in Cancer.
Veland N, Hardikar S, Zhong Y, Gayatri S, Dan J, Strahl BD, Rothbart SB, Bedford MT, Chen T., Free PMC Article | 07/21/2018 |