| Longitudinal profiling identifies co-occurring BRCA1/2 reversions, TP53BP1, RIF1 and PAXIP1 mutations in PARP inhibitor-resistant advanced breast cancer. | Longitudinal profiling identifies co-occurring BRCA1/2 reversions, TP53BP1, RIF1 and PAXIP1 mutations in PARP inhibitor-resistant advanced breast cancer.
Harvey-Jones E, Raghunandan M, Robbez-Masson L, Magraner-Pardo L, Alaguthurai T, Yablonovitch A, Yen J, Xiao H, Brough R, Frankum J, Song F, Yeung J, Savy T, Gulati A, Alexander J, Kemp H, Starling C, Konde A, Marlow R, Cheang M, Proszek P, Hubank M, Cai M, Trendell J, Lu R, Liccardo R, Ravindran N, Llop-Guevara A, Rodriguez O, Balmana J, Lukashchuk N, Dorschner M, Drusbosky L, Roxanis I, Serra V, Haider S, Pettitt SJ, Lord CJ, Tutt ANJ. | 04/15/2024 |
| Shedding Light on the Interaction Between Rif1 and Telomeres in Ovarian Cancer. | Shedding Light on the Interaction Between Rif1 and Telomeres in Ovarian Cancer.
Kordowitzki P, Graczyk S, Mechsner S, Sehouli J., Free PMC Article | 03/8/2024 |
| RIF1 suppresses the formation of single-stranded ultrafine anaphase bridges via protein phosphatase 1. | RIF1 suppresses the formation of single-stranded ultrafine anaphase bridges via protein phosphatase 1.
Kong N, Liu Z, Chan YW. | 10/5/2023 |
| MiR-30a-5p Enhances Cisplatin Sensitivity by Downregulating RIF1 in Ovarian Cancer. | MiR-30a-5p Enhances Cisplatin Sensitivity by Downregulating RIF1 in Ovarian Cancer.
Yao W, Wang Y, Huang M, Zhou J, Zheng R, Jin C, Zhang Y. | 07/17/2023 |
| Histone chaperone ASF1 acts with RIF1 to promote DNA end joining in BRCA1-deficient cells. | Histone chaperone ASF1 acts with RIF1 to promote DNA end joining in BRCA1-deficient cells.
Tang M, Chen Z, Wang C, Feng X, Lee N, Huang M, Zhang H, Li S, Xiong Y, Chen J., Free PMC Article | 07/2/2022 |
| Rif1-Dependent Control of Replication Timing. | Rif1-Dependent Control of Replication Timing.
Richards L, Das S, Nordman JT., Free PMC Article | 04/23/2022 |
| RIF1-ASF1-mediated high-order chromatin structure safeguards genome integrity. | RIF1-ASF1-mediated high-order chromatin structure safeguards genome integrity.
Feng S, Ma S, Li K, Gao S, Ning S, Shang J, Guo R, Chen Y, Blumenfeld B, Simon I, Li Q, Guo R, Xu D., Free PMC Article | 03/5/2022 |
| CXCR4 and RIF1 overexpression induces resistance of epithelial ovarian cancer to cisplatin-based chemotherapy. | CXCR4 and RIF1 overexpression induces resistance of epithelial ovarian cancer to cisplatin-based chemotherapy.
Sad LMAE, Mohamed DA, Elanwar NM, Elkady A. | 02/26/2022 |
| Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action. | Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action.
Isobe SY, Hiraga SI, Nagao K, Sasanuma H, Donaldson AD, Obuse C., Free PMC Article | 02/12/2022 |
| RIF1 Links Replication Timing with Fork Reactivation and DNA Double-Strand Break Repair. | RIF1 Links Replication Timing with Fork Reactivation and DNA Double-Strand Break Repair.
Blasiak J, Szczepańska J, Sobczuk A, Fila M, Pawlowska E., Free PMC Article | 01/15/2022 |
| Variants in NEB and RIF1 genes on chr2q23 are associated with skeletal muscle index in Koreans: genome-wide association study. | Variants in NEB and RIF1 genes on chr2q23 are associated with skeletal muscle index in Koreans: genome-wide association study.
Yoon KJ, Yi Y, Do JG, Kim HL, Lee YT, Kim HN., Free PMC Article | 09/18/2021 |
| Replication timing maintains the global epigenetic state in human cells. | Replication timing maintains the global epigenetic state in human cells.
Klein KN, Zhao PA, Lyu X, Sasaki T, Bartlett DA, Singh AM, Tasan I, Zhang M, Watts LP, Hiraga SI, Natsume T, Zhou X, Baslan T, Leung D, Kanemaki MT, Donaldson AD, Zhao H, Dalton S, Corces VG, Gilbert DM., Free PMC Article | 05/8/2021 |
| The RIF1-long splice variant promotes G1 phase 53BP1 nuclear bodies to protect against replication stress. | The RIF1-long splice variant promotes G1 phase 53BP1 nuclear bodies to protect against replication stress.
Watts LP, Natsume T, Saito Y, Garzon J, Dong Q, Boteva L, Gilbert N, Kanemaki MT, Hiraga SI, Donaldson AD., Free PMC Article | 03/20/2021 |
| we identified RIF1 as the critical effector of 53BP1. Inhibiting 53BP1 recruitment to damaged chromatin completely abolished the survival advantage after multifractionated irradiation and could not be reversed by suppressing excessive end resection. | 53BP1/RIF1 signaling promotes cell survival after multifractionated radiotherapy.
Eke I, Zong D, Aryankalayil MJ, Sandfort V, Bylicky MA, Rath BH, Graves EE, Nussenzweig A, Coleman CN., Free PMC Article | 03/21/2020 |
| 53BP1 and RIF1 assemble a higher-order structure in the vicinity of damaged chromatin to protect it from unscheduled DNA-end resection. | 53BP1-RIF1: sculpting the DNA repair focus in 3D.
Ghodke I, Soutoglou E. | 02/29/2020 |
| the differential H4K20 methylation status between pre-replicative and post-replicative DNA represents an intrinsic mechanism that locally ensures appropriate recruitment of the 53BP1-RIF1-MAD2L2 complex at DNA double strand breaks. | H4K20me2 distinguishes pre-replicative from post-replicative chromatin to appropriately direct DNA repair pathway choice by 53BP1-RIF1-MAD2L2.
Simonetta M, de Krijger I, Serrat J, Moatti N, Fortunato D, Hoekman L, Bleijerveld OB, Altelaar AFM, Jacobs JJL., Free PMC Article | 09/7/2019 |
| Study reported that RIF1 is SUMOlyated in response to DNA damage and identified PIAS4 as the primary SUMO E3 ligase required for the SUMOylation of RIF1 protein. Mammalian cells compromised of PIAS4 expression, show impaired RIF1 SUMOylation and defective for the disassembly of DNA damage responsive RIF1 foci. | Dynamics of RIF1 SUMOylation is regulated by PIAS4 in the maintenance of Genomic Stability.
Kumar R, Cheok CF., Free PMC Article | 07/20/2019 |
| RIF1 expression is upregulated in EOC tissues and is closely correlated with FIGO stage and prognosis of EOC patients. Functionally, RIF1 knockdown suppressed the expression and promoter activity of hTERT and consequently inhibited the growth and CSC-like traits of EOC cells. | RIF1 promotes human epithelial ovarian cancer growth and progression via activating human telomerase reverse transcriptase expression.
Liu YB, Mei Y, Long J, Zhang Y, Hu DL, Zhou HH., Free PMC Article | 03/30/2019 |
| data suggest that CST-Polalpha-mediated fill-in helps to control the repair of double-strand breaks by 53BP1, RIF1 and shieldin | 53BP1-RIF1-shieldin counteracts DSB resection through CST- and Polα-dependent fill-in.
Mirman Z, Lottersberger F, Takai H, Kibe T, Gong Y, Takai K, Bianchi A, Zimmermann M, Durocher D, de Lange T., Free PMC Article | 01/19/2019 |
| Low Rap1-interacting factor 1 expression is associated with Hodgkin lymphoma. | Low Rap1-interacting factor 1 and sirtuin 6 expression predict poor outcome in radiotherapy-treated Hodgkin lymphoma patients.
Bur H, Haapasaari KM, Turpeenniemi-Hujanen T, Kuittinen O, Auvinen P, Marin K, Soini Y, Karihtala P. | 01/12/2019 |
| Upregulation of RIF1 correlates with poor prognosis in Epithelial Ovarian Cancer. | Downregulation of RIF1 Enhances Sensitivity to Platinum-Based Chemotherapy in Epithelial Ovarian Cancer (EOC) by Regulating Nucleotide Excision Repair (NER) Pathway.
Liu YB, Mei Y, Tian ZW, Long J, Luo CH, Zhou HH. | 08/4/2018 |
| Data suggest that SCAI inhibits RIF1 function to allow BRCA1-mediated repair, which possibly includes alt-NHEJ and resection-dependent NHEJ in G1, as well as HDR in S/G2. | Inhibition of RIF1 by SCAI Allows BRCA1-Mediated Repair.
Isobe SY, Nagao K, Nozaki N, Kimura H, Obuse C. | 04/7/2018 |
| 53BP1/RIF1 has a role in limiting BRCA1/CtIP-mediated end resection to control double strand break repair pathway choice | Impaired 53BP1/RIF1 DSB mediated end-protection stimulates CtIP-dependent end resection and switches the repair to PARP1-dependent end joining in G1.
Bakr A, Köcher S, Volquardsen J, Petersen C, Borgmann K, Dikomey E, Rothkamm K, Mansour WY., Free PMC Article | 02/24/2018 |
| Rif1 can mediate MCM dephosphorylation at replication forks and that the stability of dephosphorylated replisomes strongly depends on Chk1 activity. | Reversal of DDK-Mediated MCM Phosphorylation by Rif1-PP1 Regulates Replication Initiation and Replisome Stability Independently of ATR/Chk1.
Alver RC, Chadha GS, Gillespie PJ, Blow JJ., Free PMC Article | 12/2/2017 |
| DDX1, a RNA helicase also implicated in DSB repair, interacts with RIF1. Recruitment of DDX1 to DSBs is dependent on RIF1. DDX1 and RIF1 have different nucleic acid requirements for accumulation at DSBs, with RNA-DNA hybrids required for DDX1 accrual at DSBs, and single-strand RNA required for accumulation of RIF1 at these sites. | Role for RIF1-interacting partner DDX1 in BLM recruitment to DNA double-strand breaks.
Li L, Poon HY, Hildebrandt MR, Monckton EA, Germain DR, Fahlman RP, Godbout R. | 08/12/2017 |