| Bidirectional Transcription at the PPP2R2B Gene Locus in Spinocerebellar Ataxia Type 12. | Bidirectional Transcription at the PPP2R2B Gene Locus in Spinocerebellar Ataxia Type 12.
Zhou C, Liu HB, Jahanbakhsh F, Deng L, Wu B, Ying M, Margolis RL, Li PP., | 04/15/2024 |
| Comprehensive analysis of mitochondria-related genes indicates that PPP2R2B is a novel biomarker and promotes the progression of bladder cancer via Wnt signaling pathway. | Comprehensive analysis of mitochondria-related genes indicates that PPP2R2B is a novel biomarker and promotes the progression of bladder cancer via Wnt signaling pathway.
Shen D, Kang S., Free PMC Article | 02/29/2024 |
| Systematic screening identifies a 2-gene signature as a high-potential prognostic marker of undifferentiated pleomorphic sarcoma/myxofibrosarcoma. | Systematic screening identifies a 2-gene signature as a high-potential prognostic marker of undifferentiated pleomorphic sarcoma/myxofibrosarcoma.
Hu Q, Zhou S, Hu X, Zhang H, Huang S, Wang Y., Free PMC Article | 05/8/2021 |
| EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy. | EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy.
Bao Y, Oguz G, Lee WC, Lee PL, Ghosh K, Li J, Wang P, Lobie PE, Ehmsen S, Ditzel HJ, Wong A, Tan EY, Lee SC, Yu Q., Free PMC Article | 12/5/2020 |
| Transcriptional regulation of PPP2R2B (B55ss), a molecule necessary for the termination of the immune response, in patients with autoimmune diseases. PPP2R2B hypermethylation causes acquired apoptosis deficiency in systemic autoimmune diseases. | PPP2R2B hypermethylation causes acquired apoptosis deficiency in systemic autoimmune diseases.
Madera-Salcedo IK, Sánchez-Hernández BE, Svyryd Y, Esquivel-Velázquez M, Rodríguez-Rodríguez N, Trejo-Zambrano MI, García-González HB, Hernández-Molina G, Mutchinick OM, Alcocer-Varela J, Rosetti F, Crispín JC., Free PMC Article | 07/25/2020 |
| CDK1-counteracting phosphatases PP1 and PP2A-B55, together with Aurora and Polo kinases, contribute to the temporal regulation and order of events in the different stages of mitotic exit from anaphase to cytokinesis. (Review) | Getting out of mitosis: spatial and temporal control of mitotic exit and cytokinesis by PP1 and PP2A.
Holder J, Poser E, Barr FA. | 06/20/2020 |
| Dephosphorylation and total levels of beta-catenin were dependent on PR55beta in an adenoid cystic carcinoma tumor cell line. | Regulation of β-Catenin Phosphorylation by PR55β in Adenoid Cystic Carcinoma.
Ishibashi K, Ishii K, Sugiyama G, Kamata YU, Suzuki A, Kumamaru W, Ohyama Y, Nakano H, Kiyoshima T, Sumida T, Yamada T, Mori Y., Free PMC Article | 07/14/2018 |
| New pathogenic threshold of PPP2R2B CAG-43 to be pathogenic for SCA12 diagnosis. | Clinical behaviour of spinocerebellar ataxia type 12 and intermediate length abnormal CAG repeats in PPP2R2B.
Srivastava AK, Takkar A, Garg A, Faruq M. | 06/10/2017 |
| CAG triplet repeat expansion has been found in untranslated region of SCA12 gene in Indian spinocerebellar ataxia 12 patients. | Exploration of CAG triplet repeat in nontranslated region of SCA12 gene.
Lone WG, Khan IA, Poornima S, Shaik NA, Meena AK, Prabhakar Rao K, Hasan Q. | 04/1/2017 |
| Thus, Fcp1 coordinates Cdk1 and Gwl inactivation to derepress PP2A-B55, generating a dephosphorylation switch that drives mitosis progression. | Fcp1 phosphatase controls Greatwall kinase to promote PP2A-B55 activation and mitotic progression.
Della Monica R, Visconti R, Cervone N, Serpico AF, Grieco D., Free PMC Article | 08/27/2016 |
| investigated CAG copies within PPP2R2B in 29 patients with spinocerebellar ataxia who are excluded from the most common subtypes; 3 patients carried 53, 46 and 54 CAG repeats respectively, while the other 26 cases harbored CAG repeats less than 30 | Identification of 46 CAG repeats within PPP2R2B as probably the shortest pathogenic allele for SCA12.
Dong Y, Wu JJ, Wu ZY. | 01/16/2016 |
| IER5 functions as a positive feedback regulator of HSF1 and that this process involves PP2A/B55 and HSF1 dephosphorylation. | HSF1 transcriptional activity is modulated by IER5 and PP2A/B55.
Ishikawa Y, Kawabata S, Sakurai H. | 07/4/2015 |
| Bcl-2 phosphorylation at Ser70 by selective tyrosine nitration of PP2A-B56delta stabilizes its antiapoptotic activity | Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of PP2A-B56δ stabilizes its antiapoptotic activity.
Low IC, Loh T, Huang Y, Virshup DM, Pervaiz S. | 12/6/2014 |
| Inactivation of protein-phosphatase 2A causing hyperphosphorylation of paraprotein targets in monoclonal gammopathy of undetermined significance, multiple myeloma and Waldenstrom's macroglobulinemia is due to an exchange of its regulatory subunits | Inactivation of protein-phosphatase 2A causing hyperphosphorylation of autoantigenic paraprotein targets in MGUS/MM is due to an exchange of its regulatory subunits.
Preuss KD, Fadle N, Regitz E, Held G, Pfreundschuh M. | 10/25/2014 |
| Identification of the adenovirus E4orf4 protein binding site on the B55alpha and Cdc55 regulatory subunits of PP2A: Implications for PP2A | Identification of the adenovirus E4orf4 protein binding site on the B55α and Cdc55 regulatory subunits of PP2A: Implications for PP2A function, tumor cell killing and viral replication.
Mui MZ, Kucharski M, Miron MJ, Hur WS, Berghuis AM, Blanchette P, Branton PE., Free PMC Article | 06/28/2014 |
| We demonstrate that PP2A/B55 is required for Gwl dephosphorylation at the essential Cdk site Thr194. Ensa/ARPP19 dephosphorylation is mediated by the RNA | PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit.
Hégarat N, Vesely C, Vinod PK, Ocasio C, Peter N, Gannon J, Oliver AW, Novák B, Hochegger H., Free PMC Article | 06/21/2014 |
| PP2A-B55beta promotes cyclin E1 overexpression by antagonizing its degradation and its inhibition could represent a therapeutic mechanism for abrogating cyclin E1 function in cancers | PP2A-B55β antagonizes cyclin E1 proteolysis and promotes its dysregulation in cancer.
Tan Y, Sun D, Jiang W, Klotz-Noack K, Vashisht AA, Wohlschlegel J, Widschwendter M, Spruck C., Free PMC Article | 06/14/2014 |
| Bod1 regulates protein phosphatase 2A at mitotic kinetochores. | Bod1 regulates protein phosphatase 2A at mitotic kinetochores.
Porter IM, Schleicher K, Porter M, Swedlow JR., Free PMC Article | 06/14/2014 |
| Differential autophagic neuronal cell death under stress is determined by the cytoplasmic and mitochondrial-specific PPP2R2B isoforms. | Differential autophagic cell death under stress with ectopic cytoplasmic and mitochondrial-specific PPP2R2B in human neuroblastoma cells.
Fang K, Li HF, Hsieh CH, Li DY, Song DC, Cheng WT, Guo ZX. | 11/16/2013 |
| Single nucleotide polymorphisms in PPP2R2B is associated with drug response in breast cancer. | Germline variation in TP53 regulatory network genes associates with breast cancer survival and treatment outcome.
Jamshidi M, Schmidt MK, Dörk T, Garcia-Closas M, Heikkinen T, Cornelissen S, van den Broek AJ, Schürmann P, Meyer A, Park-Simon TW, Figueroa J, Sherman M, Lissowska J, Keong GT, Irwanto A, Laakso M, Hautaniemi S, Aittomäki K, Blomqvist C, Liu J, Nevanlinna H., Free PMC Article | 05/11/2013 |
| Data indicate that PPP2R2B gene product PP2A/Bbeta2 activates the mitochondrial fission enzyme dynamin-related protein 1 (Drp1) by dephosphorylating Ser656. | N-terminal phosphorylation of protein phosphatase 2A/Bβ2 regulates translocation to mitochondria, dynamin-related protein 1 dephosphorylation, and neuronal survival.
Merrill RA, Slupe AM, Strack S., Free PMC Article | 04/13/2013 |
| This study suggested that PPP2R2B CAG expansion mutation might lead increase induction of Spinocerebellar ataxia type 12. | Spinocerebellar ataxia type 12.
O'Hearn E, Holmes SE, Margolis RL. | 12/10/2011 |
| defective production of PP2A Bbeta upon IL-2 deprivation results in apoptosis resistance and longer survival of autoreactive T cells, in a subset of SLE patients | Induction of PP2A Bβ, a regulator of IL-2 deprivation-induced T-cell apoptosis, is deficient in systemic lupus erythematosus.
Crispín JC, Apostolidis SA, Finnell MI, Tsokos GC., Free PMC Article | 10/8/2011 |
| oxidative stress induced by mitochondrial dysfunction causes elevated expression of ppp2r2b and plays a causal role in SCA12; and reduction of ROS is a potential therapeutic intervention for this neuropathy | Mitochondrial dysfunction and oxidative stress contribute to the pathogenesis of spinocerebellar ataxia type 12 (SCA12).
Wang YC, Lee CM, Lee LC, Tung LC, Hsieh-Li HM, Lee-Chen GJ, Su MT., Free PMC Article | 09/3/2011 |
| results indicate that the A variant of the rs319217 SNP of the PPP2R2B gene is a marker of better prognosis in breast cancer | A genetic variant in a PP2A regulatory subunit encoded by the PPP2R2B gene associates with altered breast cancer risk and recurrence.
Vazquez A, Kulkarni D, Grochola LF, Bond GL, Barnard N, Toppmeyer D, Levine AJ, Hirshfield KM., Free PMC Article | 05/28/2011 |