| Transcriptional Up-Regulation of FBXW7 by KCa1.1 K[+] Channel Inhibition through the Nrf2 Signaling Pathway in Human Prostate Cancer LNCaP Cell Spheroid Model. | Transcriptional Up-Regulation of FBXW7 by K(Ca)1.1 K(+) Channel Inhibition through the Nrf2 Signaling Pathway in Human Prostate Cancer LNCaP Cell Spheroid Model.
Ohya S, Kito H, Kajikuri J, Yamaguchi Y, Matsui M., Free PMC Article | 07/3/2024 |
| The SCF-FBW7beta E3 ligase mediates ubiquitination and degradation of the serine/threonine protein kinase PINK1. | The SCF-FBW7β E3 ligase mediates ubiquitination and degradation of the serine/threonine protein kinase PINK1.
Jeon SJ, Chung KC., Free PMC Article | 05/24/2024 |
| Epidermal growth factor receptor (EGFR) is a target of the tumor-suppressor E3 ligase FBXW7. | Epidermal growth factor receptor (EGFR) is a target of the tumor-suppressor E3 ligase FBXW7.
Boretto M, Geurts MH, Gandhi S, Ma Z, Staliarova N, Celotti M, Lim S, He GW, Millen R, Driehuis E, Begthel H, Smabers L, Roodhart J, van Es J, Wu W, Clevers H., Free PMC Article | 03/19/2024 |
| ASPM stabilizes the NOTCH intracellular domain 1 and promotes oncogenesis by blocking FBXW7 binding in hepatocellular carcinoma cells. | ASPM stabilizes the NOTCH intracellular domain 1 and promotes oncogenesis by blocking FBXW7 binding in hepatocellular carcinoma cells.
Chan TS, Cheng LH, Hsu CC, Yang PM, Liao TY, Hsieh HY, Lin PC, HuangFu WC, Chuu CP, Tsai KK., Free PMC Article | 03/13/2024 |
| FBXW7 polymorphism asserts susceptibility to colorectal cancer. | FBXW7 polymorphism asserts susceptibility to colorectal cancer.
Uroog L, Zeya B, Imtiyaz K, Ahmad Wani R, Moshahid Alam Rizvi M. | 02/7/2024 |
| Fbxw7 suppresses carcinogenesis and stemness in triple-negative breast cancer through CHD4 degradation and Wnt/beta-catenin pathway inhibition. | Fbxw7 suppresses carcinogenesis and stemness in triple-negative breast cancer through CHD4 degradation and Wnt/β-catenin pathway inhibition.
Xiao G, Lu W, Yuan J, Liu Z, Wang P, Fan H., Free PMC Article | 02/6/2024 |
| FBXW7 inhibits the progression of ESCC by directly inhibiting the stemness of tumor cells. | FBXW7 inhibits the progression of ESCC by directly inhibiting the stemness of tumor cells.
Bi Y, Yang Y, Zhang Y, Cheng C, Tang P, Xiao H, Yuan F, Wu W, Yang B. | 02/2/2024 |
| FBXW7-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe. | FBXW7-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe.
O'Brien S, Ubhi T, Wolf L, Gandhi K, Lin S, Chaudary N, Dhani NC, Milosevic M, Brown GW, Angers S., Free PMC Article | 01/3/2024 |
| FBXW7 affects autophagy through MCL1 in oral squamous cell carcinoma. | FBXW7 affects autophagy through MCL1 in oral squamous cell carcinoma.
Sun Y, Nie W, Qiu B, Yang Q, Zhao H. | 12/15/2023 |
| E3-ubiquitin ligase, FBXW7 regulates mitotic progression by targeting BubR1 for ubiquitin-mediated degradation. | E3-ubiquitin ligase, FBXW7 regulates mitotic progression by targeting BubR1 for ubiquitin-mediated degradation.
Nair VM, Sabu AS, Hussain A, Kombarakkaran DP, Lakshmi RB, Manna TK., Free PMC Article | 11/30/2023 |
| The Highs and Lows of FBXW7: New Insights into Substrate Affinity in Disease and Development. | The Highs and Lows of FBXW7: New Insights into Substrate Affinity in Disease and Development.
de la Cova CC., Free PMC Article | 09/22/2023 |
| FBXW7 Enhances Cisplatin-Induced Apoptosis in Oral Cancer Cell Lines. | FBXW7 Enhances Cisplatin-Induced Apoptosis in Oral Cancer Cell Lines.
Yang Q, Sun Y, Qiu B, Zhao H., Free PMC Article | 09/19/2023 |
| FBXW7 in breast cancer: mechanism of action and therapeutic potential. | FBXW7 in breast cancer: mechanism of action and therapeutic potential.
Chen S, Leng P, Guo J, Zhou H., Free PMC Article | 09/7/2023 |
| The Role of FBXW7 in Gynecologic Malignancies. | The Role of FBXW7 in Gynecologic Malignancies.
Di Fiore R, Suleiman S, Drago-Ferrante R, Subbannayya Y, Suleiman S, Vasileva-Slaveva M, Yordanov A, Pentimalli F, Giordano A, Calleja-Agius J., Free PMC Article | 07/12/2023 |
| Enhancement of TKI sensitivity in lung adenocarcinoma through m6A-dependent translational repression of Wnt signaling by circ-FBXW7. | Enhancement of TKI sensitivity in lung adenocarcinoma through m6A-dependent translational repression of Wnt signaling by circ-FBXW7.
Li K, Peng ZY, Wang R, Li X, Du N, Liu DP, Zhang J, Zhang YF, Ma L, Sun Y, Tang SC, Ren H, Yang YP, Sun X., Free PMC Article | 07/3/2023 |
| Epigenetic status of FBXW7 gene and its role in Ovarian cancer pathogenesis. | Epigenetic status of FBXW7 gene and its role in Ovarian cancer pathogenesis.
Al Hinai M, Malgundkar SH, Gupta I, Lakhtakia R, Al Kalbani M, Burney I, Al Moundhri M, Okamoto A, Tamimi Y., Free PMC Article | 06/2/2023 |
| FBXW7 promotes autophagy and inhibits proliferation of oral squamous cell carcinoma. | FBXW7 promotes autophagy and inhibits proliferation of oral squamous cell carcinoma.
Qiu B, Sun Y, Nie W, Yang Q, Guo X., Free PMC Article | 05/31/2023 |
| FBXW7beta loss-of-function enhances FASN-mediated lipogenesis and promotes colorectal cancer growth. | FBXW7β loss-of-function enhances FASN-mediated lipogenesis and promotes colorectal cancer growth.
Wei W, Qin B, Wen W, Zhang B, Luo H, Wang Y, Xu H, Xie X, Liu S, Jiang X, Wang M, Tang Q, Zhang J, Yang R, Fan Z, Lyu H, Lin J, Li K, Lee MH., Free PMC Article | 05/23/2023 |
| Different miRNAs Related to FBXW7 Mutations or High Mitotic Indices Contribute to Rectal Neuroendocrine Tumors: A Pilot Study. | Different miRNAs Related to FBXW7 Mutations or High Mitotic Indices Contribute to Rectal Neuroendocrine Tumors: A Pilot Study.
Kang HS, Park HY, Lim H, Son IT, Kim MJ, Kim NY, Kim MJ, Nam ES, Cho SJ, Kwon MJ., Free PMC Article | 04/14/2023 |
| Molecular mechanism of FBXW7-mediated ubiquitination modification in nasopharyngeal carcinoma cell proliferation in vitro and in vivo. | Molecular mechanism of FBXW7-mediated ubiquitination modification in nasopharyngeal carcinoma cell proliferation in vitro and in vivo.
Zhong Q, Wang Z, Kang H, Wu R. | 04/12/2023 |
| FBXW7beta isoform drives transcriptional activation of the proinflammatory TNF cluster in human pro-B cells. | FBXW7β isoform drives transcriptional activation of the proinflammatory TNF cluster in human pro-B cells.
Yang SY, Hayer KE, Fazelinia H, Spruce LA, Asnani M, Black KL, Naqvi AS, Pillai V, Barash Y, Elenitoba-Johnson KSJ, Thomas-Tikhonenko A., Free PMC Article | 04/6/2023 |
| FBXW7 loss of function promotes esophageal squamous cell carcinoma progression via elevating MAP4 and ERK phosphorylation. | FBXW7 loss of function promotes esophageal squamous cell carcinoma progression via elevating MAP4 and ERK phosphorylation.
Pan Y, Liu J, Gao Y, Guo Y, Wang C, Liang Z, Wu M, Qian Y, Li Y, Shen J, Lu C, Ma S., Free PMC Article | 04/6/2023 |
| FBXW7 tumor suppressor regulation by dualspecificity tyrosine-regulated kinase 2. | FBXW7 tumor suppressor regulation by dualspecificity tyrosine-regulated kinase 2.
Jiménez-Izquierdo R, Morrugares R, Suanes-Cobos L, Correa-Sáez A, Garrido-Rodríguez M, Cerero-Tejero L, Khan OM, de la Luna S, Sancho R, Calzado MA., Free PMC Article | 03/24/2023 |
| Pan-cancer analysis of FBXW family with potential implications in prognosis and immune infiltration. | Pan-cancer analysis of FBXW family with potential implications in prognosis and immune infiltration.
Huang T, OuYang X, Li J, Shi B, Shan Z, Shi Z, Yang Z., Free PMC Article | 01/14/2023 |
| The SCF-FBXW7 E3 ubiquitin ligase triggers degradation of histone 3 lysine 4 methyltransferase complex component WDR5 to prevent mitotic slippage. | The SCF-FBXW7 E3 ubiquitin ligase triggers degradation of histone 3 lysine 4 methyltransferase complex component WDR5 to prevent mitotic slippage.
Hänle-Kreidler S, Richter KT, Hoffmann I., Free PMC Article | 01/7/2023 |