| PPP3CB overexpression mediates EGFR TKI resistance in lung tumors via calcineurin/MEK/ERK signaling. | PPP3CB overexpression mediates EGFR TKI resistance in lung tumors via calcineurin/MEK/ERK signaling.
Gazzeri S, Zubchuk N, Montaudon E, Nemati F, Huot-Marchand S, Berardi G, Pucciarelli A, Dib Y, Nerini D, Oddou C, Pezet M, David-Boudet L, Ardin C, de Fraipont F, Maraver A, Girard N, Decaudin D, Toffart AC, Eymin B., Free PMC Article | 10/8/2024 |
| High PPP3CB expression is associated with neuroblastoma. | PPP3CB contributes to poor prognosis through activating nuclear factor of activated T-cells signaling in neuroblastoma.
Shakhova I, Li Y, Yu F, Kaneko Y, Nakamura Y, Ohira M, Izumi H, Mae T, Varfolomeeva SR, Rumyantsev AG, Nakagawara A. | 07/13/2019 |
| Study demonstrates that PPP3CB overexpression inhibits EMT and migration of G401 kidney cell line and promotes tumor proliferation. Depletion of PPP3CB leads to acquisition of a mesenchymal state, thus enhancing cell migration. | PPP3CB Inhibits Migration of G401 Cells via Regulating Epithelial-to-Mesenchymal Transition and Promotes G401 Cells Growth.
Chen L, He Q, Liu Y, Wu Y, Ni D, Liu J, Hu Y, Gu Y, Xie Y, Zhou Q, Li Q., Free PMC Article | 05/4/2019 |
| The mRNA expressions of PPP3CB and MEF2C were significantly up-regulated, and CAMK1 and PPP3R1 were significantly down-regulated in mitral regurgitation(MR) patients compared to normal subjects. Moreover, MR patients had significantly increased mRNA levels of PPP3CB, MEF2C and PLCE1 compared to aortic valve disease patients | Exploring Regulatory Mechanisms of Atrial Myocyte Hypertrophy of Mitral Regurgitation through Gene Expression Profiling Analysis: Role of NFAT in Cardiac Hypertrophy.
Chang TH, Chen MC, Chang JP, Huang HD, Ho WC, Lin YS, Pan KL, Huang YK, Liu WH, Wu CC., Free PMC Article | 07/1/2017 |
| These findings therefore provide initial support for the novel mechanistic hypothesis that oxidation-induced global and/or local conformational changes within calcineurin | Oxidation-induced conformational changes in calcineurin determined by covalent labeling and tandem mass spectrometry.
Zhou X, Mester C, Stemmer PM, Reid GE., Free PMC Article | 01/3/2015 |
| lower expression of PPP3CA and PPP3CB genes in atrium myocardium can be related to expressed postinfarction LV remodeling. | [Expression profile of calcineurin pathway genes in myocardium tissues in relation to ischemic heart remodeling in humans].
Polovlkova OG, Makeeva OA, Lezhnev AA, Goncharova IA, Kulish EV, Shipulin VM, Puzyrev VP. | 08/31/2013 |
| Present findings indicate that downregulation of hemoxygenase-1 expression in neutrophils from hypertensive subjects is likely mediated by CN, which acts by hindering translocation to the nucleus of the transcription factor NRF2. | Calcineurin expression and activity is regulated by the intracellular redox status and under hypertension in human neutrophils.
Alba G, Santa-María C, Reyes-Quiroz ME, El Bekay R, Geniz I, Martín-Nieto J, Pintado E, Sobrino F. | 12/22/2012 |
| The C allele of protein phosphatase 3 subunit alpha rs3804358 polymorphism was overrepresented in athletes compared with controls, whereas the T allele of protein phosphatase 3 subunit beta rs3763679 polymorphism was underrepresented in athletes. | Are calcineurin genes associated with athletic status? A function, replication study.
He ZH, Hu Y, Li YC, Yvert T, Santiago C, Gómez-Gallego F, Ruiz JR, Lucia A. | 12/3/2011 |
| ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes are potential candidate genes for schizophrenia, especially in patients with deficits in sustained attention and executive function. | ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes at chromosome 10q22 associated with the subgroup of schizophrenia with deficits in attention and executive function.
Liu CM, Fann CS, Chen CY, Liu YL, Oyang YJ, Yang WC, Chang CC, Wen CC, Chen WJ, Hwang TJ, Hsieh MH, Liu CC, Faraone SV, Tsuang MT, Hwu HG. | 10/29/2011 |
| The expression of a constitutively active Calcineurin stimulates myoblast differentiation, whereas a Calcineurin antisense has the opposite effect. | P43-dependent mitochondrial activity regulates myoblast differentiation and slow myosin isoform expression by control of Calcineurin expression.
Seyer P, Grandemange S, Rochard P, Busson M, Pessemesse L, Casas F, Cabello G, Wrutniak-Cabello C. | 09/24/2011 |
| A novel-splicing variant of calcineurin Ass CnAss-FK, which is encoded by an intron-retaining mRNA and is deficient in the autoinhibitory domain, is predominantly expressed in mature follicular keratinocytes. | Expression of a constitutively active calcineurin encoded by an intron-retaining mRNA in follicular keratinocytes.
Fujimura A, Michiue H, Nishiki T, Ohmori I, Wei FY, Matsui H, Tomizawa K., Free PMC Article | 07/9/2011 |
| two new complementary roles for calcineurin in the regulation of the early UPR (Unfolded Protein Responses) | Calcineurin interacts with PERK and dephosphorylates calnexin to relieve ER stress in mammals and frogs.
Bollo M, Paredes RM, Holstein D, Zheleznova N, Camacho P, Lechleiter JD., Free PMC Article | 11/6/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | See all PubMed (2) articlesUsing genetic and clinical factors to predict tacrolimus dose in renal transplant recipients.
Wang P, Mao Y, Razo J, Zhou X, Wong ST, Patel S, Elliott E, Shea E, Wu AH, Gaber AO. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators. | 09/15/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Polymorphisms in the calcineurin genes are associated with the training responsiveness of cardiac phenotypes in Chinese young adults.
He ZH, Hu Y, Li YC, Bao DP, Ruiz JR, Lucia A. | 09/15/2010 |
| [review] The nuclear localization sequence, a region spanning amino acids 172-183 of calcineurin A beta, is essential for recognition and shuttling of calcineurin into the nucleus by importin beta. | Inhibition of the calcineurin-NFAT signalling cascade in the treatment of heart failure.
Panther F, Williams T, Ritter O. | 08/9/2010 |
| Observational study and genome-wide association study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Biological pathway-based genome-wide association analysis identified the vasoactive intestinal peptide (VIP) pathway important for obesity.
Liu YJ, Guo YF, Zhang LS, Pei YF, Yu N, Yu P, Papasian CJ, Deng HW., Free PMC Article | 06/30/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesAre calcineurin genes associated with endurance phenotype traits?
He ZH, Hu Y, Wang HY, Li YC, Lu YL, Zhang L, Bao BP, Ruiz JR, Lucia A. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. | 04/7/2010 |
| calcineurin can dephosphorylate GSK-3beta at Ser-9 and form a stable complex with GSK-3beta, suggesting the possibility that calcineurin regulates the dephosphorylation and activation of GSK-3betain vivo | Calcineurin dephosphorylates glycogen synthase kinase-3 beta at serine-9 in neuroblast-derived cells.
Kim Y, Lee YI, Seo M, Kim SY, Lee JE, Youn HD, Kim YS, Juhnn YS. | 01/21/2010 |
| Study demonstrates that all CaN isoforms display the same cytoplasmic subcellular distribution and are expressed in each tested cell line, differences in substrate specificities may determine specific physiological functions of the distinct isoforms. | The proline-rich N-terminal sequence of calcineurin Abeta determines substrate binding.
Kilka S, Erdmann F, Migdoll A, Fischer G, Weiwad M. | 01/21/2010 |
| calcineurin is inhibited by cyclosporine A, which then exerts multiple effects on human melanoma cell lines HT168 and WM35 | Inhibition of calcineurin by cyclosporine A exerts multiple effects on human melanoma cell lines HT168 and WM35.
Juhász T, Matta C, Veress G, Nagy G, Szíjgyártó Z, Molnár Z, Fodor J, Zákány R, Gergely P. | 01/21/2010 |
| TAK1-TAB1-TAB2 selectively induces calcineurin-NFAT signalling through direct phosphorylation of RCAN1, while calcineurin activation diminishes TAK1 signalling by dephosphorylation of TAK1 and TAB1. | Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signalling nodal control point.
Liu Q, Busby JC, Molkentin JD., Free PMC Article | 01/21/2010 |
| We describe a case of Calcineurin inhibitor-mediated bilateral hippocampal injury after bone marrow transplantation. | Calcineurin inhibitor-mediated bilateral hippocampal injury after bone marrow transplantation.
Lee SH, Kim BC, Yang DH, Park MS, Choi SM, Kim MK, Cho KH. | 01/21/2010 |
| Data show that the calcineurin pathway is activated in hypertrophic myocardium as demonstrated by increased calcineurin activity and expression of calcineurin A-beta and B, and GATA-4, and a shift of cytoplasmic NFAT-3 into the nucleus. | Activation of the calcineurin/NFAT signalling cascade starts early in human hypertrophic myocardium.
Diedrichs H, Hagemeister J, Chi M, Boelck B, Müller-Ehmsen J, Schneider CA. | 01/21/2010 |
| depressed NCX activity might contribute to the etiology of in vivo cardiac hypertrophy and dysfunction occurring under conditions in which both calcineurin and protein kinase C are chronically activated | Calcineurin inhibits Na+/Ca2+ exchange in phenylephrine-treated hypertrophic cardiomyocytes.
Katanosaka Y, Iwata Y, Kobayashi Y, Shibasaki F, Wakabayashi S, Shigekawa M. | 01/21/2010 |
| Calcineurin A beta expression is an additional means of regulating calcineurin activity in the heart. | Regulation of calcineurin through transcriptional induction of the calcineurin A beta promoter in vitro and in vivo.
Oka T, Dai YS, Molkentin JD., Free PMC Article | 01/21/2010 |