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    TRPV6 transient receptor potential cation channel subfamily V member 6 [ Homo sapiens (human) ]

    Gene ID: 55503, updated on 28-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    An overlooked African gene variant linked to the calcium selective channel TRPV6: A mini-review.

    An overlooked African gene variant linked to the calcium selective channel TRPV6: A mini-review.
    Hilliard CB.

    06/9/2023
    The Coexistence of TRPV6 Variants With Other Pancreatitis-Associated Genes Affects Pediatric-Onset Pancreatitis.

    The Coexistence of TRPV6 Variants With Other Pancreatitis-Associated Genes Affects Pediatric-Onset Pancreatitis.
    Hirai S, Suzuki M, Sakurai Y, Nakano S, Minowa K, Eguchi H, Okazaki Y, Shimizu T.

    03/27/2023
    Biochemistry and pathophysiology of the Transient Potential Receptor Vanilloid 6 (TRPV6) calcium channel.

    Biochemistry and pathophysiology of the Transient Potential Receptor Vanilloid 6 (TRPV6) calcium channel.
    Walker V, Vuister GW.

    03/7/2023
    Vital but vulnerable: Human TRPV6 is a trade-off of powerful Ca(2+) uptake and susceptibility to epithelial barrier dysfunction.

    Vital but vulnerable: Human TRPV6 is a trade-off of powerful Ca(2+) uptake and susceptibility to epithelial barrier dysfunction.
    Mori Y, Omori M, Nakao A.

    10/29/2022
    TRPV6 Regulation by Cis-22a and Cholesterol.

    TRPV6 Regulation by Cis-22a and Cholesterol.
    Humer C, Lindinger S, Carrel AL, Romanin C, Höglinger C., Free PMC Article

    07/2/2022
    TRPV6 channel mediates alcohol-induced gut barrier dysfunction and systemic response.

    TRPV6 channel mediates alcohol-induced gut barrier dysfunction and systemic response.
    Meena AS, Shukla PK, Bell B, Giorgianni F, Caires R, Fernández-Peña C, Beranova S, Aihara E, Montrose MH, Chaib M, Makowski L, Neeli I, Radic MZ, Vásquez V, Jaggar JH, Cordero-Morales JF, Rao R., Free PMC Article

    07/2/2022
    Functionally deficient TRPV6 variants contribute to hereditary and familial chronic pancreatitis.

    Functionally deficient TRPV6 variants contribute to hereditary and familial chronic pancreatitis.
    Hamada S, Masson E, Chen JM, Sakaguchi R, Rebours V, Buscail L, Matsumoto R, Tanaka Y, Kikuta K, Kataoka F, Sasaki A, Le Rhun M, Audin H, Lachaux A, Caumont B, Lorenzo D, Billiemaz K, Besnard R, Koch S, Lamireau T, De Koninck X, GREPAN (Genetic REsearch on PANcreatitis) Study Group, Génin E, Cooper DN, Mori Y, Masamune A, Férec C.

    05/7/2022
    Down-regulation of TRPV6 Is Associated With Adverse Prognosis in Hepatocellular Carcinoma Treated With Curative Resection.

    Down-regulation of TRPV6 Is Associated With Adverse Prognosis in Hepatocellular Carcinoma Treated With Curative Resection.
    Koh HH, Choi S, Park CK, Ha SY., Free PMC Article

    03/19/2022
    Loss of function TRPV6 variants are associated with chronic pancreatitis in nonalcoholic early-onset Polish and German patients.

    Loss of function TRPV6 variants are associated with chronic pancreatitis in nonalcoholic early-onset Polish and German patients.
    Oracz G, Zaród M, Ewers M, Laumen H, Gambin T, Kamiński P, Grabowska I, Drożak A, Kwiatkowski S, Wertheim-Tysarowska K, Kołodziejczyk E, Domaszewicz A, Dorożko B, Kosińska J, Głuszek S, Kozieł D, Płoski R, Rosendahl J, Witt H, Drożak J, Rygiel AM.

    03/5/2022
    Calcium selective channel TRPV6: Structure, function, and implications in health and disease.

    Calcium selective channel TRPV6: Structure, function, and implications in health and disease.
    Khattar V, Wang L, Peng JB., Free PMC Article

    02/26/2022
    Mutations That Affect the Surface Expression of TRPV6 Are Associated with the Upregulation of Serine Proteases in the Placenta of an Infant.

    Mutations That Affect the Surface Expression of TRPV6 Are Associated with the Upregulation of Serine Proteases in the Placenta of an Infant.
    Fecher-Trost C, Wolske K, Wesely C, Löhr H, Klawitter DS, Weissgerber P, Gradhand E, Burren CP, Mason AE, Winter M, Wissenbach U., Free PMC Article

    02/5/2022
    RNA interference mediated suppression of TRPV6 inhibits the progression of prostate cancer in vitro by modulating cathepsin B and MMP9 expression.

    RNA interference mediated suppression of TRPV6 inhibits the progression of prostate cancer in vitro by modulating cathepsin B and MMP9 expression.
    Kim DY, Kim SH, Yang EK., Free PMC Article

    02/5/2022
    Colorectal Cancer-Derived CAT1-Positive Extracellular Vesicles Alter Nitric Oxide Metabolism in Endothelial Cells and Promote Angiogenesis.

    Colorectal Cancer-Derived CAT1-Positive Extracellular Vesicles Alter Nitric Oxide Metabolism in Endothelial Cells and Promote Angiogenesis.
    Ikeda A, Nagayama S, Sumazaki M, Konishi M, Fujii R, Saichi N, Muraoka S, Saigusa D, Shimada H, Sakai Y, Ueda K.

    01/29/2022
    Calcium channel TRPV6 promotes breast cancer metastasis by NFATC2IP.

    Calcium channel TRPV6 promotes breast cancer metastasis by NFATC2IP.
    Xu X, Li N, Wang Y, Yu J, Mi J.

    01/8/2022
    Roles of Ion Fluxes, Metabolism, and Redox Balance in Cancer Therapy.

    Roles of Ion Fluxes, Metabolism, and Redox Balance in Cancer Therapy.
    Lai HL, Fan XX, Li RZ, Wang YW, Zhang J, Liu L, Neher E, Yao XJ, Leung EL.

    01/8/2022
    Germline Mutation of PLCD1 Contributes to Human Multiple Pilomatricomas through Protein Kinase D/Extracellular Signal-Regulated Kinase1/2 Cascade and TRPV6.

    Germline Mutation of PLCD1 Contributes to Human Multiple Pilomatricomas through Protein Kinase D/Extracellular Signal-Regulated Kinase1/2 Cascade and TRPV6.
    Liu K, Luo J, Ma T, Fang M, Xu Z, Wang L, Zhang XY, Wen J, Liu C, Cao Y, Li X, Zhang L, Guo A, Wang N, Yi P, Liu JY.

    12/25/2021
    Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole.

    Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole.
    Neuberger A, Nadezhdin KD, Sobolevsky AI., Free PMC Article

    12/25/2021
    Human TRPV6-pathies caused by gene mutations.

    Human TRPV6-pathies caused by gene mutations.
    Nett V, Erhardt N, Wyatt A, Wissenbach U.

    11/13/2021
    TRPV6 variants confer susceptibility to chronic pancreatitis in the Chinese population.

    TRPV6 variants confer susceptibility to chronic pancreatitis in the Chinese population.
    Zou WB, Wang YC, Ren XL, Wang L, Deng SJ, Mao XT, Li ZS, Liao Z.

    11/13/2021
    Why endogenous TRPV6 currents are not detectable-what can we learn from bats?

    Why endogenous TRPV6 currents are not detectable-what can we learn from bats?
    Wolske K, Fecher-Trost C, Wesely C, Löhr H, Philipp S, Belkacemi A, Pacheco G, Wissenbach U.

    09/25/2021
    TRPV6 Is Associated with Prognosis of ST-Elevation Acute Myocardial Infarction.

    TRPV6 Is Associated with Prognosis of ST-Elevation Acute Myocardial Infarction.
    Zhang H, Ding P, Zheng L.

    06/12/2021
    Novel TRPV6 mutations in the spectrum of transient neonatal hyperparathyroidism.

    Novel TRPV6 mutations in the spectrum of transient neonatal hyperparathyroidism.
    Suzuki Y, Sawada H, Tokumasu T, Suzuki S, Ninomiya S, Shirai M, Mukai T, Saito CT, Nishimura G, Tominaga M., Free PMC Article

    05/22/2021
    TRPV6 calcium channel directs homeostasis of the mammary epithelial sheets and controls epithelial mesenchymal transition.

    TRPV6 calcium channel directs homeostasis of the mammary epithelial sheets and controls epithelial mesenchymal transition.
    Kärki T, Rajakylä EK, Acheva A, Tojkander S., Free PMC Article

    03/13/2021
    Variants That Affect Function of Calcium Channel TRPV6 Are Associated With Early-Onset Chronic Pancreatitis.

    Variants That Affect Function of Calcium Channel TRPV6 Are Associated With Early-Onset Chronic Pancreatitis.
    Masamune A, Kotani H, Sörgel FL, Chen JM, Hamada S, Sakaguchi R, Masson E, Nakano E, Kakuta Y, Niihori T, Funayama R, Shirota M, Hirano T, Kawamoto T, Hosokoshi A, Kume K, Unger L, Ewers M, Laumen H, Bugert P, Mori MX, Tsvilovskyy V, Weißgerber P, Kriebs U, Fecher-Trost C, Freichel M, Diakopoulos KN, Berninger A, Lesina M, Ishii K, Itoi T, Ikeura T, Okazaki K, Kaune T, Rosendahl J, Nagasaki M, Uezono Y, Algül H, Nakayama K, Matsubara Y, Aoki Y, Férec C, Mori Y, Witt H, Shimosegawa T.

    10/24/2020
    The ZFHX3 plays an important role in intracellular calcium homeostasis in mammary epithelial cells, at least in part, by regulating TRPV6.

    Transcription factor ZFHX3 regulates calcium influx in mammary epithelial cells in part via the TRPV6 calcium channel.
    Zhao D, Han X, Huang L, Wang J, Zhang X, Jeon JH, Zhao Q, Dong JT.

    07/4/2020
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