| PRIM2: A Marker of MYC-driven Hyper-proliferation, Disease Progression, Tumor Aggressiveness and Poor Survival in Glioma Patients. | PRIM2: A Marker of MYC-driven Hyper-proliferation, Disease Progression, Tumor Aggressiveness and Poor Survival in Glioma Patients.
Sun R, Shao X, Akter F, Zahid KR, Yao S, Ma L, Xu G., Free PMC Article | 03/5/2024 |
| Genetic variants of CHEK1, PRIM2 and CDK6 in the mitotic phase-related pathway are associated with nonsmall cell lung cancer survival. | Genetic variants of CHEK1, PRIM2 and CDK6 in the mitotic phase-related pathway are associated with nonsmall cell lung cancer survival.
Mu R, Liu H, Luo S, Patz EF Jr, Glass C, Su L, Du M, Christiani DC, Jin L, Wei Q., Free PMC Article | 09/18/2021 |
| Study results show that although human DNA primase C-terminal domain (p58C) can be stabilized in different conformations in the crystalline state, in solution there is effectively no difference in the structure and functional properties of p58C constructs of different lengths. | Functional and structural similarity of human DNA primase [4Fe4S] cluster domain constructs.
Holt ME, Salay LE, O'Brien E, Barton JK, Chazin WJ., Free PMC Article | 06/1/2019 |
| Data suggest that PRIM1-p58,C-terminal domain stays bound to initiating NTP and 3prime-overhang DNA during whole cycle of RNA primer synthesis; meanwhile, PRIM1-p49 slides along DNA template toward 5prime-end with PRIM1-p58,N-terminal domain attached. | Insight into the Human DNA Primase Interaction with Template-Primer.
Baranovskiy AG, Zhang Y, Suwa Y, Gu J, Babayeva ND, Pavlov YI, Tahirov TH., Free PMC Article | 08/6/2016 |
| Data indicate that the conformational changes in primase are necessary to accomplish the initiation and then elongation of RNA synthesis. | Crystal structure of the human primase.
Baranovskiy AG, Zhang Y, Suwa Y, Babayeva ND, Gu J, Pavlov YI, Tahirov TH., Free PMC Article | 05/16/2015 |
| the N-terminal domain of the large subunit of primase (p58N) directly interacts with the C-terminal domain of the catalytic subunit of polalpha (p180C) | The C-terminal domain of the DNA polymerase catalytic subunit regulates the primase and polymerase activities of the human DNA polymerase α-primase complex.
Zhang Y, Baranovskiy AG, Tahirov TH, Pavlov YI., Free PMC Article | 02/21/2015 |
| PRIM2 gene is not imprinted in the placenta. | Lack of genomic imprinting of DNA primase, polypeptide 2 (PRIM2) in human term placenta and white blood cells.
Chung J, Tsai S, James AH, Thames BH, Shytle S, Piedrahita JA., Free PMC Article | 10/13/2012 |
| The fragment that forms a beta-sheet in the reported structure p58C/3L9Q of the same human primase domain is folded in three alpha-helices in our p58C/3Q36 structure, similarly to yeast primase. | Crystal structure of the C-terminal domain of human DNA primase large subunit: implications for the mechanism of the primase-polymerase α switch.
Agarkar VB, Babayeva ND, Pavlov YI, Tahirov TH., Free PMC Article | 08/27/2011 |
| p58C(C-terminal regulatory domain of the large subunit) structure reveals a novel arrangement of an evolutionarily conserved 4Fe-4S cluster buried deeply within the protein core and is not similar to any known protein structure. | Insights into eukaryotic DNA priming from the structure and functional interactions of the 4Fe-4S cluster domain of human DNA primase.
Vaithiyalingam S, Warren EM, Eichman BF, Chazin WJ., Free PMC Article | 09/13/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| analysis of the iron-sulfur cluster in the C-terminal domain of the p58 subunit of human DNA primase | An iron-sulfur cluster in the C-terminal domain of the p58 subunit of human DNA primase.
Weiner BE, Huang H, Dattilo BM, Nilges MJ, Fanning E, Chazin WJ. | 01/21/2010 |