| Hair cell alpha9alpha10 nicotinic acetylcholine receptor functional expression regulated by ligand binding and deafness gene products. | Hair cell α9α10 nicotinic acetylcholine receptor functional expression regulated by ligand binding and deafness gene products.
Gu S, Knowland D, Matta JA, O'Carroll ML, Davini WB, Dhara M, Kweon HJ, Bredt DS., Free PMC Article | 12/19/2020 |
| REVIEW: details the history and state of the field regarding the role that alpha9-containing nAChRs may play in neuropathic pain | α9-containing nicotinic acetylcholine receptors and the modulation of pain.
Hone AJ, Servent D, McIntosh JM., Free PMC Article | 08/10/2019 |
| phosphocholine inhibits ion-channel function of ATP receptor P2X7 in monocytic cells via nAChR containing alpha9 and alpha10 subunits. | Phosphocholine - an agonist of metabotropic but not of ionotropic functions of α9-containing nicotinic acetylcholine receptors.
Richter K, Mathes V, Fronius M, Althaus M, Hecker A, Krasteva-Christ G, Padberg W, Hone AJ, McIntosh JM, Zakrzewicz A, Grau V., Free PMC Article | 05/12/2018 |
| Behavioural and physiological stress-induced changes observed in alpha9-nAChR KO mice demonstrate a novel role of the alpha9alpha10-nAChR in mounting a normal stress response. The lack of functioning alpha9alpha10-nAChRs leads to negative affective changes after a relatively short period of stress. KO mice exhibited unusual patterns of circadian activity and a dysfunction in reward seeking after a period of reduced acc... | α9-nAChR knockout mice exhibit dysregulation of stress responses, affect and reward-related behaviour.
Mohammadi SA, Burton TJ, Christie MJ. | 02/10/2018 |
| Chemotherapy induced cold allodynia is reduced in alpha 9 knockout mice. | Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain.
Romero HK, Christensen SB, Di Cesare Mannelli L, Gajewiak J, Ramachandra R, Elmslie KS, Vetter DE, Ghelardini C, Iadonato SP, Mercado JL, Olivera BM, McIntosh JM., Free PMC Article | 03/22/2017 |
| The rare variants in CHRNA9 were significantly associated with smoking status. | The contribution of rare and common variants in 30 genes to risk nicotine dependence.
Yang J, Wang S, Yang Z, Hodgkinson CA, Iarikova P, Ma JZ, Payne TJ, Goldman D, Li MD., Free PMC Article | 08/6/2016 |
| Our findings support a significant interaction effect existing between the CHRNA9 gene and smoking exposure on the risk of breast cancer development. | CHRNA9 polymorphisms and smoking exposure synergize to increase the risk of breast cancer in Taiwan.
Hsieh YC, Lee CH, Tu SH, Wu CH, Hung CS, Hsieh MC, Chuang CW, Ho YS, Chiou HY. | 03/21/2015 |
| CHRNA9 polymorphisms are associated with non-small cell lung cancer. | Neuronal acetylcholine receptor subunit alpha-9 (CHRNA9) polymorphisms are associated with NSCLC risk in a Chinese population.
Wang Y, Zhang Y, Gu C, Bao W, Bao Y. | 12/20/2014 |
| Thia case-control analysis revealed that an increased risk of lung cancer is associated with two SNPs in CHRNA9, rs56159866 and rs6819385. | New associations of the genetic polymorphisms in nicotinic receptor genes with the risk of lung cancer.
Chikova A, Bernard HU, Shchepotin IB, Grando SA., Free PMC Article | 02/23/2013 |
| Data suggest that the biologic activities of Alpha9 nicotinic receptor (CHRNA9) may be regulated at the splicing level, and genetic polymorphisms in CHRNA9 affecting protein levels, amino acid sequence and RNA splicing may influence the risk for lung cancer. | Naturally occurring variants of human Α9 nicotinic receptor differentially affect bronchial cell proliferation and transformation.
Chikova A, Grando SA., Free PMC Article | 11/24/2012 |
| A two order of magnitude species difference in potency of alpha-conotoxin RgIA is reported for rat versus human alpha9alpha10 nAChR. | Molecular basis for the differential sensitivity of rat and human α9α10 nAChRs to α-conotoxin RgIA.
Azam L, McIntosh JM., Free PMC Article | 11/24/2012 |
| Estrogen receptor-alpha plays a central role in mediating alpha9-nAChR gene up-regulation in response to either nicotine or estradiol stimulation. | Crosstalk between nicotine and estrogen-induced estrogen receptor activation induces α9-nicotinic acetylcholine receptor expression in human breast cancer cells.
Lee CH, Chang YC, Chen CS, Tu SH, Wang YJ, Chen LC, Chang YJ, Wei PL, Chang HW, Chang CH, Huang CS, Wu CH, Ho YS. | 09/15/2012 |
| Significant increases in the alpha9-nAChR mRNA and protein levels in MCF-7 cells were detected 6 h after nicotine treatment. Nicotine- and estrogen-induced alpha9-nicotinic acetylcholine receptor upregulation was blocked by (-)-epigallocatechin-3-gallate. | Tea polyphenol (-)-epigallocatechin-3-gallate inhibits nicotine- and estrogen-induced α9-nicotinic acetylcholine receptor upregulation in human breast cancer cells.
Tu SH, Ku CY, Ho CT, Chen CS, Huang CS, Lee CH, Chen LC, Pan MH, Chang HW, Chang CH, Chang YJ, Wei PL, Wu CH, Ho YS. | 06/18/2011 |
| These results suggest that alpha9-nAChR-mediated cyclin D3 overexpression is important for nicotine-induced transformation of normal human breast epithelial cells. | Nicotine-induced human breast cancer cell proliferation attenuated by garcinol through down-regulation of the nicotinic receptor and cyclin D3 proteins.
Chen CS, Lee CH, Hsieh CD, Ho CT, Pan MH, Huang CS, Tu SH, Wang YJ, Chen LC, Chang YJ, Wei PL, Yang YY, Wu CH, Ho YS. | 03/26/2011 |
| The alpha9-nAChR is important for nicotine-induced transformation of normal human breast epithelial cells. Results imply that receptor-mediated carcinogenic signals play a decisive role in biological functions related to human breast cancer development. | Overexpression and activation of the alpha9-nicotinic receptor during tumorigenesis in human breast epithelial cells.
Lee CH, Huang CS, Chen CS, Tu SH, Wang YJ, Chang YJ, Tam KW, Wei PL, Cheng TC, Chu JS, Chen LC, Wu CH, Ho YS. | 10/4/2010 |
| Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.
Need AC, Keefe RS, Ge D, Grossman I, Dickson S, McEvoy JP, Goldstein DB., Free PMC Article | 02/11/2009 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function.
Rigbi A, Kanyas K, Yakir A, Greenbaum L, Pollak Y, Ben-Asher E, Lancet D, Kertzman S, Lerer B. | 03/13/2008 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (4) articlesA large-scale candidate gene association study of age at menarche and age at natural menopause.
He C, Kraft P, Chasman DI, Buring JE, Chen C, Hankinson SE, Paré G, Chanock S, Ridker PM, Hunter DJ. Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.
Saccone NL, Saccone SF, Hinrichs AL, Stitzel JA, Duan W, Pergadia ML, Agrawal A, Breslau N, Grucza RA, Hatsukami D, Johnson EO, Madden PA, Swan GE, Wang JC, Goate AM, Rice JP, Bierut LJ. No evidence for association between 19 cholinergic genes and bipolar disorder.
Shi J, Hattori E, Zou H, Badner JA, Christian SL, Gershon ES, Liu C. Why do young women smoke? I. Direct and interactive effects of environment, psychological characteristics and nicotinic cholinergic receptor genes.
Greenbaum L, Kanyas K, Karni O, Merbl Y, Olender T, Horowitz A, Yakir A, Lancet D, Ben-Asher E, Lerer B. | 03/13/2008 |
| Signaling through alpha9 AChR is critical for completion of the very early stages of epithelialization. | Central role of alpha9 acetylcholine receptor in coordinating keratinocyte adhesion and motility at the initiation of epithelialization.
Chernyavsky AI, Arredondo J, Vetter DE, Grando SA., Free PMC Article | 01/21/2010 |
| Chromosome location and characterization of the CHRNA9 gene. | Chromosome location and characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) gene.
Lustig LR, Peng H. | 01/21/2010 |
| two cis-elements of the alpha9 nicotinic receptor subunit promoter control in opposite ways the basal transcriptional activity of the gene | Transcriptional regulation by activation and repression elements located at the 5'-noncoding region of the human alpha9 nicotinic receptor subunit gene.
Valor LM, Castillo M, Ortiz JA, Criado M. | 01/21/2010 |