| OTUB1 accelerates hepatocellular carcinoma by stabilizing RACK1 via its non-canonical ubiquitination. | OTUB1 accelerates hepatocellular carcinoma by stabilizing RACK1 via its non-canonical ubiquitination.
Peng L, Wu T, Liu Y, Zhao D, He W, Yuan Y., Free PMC Article | 07/24/2024 |
| OTUB1 Targets CHK1 for Deubiquitination and Stabilization to Facilitate Lung Cancer Progression and Radioresistance. | OTUB1 Targets CHK1 for Deubiquitination and Stabilization to Facilitate Lung Cancer Progression and Radioresistance.
Wang J, Liu Y, Wu D, Tian C, Gao J, Yang Q, Hong X, Gu F, Zhang K, Hu Y, Xu S, Liu L, Zeng Y. | 07/16/2024 |
| Targeting deubiquitinase OTUB1 protects vascular smooth muscle cells in atherosclerosis by modulating PDGFRbeta. | Targeting deubiquitinase OTUB1 protects vascular smooth muscle cells in atherosclerosis by modulating PDGFRβ.
Xu F, Chen H, Zhou C, Zang T, Wang R, Shen S, Li C, Yu Y, Pei Z, Shen L, Qian J, Ge J. | 07/3/2024 |
| OTUB1 contributes to the stability and function of Influenza A virus NS2. | OTUB1 contributes to the stability and function of Influenza A virus NS2.
Li YJ, Chen CY, Kuo YS, Huang YW, Kuo RL, Chang LK, Yang JH, Lai CH, Shih SR, Chiu YF., Free PMC Article | 06/15/2024 |
| YTHDF2 protein stabilization by the deubiquitinase OTUB1 promotes prostate cancer cell proliferation via PRSS8 mRNA degradation. | YTHDF2 protein stabilization by the deubiquitinase OTUB1 promotes prostate cancer cell proliferation via PRSS8 mRNA degradation.
Zhao X, Lv S, Li N, Zou Q, Sun L, Song T., Free PMC Article | 05/8/2024 |
| Involvement of the OTUB1-YAP1 axis in driving malignant behaviors of head and neck squamous cell carcinoma. | Involvement of the OTUB1-YAP1 axis in driving malignant behaviors of head and neck squamous cell carcinoma.
Jin S, Tsunematsu T, Horiguchi T, Mouri Y, Shao W, Miyoshi K, Hagita H, Sarubo M, Fujiwara N, Qi G, Ishimaru N, Kudo Y., Free PMC Article | 01/16/2024 |
| The Interaction of OTUB1 and TRAF3 Mediates NLRP3 Inflammasome Activity to Regulate TGF-beta1-induced BEAS-2B Cell Injury. | The Interaction of OTUB1 and TRAF3 Mediates NLRP3 Inflammasome Activity to Regulate TGF-β1-induced BEAS-2B Cell Injury.
Shang L, Du Y, Zhao Y, Zhang Y, Liu C. | 11/15/2023 |
| OTUB1's role in promoting OSCC development by stabilizing RACK1 involves cell proliferation, migration, invasion, and tumor-associated macrophage M1 polarization. | OTUB1's role in promoting OSCC development by stabilizing RACK1 involves cell proliferation, migration, invasion, and tumor-associated macrophage M1 polarization.
Li Y, Li R, Qin H, He H, Li S. | 09/1/2023 |
| OTUB1 inhibits breast cancer by non-canonically stabilizing CCN6. | OTUB1 inhibits breast cancer by non-canonically stabilizing CCN6.
Zhao Y, Ruan J, Li Z, Su X, Chen K, Lin Y, Cai Y, Wang P, Liu B, Schlüter D, Liang G, Wang X., Free PMC Article | 08/30/2023 |
| SET7 methylates the deubiquitinase OTUB1 at Lys [122] to impair its binding to E2 enzyme UBC13 and relieve its suppressive role on ferroptosis. | SET7 methylates the deubiquitinase OTUB1 at Lys (122) to impair its binding to E2 enzyme UBC13 and relieve its suppressive role on ferroptosis.
Deng H, Jia S, Tang J, Rong F, Xu C, Chen X, Wang Z, Zhu C, Sun X, Liao Q, Liu W, Li W, Xiao W, Liu X., Free PMC Article | 05/1/2023 |
| OTUB1 Catalytic-Independently Deubiquitinates TGFBI and Mediates the Angiogenesis in Infantile Hemangioma by Regulating Glycolysis. | OTUB1 Catalytic-Independently Deubiquitinates TGFBI and Mediates the Angiogenesis in Infantile Hemangioma by Regulating Glycolysis.
Li M, Wang X, Yang E, Li Y, Geng Y, Chen Z, Huang S, Zhang D, Wu H. | 05/1/2023 |
| OTUB1 suppresses Hippo signaling via modulating YAP protein in gastric cancer. | OTUB1 suppresses Hippo signaling via modulating YAP protein in gastric cancer.
Yan C, Yang H, Su P, Li X, Li Z, Wang D, Zang Y, Wang T, Liu Z, Bao Z, Dong S, Zhuang T, Zhu J, Ding Y., Free PMC Article | 12/3/2022 |
| Mutant p53 driven-LINC00857, a protein scaffold between FOXM1 and deubiquitinase OTUB1, promotes the metastasis of pancreatic cancer. | Mutant p53 driven-LINC00857, a protein scaffold between FOXM1 and deubiquitinase OTUB1, promotes the metastasis of pancreatic cancer.
Zhang W, Qian W, Gu J, Gong M, Zhang W, Zhang S, Zhou C, Jiang Z, Jiang J, Han L, Wang X, Wu Z, Ma Q, Wang Z. | 11/19/2022 |
| Overexpression of OTU domain-containing ubiquitin aldehyde-binding protein 1 exacerbates colorectal cancer malignancy by inhibiting protein degradation of beta-Catenin via Ubiquitin-proteasome pathway. | Overexpression of OTU domain-containing ubiquitin aldehyde-binding protein 1 exacerbates colorectal cancer malignancy by inhibiting protein degradation of β-Catenin via Ubiquitin-proteasome pathway.
Ye D, Wang S, Wang X, Lin Y, Huang Y, Chi P., Free PMC Article | 07/9/2022 |
| OTUB1 augments hypoxia signaling via its non-canonical ubiquitination inhibition of HIF-1alpha during hypoxia adaptation. | OTUB1 augments hypoxia signaling via its non-canonical ubiquitination inhibition of HIF-1α during hypoxia adaptation.
Liu X, Deng H, Tang J, Wang Z, Zhu C, Cai X, Rong F, Chen X, Sun X, Jia S, Ouyang G, Li W, Xiao W., Free PMC Article | 07/2/2022 |
| The deubiquitinase OTUB1 fosters papillary thyroid carcinoma growth through EYA1 stabilization. | The deubiquitinase OTUB1 fosters papillary thyroid carcinoma growth through EYA1 stabilization.
Xie P, Chao Q, Mao J, Liu Y, Fang J, Xie J, Zhen J, Ding Y, Fu B, Ke Y, Huang D., Free PMC Article | 04/2/2022 |
| OTUB1 knockdown promotes apoptosis in melanoma cells by upregulating TRAIL expression. | OTUB1 knockdown promotes apoptosis in melanoma cells by upregulating TRAIL expression.
Lee BS, Kang SU, Huang M, Kim YS, Lee YS, Park JY, Kim CH., Free PMC Article | 03/19/2022 |
| The ubiquitin hydrolase OTUB1 promotes glioma cell stemness via suppressing ferroptosis through stabilizing SLC7A11 protein. | The ubiquitin hydrolase OTUB1 promotes glioma cell stemness via suppressing ferroptosis through stabilizing SLC7A11 protein.
Zhao X, Zhou M, Yang Y, Luo M., Free PMC Article | 02/19/2022 |
| Endogenous hydrogen sulfide regulates xCT stability through persulfidation of OTUB1 at cysteine 91 in colon cancer cells. | Endogenous hydrogen sulfide regulates xCT stability through persulfidation of OTUB1 at cysteine 91 in colon cancer cells.
Chen S, Bu D, Zhu J, Yue T, Guo S, Wang X, Pan Y, Liu Y, Wang P., Free PMC Article | 01/1/2022 |
| Molecular recognition and deubiquitination of cyclic K48-linked ubiquitin chains by OTUB1. | Molecular recognition and deubiquitination of cyclic K48-linked ubiquitin chains by OTUB1.
Sorada T, Morimoto D, Walinda E, Sugase K. | 09/11/2021 |
| OTUB1 stabilizes mismatch repair protein MSH2 by blocking ubiquitination. | OTUB1 stabilizes mismatch repair protein MSH2 by blocking ubiquitination.
Wu Q, Huang Y, Gu L, Chang Z, Li GM., Free PMC Article | 08/28/2021 |
| OTUB1 facilitates bladder cancer progression by stabilizing ATF6 in response to endoplasmic reticulum stress. | OTUB1 facilitates bladder cancer progression by stabilizing ATF6 in response to endoplasmic reticulum stress.
Zhang HH, Li C, Ren JW, Liu L, Du XH, Gao J, Liu T, Li SZ., Free PMC Article | 06/19/2021 |
| OTUB1 Is a Key Regulator of RIG-I-Dependent Immune Signaling and Is Targeted for Proteasomal Degradation by Influenza A NS1. | OTUB1 Is a Key Regulator of RIG-I-Dependent Immune Signaling and Is Targeted for Proteasomal Degradation by Influenza A NS1.
Jahan AS, Biquand E, Muñoz-Moreno R, Le Quang A, Mok CK, Wong HH, Teo QW, Valkenburg SA, Chin AWH, Man Poon LL, Te Velthuis A, García-Sastre A, Demeret C, Sanyal S. | 03/20/2021 |
| Activation and selectivity of OTUB-1 and OTUB-2 deubiquitinylases. | Activation and selectivity of OTUB-1 and OTUB-2 deubiquitinylases.
Sivakumar D, Kumar V, Naumann M, Stein M., Free PMC Article | 12/26/2020 |
| The Otub1 deficiency not only promotes signal-induced p100 processing and noncanonical NF-kappaB activation but also causes steady-state p100 degradation, leading to aberrant NF-kappaB activation in the canonical pathway. | Preventing abnormal NF-κB activation and autoimmunity by Otub1-mediated p100 stabilization.
Li Y, Yang JY, Xie X, Jie Z, Zhang L, Shi J, Lin D, Gu M, Zhou X, Li HS, Watowich SS, Jain A, Yun Jung S, Qin J, Cheng X, Sun SC., Free PMC Article | 09/12/2020 |