| ACAP4 physically interacts with CrkII. Functional characterization showed that the interaction is required for the recruitment of ACAP4 to the plasma membrane where ACAP4 functions to regulate the recycling of the signal transducer integrin beta1. | ACAP4 interacts with CrkII to promote the recycling of integrin β1.
Song X, Xu W, Xu G, Kong S, Ding L, Xiao J, Cao X, Wang F. | 07/18/2020 |
| ARF6 GTPase-activating protein ACAP4 regulates CCL18-elicited breast cancer cell migration via the acetyltransferase PCAF-mediated acetylation. CCL18 stimulation elicited breast cancer cell migration and invasion via PCAF-dependent acetylation. | Acetylation of ACAP4 regulates CCL18-elicited breast cancer cell migration and invasion.
Song X, Liu W, Yuan X, Jiang J, Wang W, Mullen M, Zhao X, Zhang Y, Liu F, Du S, Rehman A, Tian R, Li J, Frost A, Song Z, Green HN, Henry C, Liu X, Ding X, Wang D, Yao X., Free PMC Article | 09/21/2019 |
| MiR-143-3p acts as an anti-oncogene by downregulating ITGA6/ASAP3 protein expression and could offer new insight into potential therapeutic targets for CRC. | MicroRNA-143-3p inhibits colorectal cancer metastases by targeting ITGA6 and ASAP3.
Guo L, Fu J, Sun S, Zhu M, Zhang L, Niu H, Chen Z, Zhang Y, Guo L, Wang S., Free PMC Article | 02/16/2019 |
| Results show that ASAP3 was amplified in colorectal cancer (CRC) tissues, and its upregulation was associated with poor prognosis of patients with CRC. Also, it promoted growth of colon tumors, and accelerated cell invasion and migration through its binding to NEMO. These results suggest that ASAP3 acts as an oncogene. | Upregulation of ASAP3 contributes to colorectal carcinogenesis and indicates poor survival outcome.
Tian H, Qian J, Ai L, Li Y, Su W, Kong XM, Xu J, Fang JY., Free PMC Article | 09/30/2017 |
| The data, for the first time, link ASAP3 with ACTG1 in the regulation of cytoskeletal maintenance and cell motility | Loss of ASAP3 destabilizes cytoskeletal protein ACTG1 to suppress cancer cell migration.
Luo Y, Kong F, Wang Z, Chen D, Liu Q, Wang T, Xu R, Wang X, Yang JY. | 08/30/2014 |
| ). These data indicate that ASAP3 is elevated in NSCLC and may contribute to cancer development and patients' poor clinical outcome, which is possibly due to its critical roles in regulating cancer invasion. | ASAP3 expression in non-small cell lung cancer: association with cancer development and patients' clinical outcome.
Fan C, Tian Y, Miao Y, Lin X, Zhang X, Jiang G, Luan L, Wang E. | 05/3/2014 |
| Phosphorylation of the N-terminal region of ACAP4 (named the Bin, Amphiphysin, and RSV161/167[BAR] domain at Tyr34) is necessary for epidermal growth factor (EGF)-elicited membrane remodeling. | Phosphorylation of the Bin, Amphiphysin, and RSV161/167 (BAR) domain of ACAP4 regulates membrane tubulation.
Zhao X, Wang D, Liu X, Liu L, Song Z, Zhu T, Adams G, Gao X, Tian R, Huang Y, Chen R, Wang F, Liu D, Yu X, Chen Y, Chen Z, Teng M, Ding X, Yao X., Free PMC Article | 09/28/2013 |
| ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin beta1 recycling in cell migration | ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin β1 recycling in cell migration.
Yu X, Wang F, Liu H, Adams G, Aikhionbare F, Liu D, Cao X, Fan L, Hu G, Chen Y, Frost A, Partridge E, Ding X, Yao X., Free PMC Article | 02/25/2012 |
| The ArfGAP catalytic mechanism and shows a glutamine from Arf6 and an arginine fingerASAP3 as the important catalytic residues; unexpectedly the structure shows a calcium ion, liganded by both proteins in the complex interface. | The structure of an Arf-ArfGAP complex reveals a Ca2+ regulatory mechanism.
Ismail SA, Vetter IR, Sot B, Wittinghofer A. | 06/28/2010 |
| ASAP3 functions nonredundantly with ASAP1 to control cell movement and may have a role in cancer cell invasion. | ASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasion.
Ha VL, Bharti S, Inoue H, Vass WC, Campa F, Nie Z, de Gramont A, Ward Y, Randazzo PA., Free PMC Article | 01/21/2010 |
| ACAP4 is involved in ARF6-mediated cell migration. | Proteomic identification and functional characterization of a novel ARF6 GTPase-activating protein, ACAP4.
Fang Z, Miao Y, Ding X, Deng H, Liu S, Wang F, Zhou R, Watson C, Fu C, Hu Q, Lillard JW Jr, Powell M, Chen Y, Forte JG, Yao X. | 01/21/2010 |