| Taspase1 Facilitates Topoisomerase IIbeta-Mediated DNA Double-Strand Breaks Driving Estrogen-Induced Transcription. | Taspase1 Facilitates Topoisomerase IIβ-Mediated DNA Double-Strand Breaks Driving Estrogen-Induced Transcription.
Oelschläger L, Stahl P, Kaschani F, Stauber RH, Knauer SK, Hensel A., Free PMC Article | 02/15/2023 |
| Silencing of circTASP1 inhibits proliferation and induces apoptosis of acute myeloid leukaemia cells through modulating miR-515-5p/HMGA2 axis. | Silencing of circTASP1 inhibits proliferation and induces apoptosis of acute myeloid leukaemia cells through modulating miR-515-5p/HMGA2 axis.
Lin Y, Huang Y, Liang C, Xie S, Xie A., Free PMC Article | 02/5/2022 |
| Structural insights into the function of the catalytically active human Taspase1. | Structural insights into the function of the catalytically active human Taspase1.
Nagaratnam N, Delker SL, Jernigan R, Edwards TE, Snider J, Thifault D, Williams D, Nannenga BL, Stofega M, Sambucetti L, Hsieh JJ, Flint AJ, Fromme P, Martin-Garcia JM. | 01/15/2022 |
| TASP1 Promotes Proliferation and Migration in Gastric Cancer via EMT and AKT/P-AKT Pathway. | TASP1 Promotes Proliferation and Migration in Gastric Cancer via EMT and AKT/P-AKT Pathway.
Wan XM, Zhou XL, Du YJ, Shen H, Yang Z, Ding Y., Free PMC Article | 12/4/2021 |
| TASP1 Promotes Gallbladder Cancer Cell Proliferation and Metastasis by Up-regulating FAM49B via PI3K/AKT Pathway. | TASP1 Promotes Gallbladder Cancer Cell Proliferation and Metastasis by Up-regulating FAM49B via PI3K/AKT Pathway.
Zhang Y, Du P, Li Y, Zhu Q, Song X, Liu S, Hao J, Liu L, Liu F, Hu Y, Jiang L, Ma Q, Lu W, Liu Y., Free PMC Article | 06/12/2021 |
| TASP1 is a novel disease-related gene that is associated with a disease phenotype overlapping with Wiedemann-Steiner syndrome as both are caused by defects in the same pathway. | TASP1 is deleted in an infant with developmental delay, microcephaly, distinctive facial features, and multiple congenital anomalies.
Suleiman J, Mundt M, Sampath S, El-Hattab AW. | 10/26/2019 |
| Taspase 1 processing promotes TFIIA's nuclear accumulation by evolutionary conserved nuclear export signal (NES, amino acids 21VINDVRDIFL30) masking, and modulates its transcriptional activity. | TFIIA transcriptional activity is controlled by a 'cleave-and-run' Exportin-1/Taspase 1-switch.
Schrenk C, Fetz V, Vallet C, Heiselmayer C, Schröder E, Hensel A, Hahlbrock A, Wünsch D, Goesswein D, Bier C, Habtemichael N, Schneider G, Stauber RH, Knauer SK. | 09/14/2019 |
| Proteolytic processing of TFIIA by Taspase1 was found to mask evolutionary conserved nuclear export signal, thereby promoting nuclear localization and transcriptional activation of TFIIA target genes, such as CDKN2A. | Disease-relevant signalling-pathways in head and neck cancer: Taspase1's proteolytic activity fine-tunes TFIIA function.
Gribko A, Hahlbrock A, Strieth S, Becker S, Hagemann J, Deichelbohrer M, Hildebrandt A, Habtemichael N, Wünsch D., Free PMC Article | 07/20/2019 |
| Studies indicate that threonine Aspartase1 (Taspase1) is overexpressed in numerous liquid and solid malignancies and was characterized as a 'non-oncogene addiction' protease. | Taspase1: a 'misunderstood' protease with translational cancer relevance.
Wünsch D, Hahlbrock A, Jung S, Schirmeister T, van den Boom J, Schilling O, Knauer SK, Stauber RH. | 09/16/2017 |
| simultaneous expression of the leukemogenic AF4-MLL and dnTASP1 causes the disappearance of the leukemogenic oncoprotein, because the uncleaved AF4-MLL protein (328 kDa) is subject to proteasomal degradation. | Unraveling the Activation Mechanism of Taspase1 which Controls the Oncogenic AF4-MLL Fusion Protein.
Sabiani S, Geppert T, Engelbrecht C, Kowarz E, Schneider G, Marschalek R., Free PMC Article | 08/13/2016 |
| Our results provide first evidence that Taspase1 processing affects TFIIA regulation of TFIID and suggest that Taspase1 processing of TFIIA is required to establish INR-selective core promoter activity in the presence of NC2. | Taspase1 processing alters TFIIA cofactor properties in the regulation of TFIID.
Malecová B, Caputo VS, Lee DF, Hsieh JJ, Oelgeschläger T., Free PMC Article | 12/5/2015 |
| inefficient heterodimerization appears to be the mechanism by which inactive Taspase1 variants fail to inhibit wild type Taspase1's activity in trans. | Overexpression of the catalytically impaired Taspase1 T234V or Taspase1 D233A variants does not have a dominant negative effect in T(4;11) leukemia cells.
Bier C, Hecht R, Kunst L, Scheiding S, Wünsch D, Goesswein D, Schneider G, Krämer OH, Knauer SK, Stauber RH., Free PMC Article | 01/26/2013 |
| Taspase1 appears to exploit the nuclear export activity of importin-alpha/nucleophosmin to gain transient access to the cytoplasm required to also cleave its cytoplasmic substrates. | The importin-alpha/nucleophosmin switch controls taspase1 protease function.
Bier C, Knauer SK, Docter D, Schneider G, Krämer OH, Stauber RH. | 08/27/2011 |
| Cell-based analysis of structure-function activity of threonine aspartase 1. | Cell-based analysis of structure-function activity of threonine aspartase 1.
Bier C, Knauer SK, Klapthor A, Schweitzer A, Rekik A, Krämer OH, Marschalek R, Stauber RH., Free PMC Article | 03/5/2011 |
| Taspase1 is overexpressed in primary human cancers, and deficiency of Taspase1 in cancer cells not only disrupts proliferation but also enhances apoptosis. | Taspase1 functions as a non-oncogene addiction protease that coordinates cancer cell proliferation and apoptosis.
Chen DY, Liu H, Takeda S, Tu HC, Sasagawa S, Van Tine BA, Lu D, Cheng EH, Hsieh JJ., Free PMC Article | 08/16/2010 |
| TASP1, EPS15R, and PRPF3 expression were significantly induced in HCCs of transgenic EGF2B mice as was P2 promoter-driven HNF4alpha | EPS15R, TASP1, and PRPF3 are novel disease candidate genes targeted by HNF4alpha splice variants in hepatocellular carcinomas.
Niehof M, Borlak J. | 01/21/2010 |
| purification and cloning of threonine aspartase 1 responsible for cleaving MLL; RNAi-mediated knockdown of Taspase1 results in the appearance of unprocessed MLL and the loss of proper HOX gene expression | Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression.
Hsieh JJ, Cheng EH, Korsmeyer SJ. | 01/21/2010 |
| Transfected taspase 1 enhances cleavage of TFIIA, and RNA interference knockdown of endogenous taspase 1 diminishes cleavage of TFIIA in vivo. | Uncleaved TFIIA is a substrate for taspase 1 and active in transcription.
Zhou H, Spicuglia S, Hsieh JJ, Mitsiou DJ, Høiby T, Veenstra GJ, Korsmeyer SJ, Stunnenberg HG., Free PMC Article | 01/21/2010 |