| STAP-2 facilitates insulin signaling through binding to CAP/c-Cbl and regulates adipocyte differentiation. | STAP-2 facilitates insulin signaling through binding to CAP/c-Cbl and regulates adipocyte differentiation.
Sekine Y, Kikkawa K, Honda S, Sasaki Y, Kawahara S, Mizushima A, Togi S, Fujimuro M, Oritani K, Matsuda T., Free PMC Article | 03/28/2024 |
| Signal-transducing adaptor protein-1 and protein-2 in hematopoiesis and diseases. | Signal-transducing adaptor protein-1 and protein-2 in hematopoiesis and diseases.
Ichii M, Oritani K, Toda J, Hosen N, Matsuda T, Kanakura Y. | 02/26/2022 |
| These findings indicate an essential role for STAP2 in the generation of a high-quality memory CD8+ CTLs periphery, and suggest the therapeutic potential of STAP2 in cancer patients. | Signal-transducing adaptor protein-2 promotes generation of functional long-term memory CD8+ T cells by preventing terminal effector differentiation.
Muraoka D, Seo N, Hayashi T, Hyuga-Amaike C, Okamori K, Tawara I, Harada N, Shiku H., Free PMC Article | 03/10/2018 |
| High STAP2 expression is associated with prostate cancer. | STAP-2 protein promotes prostate cancer growth by enhancing epidermal growth factor receptor stabilization.
Kitai Y, Iwakami M, Saitoh K, Togi S, Isayama S, Sekine Y, Muromoto R, Kashiwakura JI, Yoshimura A, Oritani K, Matsuda T., Free PMC Article | 01/27/2018 |
| The Pyk2/STAP-2 interaction is a novel mechanism to regulate SDF-1alpha-dependent T-cell chemotaxis. | STAP-2 interacts with Pyk2 and enhances Pyk2 activity in T-cells.
Saitoh K, Tsuchiya T, Kashiwakura JI, Muromoto R, Kitai Y, Sekine Y, Oritani K, Matsuda T. | 09/23/2017 |
| STAP2 is upregulated in uterosacral ligaments in pelvic organ prolapse | Estrogen-related genome-based expression profiling study of uterosacral ligaments in women with pelvic organ prolapse.
Moon YJ, Bai SW, Jung CY, Kim CH. | 06/28/2014 |
| Our results demonstrate a critical contribution of STAP-2 in BCR-ABL activity. | STAP-2 interacts with and modulates BCR-ABL-mediated tumorigenesis.
Sekine Y, Ikeda O, Mizushima A, Ueno Y, Muromoto R, Yoshimura A, Kanakura Y, Oritani K, Matsuda T. | 02/9/2013 |
| STAP-2 is a novel participant in the regulation of T cell apoptosis after stimulation | Signal-transducing adaptor protein-2 modulates Fas-mediated T cell apoptosis by interacting with caspase-8.
Sekine Y, Yamamoto C, Kakisaka M, Muromoto R, Kon S, Ashitomi D, Fujita N, Yoshimura A, Oritani K, Matsuda T. | 08/18/2012 |
| Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells. | Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells.
Ikeda O, Sekine Y, Mizushima A, Nakasuji M, Miyasaka Y, Yamamoto C, Muromoto R, Nanbo A, Oritani K, Yoshimura A, Matsuda T., Free PMC Article | 01/1/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
Shimada M, Miyagawa T, Kawashima M, Tanaka S, Honda Y, Honda M, Tokunaga K. | 09/15/2010 |
| STAP-2 expression in Jurkat T cells affects migration following stromal cell-derived factor-1alpha (SDF-1alpha) treatment; STAP-2 association with Vav1, the guanine-nucleotide exchanging factor for Rac1, enhances downstream Vav1/Rac1 signaling. | Signal-transducing adaptor protein-2 regulates stromal cell-derived factor-1 alpha-induced chemotaxis in T cells.
Sekine Y, Ikeda O, Tsuji S, Yamamoto C, Muromoto R, Nanbo A, Oritani K, Yoshimura A, Matsuda T. | 02/15/2010 |
| STAP-2 is phosphorylated at Tyr250 by Brk, and plays an important role in Brk-mediated STAT3 activation. | STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation.
Ikeda O, Miyasaka Y, Sekine Y, Mizushima A, Muromoto R, Nanbo A, Yoshimura A, Matsuda T. | 01/21/2010 |
| These results indicate that Cbl regulates STAP-2 protein levels and Brk/STAP-2-mediated STAT3 activation. | The protein content of an adaptor protein, STAP-2 is controlled by E3 ubiquitin ligase Cbl.
Sekine Y, Yamamoto C, Ikeda O, Muromoto R, Nanbo A, Oritani K, Yoshimura A, Matsuda T. | 01/21/2010 |
| These results suggest that STAP-2 acts as an endogenous negative regulator of Epstein-Barr virus LMP1-mediated signaling through TRAF3 and TRADD. | STAP-2 negatively regulates both canonical and noncanonical NF-kappaB activation induced by Epstein-Barr virus-derived latent membrane protein 1.
Ikeda O, Sekine Y, Yasui T, Oritani K, Sugiyma K, Muromoto R, Ohbayashi N, Yoshimura A, Matsuda T., Free PMC Article | 01/21/2010 |
| STAP-2 associates with FAK and enhances its degradation, proteasome inhibitors block FAK degradation, and STAP-2 recruits an endogenous E3 ubiquitin ligase, Cbl, to FAK. | Signal-transducing adaptor protein-2 regulates integrin-mediated T cell adhesion through protein degradation of focal adhesion kinase.
Sekine Y, Tsuji S, Ikeda O, Sugiyma K, Oritani K, Shimoda K, Muromoto R, Ohbayashi N, Yoshimura A, Matsuda T. | 01/21/2010 |
| STAP-2/BKS is a modulator of STAT5-mediated signaling | Physical and functional interactions between STAP-2/BKS and STAT5.
Sekine Y, Yamamoto T, Yumioka T, Sugiyama K, Tsuji S, Oritani K, Shimoda K, Minoguchi M, Yoshimura A, Matsuda T. | 01/21/2010 |
| These data indicate that STAP-2/BKS negatively controls the FcepsilonRI-mediated calcium mobilization and degranulation by direct modulation of tyrosine phosphorylation of PLC-gamma. | Regulation of FcepsilonRI-mediated signaling by an adaptor protein STAP-2/BSK in rat basophilic leukemia RBL-2H3 cells.
Yamamoto T, Yumioka T, Sekine Y, Sato N, Minoguchi M, Yoshimura A, Matsuda T. | 01/21/2010 |