| The BHLHE40-PPM1F-AMPK pathway regulates energy metabolism and is associated with the aggressiveness of endometrial cancer. | The BHLHE40‒PPM1F‒AMPK pathway regulates energy metabolism and is associated with the aggressiveness of endometrial cancer.
Asanoma K, Yagi H, Onoyama I, Cui L, Hori E, Kawakami M, Maenohara S, Hachisuga K, Tomonobe H, Kodama K, Yasunaga M, Ohgami T, Okugawa K, Yahata H, Kitao H, Kato K., Free PMC Article | 04/10/2024 |
| AMPKalpha2 promotes tumor immune escape by inducing CD8+ T-cell exhaustion and CD4+ Treg cell formation in liver hepatocellular carcinoma. | AMPKα2 promotes tumor immune escape by inducing CD8+ T-cell exhaustion and CD4+ Treg cell formation in liver hepatocellular carcinoma.
Ouyang Y, Gu Y, Zhang X, Huang Y, Wei X, Tang F, Zhang S., Free PMC Article | 03/5/2024 |
| Frequent loss-of-function mutations in the AMPK-alpha2 catalytic subunit suggest a tumour suppressor role in human skin cancers. | Frequent loss-of-function mutations in the AMPK-α2 catalytic subunit suggest a tumour suppressor role in human skin cancers.
Ross FA, Hawley SA, Russell FM, Goodman N, Hardie DG., Free PMC Article | 12/6/2023 |
| Assessing the gene expression of the adenosine 5'-monophosphate-activated protein kinase (AMPK) and its relation with the IL-6 and IL-10 plasma levels in COVID-19 patients. | Assessing the gene expression of the adenosine 5'-monophosphate-activated protein kinase (AMPK) and its relation with the IL-6 and IL-10 plasma levels in COVID-19 patients.
Assar S, Dastbaz M, Amini K, Roghani SA, Lotfi R, Taghadosi M, Kafi H, Abdan Z, Allahyari H, Rostampour R, Shahrokhvand SZ. | 11/30/2023 |
| AMPK/mTOR/p70S6K axis prevents apoptosis of Porphyromonas gingivalis-infected gingival epithelial cells via Bad[Ser136] phosphorylation. | AMPK/mTOR/p70S6K axis prevents apoptosis of Porphyromonas gingivalis-infected gingival epithelial cells via Bad(Ser136) phosphorylation.
Wang Y, Dong Y, Zhang W, Wang Y, Jao Y, Liu J, Zhang M, He H. | 07/13/2023 |
| Changes in AMPK activity induces cellular senescence in human dental follicle cells. | Changes in AMPK activity induces cellular senescence in human dental follicle cells.
Morsczeck C, Reck A, Reichert TE. | 02/4/2023 |
| Impact of AMPK on cervical carcinoma progression and metastasis. | Impact of AMPK on cervical carcinoma progression and metastasis.
Konieczny P, Adamus T, Sułkowski M, Skrzypek K, Majka M., Free PMC Article | 01/28/2023 |
| CircCDC6 restrains tumor growth and glycolysis energy metabolism in colorectal cancer via regulating miR-3187-3p and downstream PRKAA2. | CircCDC6 restrains tumor growth and glycolysis energy metabolism in colorectal cancer via regulating miR-3187-3p and downstream PRKAA2.
Zhao C, Chen H, Min K. | 07/23/2022 |
| The AMP-dependent kinase pathway is upregulated in BAP1 mutant uveal melanoma. | The AMP-dependent kinase pathway is upregulated in BAP1 mutant uveal melanoma.
Chua V, Han A, Bechtel N, Purwin TJ, Hunter E, Liao C, Harbour JW, Aplin AE. | 03/19/2022 |
| An AMPKalpha2-specific phospho-switch controls lysosomal targeting for activation. | An AMPKα2-specific phospho-switch controls lysosomal targeting for activation.
Morrison KR, Smiles WJ, Ling NXY, Hoque A, Shea G, Ngoei KRW, Yu D, Murray-Segal L, Scott JW, Galic S, Kemp BE, Petersen J, Oakhill JS. | 03/5/2022 |
| Aerobic exercise intensity does not affect the anabolic signaling following resistance exercise in endurance athletes. | Aerobic exercise intensity does not affect the anabolic signaling following resistance exercise in endurance athletes.
Jones TW, Eddens L, Kupusarevic J, Simoes DCM, Furber MJW, van Someren KA, Howatson G., Free PMC Article | 11/13/2021 |
| The myokine meteorin-like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPKalpha2. | The myokine meteorin-like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPKα2.
Lee JO, Byun WS, Kang MJ, Han JA, Moon J, Shin MJ, Lee HJ, Chung JH, Lee JS, Son CG, Song KH, Kim TW, Lee ES, Kim HM, Chung CH, Ngoei KRW, Ling NXY, Oakhill JS, Galic S, Murray-Segal L, Kemp BE, Kim KM, Lim S, Kim HS., Free PMC Article | 04/24/2021 |
| RSK2 protects human breast cancer cells under endoplasmic reticulum stress through activating AMPKalpha2-mediated autophagy. | RSK2 protects human breast cancer cells under endoplasmic reticulum stress through activating AMPKα2-mediated autophagy.
Li LY, Chen XS, Wang KS, Guan YD, Ren XC, Cao DS, Sun XY, Li AX, Tao YG, Zhang Y, Yin MZ, Wang XL, Wu MH, Yang JM, Cheng Y. | 12/19/2020 |
| AMPKA2 activation increased the expression and nuclear localization of Twist1 which regulated epithelial-mesenchymal transition. | AMP-activated protein kinase promotes epithelial-mesenchymal transition in cancer cells through Twist1 upregulation.
Saxena M, Balaji SA, Deshpande N, Ranganathan S, Pillai DM, Hindupur SK, Rangarajan A., Free PMC Article | 10/26/2019 |
| Mechanistically, AMP-activated protein kinase (AMPK)-mediated phosphorylation of BECN1 at Ser90/93/96 is required for BECN1-SLC7A11 complex formation and lipid peroxidation. | AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System X(c)(-) Activity.
Song X, Zhu S, Chen P, Hou W, Wen Q, Liu J, Xie Y, Liu J, Klionsky DJ, Kroemer G, Lotze MT, Zeh HJ, Kang R, Tang D., Free PMC Article | 10/19/2019 |
| A double-negative feedback loop between Akt and AMPK controls the switch between matrix-attached and matrix-detached states needed to coordinate cell growth and survival during breast cancer metastasis. | AMPK-Akt Double-Negative Feedback Loop in Breast Cancer Cells Regulates Their Adaptation to Matrix Deprivation.
Saha M, Kumar S, Bukhari S, Balaji SA, Kumar P, Hindupur SK, Rangarajan A., Free PMC Article | 05/25/2019 |
| It is an intracellular central metabolic sensor as well as a regulator, has been demonstrated to play significant roles in the contracting skeletal muscles, suggesting that AMPK should be one of the key molecules mediating metabolic effects during physical exercise. | [AMPK as a Metabolic Intersection between Diet and Physical Exercise].
Miyamoto L. | 10/20/2018 |
| PRKAA2 Polymorphisms in rs10789038 and rs2796498 are associated with the susceptibility to type 2 diabetes mellitus and diabetic nephropathy. | Effect of AMP-activated protein kinase subunit alpha 2 (PRKAA2) genetic polymorphisms on susceptibility to type 2 diabetes mellitus and diabetic nephropathy in a Chinese population.
Li Q, Li C, Li H, Zeng L, Kang Z, Mao Y, Tang X, Zheng P, He L, Luo F, Li Z. | 08/18/2018 |
| Lack of mitochondrial DNA impairs chemical hypoxia-induced autophagy in liver tumor cells through reactive oxygen species-AMPK-ULK1 signaling dysregulation independently of HIF-1A. | Lack of mitochondrial DNA impairs chemical hypoxia-induced autophagy in liver tumor cells through ROS-AMPK-ULK1 signaling dysregulation independently of HIF-1α.
Marin JJG, Lozano E, Perez MJ. | 12/30/2017 |
| PRKAA deletion promoted mitochondrial fragmentation in vascular endothelial cells by inhibiting the autophagy-dependent degradation of DNM1L. | Deletion of PRKAA triggers mitochondrial fission by inhibiting the autophagy-dependent degradation of DNM1L.
Wang Q, Wu S, Zhu H, Ding Y, Dai X, Ouyang C, Han YM, Xie Z, Zou MH., Free PMC Article | 12/2/2017 |
| AMPK phosphorylates DNMT1, RBBP7, and HAT1 and increases interactions of DNMT1, RBBP7, and HAT1. | AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1.
Marin TL, Gongol B, Zhang F, Martin M, Johnson DA, Xiao H, Wang Y, Subramaniam S, Chien S, Shyy JY., Free PMC Article | 11/18/2017 |
| PGC-1alpha protein was higher after HIHVT than after SIT (p < 0.05). Moreover, the AMPKpTHR172/AMPK ratio increased at post after SIT (p < 0.05), whereas this effect was delayed after HIHVT as it increased after 3 h | High-intensity high-volume swimming induces more robust signaling through PGC-1α and AMPK activation than sprint interval swimming in m. triceps brachii.
Casuso RA, Plaza-Díaz J, Ruiz-Ojeda FJ, Aragón-Vela J, Robles-Sanchez C, Nordsborg NB, Hebberecht M, Salmeron LM, Huertas JR., Free PMC Article | 11/4/2017 |
| TNF-alpha treatment of colonic rho(0) cells augmented IL-8 expression by 9-fold (P < 0.01) via NF-kappaB compared to TNF-alpha-treated control. Moreover, reduced mitochondrial function facilitated TNF-alpha-mediated NF-kappaB luciferase promoter activity as a result of lowered inhibitory IkappaBalpha (nuclear factor of kappa light polypeptide gene enhancer in B-cell inhibitor, alpha), leading to elevated NF-kappaB. ... | Reduced mitochondrial activity in colonocytes facilitates AMPKα2-dependent inflammation.
Heller S, Penrose HM, Cable C, Biswas D, Nakhoul H, Baddoo M, Flemington E, Crawford SE, Savkovic SD., Free PMC Article | 10/7/2017 |
| Results highlight the contribution of AMPKalpha2 as a mechanism for controlling bladder cancer growth by regulating proliferation through mTOR suppression and induction of p27 protein levels, thus indicating how AMPKalpha2 loss may contribute to tumorigenesis. | AMPKα2 Regulates Bladder Cancer Growth through SKP2-Mediated Degradation of p27.
Kopsiaftis S, Sullivan KL, Garg I, Taylor JA 3rd, Claffey KP., Free PMC Article | 08/5/2017 |
| AMPK phosphorylation of cortactin followed by SIRT1 deacetylation modulates the interaction of cortactin and cortical-actin in response to shear stress. Functionally, this AMPK/SIRT1 coregulated cortactin-F-actin dynamics is required for endothelial nitric oxide synthase subcellular translocation/activation and is atheroprotective. | AMP-Activated Protein Kinase and Sirtuin 1 Coregulation of Cortactin Contributes to Endothelial Function.
Shentu TP, He M, Sun X, Zhang J, Zhang F, Gongol B, Marin TL, Zhang J, Wen L, Wang Y, Geary GG, Zhu Y, Johnson DA, Shyy JY., Free PMC Article | 06/24/2017 |