| [Extracellular Matrix Stiffness Induces Mitochondrial Morphological Heterogeneity via AMPK Activation]. | [Extracellular Matrix Stiffness Induces Mitochondrial Morphological Heterogeneity via AMPK Activation].
Duan P, Liu Y, Lin X, Ren J, He J, Liu X, Xie J., Free PMC Article | 03/12/2024 |
| Endothelial H2S-AMPK dysfunction upregulates the angiocrine factor PAI-1 and contributes to lung fibrosis. | Endothelial H(2)S-AMPK dysfunction upregulates the angiocrine factor PAI-1 and contributes to lung fibrosis.
Chen X, Wang H, Wu C, Li X, Huang X, Ren Y, Pu Q, Cao Z, Tang X, Ding BS., Free PMC Article | 02/27/2024 |
| Phosphorylation of INF2 by AMPK promotes mitochondrial fission and oncogenic function in endometrial cancer. | Phosphorylation of INF2 by AMPK promotes mitochondrial fission and oncogenic function in endometrial cancer.
Ding Y, Lv Z, Cao W, Shi W, He Q, Gao K., Free PMC Article | 01/30/2024 |
| Direct effects of adipocyte lipolysis on AMPK through intracellular long-chain acyl-CoA signaling. | Direct effects of adipocyte lipolysis on AMPK through intracellular long-chain acyl-CoA signaling.
Rahman AA, Butcko AJ, Songyekutu E, Granneman JG, Mottillo EP., Free PMC Article | 01/8/2024 |
| AMPK is a mechano-metabolic sensor linking cell adhesion and mitochondrial dynamics to Myosin-dependent cell migration. | AMPK is a mechano-metabolic sensor linking cell adhesion and mitochondrial dynamics to Myosin-dependent cell migration.
Crosas-Molist E, Graziani V, Maiques O, Pandya P, Monger J, Samain R, George SL, Malik S, Salise J, Morales V, Le Guennec A, Atkinson RA, Marti RM, Matias-Guiu X, Charras G, Conte MR, Elosegui-Artola A, Holt M, Sanz-Moreno V., Free PMC Article | 05/31/2023 |
| Exosomal miR-663b from "M1" macrophages promotes pulmonary artery vascular smooth muscle cell dysfunction through inhibiting the AMPK/Sirt1 axis. | Exosomal miR-663b from "M1" macrophages promotes pulmonary artery vascular smooth muscle cell dysfunction through inhibiting the AMPK/Sirt1 axis.
Ma H, Yu Y, Mo L, Chen Q, Dong H, Xu Y, Zhuan B., Free PMC Article | 05/23/2023 |
| Promoting AMPK/SR-A1-mediated clearance of HMGB1 attenuates chemotherapy-induced peripheral neuropathy. | Promoting AMPK/SR-A1-mediated clearance of HMGB1 attenuates chemotherapy-induced peripheral neuropathy.
Yang X, Jia R, Hu F, Fan W, Lin T, Zhang X, Xu C, Ruan S, Jiang C, Li Y, Pan C, Yang Y, Hu L, Chen Q, Liu WT., Free PMC Article | 05/11/2023 |
| AMPKbeta1 and AMPKbeta2 define an isoform-specific gene signature in human pluripotent stem cells, differentially mediating cardiac lineage specification. | AMPKβ1 and AMPKβ2 define an isoform-specific gene signature in human pluripotent stem cells, differentially mediating cardiac lineage specification.
Ziegler N, Bader E, Epanchintsev A, Margerie D, Kannt A, Schmoll D., Free PMC Article | 04/3/2021 |
| Inhibitory mechanism of muscone in liver cancer involves the induction of apoptosis and autophagy. | Inhibitory mechanism of muscone in liver cancer involves the induction of apoptosis and autophagy.
Qi W, Li Z, Yang C, Jiangshan Dai J, Zhang Q, Wang D, Wu C, Xia L, Xu S., Free PMC Article | 09/26/2020 |
| CAMKK2 and AMPK have opposing effects on lipogenesis, providing a potential mechanism for their contrasting effects on prostate cancer progression in vivo | CAMKK2 Promotes Prostate Cancer Independently of AMPK via Increased Lipogenesis.
Penfold L, Woods A, Muckett P, Nikitin AY, Kent TR, Zhang S, Graham R, Pollard A, Carling D., Free PMC Article | 10/12/2019 |
| AMPK activity in response to redox changes is not due to direct action on AMPK itself, but is a secondary consequence of redox effects on other processes, such as mitochondrial ATP production. | Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly.
Hinchy EC, Gruszczyk AV, Willows R, Navaratnam N, Hall AR, Bates G, Bright TP, Krieg T, Carling D, Murphy MP., Free PMC Article | 06/1/2019 |
| Oncogenic stress chronically activates AMPK in glioblastoma tumor stem cells that coopt the AMPK-CREB1 pathway to coordinate tumour bioenergetics through the transcription factors HIF1alpha and GABPA. | AMP kinase promotes glioblastoma bioenergetics and tumour growth.
Chhipa RR, Fan Q, Anderson J, Muraleedharan R, Huang Y, Ciraolo G, Chen X, Waclaw R, Chow LM, Khuchua Z, Kofron M, Weirauch MT, Kendler A, McPherson C, Ratner N, Nakano I, Dasgupta N, Komurov K, Dasgupta B., Free PMC Article | 04/13/2019 |
| we studied the role of the beta 1 subunit in erythrocytes and observed microcytic anemia with compensatory extramedullary hematopoiesis together with splenomegaly and increased osmotic resistance. | The AMP-activated protein kinase beta 1 subunit modulates erythrocyte integrity.
Cambridge EL, McIntyre Z, Clare S, Arends MJ, Goulding D, Isherwood C, Caetano SS, Reviriego CB, Swiatkowska A, Kane L, Harcourt K, Sanger Mouse Genetics Project, Adams DJ, White JK, Speak AO., Free PMC Article | 06/10/2017 |
| Salicylate activates the AMP-activated protein kinase (AMPK) by binding at the A-769662 drug binding site on the AMPK beta1-subunit | Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung cancer cells ex vivo through inhibition of de novo lipogenesis.
O'Brien AJ, Villani LA, Broadfield LA, Houde VP, Galic S, Blandino G, Kemp BE, Tsakiridis T, Muti P, Steinberg GR. | 09/26/2015 |
| findings suggest that the reduced expression of AMPK-beta1 confers lower AMPK activity, which enhances the oncogenic capacity of advanced-stage ovarian cancer. | Reduced expression of AMPK-β1 during tumor progression enhances the oncogenic capacity of advanced ovarian cancer.
Li C, Liu VW, Chiu PM, Yao KM, Ngan HY, Chan DW., Free PMC Article | 09/13/2014 |
| The effects of ethanol on AMPK and PP2A may result in activation of ChREBP, providing another potential mechanism for ethanol-induced hepatic steatosis. | Activation of carbohydrate response element-binding protein by ethanol.
Liangpunsakul S, Ross RA, Crabb DW., Free PMC Article | 12/21/2013 |
| Data indicate that a diet high in iron improves glucose tolerance by activating AMPK through mechanisms that include deacetylation. | Iron regulates glucose homeostasis in liver and muscle via AMP-activated protein kinase in mice.
Huang J, Simcox J, Mitchell TC, Jones D, Cox J, Luo B, Cooksey RC, Boros LG, McClain DA., Free PMC Article | 09/21/2013 |
| Data indicate that except AMPK-alpha1, expressions of the other five AMPK subunits -alpha2, -beta1, -beta2, -gamma1 and -gamma2 are significantly higher in ovarian carcinomas. | Over-expressions of AMPK subunits in ovarian carcinomas with significant clinical implications.
Li C, Liu VW, Chiu PM, Chan DW, Ngan HY., Free PMC Article | 05/25/2013 |
| Changes in translational control of mitochondrial proteins are signaled by the activation of AMPK and general control non-derepressible kinase 2 (GCN2), leading also to the activation of autophagy. | AMPK and GCN2-ATF4 signal the repression of mitochondria in colon cancer cells.
Martínez-Reyes I, Sánchez-Aragó M, Cuezva JM. | 07/14/2012 |
| Phosphorylation levels of AMPK and glycolysis were up-regulated to confer an advantage of survival for MERRF skin fibroblasts. | AMPK-mediated increase of glycolysis as an adaptive response to oxidative stress in human cells: implication of the cell survival in mitochondrial diseases.
Wu SB, Wei YH. | 07/14/2012 |
| Adipose tissues of markedly obese insulin resistant individuals uniformly show decreased AMPK activity and increased oxidative stress compared with insulin sensitive patients. | Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue.
Xu XJ, Gauthier MS, Hess DT, Apovian CM, Cacicedo JM, Gokce N, Farb M, Valentine RJ, Ruderman NB., Free PMC Article | 07/7/2012 |
| In breast cancer cells SESN2 is associated with AMPK. | Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells.
Sanli T, Linher-Melville K, Tsakiridis T, Singh G., Free PMC Article | 06/30/2012 |
| Adiponectin could attenuate renal dysfunction associated with mesangial cells disorders through AMPK-mTOR signal pathway. | Adiponectin inhibits PDGF-induced mesangial cell proliferation: regulation of mammalian target of rapamycin-mediated survival pathway by adenosine 5-monophosphate-activated protein kinase.
Su YX, Deng HC, Zhang MX, Long J, Peng ZG. | 04/21/2012 |
| 1q21.1 copy number variant (CNV) results in gene function changes, specifically in the deletion containing lymphobalst cell lines, where AMPK was attenuated. | Understanding the impact of 1q21.1 copy number variant.
Harvard C, Strong E, Mercier E, Colnaghi R, Alcantara D, Chow E, Martell S, Tyson C, Hrynchak M, McGillivray B, Hamilton S, Marles S, Mhanni A, Dawson AJ, Pavlidis P, Qiao Y, Holden JJ, Lewis SM, O'Driscoll M, Rajcan-Separovic E., Free PMC Article | 03/3/2012 |
| AMPK, Akt and mTOR pathways have roles in resveratrol-enhanced prostate cancer cell response to ionizing radiation | Resveratrol enhances prostate cancer cell response to ionizing radiation. Modulation of the AMPK, Akt and mTOR pathways.
Rashid A, Liu C, Sanli T, Tsiani E, Singh G, Bristow RG, Dayes I, Lukka H, Wright J, Tsakiridis T., Free PMC Article | 01/28/2012 |