| HLA-C expression in extravillous trophoblasts is determined by an ELF3-NLRP2/NLRP7 regulatory axis. | HLA-C expression in extravillous trophoblasts is determined by an ELF3-NLRP2/NLRP7 regulatory axis.
Gu B, Le GH, Herrera S, Blair SJ, Meissner TB, Strominger JL., | 07/26/2024 |
| Nlrp2 deletion ameliorates kidney damage in a mouse model of cystinosis. | Nlrp2 deletion ameliorates kidney damage in a mouse model of cystinosis.
Rossi MN, Matteo V, Diomedi-Camassei F, De Leo E, Devuyst O, Lamkanfi M, Caiello I, Loricchio E, Bellomo F, Taranta A, Emma F, De Benedetti F, Prencipe G., Free PMC Article | 05/2/2024 |
| NLRP2 in health and disease. | NLRP2 in health and disease.
Zhang T, Xing F, Qu M, Yang Z, Liu Y, Yao Y, Xing N. | 01/30/2024 |
| Gene body hypomethylation of pyroptosis-related genes NLRP7, NLRP2, and NLRP3 facilitate non-invasive surveillance of hepatocellular carcinoma. | Gene body hypomethylation of pyroptosis-related genes NLRP7, NLRP2, and NLRP3 facilitate non-invasive surveillance of hepatocellular carcinoma.
Zhang H, Dong P, Fan H, Liang H, Zhang K, Zhao Y, Guo S, Schrodi SJ, Fan Y, Zhang D. | 06/13/2023 |
| Somatic Mutation of NLRP Genes in Gastric and Colonic Cancers. | Somatic Mutation of NLRP Genes in Gastric and Colonic Cancers.
Moon SW, Son HJ, Mo HY, Yoo NJ, Lee SH., Free PMC Article | 02/12/2022 |
| NLRP2 and NLRP5 are novel mutant genes responsible for human early embryonic arrest. | Mutations in NLRP2 and NLRP5 cause female infertility characterised by early embryonic arrest.
Mu J, Wang W, Chen B, Wu L, Li B, Mao X, Zhang Z, Fu J, Kuang Y, Sun X, Li Q, Jin L, He L, Sang Q, Wang L. | 06/6/2020 |
| We now report 15 further pedigrees in which offspring had disturbance of imprinting, while their mothers had rare, predicted-deleterious variants in maternal effect genes, including NLRP2, NLRP7 and PADI6 | Maternal variants in NLRP and other maternal effect proteins are associated with multilocus imprinting disturbance in offspring.
Begemann M, Rezwan FI, Beygo J, Docherty LE, Kolarova J, Schroeder C, Buiting K, Chokkalingam K, Degenhardt F, Wakeling EL, Kleinle S, González Fassrainer D, Oehl-Jaschkowitz B, Turner CLS, Patalan M, Gizewska M, Binder G, Bich Ngoc CT, Chi Dung V, Mehta SG, Baynam G, Hamilton-Shield JP, Aljareh S, Lokulo-Sodipe O, Horton R, Siebert R, Elbracht M, Temple IK, Eggermann T, Mackay DJG., Free PMC Article | 10/5/2019 |
| Early-onset childhood atopic dermatitis is related to NLRP2 repression. | Early-onset childhood atopic dermatitis is related to NLRP2 repression.
Thürmann L, Grützmann K, Klös M, Bieg M, Winter M, Polte T, Bauer T, Schick M, Bewerunge-Hudler M, Röder S, Bauer M, Wissenbach DK, Sack U, Weichenhan D, Mücke O, Plass C, Borte M, von Bergen M, Lehmann I, Eils R, Trump S. | 08/3/2019 |
| NLRP2 served an important role in maintaining cell viability. | Downregulation of NLRP2 inhibits HUVEC viability by inhibiting the MAPK signaling pathway.
Zhang X, Lu X, Yu L, Gu Y, Qu F., Free PMC Article | 06/1/2019 |
| NLRP2 might be a potential target for developing effective therapeutic strategy to prevent Nonalcoholic fatty liver disease progression. | Suppressing NLRP2 expression accelerates hepatic steatosis: A mechanism involving inflammation and oxidative stress.
Li C, Liu Q, Xie L. | 05/18/2019 |
| The NLRP2-TBK1 axis may serve as an additional signaling cascade to maintain immune homeostasis in response to viral infection. | NLRP2 negatively regulates antiviral immunity by interacting with TBK1.
Yang Y, Lang X, Sun S, Gao C, Hu J, Ding S, Li J, Li Y, Wang F, Gong T. | 04/13/2019 |
| NLRP2 missense mutation was identified in patients with multilocus imprinting disturbances. NLRP2 pathogenic mutation affects protein conformation and activity. | Characterization of multi-locus imprinting disturbances and underlying genetic defects in patients with chromosome 11p15.5 related imprinting disorders.
Fontana L, Bedeschi MF, Maitz S, Cereda A, Faré C, Motta S, Seresini A, D'Ursi P, Orro A, Pecile V, Calvello M, Selicorni A, Lalatta F, Milani D, Sirchia SM, Miozzo M, Tabano S., Free PMC Article | 03/9/2019 |
| During transition from the pluripotent stage towards the neural developmental stage, NLRP2 is differentially expressed in bipolar patient derived cells compared to control derived cells. | Early onset of inflammation during ontogeny of bipolar disorder: the NLRP2 inflammasome gene distinctly differentiates between patients and healthy controls in the transition between iPS cell and neural stem cell stages.
Vizlin-Hodzic D, Zhai Q, Illes S, Södersten K, Truvé K, Parris TZ, Sobhan PK, Salmela S, Kosalai ST, Kanduri C, Strandberg J, Seth H, Bontell TO, Hanse E, Ågren H, Funa K., Free PMC Article | 11/18/2017 |
| genetic polymorphism is associated with chronic pancreatitis | The Q705K and F359L Single-Nucleotide Polymorphisms of NOD-Like Receptor Signaling Pathway: Association with Chronic Pancreatitis, Pancreatic Cancer, and Periodontitis.
Miskiewicz A, Szparecki G, Durlik M, Rydzewska G, Ziobrowski I, Górska R., Free PMC Article | 09/3/2016 |
| No disease-causing mutations were identified in NLRP2, NLRP7 and KHDC3L in cohorts of unexplained infertility and recurrent pregnancy loss. | No evidence for mutations in NLRP7, NLRP2 or KHDC3L in women with unexplained recurrent pregnancy loss or infertility.
Aghajanova L, Mahadevan S, Altmäe S, Stavreus-Evers A, Regan L, Sebire N, Dixon P, Fisher RA, Van den Veyver IB., Free PMC Article | 04/9/2016 |
| This study indicates that polymorphisms in SPARC and NLRP2 are related to rheumatoid arthritis susceptibility in a Chinese Han population. | Association of polymorphisms in SPARC and NLRP2 genes with rheumatoid arthritis in a Chinese Han population.
Yang XL, Hu ZD, Wu Q, Liu X, Liu QJ, Zhang YC, Yang QR. | 08/22/2015 |
| Findings suggest that NLR family pyrin domain containing 2 (NLRP2P) is a processed pseudogene that regulates NF-kappaB RelA/p65 activity and thus represents the newest member of the POP family, pyrin-only protein 4 (POP4; NLRP4). | The CLRX.1/NOD24 (NLRP2P) pseudogene codes a functional negative regulator of NF-κB, pyrin-only protein 4.
Porter KA, Duffy EB, Nyland P, Atianand MK, Sharifi H, Harton JA., Free PMC Article | 06/27/2015 |
| The results of this study suggest that the astrocytic NLRP2 inflammasome is an important component of the CNS inflammatory response | Human astrocytes express a novel NLRP2 inflammasome.
Minkiewicz J, de Rivero Vaccari JP, Keane RW. | 02/15/2014 |
| There is a significant association of a tag single-nucleotide polymorphism (SNP) of NLRP7 (rs26949) with idiopathic recurrent miscarriage | A genetic association study of NLRP2 and NLRP7 genes in idiopathic recurrent miscarriage.
Huang JY, Su M, Lin SH, Kuo PL. | 09/28/2013 |
| single nucleotide polymorphisms in NALP2 gene is associated with arsenic induced skin lesions, peripheral neuropathy, eye problem and respiratory diseases. | Association of NALP2 polymorphism with arsenic induced skin lesions and other health effects.
Bhattacharjee P, Das N, Chatterjee D, Banerjee A, Das JK, Basu S, Banerjee S, Majumder P, Goswami P, Giri AK. | 09/7/2013 |
| Observations suggest that although NLRP7 and C6orf221 mutations are related to diploid biparental FRHMs, neither of these genes, nor NLRP2, are related to diploid HMs with biparental contributions to the molar genome. | Mosaic moles and non-familial biparental moles are not caused by mutations in NLRP7, NLRP2 or C6orf221.
Andreasen L, Bolund L, Niemann I, Hansen ES, Sunde L. | 05/11/2013 |
| POP2 acts as a regulator of inflammatory signals and exerts its two known functions through distinct modalities employed by its first alpha-helix | Uncoupling of Pyrin-only protein 2 (POP2)-mediated dual regulation of NF-κB and the inflammasome.
Atianand MK, Harton JA., Free PMC Article | 01/21/2012 |
| Our observations are the first to implicate SPARC, SLPI, and NLRP2, a component of the innate immune system, in the pathogenesis of axial spondyloarthropathy | Insights in to the pathogenesis of axial spondyloarthropathy based on gene expression profiles.
Sharma SM, Choi D, Planck SR, Harrington CA, Austin CR, Lewis JA, Diebel TN, Martin TM, Smith JR, Rosenbaum JT., Free PMC Article | 05/31/2010 |
| Roles of the pyrin protein which seems to have various roles in regulation of innate immunity, inflammation, and apoptosis. | An overview of familial Mediterranean fever with emphasis on pyrin and colchicine.
Dbouk HA, Uthman IW. | 01/21/2010 |
| NLRP2 has a previously unrecognised role in establishing or maintaining genomic imprinting in humans. | Germline mutation in NLRP2 (NALP2) in a familial imprinting disorder (Beckwith-Wiedemann Syndrome).
Meyer E, Lim D, Pasha S, Tee LJ, Rahman F, Yates JR, Woods CG, Reik W, Maher ER., Free PMC Article | 01/21/2010 |