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    PRKACA protein kinase cAMP-activated catalytic subunit alpha [ Homo sapiens (human) ]

    Gene ID: 5566, updated on 28-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Increased Protein Kinase A Activity Induces Fibrolamellar Hepatocellular Carcinoma Features Independent of DNAJB1.

    Increased Protein Kinase A Activity Induces Fibrolamellar Hepatocellular Carcinoma Features Independent of DNAJB1.
    Shirani M, Levin S, Shebl B, Requena D, Finkelstein TM, Johnson DS, Ng D, Lalazar G, Heissel S, Hojrup P, Molina H, de Jong YP, Rice CM, Singhi AD, Torbenson MS, Coffino P, Lyons B, Simon SM., Free PMC Article

    08/21/2024
    PRKACA/PRKACB Fusions in Pancreatobiliary Intraductal Oncocytic Papillary Neoplasms Including Those With Atypical Morphology: An Analysis of 22 Cases Expanding Morphologic Spectrum.

    PRKACA/PRKACB Fusions in Pancreatobiliary Intraductal Oncocytic Papillary Neoplasms Including Those With Atypical Morphology: An Analysis of 22 Cases Expanding Morphologic Spectrum.
    Tanaka M, Takeshita K, Kunita A, Hasegawa K, Ushiku T.

    08/5/2024
    Protein kinase A is a functional component of focal adhesions.

    Protein kinase A is a functional component of focal adhesions.
    Kang M, Senatore AJ, Naughton H, McTigue M, Beltman RJ, Herppich AA, Pflum MKH, Howe AK., Free PMC Article

    06/5/2024
    The PKA-CREB1 axis regulates coronavirus proliferation by viral helicase nsp13 association.

    The PKA-CREB1 axis regulates coronavirus proliferation by viral helicase nsp13 association.
    Zheng T, Shen B, Bai Y, Li E, Zhang X, Hu Y, Gao T, Dong Q, Zhu L, Jin R, Shi H, Liu H, Gao Y, Liu X, Cao C., Free PMC Article

    05/3/2024
    Gene Rearrangement and Expression of PRKACA and PRKACB Govern Morphobiology of Pancreatobiliary Oncocytic Neoplasms.

    Gene Rearrangement and Expression of PRKACA and PRKACB Govern Morphobiology of Pancreatobiliary Oncocytic Neoplasms.
    Itoh T, Omori Y, Seino M, Hirose K, Date F, Ono Y, Mizukami Y, Aoki S, Ishida M, Mizuma M, Morikawa T, Higuchi R, Honda G, Okamura Y, Kinoshita K, Unno M, Furukawa T.

    01/26/2024
    PKA mediates modality-specific modulation of the mechanically gated ion channel PIEZO2.

    PKA mediates modality-specific modulation of the mechanically gated ion channel PIEZO2.
    Schaefer I, Verkest C, Vespermann L, Mair T, Voß H, Zeitzschel N, Lechner SG., Free PMC Article

    07/13/2023
    Investigation of -PRKACA/-PRKACB fusion genes in oncocytic tumors of the pancreatobiliary and other systems.

    Investigation of -PRKACA/-PRKACB fusion genes in oncocytic tumors of the pancreatobiliary and other systems.
    Maimaitiaili Y, Fukumura Y, Hirabayashi K, Kinowaki Y, Naito Y, Saito A, Rong L, Nakahodo J, Yao T.

    01/11/2023
    Defective synaptic plasticity in a model of Coffin-Lowry syndrome is rescued by simultaneously targeting PKA and MAPK pathways.

    Defective synaptic plasticity in a model of Coffin-Lowry syndrome is rescued by simultaneously targeting PKA and MAPK pathways.
    Liu RY, Zhang Y, Smolen P, Cleary LJ, Byrne JH., Free PMC Article

    12/17/2022
    Genotype-specific cortisol production associated with Cushing's syndrome adenoma with PRKACA mutations.

    Genotype-specific cortisol production associated with Cushing's syndrome adenoma with PRKACA mutations.
    Baba R, Oki K, Gomez-Sanchez CE, Otagaki Y, Itcho K, Kobuke K, Kodama T, Nagano G, Ohno H, Yoneda M, Hattori N., Free PMC Article

    04/2/2022
    DNAJB1-PRKACA in HEK293T cells induces LINC00473 overexpression that depends on PKA signaling.

    DNAJB1-PRKACA in HEK293T cells induces LINC00473 overexpression that depends on PKA signaling.
    Kim SS, Kycia I, Karski M, Ma RK, Bordt EA, Kwan J, Karki A, Winter E, Aktas RG, Wu Y, Emili A, Bauer DE, Sethupathy P, Vakili K., Free PMC Article

    02/26/2022
    Is Disrupted Nucleotide-Substrate Cooperativity a Common Trait for Cushing's Syndrome Driving Mutations of Protein Kinase A?

    Is Disrupted Nucleotide-Substrate Cooperativity a Common Trait for Cushing's Syndrome Driving Mutations of Protein Kinase A?
    Walker C, Wang Y, Olivieri C, V S M, Gao J, Bernlohr DA, Calebiro D, Taylor SS, Veglia G., Free PMC Article

    01/8/2022
    KARATE: PKA-induced KRAS4B-RHOA-mTORC2 supercomplex phosphorylates AKT in insulin signaling and glucose homeostasis.

    KARATE: PKA-induced KRAS4B-RHOA-mTORC2 supercomplex phosphorylates AKT in insulin signaling and glucose homeostasis.
    Senoo H, Murata D, Wai M, Arai K, Iwata W, Sesaki H, Iijima M.

    01/8/2022
    Reconstitution of beta-adrenergic regulation of CaV1.2: Rad-dependent and Rad-independent protein kinase A mechanisms.

    Reconstitution of β-adrenergic regulation of Ca(V)1.2: Rad-dependent and Rad-independent protein kinase A mechanisms.
    Katz M, Subramaniam S, Chomsky-Hecht O, Tsemakhovich V, Flockerzi V, Klussmann E, Hirsch JA, Weiss S, Dascal N., Free PMC Article

    12/4/2021
    PKA and AKIP1 interact to mediate cAMP-driven COX-2 expression: A potentially pivotal interaction in preterm and term labour.

    PKA and AKIP1 interact to mediate cAMP-driven COX-2 expression: A potentially pivotal interaction in preterm and term labour.
    Yulia A, Singh N, Varley AJ, Lei K, Markovic D, Sooranna SR, Johnson MR., Free PMC Article

    11/13/2021
    Protein Kinase A-Mediated Septin7 Phosphorylation Disrupts Septin Filaments and Ciliogenesis.

    Protein Kinase A-Mediated Septin7 Phosphorylation Disrupts Septin Filaments and Ciliogenesis.
    Wang HY, Lin CH, Shen YR, Chen TY, Wang CY, Kuo PL., Free PMC Article

    10/16/2021
    PP1, PKA and DARPP-32 in breast cancer: A retrospective assessment of protein and mRNA expression.

    PP1, PKA and DARPP-32 in breast cancer: A retrospective assessment of protein and mRNA expression.
    Saidy B, Kotecha S, Butler A, Rakha EA, Ellis IO, Green AR, Martin SG, Storr SJ., Free PMC Article

    10/2/2021
    FMRP-PKA Activity Negative Feedback Regulates RNA Binding-Dependent Fibrillation in Brain Learning and Memory Circuitry.

    FMRP-PKA Activity Negative Feedback Regulates RNA Binding-Dependent Fibrillation in Brain Learning and Memory Circuitry.
    Sears JC, Broadie K., Free PMC Article

    09/25/2021
    The Phosphorylation Status of Drp1-Ser637 by PKA in Mitochondrial Fission Modulates Mitophagy via PINK1/Parkin to Exert Multipolar Spindles Assembly during Mitosis.

    The Phosphorylation Status of Drp1-Ser637 by PKA in Mitochondrial Fission Modulates Mitophagy via PINK1/Parkin to Exert Multipolar Spindles Assembly during Mitosis.
    Ko HJ, Tsai CY, Chiou SJ, Lai YL, Wang CH, Cheng JT, Chuang TH, Huang CF, Kwan AL, Loh JK, Hong YR., Free PMC Article

    09/18/2021
    Cyclic AMP-Dependent Protein Kinase Exhibits Antagonistic Effects on the Replication Efficiency of Different Human Papillomavirus Types.

    Cyclic AMP-Dependent Protein Kinase Exhibits Antagonistic Effects on the Replication Efficiency of Different Human Papillomavirus Types.
    Lototskaja E, Sahharov O, Piirsoo M, Kala M, Ustav M, Piirsoo A., Free PMC Article

    08/28/2021
    Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A.

    Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A.
    Olivieri C, Walker C, Karamafrooz A, Wang Y, Manu VS, Porcelli F, Blumenthal DK, Thomas DD, Bernlohr DA, Simon SM, Taylor SS, Veglia G., Free PMC Article

    08/14/2021
    Nanoscale regulation of L-type calcium channels differentiates between ischemic and dilated cardiomyopathies.

    Nanoscale regulation of L-type calcium channels differentiates between ischemic and dilated cardiomyopathies.
    Sanchez-Alonso JL, Loucks A, Schobesberger S, van Cromvoirt AM, Poulet C, Chowdhury RA, Trayanova N, Gorelik J., Free PMC Article

    05/29/2021
    From Inflammation to the Onset of Fibrosis through A2A Receptors in Kidneys from Deceased Donors.

    From Inflammation to the Onset of Fibrosis through A(2A) Receptors in Kidneys from Deceased Donors.
    Guillén-Gómez E, Silva I, Serra N, Caballero F, Leal J, Breda A, San Martín R, Pastor-Anglada M, Ballarín JA, Guirado L, Díaz-Encarnación MM., Free PMC Article

    03/20/2021
    Insight into the Interactome of Intramitochondrial PKA Using Biotinylation-Proximity Labeling.

    Insight into the Interactome of Intramitochondrial PKA Using Biotinylation-Proximity Labeling.
    Ould Amer Y, Hebert-Chatelain E., Free PMC Article

    03/13/2021
    Inhibition of non-homologous end joining of gamma ray-induced DNA double-strand breaks by cAMP signaling in lung cancer cells.

    Inhibition of non-homologous end joining of gamma ray-induced DNA double-strand breaks by cAMP signaling in lung cancer cells.
    Noh SE, Juhnn YS., Free PMC Article

    02/27/2021
    DNAJB1-PRKACA fusions occur in oncocytic pancreatic and biliary neoplasms and are not specific for fibrolamellar hepatocellular carcinoma.

    DNAJB1-PRKACA fusions occur in oncocytic pancreatic and biliary neoplasms and are not specific for fibrolamellar hepatocellular carcinoma.
    Vyas M, Hechtman JF, Zhang Y, Benayed R, Yavas A, Askan G, Shia J, Klimstra DS, Basturk O., Free PMC Article

    02/2/2021
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