| Integrins regulate hERG1 dynamics by girdin-dependent Galphai3: signaling and modeling in cancer cells. | Integrins regulate hERG1 dynamics by girdin-dependent Gαi3: signaling and modeling in cancer cells.
Duranti C, Iorio J, Bagni G, Chioccioli Altadonna G, Fillion T, Lulli M, D'Alessandro FN, Montalbano A, Lastraioli E, Fanelli D, Coppola S, Schmidt T, Piazza F, Becchetti A, Arcangeli A., Free PMC Article | 11/14/2023 |
| Upregulation of girdin delays endothelial cell apoptosis via promoting engulfment of platelets. | Upregulation of girdin delays endothelial cell apoptosis via promoting engulfment of platelets.
Lan Y, Dong M, Li Y, Diao Y, Chen Z, Wu Z. | 09/27/2023 |
| An unusual signal transducer GIV/Girdin engages in the roles of adipocyte-derived hormone leptin in liver fibrosis. | An unusual signal transducer GIV/Girdin engages in the roles of adipocyte-derived hormone leptin in liver fibrosis.
Jia X, Xu F, Lu S, Jie H, Guan W, Zhou Y. | 08/7/2023 |
| hsa-miR-199b-3p suppresses osteosarcoma progression by targeting CCDC88A, inhibiting epithelial-to-mesenchymal transition, and Wnt/beta-catenin signaling pathway. | hsa-miR-199b-3p suppresses osteosarcoma progression by targeting CCDC88A, inhibiting epithelial-to-mesenchymal transition, and Wnt/beta-catenin signaling pathway.
Zhu D, Qi H, Zhu H., Free PMC Article | 08/4/2023 |
| Girdin regulates both migration and angiogenesis in pancreatic cancer cell lines. | Girdin regulates both migration and angiogenesis in pancreatic cancer cell lines.
Hayashi Y, Matsuo Y, Denda Y, Nonoyama K, Murase H, Ueda G, Aoyama Y, Kato T, Omi K, Imafuji H, Saito K, Morimoto M, Ogawa R, Takahashi H, Mitsui A, Kimura M, Takiguchi S., Free PMC Article | 08/2/2023 |
| The association between the CCDC88A gene polymorphism at rs1437396 and alcohol use disorder, with or without major depression disorder. | The association between the CCDC88A gene polymorphism at rs1437396 and alcohol use disorder, with or without major depression disorder.
Bonea M, Coroama CI, Popp RA, Miclutia IV., Free PMC Article | 06/29/2023 |
| Girdin acts as an oncogene in gastric cancer by regulating AKT/GSK3beta/beta-catenin signaling. | Girdin acts as an oncogene in gastric cancer by regulating AKT/GSK3β/β-catenin signaling.
Wang Y, Fu Q, Tao YJ, Ying SN, Zhong HG, Zhu Y, Qian XH, Miao L, Yang LH., Free PMC Article | 01/14/2023 |
| Knockdown of Girdin Induced Apoptosis of Glioblastoma Cells via the Mitochondrion Signaling Pathway. | Knockdown of Girdin Induced Apoptosis of Glioblastoma Cells via the Mitochondrion Signaling Pathway.
Liu X, Zhang H, Zhao Y, Ma Y. | 09/24/2022 |
| CCDC88A/GIV promotes HBV replication and progeny secretion via enhancing endosomal trafficking and blocking autophagic degradation. | CCDC88A/GIV promotes HBV replication and progeny secretion via enhancing endosomal trafficking and blocking autophagic degradation.
Wang X, Wei Z, Lan T, He Y, Cheng B, Li R, Chen H, Li F, Liu G, Jiang B, Lin Y, Lu M, Meng Z., Free PMC Article | 04/30/2022 |
| The relationship among Girdin DNA methylation, its high expression, and immune infiltration in hepatocellular carcinoma: Clues from in silico analysis. | The relationship among Girdin DNA methylation, its high expression, and immune infiltration in hepatocellular carcinoma: Clues from in silico analysis.
Zhang C, Ke Y, Lei X, Liu X, Li H, Shi R, Wang L., Free PMC Article | 12/25/2021 |
| Roles of metformin-mediated girdin expression in metastasis of epithelial ovarian cancer. | Roles of metformin-mediated girdin expression in metastasis of epithelial ovarian cancer.
Dang J, Gao J, Ma F, Luo Y, Wang J, Wang D, Li W, Sun H, Li L, Liu X, Hu D, Jin Z. | 11/13/2021 |
| A long isoform of GIV/Girdin contains a PDZ-binding module that regulates localization and G-protein binding. | A long isoform of GIV/Girdin contains a PDZ-binding module that regulates localization and G-protein binding.
Ear J, Abd El-Hafeez AA, Roy S, Ngo T, Rajapakse N, Choi J, Khandelwal S, Ghassemian M, McCaffrey L, Kufareva I, Sahoo D, Ghosh P., Free PMC Article | 09/11/2021 |
| LncRNA FAM83H-AS1 promotes oesophageal squamous cell carcinoma progression via miR-10a-5p/Girdin axis. | LncRNA FAM83H-AS1 promotes oesophageal squamous cell carcinoma progression via miR-10a-5p/Girdin axis.
Feng B, Wang G, Liang X, Wu Z, Wang X, Dong Z, Guo Y, Shen S, Liang J, Guo W., Free PMC Article | 05/8/2021 |
| Girdin interaction with vimentin induces EMT and promotes the growth and metastasis of pancreatic ductal adenocarcinoma. | Girdin interaction with vimentin induces EMT and promotes the growth and metastasis of pancreatic ductal adenocarcinoma.
Wang W, Chen H, Gao W, Wang S, Wu K, Lu C, Luo X, Li L, Yu C., Free PMC Article | 03/13/2021 |
| Quantitative acetylome and phosphorylome analysis reveals Girdin affects pancreatic cancer progression through regulating Cortactin. | Quantitative acetylome and phosphorylome analysis reveals Girdin affects pancreatic cancer progression through regulating Cortactin.
Yang L, Fu Q, Miao L, Ding Q, Li X, Wang J, Jiang G, Wang Y., Free PMC Article | 02/27/2021 |
| The Galpha-interacting vesicle-associated protein interacts with and promotes cell surface localization of GRP78 during endoplasmic reticulum stress. | The Gα-interacting vesicle-associated protein interacts with and promotes cell surface localization of GRP78 during endoplasmic reticulum stress.
Limso C, Ngo JM, Nguyen P, Leal S, Husain A, Sahoo D, Ghosh P, Bhandari D., Free PMC Article | 01/16/2021 |
| PP2A inhibits breast cancer metastasis via dephosphorylation of Girdin. | Dephosphorylation of Girdin by PP2A inhibits breast cancer metastasis.
Li J, Enomoto A, Weng L, Sun L, Takahashi M. | 03/28/2020 |
| Here, we present a 2.0-A crystal structure of Galpha i in complex with the GEM motif of GIV/Girdin. Nucleotide exchange assays, molecular dynamics simulations, and hydrogen-deuterium exchange experiments demonstrate that GEM binding to the conformational switch II causes structural changes that allosterically propagate to the hydrophobic core of the Galpha i GTPase domain | Structural basis for GPCR-independent activation of heterotrimeric Gi proteins.
Kalogriopoulos NA, Rees SD, Ngo T, Kopcho NJ, Ilatovskiy AV, Sun N, Komives EA, Chang G, Ghosh P, Kufareva I., Free PMC Article | 03/28/2020 |
| Model reveals that GIV acts as a tunable control valve that regulates cAMP flux after growth factor stimulation. | A predictive computational model reveals that GIV/girdin serves as a tunable valve for EGFR-stimulated cyclic AMP signals.
Getz M, Swanson L, Sahoo D, Ghosh P, Rangamani P., Free PMC Article | 01/11/2020 |
| MiR-144-3p, which was up-regulated in pediatric Wilms' tumor, might inhibit the proliferation and metastasis of the cells by directly targeting Girdin | MiR-144-3p inhibits the proliferation and metastasis of pediatric Wilms' tumor cells by regulating Girdin.
Liu CL, Wang WH, Sun YL, Zhuang HW, Xu M, Chen HF, Liu JX. | 11/23/2019 |
| Together, this study shows a novel, cytoprotective role for GIV in ER-stressed cells and furthers our understanding of the mechanisms that contribute to cell survival during ER stress. | GIV/Girdin promotes cell survival during endoplasmic reticulum stress.
Nguyen P, Calderon R, Rodriguez-Ledezma Y, Araujo K, Bhandari D., Free PMC Article | 03/2/2019 |
| Cytoplasmic and nuclear girdin exhibited different roles in prognosis of breast cancer: cytoplasmic girdin expression was an independent prognostic factor for progression-free survival (PFS), whereas nuclear girdin expression was an independent prognostic factor for overall survival (OS). | Combination of cytoplasmic and nuclear girdin expression is an independent prognosis factor of breast cancer.
Zhang H, Yu F, Qin F, Shao Y, Chong W, Guo Z, Liu X, Fu L, Gu F, Ma Y. | 01/12/2019 |
| Results showed a role of Girdin in the collective invasion of skin cancer cells, where it interacts with beta-catenin. Also, Girdin is indispensable for stable cell-cell interaction, supracellular cytoskeletal organization, and the collective migration of cancer. | Girdin/GIV regulates collective cancer cell migration by controlling cell adhesion and cytoskeletal organization.
Wang X, Enomoto A, Weng L, Mizutani Y, Abudureyimu S, Esaki N, Tsuyuki Y, Chen C, Mii S, Asai N, Haga H, Ishida S, Yokota K, Akiyama M, Takahashi M., Free PMC Article | 11/24/2018 |
| Study revealed that the downregulation of the expression of Girdin can inhibit the proliferation, invasion and migration of colorectal cancer cells through decrease in proinflammatory cytokine production and inhibition of JAK/STAT signaling. | Silencing of Girdin suppresses the malignant behavior of colorectal carcinoma cells.
Lu J, Zhang L, Zhou H, Du Z, Zhang G. | 10/27/2018 |
| Girdin may regulate cell processes. | Girdin regulates the proliferation and apoptosis of pancreatic cancer cells via the PI3K/Akt signalling pathway.
Wang S, Lei Y, Cai Z, Ye X, Li L, Luo X, Yu C., Free PMC Article | 10/20/2018 |