| S-nitrosylation of AMPKgamma impairs coronary collateral circulation and disrupts VSMC reprogramming. | S-nitrosylation of AMPKγ impairs coronary collateral circulation and disrupts VSMC reprogramming.
Bai W, Guo T, Wang H, Li B, Sun Q, Wu W, Zhang J, Zhou J, Luo J, Zhu M, Lu J, Li P, Dong B, Han S, Pang X, Zhang G, Bai Y, Wang S., Free PMC Article | 06/24/2024 |
| DNA-dependent protein kinase regulates lysosomal AMP-dependent protein kinase activation and autophagy. | DNA-dependent protein kinase regulates lysosomal AMP-dependent protein kinase activation and autophagy.
Puustinen P, Keldsbo A, Corcelle-Termeau E, Ngoei K, Sønder SL, Farkas T, Kaae Andersen K, Oakhill JS, Jäättelä M., Free PMC Article | 10/2/2021 |
| AMPK Complex Activation Promotes Sarcolemmal Repair in Dysferlinopathy. | AMPK Complex Activation Promotes Sarcolemmal Repair in Dysferlinopathy.
Ono H, Suzuki N, Kanno SI, Kawahara G, Izumi R, Takahashi T, Kitajima Y, Osana S, Nakamura N, Akiyama T, Ikeda K, Shijo T, Mitsuzawa S, Nagatomi R, Araki N, Yasui A, Warita H, Hayashi YK, Miyake K, Aoki M., Free PMC Article | 04/13/2021 |
| The importance of the AMPK gamma 1 subunit in metformin suppression of liver glucose production. | The importance of the AMPK gamma 1 subunit in metformin suppression of liver glucose production.
An H, Wang Y, Qin C, Li M, Maheshwari A, He L., Free PMC Article | 12/12/2020 |
| AMPK activity in response to redox changes is not due to direct action on AMPK itself, but is a secondary consequence of redox effects on other processes, such as mitochondrial ATP production. | Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly.
Hinchy EC, Gruszczyk AV, Willows R, Navaratnam N, Hall AR, Bates G, Bright TP, Krieg T, Carling D, Murphy MP., Free PMC Article | 06/1/2019 |
| AMP-activated protein kinase can be modulated by diverse ligands and by phosphorylation. | Conformational heterogeneity of the allosteric drug and metabolite (ADaM) site in AMP-activated protein kinase (AMPK).
Gu X, Bridges MD, Yan Y, de Waal PW, Zhou XE, Suino-Powell KM, Xu HE, Hubbell WL, Melcher K., Free PMC Article | 06/1/2019 |
| Data suggest different gamma-isoforms in AMPK can have different effects on enzyme activation; here, activation of AMPK by compound 991 is greater if AMPK contains PRKAG2 versus PRKAG1 or PRKAG3. | Effect of different γ-subunit isoforms on the regulation of AMPK.
Willows R, Navaratnam N, Lima A, Read J, Carling D., Free PMC Article | 06/24/2017 |
| A subunit composition of AMPK (alpha2beta2gamma1) is preferred for colorectal cancer cell survival, at least in part, by stabilizing the tumor-specific expression of PGC1B. | AMPK Promotes Aberrant PGC1β Expression To Support Human Colon Tumor Cell Survival.
Fisher KW, Das B, Kim HS, Clymer BK, Gehring D, Smith DR, Costanzo-Garvey DL, Fernandez MR, Brattain MG, Kelly DL, MacMillan J, White MA, Lewis RE., Free PMC Article | 02/6/2016 |
| Pin1 plays an important role in the pathogenic mechanisms underlying impaired glucose and lipid metabolism, functioning as a negative regulator of AMPK | Prolyl isomerase Pin1 negatively regulates AMP-activated protein kinase (AMPK) by associating with the CBS domain in the γ subunit.
Nakatsu Y, Iwashita M, Sakoda H, Ono H, Nagata K, Matsunaga Y, Fukushima T, Fujishiro M, Kushiyama A, Kamata H, Takahashi S, Katagiri H, Honda H, Kiyonari H, Uchida T, Asano T., Free PMC Article | 01/16/2016 |
| Letter: report PRKAG1 frameshift mutations in colorectal cancer. | Frameshift mutations of PRKAG1 gene encoding an AMPK gamma subunit in colorectal cancers.
Choi MR, An CH, Yoo NJ, Lee SH. | 05/30/2015 |
| Electrogenic phosphate transport in sodium/phosphate cotransporter NaPi-IIa-expressing Xenopus oocytes is markedly decreased by the coexpression of constitutively active AMPKgammaR70Q, but not of AMPK(alphaK45R). | Down-regulation of the Na+-coupled phosphate transporter NaPi-IIa by AMP-activated protein kinase.
Dërmaku-Sopjani M, Almilaji A, Pakladok T, Munoz C, Hosseinzadeh Z, Blecua M, Sopjani M, Lang F. | 08/30/2014 |
| PRKAG1 interacts with DSCAM through its gamma subunit, and netrin-1 activates AMPK phosphorylation in cortical neurons. | AMPK interacts with DSCAM and plays an important role in netrin-1 induced neurite outgrowth.
Zhu K, Chen X, Liu J, Ye H, Zhu L, Wu JY., Free PMC Article | 09/7/2013 |
| Data indicate that except AMPK-alpha1, expressions of the other five AMPK subunits -alpha2, -beta1, -beta2, -gamma1 and -gamma2 are significantly higher in ovarian carcinomas. | Over-expressions of AMPK subunits in ovarian carcinomas with significant clinical implications.
Li C, Liu VW, Chiu PM, Chan DW, Ngan HY., Free PMC Article | 05/25/2013 |
| Studies suggest insights into the regulation of AMPK, its diverse biological actions, and therapeutic potential in the heart. | AMP-activated protein kinase regulation and biological actions in the heart.
Zaha VG, Young LH., Free PMC Article | 12/8/2012 |
| In breast cancer cells SESN2 is associated with AMPK. | Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells.
Sanli T, Linher-Melville K, Tsakiridis T, Singh G., Free PMC Article | 06/30/2012 |
| Conclude that cTnI phosphorylation by AMPK may represent a novel mechanism of regulation of cardiac function. | AMP-activated protein kinase phosphorylates cardiac troponin I and alters contractility of murine ventricular myocytes.
Oliveira SM, Zhang YH, Solis RS, Isackson H, Bellahcene M, Yavari A, Pinter K, Davies JK, Ge Y, Ashrafian H, Walker JW, Carling D, Watkins H, Casadei B, Redwood C. | 06/23/2012 |
| Studies indicate that in most species, AMPK exists as an obligate heterotrimer, containing a catalytic subunit (alpha), and two regulatory subunits (beta and gamma). | The AMPK signalling pathway coordinates cell growth, autophagy and metabolism.
Mihaylova MM, Shaw RJ., Free PMC Article | 12/10/2011 |
| Findings reveal that hypoxia can trigger AMPK activation in the apparent absence of increased [AMP] through ROS-dependent CRAC channel activation, leading to increases in cytosolic calcium that activate the AMPK upstream kinase CaMKKbeta. | Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels.
Mungai PT, Waypa GB, Jairaman A, Prakriya M, Dokic D, Ball MK, Schumacker PT., Free PMC Article | 10/15/2011 |
| Results suggest that AMPK association with ULK1 plays an important role in autophagy induction. | The association of AMPK with ULK1 regulates autophagy.
Lee JW, Park S, Takahashi Y, Wang HG., Free PMC Article | 04/30/2011 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program.
Jablonski KA, McAteer JB, de Bakker PI, Franks PW, Pollin TI, Hanson RL, Saxena R, Fowler S, Shuldiner AR, Knowler WC, Altshuler D, Florez JC, Diabetes Prevention Program Research Group., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesInvestigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?
Ruaño G, Thompson PD, Kane JP, Pullinger CR, Windemuth A, Seip RL, Kocherla M, Holford TR, Wu AH. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. | 09/15/2010 |
| Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator) | Integrative predictive model of coronary artery calcification in atherosclerosis.
McGeachie M, Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, Herrington D, Guo X, Lima JA, Post W, Rotter JI, Rich S, Sale M, Ramoni MF., Free PMC Article | 04/7/2010 |
| Inhibition of the KCa3.1 channels by AMP-activated protein kinase in human airway epithelial cells. | Inhibition of the KCa3.1 channels by AMP-activated protein kinase in human airway epithelial cells.
Klein H, Garneau L, Trinh NT, Privé A, Dionne F, Goupil E, Thuringer D, Parent L, Brochiero E, Sauvé R., Free PMC Article | 01/21/2010 |
| AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells. | AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells.
Hallows KR, Alzamora R, Li H, Gong F, Smolak C, Neumann D, Pastor-Soler NM., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | See all PubMed (3) articlesAssociation study of energy homeostasis genes and antipsychotic-induced weight gain in patients with schizophrenia.
Jassim G, Fernø J, Theisen FM, Haberhausen M, Christoforou A, Håvik B, Gebhardt S, Remschmidt H, Mehler-Wex C, Hebebrand J, Lehellard S, Steen VM. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators. Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone.
Ruaño G, Bernene J, Windemuth A, Bower B, Wencker D, Seip RL, Kocherla M, Holford TR, Petit WA, Hanks S. | 03/25/2009 |