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    AXL AXL receptor tyrosine kinase [ Homo sapiens (human) ]

    Gene ID: 558, updated on 14-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    First evidence of AXL expression on circulating tumor cells in metastatic breast cancer patients: A proof-of-concept study.

    First evidence of AXL expression on circulating tumor cells in metastatic breast cancer patients: A proof-of-concept study.
    Bardol T, Eslami-S Z, Masmoudi D, Alexandre M, Duboys de Labarre M, Bobrie A, D'Hondt V, Guiu S, Kurma K, Cayrefourcq L, Jacot W, Alix-Panabières C., Free PMC Article

    09/12/2024
    Aberrant activation of AXL may drive progression of squamous cell carcinoma in CLL patients: a mechanistic study with clinical implications.

    Aberrant activation of AXL may drive progression of squamous cell carcinoma in CLL patients: a mechanistic study with clinical implications.
    Sinha S, Guo R, Del Busso MD, Han W, Boysen J, Wellik LE, Ghosh AK, Kay NE.,

    09/11/2024
    Serum GAS6, sAXL, IL-10, NO, and BCL-2 levels are decreased in patients with Behcet's disease.

    Serum GAS6, sAXL, IL-10, NO, and BCL-2 levels are decreased in patients with Behçet's disease.
    Baskol G, Yetkin MÖ, Sevim DG, Guclu K, Arda H, Saracoglu H, Gahramanov K, Evereklioglu C., Free PMC Article

    05/7/2024
    ARRDC3 regulates the targeted therapy sensitivity of clear cell renal cell carcinoma by promoting AXL degradation.

    ARRDC3 regulates the targeted therapy sensitivity of clear cell renal cell carcinoma by promoting AXL degradation.
    Chen M, Yin B, Liu Y, Li M, Shen S, Wu J, Li W, Fan J.,

    04/12/2024
    Signaling Pathways of AXL Receptor Tyrosine Kinase Contribute to the Pathogenetic Mechanisms of Glioblastoma.

    Signaling Pathways of AXL Receptor Tyrosine Kinase Contribute to the Pathogenetic Mechanisms of Glioblastoma.
    Repici A, Ardizzone A, De Luca F, Colarossi L, Prestifilippo A, Pizzino G, Paterniti I, Esposito E, Capra AP., Free PMC Article

    04/3/2024
    AXL signal mediates adaptive resistance to KRAS G12C inhibitors in KRAS G12C-mutant tumor cells.

    AXL signal mediates adaptive resistance to KRAS G12C inhibitors in KRAS G12C-mutant tumor cells.
    Morimoto K, Yamada T, Hirai S, Katayama Y, Fukui S, Sawada R, Tachibana Y, Matsui Y, Nakamura R, Ishida M, Kawachi H, Kunimasa K, Sasaki T, Nishida M, Furuya N, Watanabe S, Shiotsu S, Nishioka N, Horinaka M, Sakai T, Uehara H, Yano S, Son BK, Tokuda S, Takayama K.

    03/26/2024
    Axl and MerTK regulate synovial inflammation and are modulated by IL-6 inhibition in rheumatoid arthritis.

    Axl and MerTK regulate synovial inflammation and are modulated by IL-6 inhibition in rheumatoid arthritis.
    Nerviani A, Boutet MA, Ghirardi GM, Goldmann K, Sciacca E, Rivellese F, Pontarini E, Prediletto E, Abatecola F, Caliste M, Pagani S, Mauro D, Bellan M, Cubuk C, Lau R, Church SE, Hudson BM, Humby F, Bombardieri M, Lewis MJ, Pitzalis C., Free PMC Article

    03/18/2024
    AXL/WRNIP1 Mediates Replication Stress Response and Promotes Therapy Resistance and Metachronous Metastasis in HER2+ Breast Cancer.

    AXL/WRNIP1 Mediates Replication Stress Response and Promotes Therapy Resistance and Metachronous Metastasis in HER2+ Breast Cancer.
    Marquez-Palencia M, Reza Herrera L, Parida PK, Ghosh S, Kim K, Das NM, Gonzalez-Ericsson PI, Sanders ME, Mobley BC, Diegeler S, Aguilera TA, Peng Y, Lewis CM, Arteaga CL, Hanker AB, Whitehurst AW, Lorens JB, Brekken RA, Davis AJ, Malladi S., Free PMC Article

    03/6/2024
    AXL - a new player in resistance to HER2 blockade.

    AXL - a new player in resistance to HER2 blockade.
    Adam-Artigues A, Arenas EJ, Arribas J, Prat A, Cejalvo JM.

    11/27/2023
    AXL receptor tyrosine kinase modulates gonadotropin-releasing hormone receptor signaling.

    AXL receptor tyrosine kinase modulates gonadotropin-releasing hormone receptor signaling.
    Mohammadzadeh P, Roueinfar M, Amberg GC., Free PMC Article

    11/18/2023
    AXL transcriptionally up-regulates TMEM14A expression to mediate cell proliferation in non-small-cell lung cancer cells.

    AXL transcriptionally up-regulates TMEM14A expression to mediate cell proliferation in non-small-cell lung cancer cells.
    Jang TH, Lin SC, Yang YY, Wu SH, Kuo TH, Chuang SE.

    11/7/2023
    Prognostic significance of immunhistochemical axl expression in pancreas ductal adenocarcinomas.

    Prognostic significance of ımmunhistochemical axl expression in pancreas ductal adenocarcinomas.
    Oz O, Argon A, Kebat TA, Ozdemir O, Yakan S.

    11/6/2023
    Investigation of the impact of AXL, TLR3, and STAT2 in congenital Zika syndrome through genetic polymorphisms and protein-protein interaction network analyses.

    Investigation of the impact of AXL, TLR3, and STAT2 in congenital Zika syndrome through genetic polymorphisms and protein-protein interaction network analyses.
    Gomes JA, Sgarioni E, Boquett JA, Kowalski TW, Fraga LR, Terças-Trettel ACP, da Silva JH, Ribeiro BFR, Galera MF, de Oliveira TM, Carvalho de Andrade MDF, Carvalho IF, Schüler-Faccini L, Vianna FSL.

    10/4/2023
    Targeting AXL in mesothelioma: From functional characterization to clinical implication.

    Targeting AXL in mesothelioma: From functional characterization to clinical implication.
    Bhadresha K, Mirza S, Penny C, Mughal MJ.

    08/2/2023
    Overexpression of AXL on macrophages associates with disease severity and recurrence in chronic rhinosinusitis with nasal polyps.

    Overexpression of AXL on macrophages associates with disease severity and recurrence in chronic rhinosinusitis with nasal polyps.
    Wang T, Chen Y, Gao R, Shui J, Xie B.

    07/26/2023
    AXL/Gas6 signaling mechanisms in the hypothalamic-pituitary-gonadal axis.

    AXL/Gas6 signaling mechanisms in the hypothalamic-pituitary-gonadal axis.
    Mohammadzadeh P, Amberg GC., Free PMC Article

    07/6/2023
    AXL in cancer: a modulator of drug resistance and therapeutic target.

    AXL in cancer: a modulator of drug resistance and therapeutic target.
    Tang Y, Zang H, Wen Q, Fan S., Free PMC Article

    06/23/2023
    Identifying key genes related to inflammasome in severe COVID-19 patients based on a joint model with random forest and artificial neural network.

    Identifying key genes related to inflammasome in severe COVID-19 patients based on a joint model with random forest and artificial neural network.
    Ou H, Fan Y, Guo X, Lao Z, Zhu M, Li G, Zhao L., Free PMC Article

    05/12/2023
    Axl contributes to efficient migration and invasion of melanoma cells.

    Axl contributes to efficient migration and invasion of melanoma cells.
    Shao H, Teramae D, Wells A., Free PMC Article

    04/12/2023
    LZTR1 Mutation Mediates Oncogenesis through Stabilization of EGFR and AXL.

    LZTR1 Mutation Mediates Oncogenesis through Stabilization of EGFR and AXL.
    Ko A, Hasanain M, Oh YT, D'Angelo F, Sommer D, Frangaj B, Tran S, Bielle F, Pollo B, Paterra R, Mokhtari K, Soni RK, Peyre M, Eoli M, Papi L, Kalamarides M, Sanson M, Iavarone A, Lasorella A.

    03/6/2023
    High levels of AXL expression in untreated EGFR-mutated non-small cell lung cancer negatively impacts the use of osimertinib.

    High levels of AXL expression in untreated EGFR-mutated non-small cell lung cancer negatively impacts the use of osimertinib.
    Yoshimura A, Yamada T, Serizawa M, Uehara H, Tanimura K, Okuma Y, Fukuda A, Watanabe S, Nishioka N, Takeda T, Chihara Y, Takemoto S, Harada T, Hiranuma O, Shirai Y, Shukuya T, Nishiyama A, Goto Y, Shiotsu S, Kunimasa K, Morimoto K, Katayama Y, Suda K, Mitsudomi T, Yano S, Kenmotsu H, Takahashi T, Takayama K., Free PMC Article

    02/11/2023
    Identification of AXL as a co-receptor for human parvovirus B19 infection of human erythroid progenitors.

    Identification of AXL as a co-receptor for human parvovirus B19 infection of human erythroid progenitors.
    Ning K, Zou W, Xu P, Cheng F, Zhang EY, Zhang-Chen A, Kleiboeker S, Qiu J., Free PMC Article

    02/11/2023
    Decreased CSTB, RAGE, and Axl Receptor Are Associated with Zika Infection in the Human Placenta.

    Decreased CSTB, RAGE, and Axl Receptor Are Associated with Zika Infection in the Human Placenta.
    Borges-Vélez G, Arroyo JA, Cantres-Rosario YM, Rodriguez de Jesus A, Roche-Lima A, Rosado-Philippi J, Rosario-Rodríguez LJ, Correa-Rivas MS, Campos-Rivera M, Meléndez LM., Free PMC Article

    12/3/2022
    AXL, along with PROS1, is overexpressed in papillary thyroid carcinoma and regulates its biological behaviour.

    AXL, along with PROS1, is overexpressed in papillary thyroid carcinoma and regulates its biological behaviour.
    Wei M, Wang Y, Liu Y, Li D, He X., Free PMC Article

    10/15/2022
    Axon guidance receptor ROBO3 modulates subtype identity and prognosis via AXL-associated inflammatory network in pancreatic cancer.

    Axon guidance receptor ROBO3 modulates subtype identity and prognosis via AXL-associated inflammatory network in pancreatic cancer.
    Krebs N, Klein L, Wegwitz F, Espinet E, Maurer HC, Tu M, Penz F, Küffer S, Xu X, Bohnenberger H, Cameron S, Brunner M, Neesse A, Kishore U, Hessmann E, Trumpp A, Ströbel P, Brekken RA, Ellenrieder V, Singh SK., Free PMC Article

    09/17/2022
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