| The role of phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG1) in regulating the progression of oral squamous cell carcinoma. | The role of phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG1) in regulating the progression of oral squamous cell carcinoma.
Sun Y, Yang X, Guan S, Ma T, Jiang Z, Gao M, Xu Y, Cong B. | 11/29/2023 |
| Transmembrane adaptor protein PAG is a mediator of PD-1 inhibitory signaling in human T cells. | Transmembrane adaptor protein PAG is a mediator of PD-1 inhibitory signaling in human T cells.
Strazza M, Azoulay-Alfaguter I, Peled M, Adam K, Mor A., Free PMC Article | 08/21/2021 |
| PAG1 stimulates proliferation and metastasis of nasopharyngeal carcinoma through downregulating PTEN. | PAG1 stimulates proliferation and metastasis of nasopharyngeal carcinoma through downregulating PTEN.
Lin JJ, Fan JJ, Ge XJ, Sha HB. | 07/3/2021 |
| PAG1 directs SRC-family kinase intracellular localization to mediate receptor tyrosine kinase-induced differentiation. | PAG1 directs SRC-family kinase intracellular localization to mediate receptor tyrosine kinase-induced differentiation.
Foltz L, Palacios-Moreno J, Mayfield M, Kinch S, Dillon J, Syrenne J, Levy T, Grimes M., Free PMC Article | 06/26/2021 |
| PAG1 conferred inherent radioresistance by activating STAT3. | PAG1 promotes the inherent radioresistance of laryngeal cancer cells via activation of STAT3.
Shen L, Ke Q, Chai J, Zhang C, Qiu L, Peng F, Deng X, Luo Z. | 09/21/2019 |
| Low PAG1 expression is associated neuroblastoma. | Transmembrane adaptor protein PAG1 is a novel tumor suppressor in neuroblastoma.
Agarwal S, Ghosh R, Chen Z, Lakoma A, Gunaratne PH, Kim ES, Shohet JM., Free PMC Article | 02/24/2018 |
| Our study highlights the underlying mechanism of cross interaction between ASCs and breast cancer cells, and indicates that PAG1/Cbp in breast cancer cell may modulate tumor progression and acquired chemoresistance in the ASCs-associated breast cancer microenvironment through Src and AKT/mTOR pathways. | Upregulation of PAG1/Cbp contributes to adipose-derived mesenchymal stem cells promoted tumor progression and chemoresistance in breast cancer.
Lu Y, Yang Y, Liu Y, Hao Y, Zhang Y, Hu Y, Jiang L, Gong Y, Wu K, Liu Y. | 11/25/2017 |
| Up-regulated expression of CBP in Jurkat cells could reduce cell homogeneity and promote cell apoptosis | [Phenotypic changes and apoptosis of Jurkat cells induced by over-expression of C-Src kinase-binding protein].
Gao M, Cong B, Wang B, Wang L, Shao Z. | 11/14/2015 |
| No association Pag1 mutation with patient with Schizophrenia. | Sequencing and expression analyses of the synaptic lipid raft adapter gene PAG1 in schizophrenia.
Balan S, Iwayama Y, Yamada K, Toyota T, Ohnishi T, Toyoshima M, Shimamoto C, Ide M, Iwata Y, Suzuki K, Kikuchi M, Hashimoto T, Kanahara N, Yoshikawa T, Maekawa M. | 11/14/2015 |
| The risk-associated allele of rs2370615 predisposes to allergic disease by increasing PAG1 expression, which might promote B cell activation and have a pro-inflammatory effect. | Long-Range Modulation of PAG1 Expression by 8q21 Allergy Risk Variants.
Vicente CT, Edwards SL, Hillman KM, Kaufmann S, Mitchell H, Bain L, Glubb DM, Lee JS, French JD, Ferreira MA., Free PMC Article | 10/31/2015 |
| CBP may decrease the metastasis of esophageal carcinoma by inhibiting the activation of Src. | Overexpression of Csk-binding protein decreases growth, invasion, and migration of esophageal carcinoma cells by controlling Src activation.
Zhou D, Dong P, Li YM, Guo FC, Zhang AP, Song RZ, Zhang YM, Li ZY, Yuan D, Yang C., Free PMC Article | 09/26/2015 |
| The inhibitory function of novobiocin in disrupting the HIF1alpha/p300 complex might be important in tumor cell growth. | A novel function of novobiocin: disrupting the interaction of HIF 1α and p300/CBP through direct binding to the HIF1α C-terminal activation domain.
Wu D, Zhang R, Zhao R, Chen G, Cai Y, Jin J., Free PMC Article | 12/21/2013 |
| siRNA directed against PAG1 in a radioresistant (Hep-2max) cell line dramatically enhanced the radiosensitivity and IR-induced cell death. | Identification of the PAG1 gene as a novel target of inherent radioresistance in human laryngeal carcinoma cells.
Ke Q, Wu J, Ming B, Zhu S, Yu M, Wang Y, Hu C, Xu S, Luo Z. | 08/31/2013 |
| expression of CBP gene is decreased in esophageal carcinoma, which might contribute to the tumorigenesis and progression. | [Expression of Csk-binding protein in esophageal carcinoma and its possible implications].
Zhou D, Zhang AP, Liu T, Li ZY, Yang YZ, Song RZ. | 05/18/2013 |
| findings support a negative regulatory function for Cbp/PAG in proximal B cell receptor signaling in normal and EBV-transformed B cells | Modulation of proximal signaling in normal and transformed B cells by transmembrane adapter Cbp/PAG.
Kalland ME, Solheim SA, Skånland SS, Taskén K, Berge T. | 09/15/2012 |
| An over-expression of PAG1 in PC-3M-1E8 cells effectively suppresses the activation of Ras and ERK, as well as the cyclin D1 expression, leading to an inhibition of the proliferation ability of tumor cells. | [Influence of phosphoprotein associated with glycosphingolipid microdomains 1 on biologic behavior of human prostatic cancer cell line in-vitro].
Yu WJ, Wang YW, You JF, Wang JL, Cui XL, Pei F, Zheng J. | 09/24/2011 |
| Cbp down-regulation is primarily mediated by epigenetic histone modifications via oncogenic MAPK/PI3K pathways in a subset of cancer cells. | Down-regulation of the tumor suppressor C-terminal Src kinase (Csk)-binding protein (Cbp)/PAG1 is mediated by epigenetic histone modifications via the mitogen-activated protein kinase (MAPK)/phosphatidylinositol 3-kinase (PI3K) pathway.
Suzuki K, Oneyama C, Kimura H, Tajima S, Okada M., Free PMC Article | 07/2/2011 |
| Results indicate that Cbp is required for the Csk-mediated inactivation of c-Src and may control the promotion of malignancy in NSCLC tumors that are characterized by c-Src upregulation. | The transmembrane adaptor Cbp/PAG1 controls the malignant potential of human non-small cell lung cancers that have c-src upregulation.
Kanou T, Oneyama C, Kawahara K, Okimura A, Ohta M, Ikeda N, Shintani Y, Okumura M, Okada M. | 05/7/2011 |
| PAG1 protein was downregulated in PC-3M-1E8 prostate cancer cell line. | [Screening of phosphoprotein associated with glycosphingolipid microdomains 1 (PAG1) by cDNA microarray and influence of overexpression of PAG1 on biologic behavior of human metastatic prostatic cancer cell line in vitro].
Yu WJ, Wang YW, Xie ZG, You JF, Wang JL, Cui XL, Pei F, Zheng J. | 04/2/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 09/15/2010 |
| In the membrane environment of ALK+ lymphoma rafts, where the glycosphingolipid to signaling protein ratio is higher than in B-NHL rafts, the Lyn activity is suboptimal and does not allow the formation of an efficient Lyn-Cbp/PAG signalosome | The sphingolipid-rich rafts of ALK+ lymphomas downregulate the Lyn-Cbp/PAG signalosome.
Yerly S, Ding H, Tauzin S, van Echten-Deckert G, Borisch B, Hoessli DC. | 08/23/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| new insights into the function of Cbp in modulating RhoA activation, by which Cbp might contribute to renal cell carcinogenesis | Overexpression of Csk-binding protein contributes to renal cell carcinogenesis.
Feng X, Lu X, Man X, Zhou W, Jiang LQ, Knyazev P, Lei L, Huang Q, Ullrich A, Zhang Z, Chen Z. | 01/21/2010 |
| role in control of proliferation and survival in most B-non-Hodgkin lymphomas | Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts.
Tauzin S, Ding H, Khatib K, Ahmad I, Burdevet D, van Echten-Deckert G, Lindquist JA, Schraven B, Din NU, Borisch B, Hoessli DC. | 01/21/2010 |