| PRKCH polymorphism is associated with rheumatoid arthritis in a Chinese population. | PRKCH polymorphism is associated with rheumatoid arthritis in a Chinese population.
Zhuang Y, Di Y, Huang L, Zhu J. | 10/3/2020 |
| Study provides mechanistic evidence that inhibition of PKCeta isoform alleviated mitochondrial injuries and function, attenuated apoptosis, and renal fibrosis in high glucose (HG)-cultured advanced oxidation protein products (AOPPs)-induced HK-2 cells. Thus, AOPPs-induced mitochondrial dysfunction and oxidative stress cause tubulointerstitial fibrosis in diabetic nephropathy via activation of the PKCeta isoform. | Advanced Oxidation Protein Products Aggravate Tubulointerstitial Fibrosis Through Protein Kinase C-Dependent Mitochondrial Injury in Early Diabetic Nephropathy.
Li X, Xu L, Hou X, Geng J, Tian J, Liu X, Bai X. | 07/25/2020 |
| The author show that knockdown of PKCeta caused resistance to chemotherapeutic drug-induced apoptosis and this could be explained by the induction of cellular senescence. | Differential effects of protein kinase C-eta on apoptosis versus senescence.
Basu A, Pal D, Blaydes R. | 04/11/2020 |
| These results suggest that PKCeta utilizes the ERK signaling pathway to protect against ubiquitin-mediated proteasomal degradation of Mcl-1 | Protein kinase C-eta regulates Mcl-1 level via ERK1.
Pal D, Basu A. | 06/16/2018 |
| PRKCH rs2230500 gene polymorphism is significantly related to the efficiency in telmisartan therapy (p = 0.02). The PRKCH rs2230500 may influence the antihypertensive efficacy of telmisartan in Chinese EH patients. | Influence of PRKCH gene polymorphism on antihypertensive response to amlodipine and telmisartan.
Zhang ZL, Zhu MM, Li HL, Shi LH, Chen XP, Luo J, Zhao JF. | 05/19/2018 |
| PRKCH is highly expressed in hematopoietic stem cell (HSC) and is necessary for optimal HSC function. | PRKCH regulates hematopoietic stem cell function and predicts poor prognosis in acute myeloid leukemia.
Porter SN, Magee JA., Free PMC Article | 09/30/2017 |
| The association between PRKCH 1425G/A and lacunar infarction was independent of traditional stroke risk factors | Protein kinase Cη polymorphism and the susceptibility to ischemic stroke in the Taiwan population.
Chen YC, Huang CJ, Chen P, Wu YR, Shie SS, Chen ST, Lee-Chen GJ, Chen CM. | 12/17/2016 |
| Data suggest that targeted manipulation of protein kinase C isoforms PKCalpha, PKCbeta, and PKCeta might be beneficial in certain proteinuric kidney diseases with altered transient receptor potential cation channel subfamily C member 6 protein (TRPC6) functions. | Inhibition of TRPC6 by protein kinase C isoforms in cultured human podocytes.
Ambrus L, Oláh A, Oláh T, Balla G, Saleem MA, Orosz P, Zsuga J, Bíró K, Csernoch L, Bíró T, Szabó T., Free PMC Article | 12/17/2016 |
| variant genotypes of PRKCH 1425G/A are an independent prognostic factor for ischemic stroke in the final multivariate Cox regression model | PRKCH 1425G/A Polymorphism Predicts Recurrence of Ischemic Stroke in a Chinese Population.
Zhang Z, Xu G, Zhu W, Cao L, Yan B, Liu X. | 09/3/2016 |
| Meta-analysis indicated that the 1425G/A SNP in PRKCH may contribute to susceptibility of stroke, especially for ischemic stroke. | A quantitative assessment of the association between 1425G/A polymorphism in PRKCH and risk of stroke.
Sun L, Zhang Z, Ma M, Xu G, Liu X. | 07/25/2015 |
| PKCeta promotes senescence through its ability to upregulate the expression of the cell cycle inhibitors p21Cip1 and p27Kip1 and enhance transcription and secretion of IL-6. | PKCη promotes senescence induced by oxidative stress and chemotherapy.
Zurgil U, Ben-Ari A, Atias K, Isakov N, Apte R, Livneh E., Free PMC Article | 07/4/2015 |
| The 1425G/A polymorphism in PRKCH is not a significant predictor of stroke recurrence in patients with acute ischemic stroke during a 2-year follow-up period. | Impact of the 1425G/A polymorphism of PRKCH on the recurrence of ischemic stroke: Fukuoka Stroke Registry.
Matsuo R, Ago T, Hata J, Kuroda J, Wakisaka Y, Sugimori H, Kitazono T, Kamouchi M, FSR Investigators. | 02/28/2015 |
| PKC-eta associates with NHE3 and gamma tubulin to promote the cell polarity during migration. | NHE3 phosphorylation via PKCη marks the polarity and orientation of directionally migrating cells.
Özkucur N, Song B, Bola S, Zhang L, Reid B, Fu G, Funk RHW, Zhao M., Free PMC Article | 01/17/2015 |
| These results suggest that siRNA-mediated silencing of PKCeta can be a potent tool to complement existing chemotherapy regimens for treating EBV(+) B lymphoma. | Silencing of PKCη induces cycle arrest of EBV(+) B lymphoma cells by upregulating expression of p38-MAPK/TAp73/GADD45α and increases susceptibility to chemotherapeutic agents.
Park GB, Choi Y, Kim YS, Lee HK, Kim D, Hur DY. | 08/9/2014 |
| the PKC family genes may play a role in the pathogenesis of MS relapse through modulating the association between 25(OH)D and relapse. | Novel modulating effects of PKC family genes on the relationship between serum vitamin D and relapse in multiple sclerosis.
Lin R, Taylor BV, Simpson S Jr, Charlesworth J, Ponsonby AL, Pittas F, Dwyer T, van der Mei IA. | 05/3/2014 |
| Upregulation of PKCeta contributes to breast cancer cell growth and targeting either PKCepsilon or PDK1 triggers PKCeta downregulation | Upregulation of PKCη by PKCε and PDK1 involves two distinct mechanisms and promotes breast cancer cell survival.
Pal D, Outram SP, Basu A., Free PMC Article | 08/31/2013 |
| study demonstrates that type V collagen induces the down-regulation of protein kinase C eta | Type V collagen and protein kinase C η down-regulation in 8701-BC breast cancer cells.
Luparello C, Sirchia R, Longo A. | 06/8/2013 |
| these results suggest that the regulation of PKCeta is unique and PKCepsilon is required for the PKC activator-induced upregulation of PKCeta. | Novel regulation of protein kinase C-η.
Pal D, Outram SP, Basu A., Free PMC Article | 01/26/2013 |
| The single nucleotide polymorphism (rs2230500) in PRKCH decreases the risk of carotid intima-media thickness. | The SNP (rs2230500) in PRKCH decreases the risk of carotid intima-media thickness in a Chinese young adult population.
Wu L, Xi B, Hou D, Zhao X, Liu J, Cheng H, Zhou X, Shen Y, Wang X, Mi J., Free PMC Article | 01/12/2013 |
| There was loss of the negative correlation in the expression levels of CD3eta and FcepsilonRIgamma genes in CLL patients. | Expression feature of CD3, FcεRIγ, and Zap-70 in patients with chronic lymphocytic leukemia.
Huang L, Chen S, Zha X, Yang L, Li B, Yu Z, Wang L, Li Y. | 12/22/2012 |
| Protein kinase Ceta 1425G/A variant was not a risk locus for deep intracerebral hemorrhage phenotype. | Protein kinase Cη polymorphism and the susceptibilities to intracerebral hemorrhage in the Taiwan population.
Chen YC, Chen P, Wu YR, Shie SS, Chen ST, Lee-Chen GJ, Chen CM. | 12/22/2012 |
| It was shown that the PKCeta isoform is a negative regulator of the AKT signaling pathway. The IGF-I induced phosphorylation on Ser473 of AKT was inhibited by the PKCeta-induced expression in MCF-7 breast adenocarcinoma cancer cells. | PKCη is a negative regulator of AKT inhibiting the IGF-I induced proliferation.
Shahaf G, Rotem-Dai N, Koifman G, Raveh-Amit H, Frost SA, Livneh E. | 05/19/2012 |
| A remarkable association of minor alleles (1425G/A and _15) in the PRKCH gene with an elevated risk of coronary artery disease and increased levels of LDL-C in a Chinese population. | The role of PRKCH gene variants in coronary artery disease in a Chinese population.
Zhu J, Yan JJ, Kuai ZP, Gao W, Tang JJ, Jia EZ, Yang ZJ, Wang LS. | 05/5/2012 |
| The present meta-analyses suggested that 1425G/A SNP in PRKCH was associated with ischemic stroke, particularly lacunar infarction, in Chinese and Japanese populations. | Association between 1425G/A SNP in PRKCH and ischemic stroke among Chinese and Japanese populations: a meta-analysis including 3686 cases and 4589 controls.
Li J, Luo M, Xu X, Sheng W. | 04/28/2012 |
| In the present study, a significant association between the PRKCH 1425G/A polymorphism and SSNHL risk was observed through a nested case-control analysis within the population-based study. | Contribution of 1425G/A polymorphism in protein kinase C-Eta (PRKCH) gene and brain white matter lesions to the risk of sudden sensorineural hearing loss in a Japanese nested case-control study.
Uchida Y, Sugiura S, Nakashima T, Ando F, Shimokata H. | 01/21/2012 |