| Anti-NSCLC role of SCN4B by negative regulation of the cGMP-PKG pathway: Integrated utilization of bioinformatics analysis and in vitro assay validation. | Anti-NSCLC role of SCN4B by negative regulation of the cGMP-PKG pathway: Integrated utilization of bioinformatics analysis and in vitro assay validation.
Yang X, Liu Q, Li G. | 05/8/2024 |
| Increased endogenous PKG I activity attenuates EGF-induced proliferation and migration of epithelial ovarian cancer via the MAPK/ERK pathway. | Increased endogenous PKG I activity attenuates EGF-induced proliferation and migration of epithelial ovarian cancer via the MAPK/ERK pathway.
Lan T, Li Y, Wang Y, Wang ZC, Mu CY, Tao AB, Gong JL, Zhou Y, Xu H, Li SB, Gu B, Ma P, Luo L., Free PMC Article | 01/28/2023 |
| Downexpression of miR-200c-3p Contributes to Achalasia Disease by Targeting the PRKG1 Gene. | Downexpression of miR-200c-3p Contributes to Achalasia Disease by Targeting the PRKG1 Gene.
Micale L, Fusco C, Nardella G, Palmieri O, Latiano T, Gioffreda D, Tavano F, Panza A, Merla A, Biscaglia G, Gentile M, Cuttitta A, Castori M, Perri F, Latiano A., Free PMC Article | 01/14/2023 |
| Mutual Protein-Ligand Conformational Selection Drives cGMP vs. cAMP Selectivity in Protein Kinase G. | Mutual Protein-Ligand Conformational Selection Drives cGMP vs. cAMP Selectivity in Protein Kinase G.
VanSchouwen B, Boulton S, Melacini G. | 11/27/2021 |
| Next Generation Exome Sequencing of Pediatric Asthma Identifies Rare and Novel Variants in Candidate Genes. | Next Generation Exome Sequencing of Pediatric Asthma Identifies Rare and Novel Variants in Candidate Genes.
Bogari NM, Amin AA, Rayes HH, Abdelmotelb A, Taher MM, Al-Allaf FA, Bouazzaoui A, O'Gorman L, Holloway JW., Free PMC Article | 10/30/2021 |
| Nociceptor-localized cGMP-dependent protein kinase I is a critical generator for central sensitization and neuropathic pain. | Nociceptor-localized cGMP-dependent protein kinase I is a critical generator for central sensitization and neuropathic pain.
Wang F, Ma SB, Tian ZC, Cui YT, Cong XY, Wu WB, Wang FD, Li ZZ, Han WJ, Wang TZ, Sun ZC, Zhang FL, Xie RG, Wu SX, Luo C. | 06/19/2021 |
| Expression profiles of PRKG1, SDF2L1 and PPP1R12A are predictive and prognostic factors for therapy response and survival in high-grade serous ovarian cancer. | Expression profiles of PRKG1, SDF2L1 and PPP1R12A are predictive and prognostic factors for therapy response and survival in high-grade serous ovarian cancer.
Benvenuto G, Todeschini P, Paracchini L, Calura E, Fruscio R, Romani C, Beltrame L, Martini P, Ravaggi A, Ceppi L, Sales G, Donati F, Perego P, Zanotti L, Ballabio S, Grassi T, Delle Marchette M, Tognon G, Sartori E, Adorni M, Odicino F, D'Incalci M, Bignotti E, Romualdi C, Marchini S. | 03/13/2021 |
| A substitution in cGMP-dependent protein kinase 1 associated with aortic disease induces an active conformation in the absence of cGMP. | A substitution in cGMP-dependent protein kinase 1 associated with aortic disease induces an active conformation in the absence of cGMP.
Chan MH, Aminzai S, Hu T, Taran A, Li S, Kim C, Pilz RB, Casteel DE., Free PMC Article | 01/16/2021 |
| O-GlcNAcylation activates PGK1 activity to enhance lactate production, and simultaneously induces PGK1 translocation into mitochondria. | O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth.
Nie H, Ju H, Fan J, Shi X, Cheng Y, Cang X, Zheng Z, Duan X, Yi W., Free PMC Article | 04/25/2020 |
| Increased oxidation of PKGIalpha to its disulfide-activated state found in pulmonary arteries from mice with hypoxic pulmonary arterial hypertension (PH) or lungs from patients. It caused by chronic hypoxia, and it limits progression of PH by pulmonary vasodilation that counters and offsets maladaptive vasoconstriction, and also disulfide PKGIalpha is protective by preventing maladaptive growth and fibrosis signaling. | Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension.
Rudyk O, Rowan A, Prysyazhna O, Krasemann S, Hartmann K, Zhang M, Shah AM, Ruppert C, Weiss A, Schermuly RT, Ida T, Akaike T, Zhao L, Eaton P., Free PMC Article | 04/11/2020 |
| Self-regulation and the foraging gene (PRKG1) in humans. | Self-regulation and the foraging gene (PRKG1) in humans.
Struk AA, Mugon J, Huston A, Scholer AA, Stadler G, Higgins ET, Sokolowski MB, Danckert J., Free PMC Article | 03/21/2020 |
| This case-control study supports the association of an interaction of PRKG1 and trauma exposure with Alcohol Use Disorder symptoms in a sample of African American college students. | Replication of the Interaction of PRKG1 and Trauma Exposure on Alcohol Misuse in an Independent African American Sample.
Hawn SE, Sheerin CM, Webb BT, Peterson RE, Do EK, Dick D, Kendler KS, Bacanu SA, Amstadter AB., Free PMC Article | 02/8/2020 |
| The PRKG1 (p.Arg177Gln) mutation although rare is associated with nonsyndromic type B aortic dissection in young and middle-aged individuals. | The natural history of type B aortic dissection in patients with PRKG1 mutation c.530G>A (p.Arg177Gln).
Shalhub S, Regalado ES, Guo DC, Milewicz DM, Montalcino Aortic Consortium. | 02/1/2020 |
| TSC2 phosphorylation is both required and sufficient for PKG1-mediated cardiac protection against pressure overload | PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress.
Ranek MJ, Kokkonen-Simon KM, Chen A, Dunkerly-Eyring BL, Vera MP, Oeing CU, Patel CH, Nakamura T, Zhu G, Bedja D, Sasaki M, Holewinski RJ, Van Eyk JE, Powell JD, Lee DI, Kass DA., Free PMC Article | 07/27/2019 |
| results suggest that the lack of cGKI possibly leads to stellate cell activation, which stimulates chemokine expression and activates inflammatory processes, which could disturb hepatic insulin sensitivity | cGMP-dependent protein kinase I (cGKI) modulates human hepatic stellate cell activation.
Franko A, Kovarova M, Feil S, Feil R, Wagner R, Heni M, Königsrainer A, Ruoß M, Nüssler AK, Weigert C, Häring HU, Lutz SZ, Peter A. | 05/11/2019 |
| our study provides the first genome-wide evidence regarding a mechanism by which traumatic life events interact with human genetic variation of PRKG1 in relation to alcohol misuse | A genome-wide gene-by-trauma interaction study of alcohol misuse in two independent cohorts identifies PRKG1 as a risk locus.
Polimanti R, Kaufman J, Zhao H, Kranzler HR, Ursano RJ, Kessler RC, Gelernter J, Stein MB., Free PMC Article | 12/22/2018 |
| Disulfide-activated PKGIalpha regulates cardiac diastolic relaxation and fine-tunes the Frank-Starling response. | Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank-Starling response.
Scotcher J, Prysyazhna O, Boguslavskyi A, Kistamas K, Hadgraft N, Martin ED, Worthington J, Rudyk O, Rodriguez Cutillas P, Cuello F, Shattock MJ, Marber MS, Conte MR, Greenstein A, Greensmith DJ, Venetucci L, Timms JF, Eaton P., Free PMC Article | 08/25/2018 |
| PRKG1, known to induce apoptosis when activated, is increased in all patient derived glioblastoma spheres | Reversibility of glioma stem cells' phenotypes explains their complex in vitro and in vivo behavior: Discovery of a novel neurosphere-specific enzyme, cGMP-dependent protein kinase 1, using the genomic landscape of human glioma stem cells as a discovery tool.
Wilson TJ, Zamler DB, Doherty R, Castro MG, Lowenstein PR., Free PMC Article | 05/19/2018 |
| redox-mediated guidance required PKG1 and consequently, its deficiency in vivo resulted in defective repair and enhanced neuropathic pain after nerve injury. PKG1-dependent repair functions will outweigh its signaling functions in spinal nociceptive LTP, so that inhibition of PKG1 is no option for neuropathic pain. | Redox-guided axonal regrowth requires cyclic GMP dependent protein kinase 1: Implication for neuropathic pain.
Valek L, Häussler A, Dröse S, Eaton P, Schröder K, Tegeder I., Free PMC Article | 12/2/2017 |
| Oxidant signaling underlies PKGIalpha modulation of Ca2+ sparks and BKCa in myogenically active arterioles | Oxidant signaling underlies PKGIα modulation of Ca2+ sparks and BKCa in myogenically active arterioles.
Hill MA, Braun AP. | 11/25/2017 |
| These affinity and activation measurements show that beta-phenyl-1,N2-ethenoguanosine 3',5'-monophosphate (PET-cGMP) is most selective for PKG I, whereas 8-(4-chlorophenylthio)guanosine-3'-5'-cyclic monophosphate (8-pCPT-cGMP) is most selective for PKG II. | Structural Basis of Analog Specificity in PKG I and II.
Campbell JC, Henning P, Franz E, Sankaran B, Herberg FW, Kim C., Free PMC Article | 10/14/2017 |
| Hence, SO2 exerted its vasodilatory effects at least partly by promoting disulfide-dependent dimerization of sGC and PKG, resulting in an activated sGC/cGMP/PKG pathway in blood vessels. These findings revealed a new mode of action and mechanisms by which SO2 regulated the vascular tone. | The vasodilatory effect of sulfur dioxide via SGC/cGMP/PKG pathway in association with sulfhydryl-dependent dimerization.
Yao Q, Huang Y, Liu AD, Zhu M, Liu J, Yan H, Zhang Q, Geng B, Gao Y, Du S, Huang P, Tang C, Du J, Jin H. | 07/1/2017 |
| these data indicate PKG as an intermediary in EGFR-mediated cell death, likely via apoptotic pathway. | Protein Kinase G facilitates EGFR-mediated cell death in MDA-MB-468 cells.
Jackson NM, Ceresa BP., Free PMC Article | 05/20/2017 |
| The heterozygous c.530G>A:p.Arg177Gln PRKG1 variant was associated with early-onset thoracic aortic aneurysm and dissection in a Spanish family. | PRKG1 and genetic diagnosis of early-onset thoracic aortic disease.
Gago-Díaz M, Blanco-Verea A, Teixidó G, Huguet F, Gut M, Laurie S, Gut I, Carracedo Á, Evangelista A, Brion M. | 04/22/2017 |
| cAMP is a partial agonist for PKG, and we elucidate the mechanism for cAMP partial agonism through the comparative NMR analysis of the apo, cGMP-, and cAMP-bound forms of the PKG cyclic nucleotide-binding domain B. | Mechanism of cAMP Partial Agonism in Protein Kinase G (PKG).
VanSchouwen B, Selvaratnam R, Giri R, Lorenz R, Herberg FW, Kim C, Melacini G., Free PMC Article | 03/19/2016 |