| Spire1 and Myosin Vc promote Ca(2+)-evoked externalization of von Willebrand factor in endothelial cells. | Spire1 and Myosin Vc promote Ca(2+)-evoked externalization of von Willebrand factor in endothelial cells.
Holthenrich A, Terglane J, Naß J, Mietkowska M, Kerkhoff E, Gerke V., Free PMC Article | 02/12/2022 |
| Pendred Syndrome, or Not Pendred Syndrome? That Is the Question. | Pendred Syndrome, or Not Pendred Syndrome? That Is the Question.
Tesolin P, Fiorino S, Lenarduzzi S, Rubinato E, Cattaruzzi E, Ammar L, Castro V, Orzan E, Granata C, Dell'Orco D, Morgan A, Girotto G., Free PMC Article | 02/12/2022 |
| Unveiling the interaction between the molecular motor Myosin Vc and the small GTPase Rab3A. | Unveiling the interaction between the molecular motor Myosin Vc and the small GTPase Rab3A.
Dolce LG, Ohbayashi N, Silva DFCD, Ferrari AJR, Pirolla RAS, Schwarzer ACAP, Zanphorlin LM, Cabral L, Fioramonte M, Ramos CHI, Gozzo FC, Fukuda M, Giuseppe PO, Murakami MT. | 04/17/2021 |
| MyoVc is unique in taking variable size steps, which are frequently in the backward direction. Results obtained with chimeric constructs implicate the lever arm/rod of MyoVc as being responsible for these properties. Actin bundles allow single MyoVc motors to move processively. | Myosin Vc Is Specialized for Transport on a Secretory Superhighway.
Sladewski TE, Krementsova EB, Trybus KM., Free PMC Article | 12/30/2017 |
| The myosin V structure reveals the detailed rearrangements underlying myosin force generation as well as the basis of strain-dependent ADP release that is essential for processive myosins, such as myosin V. | Force-producing ADP state of myosin bound to actin.
Wulf SF, Ropars V, Fujita-Becker S, Oster M, Hofhaus G, Trabuco LG, Pylypenko O, Sweeney HL, Houdusse AM, Schröder RR., Free PMC Article | 09/3/2016 |
| Myo5c-globular tail domain and Myo5a-globular tail domain are not interchangeable in terms of inhibiting the motor function. | Identification of the Isoform-specific Interactions between the Tail and the Head of Class V Myosin.
Yao LL, Shen M, Lu Z, Ikebe M, Li XD., Free PMC Article | 09/3/2016 |
| Rab38 and its close homolog Rab32 bind to Myosin Vc but not to Myosin Va or Myosin Vb. Binding depends on residues in the switch II region of Rab32 and Rab38 and regions of the Myosin Vc coiled-coil tail domain. | Myosin vc interacts with Rab32 and Rab38 proteins and works in the biogenesis and secretion of melanosomes.
Bultema JJ, Boyle JA, Malenke PB, Martin FE, Dell'Angelica EC, Cheney RE, Di Pietro SM., Free PMC Article | 02/14/2015 |
| Structural insights into the globular tails of the human type v myosins Myo5a, Myo5b, And Myo5c. | Structural insights into the globular tails of the human type v myosins Myo5a, Myo5b, And Myo5c.
Velvarska H, Niessing D., Free PMC Article | 09/20/2014 |
| the cargo-binding domain (CBD) structures of the three human MyoV paralogs (Va, Vb, and Vc), revealing subtle structural changes that drive functional differentiation and a novel redox mechanism controlling the CBD dimerization process | Structural insights into functional overlapping and differentiation among myosin V motors.
Nascimento AFZ, Trindade DM, Tonoli CCC, de Giuseppe PO, Assis LHP, Honorato RV, de Oliveira PSL, Mahajan P, Burgess-Brown NA, von Delft F, Larson RE, Murakami MT., Free PMC Article | 02/8/2014 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| These results provide the first live-cell imaging of Myo5c and indicate that Myo5c functions in secretory granule trafficking. | Myosin Vc is a molecular motor that functions in secretory granule trafficking.
Jacobs DT, Weigert R, Grode KD, Donaldson JG, Cheney RE., Free PMC Article | 03/15/2010 |
| These data suggest that Myo5c associated with Rab8 is involved in the release of dengue virus 2 from HepG2 cells. | Myosin Vc, a member of the actin motor family associated with Rab8, is involved in the release of DV2 from HepG2 cells.
Xu XF, Chen ZT, Gao N, Zhang JL, An J. | 01/21/2010 |
| related Rab protein, Rab10, can interact with myosin Va, myosin Vb, and myosin Vc | Alternative splicing in class V myosins determines association with Rab10.
Roland JT, Lapierre LA, Goldenring JR., Free PMC Article | 01/21/2010 |
| myosin Vc is a low duty ratio nonprocessive motor | Human myosin Vc is a low duty ratio nonprocessive motor.
Watanabe S, Watanabe TM, Sato O, Awata J, Homma K, Umeki N, Higuchi H, Ikebe R, Ikebe M., Free PMC Article | 01/21/2010 |
| Kinetic simulations reveal that the high ADP affinity of actomyosin Vc may lead to elevations of the duty ratio of myosin Vc to as high as 64% under possible physiological ADP concentrations | Human myosin Vc is a low duty ratio, nonprocessive molecular motor.
Takagi Y, Yang Y, Fujiwara I, Jacobs D, Cheney RE, Sellers JR, Kovács M. | 01/21/2010 |