| Extracellular sulfatase-2 is overexpressed in rheumatoid arthritis and mediates the TNF-alpha-induced inflammatory activation of synovial fibroblasts. | Extracellular sulfatase-2 is overexpressed in rheumatoid arthritis and mediates the TNF-α-induced inflammatory activation of synovial fibroblasts.
Siegel RJ, Singh AK, Panipinto PM, Shaikh FS, Vinh J, Han SU, Kenney HM, Schwarz EM, Crowson CS, Khuder SA, Khuder BS, Fox DA, Ahmed S., Free PMC Article | 10/8/2022 |
| SULF2 enhances GDF15-SMAD axis to facilitate the initiation and progression of pancreatic cancer. | SULF2 enhances GDF15-SMAD axis to facilitate the initiation and progression of pancreatic cancer.
He R, Shi J, Xu D, Yang J, Shen Y, Jiang YS, Tao L, Yang M, Fu X, Yang JY, Liu D, Huo Y, Shen X, Lu P, Niu N, Sun YW, Xue J, Liu W. | 06/11/2022 |
| Extracellular sulfatases as potential blood-based biomarkers for early detection of lung cancer. | Extracellular sulfatases as potential blood-based biomarkers for early detection of lung cancer.
Yang YW, Jablons DM, Lemjabbar-Alaoui H. | 01/22/2022 |
| Sulfatase 2 (SULF2) Monoclonal Antibody 5D5 Suppresses Human Cholangiocarcinoma Xenograft Growth Through Regulation of a SULF2-Platelet-Derived Growth Factor Receptor Beta-Yes-Associated Protein Signaling Axis. | Sulfatase 2 (SULF2) Monoclonal Antibody 5D5 Suppresses Human Cholangiocarcinoma Xenograft Growth Through Regulation of a SULF2-Platelet-Derived Growth Factor Receptor Beta-Yes-Associated Protein Signaling Axis.
Luo X, Campbell NA, He L, O'Brien DR, Singer MS, Lemjabbar-Alaoui H, Ahn KS, Smoot R, Torbenson MS, Rosen SD, Roberts LR., Free PMC Article | 01/15/2022 |
| miR-527 targeting SULF2 down-regulates SULF2 expression, concurrently, suppresses NSCLC epithelial-mesenchymal transition and invasion via inhibiting TGF-beta/SMAD signaling pathway in non-small-cell lung cancer | MicroRNA-527 inhibits TGF-β/SMAD induced epithelial-mesenchymal transition via downregulating SULF2 expression in non-small-cell lung cancer.
Huo W, Zhu XM, Pan XY, Du M, Sun Z, Li ZM. | 07/18/2020 |
| TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment | TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment.
Zizza P, Dinami R, Porru M, Cingolani C, Salvati E, Rizzo A, D'Angelo C, Petti E, Amoreo CA, Mottolese M, Sperduti I, Chambery A, Russo R, Ostano P, Chiorino G, Blandino G, Sacconi A, Cherfils-Vicini J, Leonetti C, Gilson E, Biroccio A., Free PMC Article | 11/2/2019 |
| Loss of SULF2 expression is associated with corticospinal tract defect. | Desulfation of Heparan Sulfate by Sulf1 and Sulf2 Is Required for Corticospinal Tract Formation.
Okada T, Keino-Masu K, Nagamine S, Kametani F, Ohto T, Hasegawa M, van Kuppevelt TH, Kunita S, Takahashi S, Masu M., Free PMC Article | 07/20/2019 |
| SULF2 plays a key role in sorafenib susceptibility. | Recapitulation of pharmacogenomic data reveals that invalidation of SULF2 enhance sorafenib susceptibility in liver cancer.
Yoon S, Lee EJ, Choi JH, Chung T, Kim DY, Im JY, Bae MH, Kwon JH, Kim HH, Kim HC, Park YN, Wang HJ, Woo HG. | 02/23/2019 |
| High SULF2 expression is associated with glioma. | Multi-tasking Sulf1/Sulf2 enzymes do not only facilitate extracellular cell signalling but also participate in cell cycle related nuclear events.
Krishnakumar K, Chakravorty I, Foy W, Allen S, Justo T, Mukherjee A, Dhoot GK. | 12/22/2018 |
| The activity of sulfatase 2, a major form of endosulfatase in hepatocellular carcinoma can be studied, in connection with the interactions between heparan sulfate and various growth factors. | Evaluating Tumor-Associated Activity of Extracellular Sulfatase by Analyzing Naturally Occurring Substrate in Tumor Microenvironment of Hepatocellular Carcinoma.
Yu Y, Li H, Yang Y, Ding Y, Wang Z, Li G. | 08/18/2018 |
| SULF2 promotes the growth and metastasis of CRC probably by activating Akt and Erk1/2 pathways. | Sulfatase-2 promotes the growth and metastasis of colorectal cancer by activating Akt and Erk1/2 pathways.
Tao Y, Han T, Zhang T, Sun C. | 02/17/2018 |
| Although no change in SULF2 was detected in squamous cell carcinoma of the head and neck (HNSCC) serum, its detection in saliva makes it worthy of further investigation as a potential HNSCC biomarker. | Expression of the extracellular sulfatase SULF2 is associated with squamous cell carcinoma of the head and neck.
Flowers SA, Zhou X, Wu J, Wang Y, Makambi K, Kallakury BV, Singer MS, Rosen SD, Davidson B, Goldman R., Free PMC Article | 12/30/2017 |
| results demonstrated that SULF2 can mediate the detrimental effects of ionizing radiation in vivo | Involvement of SULF2 in y-irradiation-induced invasion and resistance of cancer cells by inducing IL-6 expression.
Jung CH, Ho JN, Park JK, Kim EM, Hwang SG, Um HD., Free PMC Article | 12/9/2017 |
| The short variants of Sulf2 promoted FGF2-induced MDA-MB231 and MCF7 in vitro growth while full-length Sulf1 inhibited growth supporting in vivo mammary tumour cell signalling patterns of growth. | Short SULF1/SULF2 splice variants predominate in mammary tumours with a potential to facilitate receptor tyrosine kinase-mediated cell signalling.
Gill RM, Mehra V, Milford E, Dhoot GK. | 07/8/2017 |
| Most pancreatic ductal adenocarcinomas had positive SULF2 staining in tumour cells and intratumoural or tumour-adjacent stroma. Elevated SULF2 in PDAC was associated with advanced tumour stage, vascular invasion, shorter interval to radiological progression and shorter overall survival. | Sulfatase-2: a prognostic biomarker and candidate therapeutic target in patients with pancreatic ductal adenocarcinoma.
Alhasan SF, Haugk B, Ogle LF, Beale GS, Long A, Burt AD, Tiniakos D, Televantou D, Coxon F, Newell DR, Charnley R, Reeves HL., Free PMC Article | 06/24/2017 |
| The SULF1/SULF2 activation thus does not only promote regulated foetal growth and injury-induced liver regeneration but also dysregulated tumour growth. | SULF1/SULF2 reactivation during liver damage and tumour growth.
Graham K, Murphy JI, Dhoot GK. | 05/13/2017 |
| Sulf2 facilitated lymphangiogenesis in breast cancer cells by regulating VEGF-D and that the AKT1related signaling pathway was involved. | Sulfatase 2 facilitates lymphangiogenesis in breast cancer by regulating VEGF-D.
Zhu C, Qi X, Zhou X, Nie X, Gu Y., Free PMC Article | 03/25/2017 |
| renal cell carcinoma with lower SULF-2 expression might have a higher potential for cell invasion and proliferation, leading to a poorer prognosis via the activation of VEGF and/or FGF signaling | Impact of Sulfatase-2 on cancer progression and prognosis in patients with renal cell carcinoma.
Kumagai S, Ishibashi K, Kataoka M, Oguro T, Kiko Y, Yanagida T, Aikawa K, Kojima Y., Free PMC Article | 02/18/2017 |
| SULF2 is a multifaceted protein involved in triglyceride-rich lipoprotein homeostasis and angiogenesis. [review] | Role of sulfatase 2 in lipoprotein metabolism and angiogenesis.
Dallinga MG, Dallinga-Thie GM. | 12/17/2016 |
| Our data confirmed that Sulf2 promoted breast cancer progression and regulated the expression of tumor-related genes in breast cancer. | Sulfatase 2 promotes breast cancer progression through regulating some tumor-related factors.
Zhu C, He L, Zhou X, Nie X, Gu Y., Free PMC Article | 10/29/2016 |
| Tumor expression of SULF2 may affect prognosis in NSCLC, while blood SULF2 levels may have a significant role in the diagnosis of this fatal disease. | SULF2 Expression Is a Potential Diagnostic and Prognostic Marker in Lung Cancer.
Lui NS, Yang YW, van Zante A, Buchanan P, Jablons DM, Lemjabbar-Alaoui H., Free PMC Article | 08/6/2016 |
| SULF2 have a pro-tumorigenic effect in DU-145 and PC3 cancer cells, suggesting an important role of this enzyme in prostatic cancer metastasis. | SULF2 overexpression positively regulates tumorigenicity of human prostate cancer cells.
Vicente CM, Lima MA, Nader HB, Toma L., Free PMC Article | 03/5/2016 |
| Results show that SULF1 or SULF2 overexpression contributes to colorectal cancer cell proliferation, migration, and invasion. | Enhanced tumorigenic potential of colorectal cancer cells by extracellular sulfatases.
Vicente CM, Lima MA, Yates EA, Nader HB, Toma L. | 02/6/2016 |
| Substrate specificity of human SULF2. | Oligosaccharide substrate preferences of human extracellular sulfatase Sulf2 using liquid chromatography-mass spectrometry based glycomics approaches.
Huang Y, Mao Y, Buczek-Thomas JA, Nugent MA, Zaia J., Free PMC Article | 12/12/2015 |
| SULF2 blood levels increased with age in both healthy and cirrhosis patients.SULF2 blood level was higher in cirrhosis patients than healthy individuals. | SULF2, a heparan sulfate endosulfatase, is present in the blood of healthy individuals and increases in cirrhosis.
Singer MS, Phillips JJ, Lemjabbar-Alaoui H, Wang YQ, Wu J, Goldman R, Rosen SD., Free PMC Article | 10/10/2015 |