| Potentially functional genetic variants in RPS6KA4 and MAP2K5 in the MAPK signaling pathway predict HBV-related hepatocellular carcinoma survival. | Potentially functional genetic variants in RPS6KA4 and MAP2K5 in the MAPK signaling pathway predict HBV-related hepatocellular carcinoma survival.
Qiu M, Lin Q, Liu Y, Chen P, Zhou Y, Jiang Y, Zhou Z, Wen Q, Zhou X, Liang X, Gan H, Yu H. | 08/22/2023 |
| MEK5-ERK5 Axis Promotes Self-renewal and Tumorigenicity of Glioma Stem Cells. | MEK5-ERK5 Axis Promotes Self-renewal and Tumorigenicity of Glioma Stem Cells.
Fukasawa K, Lyu J, Kubo T, Tanaka Y, Suzuki A, Horie T, Tomizawa A, Osumi R, Iwahashi S, Tokumura K, Murata M, Kobayashi M, Todo T, Hirao A, Hinoi E., Free PMC Article | 08/10/2023 |
| Aberrant MEK5 signalling promotes clear cell renal cell carcinoma development via mTOR activation. | Aberrant MEK5 signalling promotes clear cell renal cell carcinoma development via mTOR activation.
Li F, Peng X, Zhou J, Chen Q, Chen Y. | 10/29/2022 |
| Inhibition of MEK5/ERK5 signaling overcomes acquired resistance to the third generation EGFR inhibitor, osimertinib, via enhancing Bim-dependent apoptosis. | Inhibition of MEK5/ERK5 signaling overcomes acquired resistance to the third generation EGFR inhibitor, osimertinib, via enhancing Bim-dependent apoptosis.
Zhao W, Yu D, Chen Z, Yao W, Yang J, Ramalingam SS, Sun SY. | 01/8/2022 |
| The Hedgehog-GLI Pathway Regulates MEK5-ERK5 Expression and Activation in Melanoma Cells. | The Hedgehog-GLI Pathway Regulates MEK5-ERK5 Expression and Activation in Melanoma Cells.
Tusa I, Gagliardi S, Tubita A, Pandolfi S, Menconi A, Lulli M, Dello Sbarba P, Stecca B, Rovida E., Free PMC Article | 12/18/2021 |
| Identification of Novel Genetic Variants Related to Trabecular Bone Score in Community-Dwelling Older Adults. | Identification of Novel Genetic Variants Related to Trabecular Bone Score in Community-Dwelling Older Adults.
Kong SH, Yoon JW, Kim JH, Park J, Choi J, Lee JH, Hong AR, Cho NH, Shin CS., Free PMC Article | 09/18/2021 |
| MEK5 promotes lung adenocarcinoma. | MEK5 promotes lung adenocarcinoma.
Sánchez-Fdez A, Ortiz-Ruiz MJ, Re-Louhau MF, Ramos I, Blanco-Múñez Ó, Ludeña D, Abad M, Sánchez-Martín M, Pandiella A, Esparís-Ogando A., Free PMC Article | 10/31/2020 |
| The MEK5-ERK5 Kinase Axis Controls Lipid Metabolism in Small-Cell Lung Cancer. | The MEK5-ERK5 Kinase Axis Controls Lipid Metabolism in Small-Cell Lung Cancer.
Cristea S, Coles GL, Hornburg D, Gershkovitz M, Arand J, Cao S, Sen T, Williamson SC, Kim JW, Drainas AP, He A, Cam LL, Byers LA, Snyder MP, Contrepois K, Sage J., Free PMC Article | 10/24/2020 |
| MEK5 is a novel autophagy modulator | Inhibition of MEK5 suppresses TDP-43 toxicity via the mTOR-independent activation of the autophagy-lysosome pathway.
Jo M, Lee S, Kim K, Lee S, Kim SR, Kim HJ. | 07/11/2020 |
| MAP2K5/SKOR1 may be associated with Chinese essential tremor patients. | A haplotype of MAP2K5/SKOR1 was associated with essential tremor in Chinese population.
Chen J, Huang P, He Y, Shen J, Du J, Cui S, Cui P, Chen S, Ma J. | 09/14/2019 |
| Study in Chinese familial non-medullary thyroid carcinoma patients revealed that MAP2K5 variants A321T or M367 T can activate MAP2K5-ERK5 pathway, alter downstream gene expression, and subsequently induce thyroid epithelial cell malignant transformation. | Whole exome and target sequencing identifies MAP2K5 as novel susceptibility gene for familial non-medullary thyroid carcinoma.
Ye F, Gao H, Xiao L, Zuo Z, Liu Y, Zhao Q, Chen H, Feng W, Fu B, Sun L, Jiang X, He D, Jiang H, Yang M, Li L, Chen F, Liu X, Li S, Li Z, Jiang Y, Cheng L, Bu H. | 06/8/2019 |
| When yeast genetic interaction partners held in common between human OPTN and ANG were validated in mammalian cells and zebrafish, MAP2K5 kinase emerged as a potential drug target for amyotrophic lateral sclerosis therapy | Yeast genetic interaction screen of human genes associated with amyotrophic lateral sclerosis: identification of MAP2K5 kinase as a potential drug target.
Jo M, Chung AY, Yachie N, Seo M, Jeon H, Nam Y, Seo Y, Kim E, Zhong Q, Vidal M, Park HC, Roth FP, Suk K., Free PMC Article | 05/5/2018 |
| For gain and loss of function studies, constitutively active MEK5 (CA-MEK5) and ERK5 shRNA lentiviruses were used to activate or knock down extracellular signal-regulated kinase 5 (ERK5). Our results confirmed that low concentrations of H2O2 promoted HUVECs angiogenesis in vitro, and ERK5 is an essential mediator of this process. Therefore, ERK5 may be a potential therapeutic target for promoting angiogenesis | Extracellular Signal-Regulated Kinase 5 is Required for Low-Concentration H(2)O(2)-Induced Angiogenesis of Human Umbilical Vein Endothelial Cells.
Jiang S, Zhang D, Huang H, Lei Y, Han Y, Han W., Free PMC Article | 03/3/2018 |
| results confirmed the association of BTBD9 and MAP2K5/SKOR1 with primary Restless Legs Syndrome in Chinese population | Association of BTBD9 and MAP2K5/SKOR1 With Restless Legs Syndrome in Chinese Population.
Li G, Tang H, Wang C, Qi X, Chen J, Chen S, Ma J. | 12/16/2017 |
| Results revealed the expression of MEK5 was higher in tumor tissues and provide evidence that MEK5 plays an important role in colorectal cancer progression. | MEK5 overexpression is associated with the occurrence and development of colorectal cancer.
Diao D, Wang L, Wan J, Chen Z, Peng J, Liu H, Chen X, Wang W, Zou L., Free PMC Article | 10/14/2017 |
| Insights into a molecular mechanism by which MEK5 transcriptionally upregulated by Stat3 augments breast cancer cell EMT, which subsequently enhances cancer cell invasion and metastasis. This finding may suggest that Stat3 and MEK5/Erk5 pathways could be an effective therapeutic target for inhibition of breast cancer invasion and metastasis. | Upregulation of MEK5 by Stat3 promotes breast cancer cell invasion and metastasis.
Liu F, Zhang H, Song H. | 04/15/2017 |
| Our findings confirm an association between the BTBD9, MEIS1, and MAP2K5/SKOR1 SNPs and periodic limb movements of sleep in an elderly cohort. | Genetic associations of periodic limb movements of sleep in the elderly for the MrOS sleep study.
Winkelman JW, Blackwell T, Stone K, Ancoli-Israel S, Tranah GJ, Redline S, Osteoporotic Fractures in Men (MrOS) Study Research Group., Free PMC Article | 09/17/2016 |
| Specifically, CKS1B and MAP2K5 significantly inhibited hepatitis C viral RNA replication. PACSIN1, by contrast, inhibited hepatitis C virus infection by decreasing the level of viral protein p7. | Identification of novel human kinases that suppress hepatitis C virus infection.
Lee A, Liu S, Wang T., Free PMC Article | 10/17/2015 |
| High MEK5 expression is associated with colorectal cancer. | SATB2 suppresses the progression of colorectal cancer cells via inactivation of MEK5/ERK5 signaling.
Mansour MA, Hyodo T, Ito S, Kurita K, Kokuryo T, Uehara K, Nagino M, Takahashi M, Hamaguchi M, Senga T. | 06/27/2015 |
| SEC16B, MC4R, MAP2K5 and KCTD15 (rs17782313, rs543874, rs2241423 and rs11084753) polymorphisms are associated with the risk for children obesity in China. | Genetic variations in SEC16B, MC4R, MAP2K5 and KCTD15 were associated with childhood obesity and interacted with dietary behaviors in Chinese school-age population.
Lv D, Zhang DD, Wang H, Zhang Y, Liang L, Fu JF, Xiong F, Liu GL, Gong CX, Luo FH, Chen SK, Li ZL, Zhu YM. | 05/2/2015 |
| Periodic leg movements during sleep are associated with polymorphisms in BTBD9, TOX3/BC034767, MEIS1, MAP2K5/SKOR1, and PTPRD | Periodic leg movements during sleep are associated with polymorphisms in BTBD9, TOX3/BC034767, MEIS1, MAP2K5/SKOR1, and PTPRD.
Moore H 4th, Winkelmann J, Lin L, Finn L, Peppard P, Mignot E., Free PMC Article | 03/7/2015 |
| Inhibitors of apoptosis proteins regulate myogenic differentiation by directly suppressing MEKK2/3-MEK5-ERK5 signaling. | Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1.
Takeda AN, Oberoi-Khanuja TK, Glatz G, Schulenburg K, Scholz RP, Carpy A, Macek B, Remenyi A, Rajalingam K., Free PMC Article | 10/25/2014 |
| MiR-330-3p and MAP2K5 are potentially important contributors to mood and anxiety-related traits | The effects of a MAP2K5 microRNA target site SNP on risk for anxiety and depressive disorders.
Jensen KP, Kranzler HR, Stein MB, Gelernter J., Free PMC Article | 10/18/2014 |
| MEK5/ERK5 signaling suppresses estrogen receptor expression and promotes hormone-independent tumorigenesis. | MEK5/ERK5 signaling suppresses estrogen receptor expression and promotes hormone-independent tumorigenesis.
Antoon JW, Martin EC, Lai R, Salvo VA, Tang Y, Nitzchke AM, Elliott S, Nam SY, Xiong W, Rhodes LV, Collins-Burow B, David O, Wang G, Shan B, Beckman BS, Nephew KP, Burow ME., Free PMC Article | 03/8/2014 |
| Single nucleotide polymorphism in the MAP2K5 gene is associated with BMI and obesity. | The MAP2K5-linked SNP rs2241423 is associated with BMI and obesity in two cohorts of Swedish and Greek children.
Rask-Andersen M, Jacobsson JA, Moschonis G, Ek AE, Chrousos GP, Marcus C, Manios Y, Fredriksson R, Schiöth HB., Free PMC Article | 12/22/2012 |