| PPM1G promotes the progression of lung adenocarcinoma by inhibiting p38 activation via dephosphorylation of MEK6. | PPM1G promotes the progression of lung adenocarcinoma by inhibiting p38 activation via dephosphorylation of MEK6.
Chen J, Li J, Sun H, Hu T, Wang Y, Kang G, Cao M, Li X. | 05/17/2023 |
| Circ_0005925 Promotes Granulosa Cell Growth by Targeting MiR-324-3p to Upregulate MAP2K6 in Polycystic Ovary Syndrome. | Circ_0005925 Promotes Granulosa Cell Growth by Targeting MiR-324-3p to Upregulate MAP2K6 in Polycystic Ovary Syndrome.
Tu P, Yan S, Zhang F. | 01/28/2023 |
| APEX1 promotes the oncogenicity of hepatocellular carcinoma via regulation of MAP2K6. | APEX1 promotes the oncogenicity of hepatocellular carcinoma via regulation of MAP2K6.
Sun Z, Chen G, Wang L, Sang Q, Xu G, Zhang N., Free PMC Article | 10/29/2022 |
| MiR-1298-5p level downregulation induced by Helicobacter pylori infection inhibits autophagy and promotes gastric cancer development by targeting MAP2K6. | MiR-1298-5p level downregulation induced by Helicobacter pylori infection inhibits autophagy and promotes gastric cancer development by targeting MAP2K6.
Li X, Zhu M, Zhao G, Zhou A, Min L, Liu S, Zhang N, Zhu S, Guo Q, Zhang S, Li P. | 07/23/2022 |
| A novel tumour suppressor protein encoded by circMAPK14 inhibits progression and metastasis of colorectal cancer by competitively binding to MKK6. | A novel tumour suppressor protein encoded by circMAPK14 inhibits progression and metastasis of colorectal cancer by competitively binding to MKK6.
Wang L, Zhou J, Zhang C, Chen R, Sun Q, Yang P, Peng C, Tan Y, Jin C, Wang T, Ji J, Sun Y., Free PMC Article | 02/26/2022 |
| The interaction of p38 with its upstream kinase MKK6. | The interaction of p38 with its upstream kinase MKK6.
Kumar GS, Page R, Peti W., Free PMC Article | 08/14/2021 |
| Based on the experimentally determined models and parameters, dynamics of the p38alpha-MKK6-MKP5 system were explored, demonstrating for the first time that bistability can arise with this model at biologically feasible parameter values | Kinetic and mechanistic studies of p38α MAP kinase phosphorylation by MKK6.
Wang YL, Zhang YY, Lu C, Zhang W, Deng H, Wu JW, Wang J, Wang ZX. | 12/14/2019 |
| The loss of MKK6 protein diminishes p38 activation, leading to further degradation of the remaining TRIM9 in glioblastoma cells. The disruption of the TRIM9s-MKK6 mutual stabilization loop ultimately leads to the inactivation of p38 signaling and promotes tumor progression. | Mutual Stabilization between TRIM9 Short Isoform and MKK6 Potentiates p38 Signaling to Synergistically Suppress Glioblastoma Progression.
Liu K, Zhang C, Li B, Xie W, Zhang J, Nie X, Tan P, Zheng L, Wu S, Qin Y, Cui J, Zhi F. | 09/21/2019 |
| Data suggest that mitogen-activated protein kinase kinase 6 (MAP2K6) might be an important regulator of leukemia inhibitory factor receptor (LIFR)-induced radioresistance in nasopharyngeal carcinoma cells (NPC). | Quantitative proteome analysis identifies MAP2K6 as potential regulator of LIFR-induced radioresistance in nasopharyngeal carcinoma cells.
Li Z, Fu J, Li N, Shen L. | 06/1/2019 |
| USP22 could interact directly with MKK6 promoter. Down-regulation of USP22 led to the decreased MKK6 mRNA expression | [Ubiquitin specific peptidase 22 regulates the transcription activity of mitogen-activated protein kinase kinase 6 gene].
Liu J, Xie X, Wu P, Xiong J. | 04/6/2019 |
| Advanced glycation end products significantly activated ASK1, MKK3, and MKK6, which led to activation of p38 MAPK, resulting in upregulated fibrotic response in human coronary smooth muscle cells. | Novel ASK1 Inhibitor AGI-1067 Attenuates AGE-Induced Fibrotic Response by Suppressing the MKKs/p38 MAPK Pathway in Human Coronary Arterial Smooth Muscle Cells.
Liu Z, Shi S, Zhu H, Chen Y, Zhang Y, Zheng Z, Wang X. | 12/22/2018 |
| Data show that miR-625-3p induces oxaliplatin resistance by abrogating MAP2K6-p38-regulated apoptosis and cell cycle control networks. | miR-625-3p regulates oxaliplatin resistance by targeting MAP2K6-p38 signalling in human colorectal adenocarcinoma cells.
Rasmussen MH, Lyskjær I, Jersie-Christensen RR, Tarpgaard LS, Primdal-Bengtson B, Nielsen MM, Pedersen JS, Hansen TP, Hansen F, Olsen JV, Pfeiffer P, Ørntoft TF, Andersen CL., Free PMC Article | 10/6/2018 |
| acts as a repressor of UCP1 expression, suggesting that its inhibition promotes adipose tissue browning and increases organismal energy expenditure | MKK6 controls T3-mediated browning of white adipose tissue.
Matesanz N, Bernardo E, Acín-Pérez R, Manieri E, Pérez-Sieira S, Hernández-Cosido L, Montalvo-Romeral V, Mora A, Rodríguez E, Leiva-Vega L, Lechuga-Vieco AV, Ruiz-Cabello J, Torres JL, Crespo-Ruiz M, Centeno F, Álvarez CV, Marcos M, Enríquez JA, Nogueiras R, Sabio G., Free PMC Article | 02/10/2018 |
| MEK2 was essential for the phosphorylation of MKK3/MKK6 and p38 MAPK that directly impacted on cyclin D1 expression. | MEK2 controls the activation of MKK3/MKK6-p38 axis involved in the MDA-MB-231 breast cancer cell survival: Correlation with cyclin D1 expression.
Huth HW, Albarnaz JD, Torres AA, Bonjardim CA, Ropert C. | 12/2/2017 |
| Data indicate that mitogen-activated protein kinase kinase 6 (MKK6) levels were substantially higher in monocytes than in neutrophils. | Monocytic cell differentiation from band-stage neutrophils under inflammatory conditions via MKK6 activation.
Köffel R, Meshcheryakova A, Warszawska J, Hennig A, Wagner K, Jörgl A, Gubi D, Moser D, Hladik A, Hoffmann U, Fischer MB, van den Berg W, Koenders M, Scheinecker C, Gesslbauer B, Knapp S, Strobl H., Free PMC Article | 01/31/2015 |
| Data show significant increase in the expression of MKK6 in Esophageal, Stomach, and Colon cancers as compared to controls. | MKK6 is upregulated in human esophageal, stomach, and colon cancers.
Parray AA, Baba RA, Bhat HF, Wani L, Mokhdomi TA, Mushtaq U, Bhat SS, Kirmani D, Kuchay S, Wani MM, Khanday FA. | 01/10/2015 |
| uncover a new mechanism of deactivation of MKK6-p38 and substantiate a novel regulatory role of FBXO31 in stress response | F-box only protein 31 (FBXO31) negatively regulates p38 mitogen-activated protein kinase (MAPK) signaling by mediating lysine 48-linked ubiquitination and degradation of mitogen-activated protein kinase kinase 6 (MKK6).
Liu J, Han L, Li B, Yang J, Huen MS, Pan X, Tsao SW, Cheung AL., Free PMC Article | 12/20/2014 |
| Serine phosphorylation of p66shc is carried out by active MKK6. beta-Amyloid-induced ROS production and apoptosis increased in the presence of MKK6 and p66shc, which directly associate. | β-Amyloid-evoked apoptotic cell death is mediated through MKK6-p66shc pathway.
Bashir M, Parray AA, Baba RA, Bhat HF, Bhat SS, Mushtaq U, Andrabi KI, Khanday FA. | 11/8/2014 |
| The models confirmed the reaction order, revealed processivity in the phosphorylation of MEK6 by ASK1, and suggested that the order of phosphorylation is dictated by both binding and catalysis rates. | Precisely ordered phosphorylation reactions in the p38 mitogen-activated protein (MAP) kinase cascade.
Humphreys JM, Piala AT, Akella R, He H, Goldsmith EJ., Free PMC Article | 11/2/2013 |
| crystal structure of human non-phosphorylated MAP2K6 (npMAP2K6) complexed with an ATP analogue was determined at 2.6 A resolution and represents an auto-inhibition state of MAP2K6 | Crystal structure of non-phosphorylated MAP2K6 in a putative auto-inhibition state.
Matsumoto T, Kinoshita T, Matsuzaka H, Nakai R, Kirii Y, Yokota K, Tada T. | 02/2/2013 |
| Data suggest aberrant MAP2K protein (MKK3, MKK4, MKK6, and MKK7) expression indicates that altered cellular signal transduction mediated via JNK and p38 may be common in bladder cancer. | Stress-activated kinase pathway alteration is a frequent event in bladder cancer.
Otto KB, Acharya SS, Robinson VL. | 12/8/2012 |
| the balance between MKK6 and MKK3 mediates p38 MAPK associated resistance to cisplatin in NSCLC | Balance between MKK6 and MKK3 mediates p38 MAPK associated resistance to cisplatin in NSCLC.
Galan-Moya EM, de la Cruz-Morcillo MA, Llanos Valero M, Callejas-Valera JL, Melgar-Rojas P, Hernadez Losa J, Salcedo M, Fernández-Aramburo A, Ramon y Cajal S, Sánchez-Prieto R., Free PMC Article | 07/21/2012 |
| activation by mechanical stretch induces HMGB1 and cytokine expression in A549 cells | Mitogen-activated protein kinase kinase 6 mediates mechanical stretch-induced high-mobility group box 1 protein expression in pulmonary alveolar epithelial cells.
Ding N, Wang F, Han Y, Xiao H, Xu L, She S. | 04/14/2012 |
| Results suggest that the p38alpha, MAPK, and MKK6 play prominent roles in IL-1beta and C/EBP-beta-mediated C3 gene expression in astrocytes. | Role of C/EBP-β, p38 MAPK, and MKK6 in IL-1β-mediated C3 gene regulation in astrocytes.
Maranto J, Rappaport J, Datta PK., Free PMC Article | 08/6/2011 |
| Impaired cytokine production in natural killer (NK)T cells is demonstrated from MKK3-deficient6+/- mice. | Translational control of NKT cell cytokine production by p38 MAPK.
Nagaleekar VK, Sabio G, Aktan I, Chant A, Howe IW, Thornton TM, Benoit PJ, Davis RJ, Rincon M, Boyson JE., Free PMC Article | 06/18/2011 |