| Proteomic analysis of human sperm reveals changes in protamine 1 phosphorylation in men with infertility. | Proteomic analysis of human sperm reveals changes in protamine 1 phosphorylation in men with infertility.
Schon SB, Moritz L, Rabbani M, Meguid J, Juliano BR, Ruotolo BT, Aston K, Hammoud SS., | 05/31/2024 |
| Molecular and Functional Characterization of Human Sex-Determining Region on the Y Chromosome Variants Using Protamine 1 Promoter. | Molecular and Functional Characterization of Human Sex-Determining Region on the Y Chromosome Variants Using Protamine 1 Promoter.
Pathak D, Baksi A, Vasan SS, Dighe RR. | 01/29/2024 |
| Reversible promoter demethylation of PDGFD confers gemcitabine resistance through STAT3 activation and RRM1 upregulation. | Reversible promoter demethylation of PDGFD confers gemcitabine resistance through STAT3 activation and RRM1 upregulation.
Qin L, Dong Z, Huang C, Liu H, Beebe J, Subramaniyan B, Hao Y, Liu Y, He Z, Liu JY, Zhang JT. | 07/6/2023 |
| Protamine 1 as a secreted colorectal cancer-specific antigen facilitating G1/S phase transition under nutrient stress conditions. | Protamine 1 as a secreted colorectal cancer-specific antigen facilitating G1/S phase transition under nutrient stress conditions.
Ren S, Yang D, Dong Y, Ni W, Wang M, Xing L, Liu T, Hou W, Sun W, Zhang H, Yu Z, Liu Y, Cao J, Yan H, Feng Y, Fang X, Wang Q, Chen F., Free PMC Article | 04/14/2023 |
| Impact of tobacco smoking in association with H2BFWT, PRM1 and PRM2 genes variants on male infertility. | Impact of tobacco smoking in association with H2BFWT, PRM1 and PRM2 genes variants on male infertility.
Amor H, Jankowski PM, Dahadhah FW, Al Zoubi MS, Hammadeh ME. | 12/10/2022 |
| Polymorphisms of sperm protamine genes and CMA3 staining in infertile men with varicocele. | Polymorphisms of sperm protamine genes and CMA3 staining in infertile men with varicocele.
Nayeri M, Talebi AR, Heidari MM, Seifati SM, Tabibnejad N. | 10/2/2021 |
| Protamine 1/Protamine 2 mRNA ratio in nonobstructive azoospermic patients. | Protamine 1/Protamine 2 mRNA ratio in nonobstructive azoospermic patients.
Amjad S, Mushtaq S, Rehman R, Munir A, Zahid N, Siddique PQR. | 08/7/2021 |
| Identification of the PRM1 gene mutations in oligoasthenoteratozoospermic men. | Identification of the PRM1 gene mutations in oligoasthenoteratozoospermic men.
Nasirshalal M, Tahmasebi-Birgani M, Dadfar M, Nikbakht R, Saberi A, Ghandil P. | 07/24/2021 |
| Evaluation of the association between polymorphisms of PRM1 and PRM2 and the risk of male infertility: a systematic review, meta-analysis, and meta-regression. | Evaluation of the association between polymorphisms of PRM1 and PRM2 and the risk of male infertility: a systematic review, meta-analysis, and meta-regression.
Nemati H, Sadeghi M, Nazeri M, Mohammadi M., Free PMC Article | 06/26/2021 |
| Tobacco smoking and its impact on the expression level of sperm nuclear protein genes: H2BFWT, TNP1, TNP2, PRM1 and PRM2. | Tobacco smoking and its impact on the expression level of sperm nuclear protein genes: H2BFWT, TNP1, TNP2, PRM1 and PRM2.
Amor H, Zeyad A, Hammadeh ME. | 06/26/2021 |
| Study revealed that CA and AA genotypes in PRM1 gene were associated significantly with low sperm concentration and decreased sperm motility. Cases carrying A allele had a 6.05-fold increased risk for idiopathic infertility than cases carrying the C allele in a sample of Egyptian men. | The c.-190 C>A transversion in promoter region of protamine 1 gene as a genetic risk factor in Egyptian men with idiopathic infertility.
Abdallah WI, Hussein TM, Elsayed ET, Bahgat RS. | 02/15/2020 |
| The expression level of PRM1 was significantly higher in colon cancer tissues and the staining degree of PRM1 in poorly-differentiated was stronger. | Impact of protamine I on colon cancer proliferation, invasion, migration, diagnosis and prognosis.
Chen Z, Shi C, Gao S, Song D, Feng Y. | 12/22/2018 |
| Bacterial infections have significant negative effects on sperm chromatin condensation and protamine P1/P2 ratio. | The effects of bacterial infection on human sperm nuclear protamine P1/P2 ratio and DNA integrity.
Zeyad A, Hamad MF, Hammadeh ME. | 09/22/2018 |
| Protamine-1 and protamine-2 mRNA levels as well as the protamine mRNA ratio and all routine semen parameters revealed significant differences between recurrent miscarriage couples and healthy volunteers. Values of protamine-1 and protamine-2 mRNAs were significantly higher and the protamine mRNA ratio was significantly lower in couples with recurrent miscarriage. | Unexplained recurrent miscarriages are associated with an aberrant sperm protamine mRNA content.
Rogenhofer N, Ott J, Pilatz A, Wolf J, Thaler CJ, Windischbauer L, Schagdarsurengin U, Steger K, von Schönfeldt V. | 05/26/2018 |
| examinded the association between protamine gene alleles (PRM1 c.-190C>A, PRM1 c.197G>T, and PRM2 c.248C>T), and YBX2 (c.187T>C and c.1095 + 16A>G) and male infertility. We found that the AA and CA genotypes of the PRM1 c.-190C>A polymorphism had a significant association with infertility (p < 0.001) and the AA genotype was also highly significantly associated with high sperm DNA damage (p < 0.001). | Genetic Polymorphisms in PRM1, PRM2, and YBX2 Genes are Associated with Male Factor Infertility.
Aydos OSE, Hekmatshoar Y, Altınok B, Özkan T, Şakirağaoğlu O, Karadağ A, Kaplan F, Ilgaz S, Taşpınar M, Yükselen I, Sunguroğlu A, Aydos K. | 05/26/2018 |
| The KDM3A to PRM1 mRNA expression ratio can be used as a reliable marker of successful testicular sperm extraction in men with obstructive and non-obstructive azoospermia with 95% sensitivity. | Expression ratio of histone demethylase KDM3A to protamine-1 mRNA is predictive of successful testicular sperm extraction in men with obstructive and non-obstructive azoospermia.
Javadirad SM, Hojati Z, Ghaedi K, Nasr-Esfahani MH. | 11/18/2017 |
| Single nucleotide polymorphisms in the human PRM1 gene are associated with a genetic risk factor for idiopathic oligozoospermia. | The c.-190 C>A transversion in promoter region of protamine1 gene as a genetic risk factor for idiopathic oligozoospermia.
Jamali S, Karimian M, Nikzad H, Aftabi Y. | 02/18/2017 |
| Studies indicate that ribonucleotide reductase M1 polypeptide (RRM1) expression is associated with the response rate and overall survival rate of advanced NSCLC patients treated with gemcitabine-based chemotherapy. | RRM1 expression is associated with the outcome of gemcitabine-based treatment of non-small cell lung cancer patients--a short report.
Zeng C, Fan W, Zhang X. | 05/7/2016 |
| The expressed human protamine1 in two fast-growing cell systems, E. coli and HeLa cells. The protamine 1 expression significantly attenuated cell proliferation when compared with control cells. | Expression of sperm-specific protamines impairs bacterial and eukaryotic cell proliferation.
Günther K, Paradowska-Dogan A, Bärmann B, Klein H, von Eichel-Streiber C, Hartley R, Weidner W, Behr R, Steger K. | 03/5/2016 |
| the quantity of PRM1, PRM2, and TNP2 transcripts and the PRM1/PRM2 mRNA ratio affect spermiogenesis, sperm morphology | Quantification of sperm specific mRNA transcripts (PRM1, PRM2, and TNP2) in teratozoospermia and normozoospermia: New correlations between mRNA content and morphology of sperm.
Savadi-Shiraz E, Edalatkhah H, Talebi S, Heidari-Vala H, Zandemami M, Pahlavan S, Modarressi MH, Akhondi MM, Paradowska-Dogan A, Sadeghi MR. | 09/26/2015 |
| Single nuclotide polymorphisms in PRM1 gene is associated with male infertility. | Protamine-1 and -2 polymorphisms and gene expression in male infertility: an Italian study.
Grassetti D, Paoli D, Gallo M, D'Ambrosio A, Lombardo F, Lenzi A, Gandini L. | 06/1/2013 |
| genetic association study in Han population in China: Data suggest that an SNP in PRM1 (rs35576928; T allele; 34R>S) is associated with severe oligozoospermia and can play a protective role against this disease. | PRM1 variant rs35576928 (Arg>Ser) is associated with defective spermatogenesis in the Chinese Han population.
He XJ, Ruan J, Du WD, Chen G, Zhou Y, Xu S, Zuo XB, Cao YX, Zhang XJ. | 05/18/2013 |
| The SNP of PRM1-190C- > A might be associated with teratozoospermia-induced male infertility in the Han Chinese. | [Association of PRM1-190C- > A polymorphism with teratozoospermia].
Yu QF, Yang XX, Li FX, Ye LW, Wu YS, Mao XM. | 01/26/2013 |
| significant correlation has been found between protamine 1 and 2 transcripts/proteins and: sperm concentration, progressive sperm motility, sperm fertilization ability as well as embryo quality | Impact of protamine transcripts and their proteins on the quality and fertilization ability of sperm and the development of preimplantation embryos.
Depa-Martynow M, Kempisty B, Jagodziński PP, Pawelczyk L, Jedrzejczak P. | 07/28/2012 |
| identified and we report for the first time five novel rare haplotypes encompassing the protamine 1 and 2 genes | Polymorphisms, haplotypes and mutations in the protamine 1 and 2 genes.
Jodar M, Oriola J, Mestre G, Castillo J, Giwercman A, Vidal-Taboada JM, Ballescà JL, Oliva R. | 01/21/2012 |