| Endothelial Scaffolding Protein ENH (Enigma Homolog Protein) Promotes PHLPP2 (Pleckstrin Homology Domain and Leucine-Rich Repeat Protein Phosphatase 2)-Mediated Dephosphorylation of AKT1 and eNOS (Endothelial NO Synthase) Promoting Vascular Remodeling. | Endothelial Scaffolding Protein ENH (Enigma Homolog Protein) Promotes PHLPP2 (Pleckstrin Homology Domain and Leucine-Rich Repeat Protein Phosphatase 2)-Mediated Dephosphorylation of AKT1 and eNOS (Endothelial NO Synthase) Promoting Vascular Remodeling.
Huang J, Cai C, Zheng T, Wu X, Wang D, Zhang K, Xu B, Yan R, Gong H, Zhang J, Shi Y, Xu Z, Zhang X, Zhang X, Shang T, Zhou J, Guo X, Zeng C, Lai EY, Xiao C, Chen J, Wan S, Liu WH, Ke Y, Cheng H. | 10/10/2020 |
| These results reveal a E2F1/miR-17-92/ENH1/Id1 regulatory axis during myogenesis. | MicroRNA-17-92 regulates myoblast proliferation and differentiation by targeting the ENH1/Id1 signaling axis.
Qiu H, Liu N, Luo L, Zhong J, Tang Z, Kang K, Qu J, Peng W, Liu L, Li L, Gou D., Free PMC Article | 12/16/2017 |
| Collectively, our results suggest that ENH1 plays an important role in the activation of myogenesis through the repression of Id2 activity. | Scaffold protein enigma homolog 1 overcomes the repression of myogenesis activation by inhibitor of DNA binding 2.
Nakatani M, Ito J, Koyama R, Iijima M, Yoshimoto N, Niimi T, Kuroda S, Maturana AD. | 05/13/2017 |
| Cypher and ENH redundantly play an essential role in sustaining Z-line structure from the earliest stages of cardiac function, and are redundantly required to maintain normal embryonic heart function and embryonic viability. | Cypher and Enigma homolog protein are essential for cardiac development and embryonic survival.
Mu Y, Jing R, Peter AK, Lange S, Lin L, Zhang J, Ouyang K, Fang X, Veevers J, Zhou X, Evans SM, Cheng H, Chen J., Free PMC Article | 02/6/2016 |
| PDLIM5 is involved in psychiatric disorders, including mood disorders | Experimental evidence for the involvement of PDLIM5 in mood disorders in hetero knockout mice.
Horiuchi Y, Ishikawa M, Kaito N, Iijima Y, Tanabe Y, Ishiguro H, Arinami T., Free PMC Article | 11/16/2013 |
| ENH1 with multiple protein-protein interaction modules is essential for differentiation of striated muscles, whereas ectopic expression of LIM domain-less ENH disrupts normal muscle differentiation. | Enigma homolog 1 promotes myogenic gene expression and differentiation of C2C12 cells.
Ito J, Takita M, Takimoto K, Maturana AD. | 08/31/2013 |
| coordinated and stepwise splicing transitions result in the production of specific ENH transcripts in mature striated muscles. | Splicing transitions of the anchoring protein ENH during striated muscle development.
Ito J, Hashimoto T, Nakamura S, Aita Y, Yamazaki T, Schlegel W, Takimoto K, Maturana AD. | 07/14/2012 |
| Deletion of ENH leads to destabilization of this protein complex and dilated cardiomyopathy in mice. | Loss of enigma homolog protein results in dilated cardiomyopathy.
Cheng H, Kimura K, Peter AK, Cui L, Ouyang K, Shen T, Liu Y, Gu Y, Dalton ND, Evans SM, Knowlton KU, Peterson KL, Chen J., Free PMC Article | 09/20/2010 |
| Antagonistic splice variants of enigma may play a central role in the adaptive changes of the link between mechanical stress-sensing and signalling occurring during embryonic development and/or heart hypertrophy. | Splice variants of enigma homolog, differentially expressed during heart development, promote or prevent hypertrophy.
Yamazaki T, Wälchli S, Fujita T, Ryser S, Hoshijima M, Schlegel W, Kuroda S, Maturana AD., Free PMC Article | 06/14/2010 |
| ENH is a restraining factor of the oncogenic activity of inhibitor of DNA binding 2 proteins in neural tumors | The protein ENH is a cytoplasmic sequestration factor for Id2 in normal and tumor cells from the nervous system.
Lasorella A, Iavarone A., Free PMC Article | 01/21/2010 |
| These results identify Enigma as a novel APS-binding protein and suggest that the APS/Enigma complex plays a critical role in actin cytoskeleton organisation. | The interaction between the adaptor protein APS and Enigma is involved in actin organisation.
Barrès R, Gonzalez T, Le Marchand-Brustel Y, Tanti JF. | 01/21/2010 |
| Western blot studies of muscle tissues revealed that ENH4 is present only in skeletal muscle and there is a specific distribution of ENH members between skeletal and cardiac muscles, which is different in human and mouse. | Characterization of a new human isoform of the enigma homolog family specifically expressed in skeletal muscle.
Niederländer N, Fayein NA, Auffray C, Pomiès P. | 01/21/2010 |