| Increase of KLK7, cytokeratin 5/6, and elafin expression in head and neck squamous cell carcinoma compared with lung squamous cell carcinoma. | Increase of KLK7, cytokeratin 5/6, and elafin expression in head and neck squamous cell carcinoma compared with lung squamous cell carcinoma.
Shanmugam A, Rudasill J, Criswell S. | 06/5/2024 |
| The Role of Kallikrein 7 in Tumorigenesis. | The Role of Kallikrein 7 in Tumorigenesis.
Xiang F, Wang Y, Cao C, Li Q, Deng H, Zheng J, Liu X, Tan X. | 05/28/2022 |
| Identification of MFGE8 and KLK5/7 as mediators of breast tumorigenesis and resistance to COX-2 inhibition. | Identification of MFGE8 and KLK5/7 as mediators of breast tumorigenesis and resistance to COX-2 inhibition.
Tian J, Wang V, Wang N, Khadang B, Boudreault J, Bakdounes K, Ali S, Lebrun JJ., Free PMC Article | 01/8/2022 |
| EGR-1 acts as a transcriptional activator of KLK7 under IL-13 stimulation. | EGR-1 acts as a transcriptional activator of KLK7 under IL-13 stimulation.
Yeo H, Ahn SS, Lee JY, Shin SY. | 04/24/2021 |
| Extracellular acidityinduced expression of Kallikreinrelated peptidases 7 and 8 is involved in increased invasiveness of gastric cancer cells. | Extracellular acidity‑induced expression of Kallikrein‑related peptidases 7 and 8 is involved in increased invasiveness of gastric cancer cells.
Lim SC, Kee KH, Lee MJ, Hong R, Han SI. | 02/6/2021 |
| Kallikrein 7 Promotes Atopic Dermatitis-Associated Itch Independently of Skin Inflammation. | Kallikrein 7 Promotes Atopic Dermatitis-Associated Itch Independently of Skin Inflammation.
Guo CJ, Mack MR, Oetjen LK, Trier AM, Council ML, Pavel AB, Guttman-Yassky E, Kim BS, Liu Q., Free PMC Article | 01/9/2021 |
| Biochemical validation supports a role for KLK7 in directly activating pro-MMP10, hydrolysis of IGFBP6 and cleavage of thrombospondin 1 with generation of a potentially bioactive N-terminal fragment. | Integration of Two In-depth Quantitative Proteomics Approaches Determines the Kallikrein-related Peptidase 7 (KLK7) Degradome in Ovarian Cancer Cell Secretome.
Silva LM, Kryza T, Stoll T, Hoogland C, Dong Y, Stephens CR, Hastie ML, Magdolen V, Kleifeld O, Gorman JJ, Clements JA., Free PMC Article | 01/18/2020 |
| KLK7 accelerated the deterioration of PTC in vitro experiments which could be reversed by sh-lnc RNA NEAT1 and miR-129-5p mimics. In vivo experiments, silence of lncRNA NEAT1 restrain tumor growth in weight and volume. | Long noncoding RNA NEAT1 regulate papillary thyroid cancer progression by modulating miR-129-5p/KLK7 expression.
Zhang H, Cai Y, Zheng L, Zhang Z, Lin X, Jiang N. | 10/5/2019 |
| Structures of BbKI complexed with the catalytic domain of human plasma kallikrein were modeled, as well as those with KLK4 and KLK7, and the structures were analyzed in order to identify the interactions that are responsible for inhibitory potency. | Crystal structures of the complex of a kallikrein inhibitor from Bauhinia bauhinioides with trypsin and modeling of kallikrein complexes.
Li M, Srp J, Gustchina A, Dauter Z, Mares M, Wlodawer A., Free PMC Article | 05/25/2019 |
| results demonstrate that aberrant KLK7 expression leads to a switch to a more malignant phenotype suggesting a potential role of KLK7 in melanoma invasion; KLK7 may represent a biomarker for melanoma progression and may be a potential therapeutic target for melanoma | Kallikrein-related peptidase 7 overexpression in melanoma cells modulates cell adhesion leading to a malignant phenotype.
Haddada M, Draoui H, Deschamps L, Walker F, Delaunay T, Brattsand M, Magdolen V, Darmoul D. | 05/18/2019 |
| he expression level of KLK7 in pancreatic ductal adenocarcinoma was higher than that in paired adjacent tissues and it is an independent risk factor for vascular invasion of pancreatic cancer. | [The expression of KLK7 in pancreatic cancer and the effects on the biological behavior of pancreatic cancer cells].
Zheng SL, Feng MY, Yang G, Xiong GB, Zheng LF, Zhang TP, Zhao YP. | 04/6/2019 |
| These results show that aberrant KLK7 expression leads to a switch from proliferative to invasive phenotype, suggesting a potential role of KLK7 in melanoma progression. | Aberrant expression of kallikrein-related peptidase 7 is correlated with human melanoma aggressiveness by stimulating cell migration and invasion.
Delaunay T, Deschamps L, Haddada M, Walker F, Soosaipillai A, Soualmia F, El Amri C, Diamandis EP, Brattsand M, Magdolen V, Darmoul D., Free PMC Article | 06/2/2018 |
| KLK7 is differentially expressed in lesional biopsy specimens from patients with atopic eczema relative to normal skin | Proteomic analysis of filaggrin deficiency identifies molecular signatures characteristic of atopic eczema.
Elias MS, Long HA, Newman CF, Wilson PA, West A, McGill PJ, Wu KC, Donaldson MJ, Reynolds NJ., Free PMC Article | 11/25/2017 |
| impaired KLK7 secretion from lamellar granules and increased LEKTI expression could underlie the insufficient activation of KLK in atopic dermatitis. | Incomplete KLK7 Secretion and Upregulated LEKTI Expression Underlie Hyperkeratotic Stratum Corneum in Atopic Dermatitis.
Igawa S, Kishibe M, Minami-Hori M, Honma M, Tsujimura H, Ishikawa J, Fujimura T, Murakami M, Ishida-Yamamoto A. | 07/22/2017 |
| Epigenetic regulation of KLK7 gene expression in pancreatic and cervical cancer cells | Epigenetic regulation of KLK7 gene expression in pancreatic and cervical cancer cells.
Raju I, Kaushal GP, Haun RS. | 07/8/2017 |
| Korean X-linked ichthyosis patients exhibited unimpaired skin barrier function and frequent association with the KLK7 gene polymorphism, which may differentiate them from Western X-linked ichthyosis patients. | Skin Barrier Function Is Not Impaired and Kallikrein 7 Gene Polymorphism Is Frequently Observed in Korean X-linked Ichthyosis Patients Diagnosed by Fluorescence in Situ Hybridization and Array Comparative Genomic Hybridization.
Lee NR, Yoon NY, Jung M, Kim JY, Seo SJ, Wang HY, Lee H, Sohn YB, Choi EH., Free PMC Article | 02/25/2017 |
| This report demonstrates that concurrent loss of KLK5 and KLK7 associates with a poor clinical outcome in Squamous-Cell Carcinoma and could therefore serve as prognostic marker in this disease. | The Co-Expression of Kallikrein 5 and Kallikrein 7 Associates with Poor Survival in Non-HPV Oral Squamous-Cell Carcinoma.
Leusink FK, van Diest PJ, Frank MH, Broekhuizen R, Braunius W, van Hooff SR, Willems SM, Koole R. | 05/14/2016 |
| Data demonstrate that elevated levels of KLK6, KLK7 and KLK9 proteins are associated with poor glioblastoma patients survival. | Prognostic significance of multiple kallikreins in high-grade astrocytoma.
Drucker KL, Gianinni C, Decker PA, Diamandis EP, Scarisbrick IA., Free PMC Article | 05/14/2016 |
| Our findings suggest that serum KLK7 may be a valuable diagnostic biomarker for cervical cancer, and may help to determine the individual prognosis of these patients. | Serum human kallikrein 7 represents a new marker for cervical cancer.
Li W, Zhao Y, Ren L, Wu X. | 11/7/2015 |
| KLK6 and KLK7 mRNA and protein overexpression is directly associated with early-stage ovarian tumors. | Kallikrein family proteases KLK6 and KLK7 are potential early detection and diagnostic biomarkers for serous and papillary serous ovarian cancer subtypes.
Tamir A, Jag U, Sarojini S, Schindewolf C, Tanaka T, Gharbaran R, Patel H, Sood A, Hu W, Patwa R, Blake P, Chirina P, Oh Jeong J, Lim H, Goy A, Pecora A, Suh KS., Free PMC Article | 10/17/2015 |
| Proteolytic cleavage of midkine, CYR61, and tenascin-C govern the pathophysiological roles of KLK7. | Novel Biological Substrates of Human Kallikrein 7 Identified through Degradomics.
Yu Y, Prassas I, Dimitromanolakis A, Diamandis EP., Free PMC Article | 10/17/2015 |
| Early-stage oral squamous cell carcinoma and high KLK7 mRNA levels were correlated with the rs10581213(wt/ins + ins/ins) genotypes | Polymorphisms in Kallikrein7 and 10 genes and oral cancer risks in Taiwan betel quid chewers and smokers.
Wang YY, Lin YC, Hung HC, Tien WY, Shieh TY. | 09/26/2015 |
| These results demonstrate the aberrant expression of KLK7 in colon cancer cells and tissues and its involvement in cell proliferation in vitro and in vivo. | Kallikrein-related peptidase 7 (KLK7) is a proliferative factor that is aberrantly expressed in human colon cancer.
Walker F, Nicole P, Jallane A, Soosaipillai A, Mosbach V, Oikonomopoulou K, Diamandis EP, Magdolen V, Darmoul D. | 06/6/2015 |
| Daata indicate that the peptide Abz-NLY( downward arrow)RVE-Q-EDDnp is the best synthetic substrate for Kallikrein-related peptidase 7 (KLK7) [kcat/Km=455 (mMs)(-1)]. | Specificity studies on Kallikrein-related peptidase 7 (KLK7) and effects of osmolytes and glycosaminoglycans on its peptidase activity.
Oliveira JR, Bertolin TC, Andrade D, Oliveira LC, Kondo MY, Santos JA, Blaber M, Juliano L, Severino B, Caliendo G, Santagada V, Juliano MA. | 05/2/2015 |
| KLK7 and KLK14 gene expression can be regarded as markers of poor prognosis for colorectal cancer patients with discriminating power between CC and adenoma patients. | Parallel overexpression and clinical significance of kallikrein-related peptidases 7 and 14 (KLK7KLK14) in colon cancer.
Devetzi M, Trangas T, Scorilas A, Xynopoulos D, Talieri M. | 11/16/2013 |