| In vivo and in vitro studies on the role of regulating Smac expression in the occurrence and development of colon cancer. | In vivo and in vitro studies on the role of regulating Smac expression in the occurrence and development of colon cancer.
Zhang D, Yang N. | 10/8/2024 |
| AREL1 resists the apoptosis induced by TGF-beta by inhibiting SMAC in vascular endothelial cells. | AREL1 resists the apoptosis induced by TGF-β by inhibiting SMAC in vascular endothelial cells.
Li Y, Song Y, Liang Y. | 10/11/2023 |
| Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex. | Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex.
Ehrmann JF, Grabarczyk DB, Heinke M, Deszcz L, Kurzbauer R, Hudecz O, Shulkina A, Gogova R, Meinhart A, Versteeg GA, Clausen T. | 04/20/2023 |
| Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases. | Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases.
Hunkeler M, Jin CY, Fischer ES. | 04/20/2023 |
| LINC-DUBR Suppresses Malignant Progression of Ovarian Cancer by Downregulating miR-107 to Induce SMAC Expression. | LINC-DUBR Suppresses Malignant Progression of Ovarian Cancer by Downregulating miR-107 to Induce SMAC Expression.
Han Z, Li D, Yang Y, Zhang H., Free PMC Article | 05/7/2022 |
| Co-overexpression of TRAIL and Smac sensitizes MDA-MB-231 cells to radiation through apoptosis depending on mitochondrial pathway. | Co-overexpression of TRAIL and Smac sensitizes MDA-MB-231 cells to radiation through apoptosis depending on mitochondrial pathway.
Xu W, Fang F, Wang Y, Qin L, Han Y, Huang Y, Li B, Liu Y, Wang Z. | 05/7/2022 |
| Mitochondria and nucleus cross-talk: Signaling in metabolism, apoptosis, and differentiation, and function in cancer. | Mitochondria and nucleus cross-talk: Signaling in metabolism, apoptosis, and differentiation, and function in cancer.
Shteinfer-Kuzmine A, Verma A, Arif T, Aizenberg O, Paul A, Shoshan-Barmaz V. | 01/29/2022 |
| BAX and SMAC regulate bistable properties of the apoptotic caspase system. | BAX and SMAC regulate bistable properties of the apoptotic caspase system.
McKenna S, García-Gutiérrez L, Matallanas D, Fey D., Free PMC Article | 11/22/2021 |
| Biophysical characterization of the interaction between the full-length XIAP and Smac/DIABLO. | Biophysical characterization of the interaction between the full-length XIAP and Smac/DIABLO.
Polykretis P, Luchinat E. | 11/22/2021 |
| Induction of interferon-beta and interferon signaling by TRAIL and Smac mimetics via caspase-8 in breast cancer cells. | Induction of interferon-β and interferon signaling by TRAIL and Smac mimetics via caspase-8 in breast cancer cells.
Granqvist V, Holmgren C, Larsson C., Free PMC Article | 10/16/2021 |
| Doxorubicin sensitizes cancer cells to Smac mimetic via synergistic activation of the CYLD/RIPK1/FADD/caspase-8-dependent apoptosis. | Doxorubicin sensitizes cancer cells to Smac mimetic via synergistic activation of the CYLD/RIPK1/FADD/caspase-8-dependent apoptosis.
Yang C, Ran Q, Zhou Y, Liu S, Zhao C, Yu X, Zhu F, Ji Y, Du Q, Yang T, Zhang W, He S. | 06/5/2021 |
| Low expression of pro-apoptotic proteins Bax, Bak and Smac indicates prolonged progression-free survival in chemotherapy-treated metastatic melanoma. | Low expression of pro-apoptotic proteins Bax, Bak and Smac indicates prolonged progression-free survival in chemotherapy-treated metastatic melanoma.
Guttà C, Rahman A, Aura C, Dynoodt P, Charles EM, Hirschenhahn E, Joseph J, Wouters J, de Chaumont C, Rafferty M, Warren M, van den Oord JJ, Gallagher WM, Rehm M., Free PMC Article | 03/13/2021 |
| Future Therapeutic Directions for Smac-Mimetics. | Future Therapeutic Directions for Smac-Mimetics.
Morrish E, Brumatti G, Silke J., Free PMC Article | 02/27/2021 |
| Targeting bone morphogenetic protein receptor 2 sensitizes lung cancer cells to TRAIL by increasing cytosolic Smac/DIABLO and the downregulation of X-linked inhibitor of apoptosis protein. | Targeting bone morphogenetic protein receptor 2 sensitizes lung cancer cells to TRAIL by increasing cytosolic Smac/DIABLO and the downregulation of X-linked inhibitor of apoptosis protein.
NeMoyer R, Mondal A, Vora M, Langenfeld E, Glover D, Scott M, Lairson L, Rongo C, Augeri DJ, Peng Y, Jabbour SK, Langenfeld J., Free PMC Article | 10/3/2020 |
| Smac plays an important role in the development of Primary Sjogren's syndrome (pSS). | Overexpression of Smac is associated with the development of primary Sjogren's syndrome.
Kang Y, Zhang Y. | 06/27/2020 |
| NF-kappaB activation by Smac mimetic contributes to Smac mimetic-mediated protection against TM-induced apoptosis. | NF-κB contributes to Smac mimetic-conferred protection from tunicamycin-induced apoptosis.
Abhari BA, McCarthy N, Agostinis P, Fulda S. | 04/4/2020 |
| TAK1, receptor-interacting kinase 1 (RIPK1) as well as canonical and non-canonical NF-kappaB signaling are differentially involved in Smac-induced cell death in breast cancer cells. | Differential involvement of TAK1, RIPK1 and NF-κB signaling in Smac mimetic-induced cell death in breast cancer cells.
Schmidt N, Kowald L, van Wijk SJL, Fulda S. | 10/5/2019 |
| SMAC/Diablo possesses additional non-apoptotic functions related to regulating lipid synthesis essential for cancer growth and development and that this may explain SMAC/Diablo overexpression in cancer. | A New Role for the Mitochondrial Pro-apoptotic Protein SMAC/Diablo in Phospholipid Synthesis Associated with Tumorigenesis.
Paul A, Krelin Y, Arif T, Jeger R, Shoshan-Barmatz V., Free PMC Article | 03/16/2019 |
| Positive expression for CD56 and CD11b with Low Smac/DIABLO Expression is associated with Chemoresistance in Acute Myeloid Leukaemia. | CD56 and CD11b Positivity with Low Smac/DIABLO Expression as Predictors of Chemoresistance in Acute Myeloid Leukaemia: Flow Cytometric Analysis.
Ibrahim A, Zahran AM, Aly SS, Refaat A, Hassan MH., Free PMC Article | 03/16/2019 |
| Mechanistic studies showed that Smac can inhibit the expression of Survivin, promote cell apoptosis of drug-resistant ovarian cancer cells and reverse the drug resistance. | Smac combined with DDP can inhibit drug resistance of ovarian cancer through regulation of Survivin expression.
Chen Q, Zhang H. | 10/6/2018 |
| Serum Smac expression level was significantly lower in the EAOC group than in the control group and benign ovarian tumor group (P< 0.05), while HE4 and CA125 expression levels were significantly higher in the EAOC group than the other two groups. | The clinical significance of the combined detection of serum Smac, HE4 and CA125 in endometriosis-associated ovarian cancer.
Xu XR, Wang X, Zhang H, Liu MY, Chen Q. | 08/25/2018 |
| SMAC expression in locally advanced breast cancer is a novel favourable prognostic factor in LABC for pathological complete remission and disease-free survival. | SMAC protein expression as a potent favorable prognostic factor in locally advanced breast cancer.
Pluta P, Jesionek-Kupnicka D, Kubicka-Wołkowska J, Pluta A, Brzozowski K, Potemski P, Piekarski J, Kordek R, Jeziorski A. | 08/4/2018 |
| administration of SMAC or BH3 mimetics following short-term paclitaxel treatment could be an effective therapeutic strategy for TNBC, while only BH3-mimetics could effectively overcome long-term paclitaxel resistance. | Targeting of apoptotic pathways by SMAC or BH3 mimetics distinctly sensitizes paclitaxel-resistant triple negative breast cancer cells.
Panayotopoulou EG, Müller AK, Börries M, Busch H, Hu G, Lev S., Free PMC Article | 05/19/2018 |
| Antagonism strategies to modulate the actions of XIAP, cIAP1/2 and survivin are the central focus of current research and this review highlights advances within this field with particular emphasis upon the development and specificity of second mitochondria-derived activator of caspase (SMAC) mimetics (synthetic analogs of endogenously expressed inhibitors of IAPs SMAC/DIABLO). | Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs).
Rathore R, McCallum JE, Varghese E, Florea AM, Büsselberg D., Free PMC Article | 03/17/2018 |
| analysis of Smac-mediated apoptosis in chronic lymphocytic leukemia cells | Reactivation of Smac-mediated apoptosis in chronic lymphocytic leukemia cells: mechanistic studies of Smac mimetic.
Balakrishnan K, Fu M, Onida F, Wierda WG, Keating MJ, Gandhi V., Free PMC Article | 01/13/2018 |