| Functional overlap between the mammalian Sar1a and Sar1b paralogs in vivo. | Functional overlap between the mammalian Sar1a and Sar1b paralogs in vivo.
Tang VT, Xiang J, Chen Z, McCormick J, Abbineni PS, Chen XW, Hoenerhoff M, Emmer BT, Khoriaty R, Lin JD, Ginsburg D., | 05/2/2024 |
| SAR1A regulates the RhoA/YAP and autophagy signaling pathways to influence osteosarcoma invasion and metastasis. | SAR1A regulates the RhoA/YAP and autophagy signaling pathways to influence osteosarcoma invasion and metastasis.
Zhan F, Deng Q, Chen Z, Xie C, Xiang S, Qiu S, Tian L, Wu C, Ou Y, Chen J, Xu L., Free PMC Article | 12/24/2022 |
| Small sequence variations between two mammalian paralogs of the small GTPase SAR1 underlie functional differences in coat protein complex II assembly. | Small sequence variations between two mammalian paralogs of the small GTPase SAR1 underlie functional differences in coat protein complex II assembly.
Melville DB, Studer S, Schekman R., Free PMC Article | 01/9/2021 |
| FABP5 promotes the budding of particles approximately 150 nm in diameter and modulates the kinetics of the SAR1 GTPase cycle. | Fatty-acid binding protein 5 modulates the SAR1 GTPase cycle and enhances budding of large COPII cargoes.
Melville D, Gorur A, Schekman R., Free PMC Article | 06/29/2019 |
| The Sar1 and PREB are upregulated following the induction of morphological differentiation, suggesting the potential role of signaling through Sar1a during morphological differentiation. | Pull down assay for GTP-bound form of Sar1a reveals its activation during morphological differentiation.
Urai Y, Yamawaki M, Watanabe N, Seki Y, Morimoto T, Tago K, Homma K, Sakagami H, Miyamoto Y, Yamauchi J. | 05/18/2019 |
| Study data suggest that SAR1A and SAR1B are the critical regulators of trafficking of Nav1.5. Moreover, SAR1A and SAR1B interact with MOG1, and are required for MOG1-mediated cell surface expression and function of Nav1.5. | Small GTPases SAR1A and SAR1B regulate the trafficking of the cardiac sodium channel Na(v)1.5.
Wang Z, Yu G, Liu Y, Liu S, Aridor M, Huang Y, Hu Y, Wang L, Li S, Xiong H, Tang B, Li X, Cheng C, Chakrabarti S, Wang F, Wu Q, Karnik SS, Xu C, Chen Q, Wang QK., Free PMC Article | 12/22/2018 |
| Study shows that the bona fide nonglycoprotein Nox5, a transmembrane superoxide-producing NADPH oxidase, is transported to the cell surface in a manner resistant to co-expression of Sar1 (H79G), a GTP-fixed mutant of the small GTPase Sar1, which blocks COPII vesicle fission from the endoplasmic reticulum. | Differential cell surface recruitment of the superoxide-producing NADPH oxidases Nox1, Nox2 and Nox5: The role of the small GTPase Sar1.
Kiyohara T, Miyano K, Kamakura S, Hayase J, Chishiki K, Kohda A, Sumimoto H. | 11/10/2018 |
| No associations were observed between any of the secretion associated Ras related GTPase 1A (SAR1a) promoter variants and baseline fetal hemoglobin HbF among sickle cell disease (SCD) patients. | SAR1a promoter polymorphisms are not associated with fetal hemoglobin in patients with sickle cell disease from Cameroon.
Pule GD, Bitoungui VJN, Chemegni BC, Kengne AP, Wonkam A., Free PMC Article | 03/24/2018 |
| Sar1 is a novel regulator of endoplasmic reticulum-mitochondrial contact sites in the metazoans. | Sar1, a Novel Regulator of ER-Mitochondrial Contact Sites.
Ackema KB, Prescianotto-Baschong C, Hench J, Wang SC, Chia ZH, Mergentaler H, Bard F, Frank S, Spang A., Free PMC Article | 03/18/2017 |
| SAR1A gene silencing in hepatocytes mimics the effect of ethanol: dedimerization of giantin, arresting PDIA3 in the endoplasmic reticulum (ER) and large-scale alterations in Golgi architecture. | Downregulation of the small GTPase SAR1A: a key event underlying alcohol-induced Golgi fragmentation in hepatocytes.
Petrosyan A, Cheng PW, Clemens DL, Casey CA., Free PMC Article | 10/8/2016 |
| Data indicate that hydroxyurea (HU) induces SAR1 protein expression, which in turn activates gamma-globin expression, predominantly through the Gialpha/JNK/Jun pathway. | Hydroxyurea-inducible SAR1 gene acts through the Giα/JNK/Jun pathway to regulate γ-globin expression.
Zhu J, Chin K, Aerbajinai W, Kumkhaek C, Li H, Rodgers GP., Free PMC Article | 05/2/2015 |
| although Sar1A antagonizes the lipoprotein secretion-promoting activity of Sar1B, both isoforms modulate the expression of genes encoding cholesterol biosynthetic enzymes and the synthesis of cholesterol de novo. | The endoplasmic reticulum coat protein II transport machinery coordinates cellular lipid secretion and cholesterol biosynthesis.
Fryer LG, Jones B, Duncan EJ, Hutchison CE, Ozkan T, Williams PA, Alder O, Nieuwdorp M, Townley AK, Mensenkamp AR, Stephens DJ, Dallinga-Thie GM, Shoulders CC., Free PMC Article | 05/3/2014 |
| Sar1 mutant proteins added to metaphase-arrested Xenopus laevis egg extracts cause dramatic effects on membrane organization. | Altering membrane topology with Sar1 does not impair spindle assembly in Xenopus egg extracts.
Riggs B, Bergman ZJ, Heald R., Free PMC Article | 05/25/2013 |
| the behavior of the human of Sar1A and Sar1B, a key component of the COPII family of vesicle coat proteins, was examined. | Modulation of membrane rigidity by the human vesicle trafficking proteins Sar1A and Sar1B.
Loftus AF, Hsieh VL, Parthasarathy R. | 02/16/2013 |
| Sedlin bound and promoted efficient cycling of Sar1, a guanosine triphosphatase that can constrict membranes, and thus allowed nascent carriers to grow and incorporate procollagen prefibrils. | Sedlin controls the ER export of procollagen by regulating the Sar1 cycle.
Venditti R, Scanu T, Santoro M, Di Tullio G, Spaar A, Gaibisso R, Beznoussenko GV, Mironov AA, Mironov A Jr, Zelante L, Piemontese MR, Notarangelo A, Malhotra V, Vertel BM, Wilson C, De Matteis MA., Free PMC Article | 11/17/2012 |
| lipid-directed and tether-assisted Sar1 organization controls membrane constriction to regulate ER export. | Sar1 assembly regulates membrane constriction and ER export.
Long KR, Yamamoto Y, Baker AL, Watkins SC, Coyne CB, Conway JF, Aridor M., Free PMC Article | 08/2/2010 |
| the intracellular trafficking of hCaR from the endoplasmic reticulum is Sar1-dependent via coat protein complex-II vesicles. | Sar1-dependent trafficking of the human calcium receptor to the cell surface.
Zhuang X, Chowdhury S, Northup JK, Ray K., Free PMC Article | 07/19/2010 |
| Kir6.2 contains a di-acidic endoplasmic reticulum exit signal, which promotes endoplasmic reticulum exit via a process that requires Sar1. | Sar1-GTPase-dependent ER exit of KATP channels revealed by a mutation causing congenital hyperinsulinism.
Taneja TK, Mankouri J, Karnik R, Kannan S, Smith AJ, Munsey T, Christesen HB, Beech DJ, Sivaprasadarao A. | 01/21/2010 |
| Sar 1 H79G mutants efficiently blocked the plasma membrane trafficking of the Kir3.1/Kir3.4 complex however they did not block the Gbeta1gamma2/Kir3.1 interaction. | Intracellular trafficking and assembly of specific Kir3 channel/G protein complexes.
Robitaille M, Ramakrishnan N, Baragli A, Hébert TE. | 01/21/2010 |
| Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Fetal haemoglobin response to hydroxycarbamide treatment and sar1a promoter polymorphisms in sickle cell anaemia.
Kumkhaek C, Taylor JG 6th, Zhu J, Hoppe C, Kato GJ, Rodgers GP., Free PMC Article | 04/3/2008 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesMaternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, Christensen K, Boyles AL, Daack-Hirsch S, Nguyen TT, Christiansen L, Lidral AC, Murray JC. Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease.
Morgan AR, Turic D, Jehu L, Hamilton G, Hollingworth P, Moskvina V, Jones L, Lovestone S, Brayne C, Rubinsztein DC, Lawlor B, Gill M, O'Donovan MC, Owen MJ, Williams J. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A. | 03/13/2008 |
| The Sec31 fragment stimulates GAP activity of Sec23/24, and a convergence of Sec31 and Sec23 residues at the Sar1 GTPase active site explains how GTP hydrolysis is triggered leading to COPII coat disassembly. | Insights into COPII coat nucleation from the structure of Sec23.Sar1 complexed with the active fragment of Sec31.
Bi X, Mancias JD, Goldberg J., Free PMC Article | 01/21/2010 |