| NTAL is a key inhibitor of mast cell chemotaxis toward PGE2, which may act through the RHOA/ERM/beta1-integrin and PI3K/AKT axes | The transmembrane adaptor protein NTAL limits mast cell chemotaxis toward prostaglandin E(2).
Halova I, Bambouskova M, Draberova L, Bugajev V, Draber P. | 12/21/2019 |
| NTAL is a negative regulator of FcepsilonRI activation events in murine bone marrow-derived mast cells, independently of possible compensatory developmental alterations. | Multiple regulatory roles of the mouse transmembrane adaptor protein NTAL in gene transcription and mast cell physiology.
Polakovicova I, Draberova L, Simicek M, Draber P., Free PMC Article | 11/14/2015 |
| Cerebral cortex hyperthyroidism of newborn mct8-deficient mice transiently suppressed by lat2 inactivation. | Cerebral cortex hyperthyroidism of newborn mct8-deficient mice transiently suppressed by lat2 inactivation.
Núñez B, Martínez de Mena R, Obregon MJ, Font-Llitjós M, Nunes V, Palacín M, Dumitrescu AM, Morte B, Bernal J., Free PMC Article | 01/24/2015 |
| Our data define a novel link between LAB and beta-catenin nuclear accumulation in dendritic cells that facilitates IFN-gamma responses during anti-fungal immunity | LAB/NTAL facilitates fungal/PAMP-induced IL-12 and IFN-γ production by repressing β-catenin activation in dendritic cells.
Orr SJ, Burg AR, Chan T, Quigley L, Jones GW, Ford JW, Hodge D, Razzook C, Sarhan J, Jones YL, Whittaker GC, Boelte KC, Lyakh L, Cardone M, O'Connor GM, Tan C, Li H, Anderson SK, Jones SA, Zhang W, Taylor PR, Trinchieri G, McVicar DW., Free PMC Article | 09/21/2013 |
| chemotaxis toward antigen is controlled in mast cells by a cross-talk among FcepsilonRI, tetraspanin CD9, transmembrane adaptor proteins NTAL and LAT, and cytoskeleton-regulatory proteins of the ERM family | Cross-talk between tetraspanin CD9 and transmembrane adaptor protein non-T cell activation linker (NTAL) in mast cell activation and chemotaxis.
Hálová I, Dráberová L, Bambousková M, Machyna M, Stegurová L, Smrž D, Dráber P., Free PMC Article | 06/1/2013 |
| Dihydrotestosterone treatment increased the expression of LAT2. | Dihydrotestosterone stimulates amino acid uptake and the expression of LAT2 in mouse skeletal muscle fibres through an ERK1/2-dependent mechanism.
Hamdi MM, Mutungi G., Free PMC Article | 04/21/2012 |
| Our study suggested a novel mechanism by which LAB functions in the regulation of innate immunity | Tyrosine phosphorylation-independent regulation of lipopolysaccharide-mediated response by the transmembrane adaptor protein LAB.
Zhu M, Fuller DM, Ou-Yang CW, Sullivan SA, Zhang W., Free PMC Article | 04/21/2012 |
| The expression of Mct8 and L-type amino acid transporters Lat2 and Lat1 are determined in brain neurons during development. | Developmental and cell type-specific expression of thyroid hormone transporters in the mouse brain and in primary brain cells.
Braun D, Kinne A, Bräuer AU, Sapin R, Klein MO, Köhrle J, Wirth EK, Schweizer U. | 12/10/2011 |
| a crucial role of NTAL in signaling, via RhoA, to mast cell cytoskeleton. | The transmembrane adaptor protein NTAL signals to mast cell cytoskeleton via the small GTPase Rho.
Tůmová M, Koffer A, Simíček M, Dráberová L, Dráber P. | 01/1/2011 |
| While SLP-76 and LAT1 depend on each other for many of their functions, LAT2/SLP-76 interactions and SLP-76-independent LAT1 functions also mediate a positive signaling pathway downstream of FcepsilonRI in mast cells. | Independent and cooperative roles of adaptor molecules in proximal signaling during FcepsilonRI-mediated mast cell activation.
Kambayashi T, Okumura M, Baker RG, Hsu CJ, Baumgart T, Zhang W, Koretzky GA., Free PMC Article | 09/20/2010 |
| LAB is a critical, LAT-independent regulator of TREM-2 signaling and macrophage development capable of controlling subsequent inflammatory responses | The linker for activation of B cells (LAB)/non-T cell activation linker (NTAL) regulates triggering receptor expressed on myeloid cells (TREM)-2 signaling and macrophage inflammatory responses independently of the linker for activation of T cells.
Whittaker GC, Orr SJ, Quigley L, Hughes L, Francischetti IM, Zhang W, McVicar DW., Free PMC Article | 03/1/2010 |
| Phosphorylated LAB recruits a complex of Grb2-dynamin and the guanine nucleotide exchange factor Vav. Vav is required for activation of the small GTPases Rac1 and Rac2. | Vav and Rac activation in B cell antigen receptor endocytosis involves Vav recruitment to the adapter protein LAB.
Malhotra S, Kovats S, Zhang W, Coggeshall KM., Free PMC Article | 01/21/2010 |
| These data show that natural killer cell immunoreceptor tyrosine-based activation motifs preferentially use a signaling cassette regulated by interplay between LAT and LAB. | Analysis of the linker for activation of T cells and the linker for activation of B cells in natural killer cells reveals a novel signaling cassette, dual usage in ITAM signaling, and influence on development of the Ly49 repertoire.
Whittaker GC, Burshtyn DN, Orr SJ, Quigley L, Hodge DL, Pascal V, Zhang W, McVicar DW., Free PMC Article | 01/21/2010 |
| NTAL negatively regulates mast cell activation by decreasing the recruitment, by T cell activation linker (LAT), of molecules involved in Fc epsilon RI-dependent positive signaling. | Non-T cell activation linker promotes mast cell survival by dampening the recruitment of SHIP1 by linker for activation of T cells.
Roget K, Malissen M, Malbec O, Malissen B, Daëron M. | 01/21/2010 |
| observations reported herein support the conclusion that NTAL may be differentially utilized by specific receptors for relaying alternative signals and this suggests a flexibility in the function of TRAPs not previously appreciated. | Kit- and Fc epsilonRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells.
Iwaki S, Spicka J, Tkaczyk C, Jensen BM, Furumoto Y, Charles N, Kovarova M, Rivera J, Horejsi V, Metcalfe DD, Gilfillan AM., Free PMC Article | 01/21/2010 |
| NTAL negatively regulates Fc-epsilon receptor I-mediated signaling events in bone marrow-derived mast cells. | Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL.
Volná P, Lebduska P, Dráberová L, Símová S, Heneberg P, Boubelík M, Bugajev V, Malissen B, Wilson BS, Horejsí V, Malissen M, Dráber P., Free PMC Article | 01/21/2010 |
| LAT2 and LAT1 form separate membrane microdomains in bone marrow-derived mast cells. | Topography of signaling molecules as detected by electron microscopy on plasma membrane sheets isolated from non-adherent mast cells.
Lebduska P, Korb J, Tůmová M, Heneberg P, Dráber P. | 01/8/2008 |
| Our results show that system L isoform LAT2 is critical for alanine uptake into astrocytes. However, alanine does not provide any significant carbon for energy or neurotransmitter metabolism under the conditions studied. | Alanine metabolism, transport, and cycling in the brain.
Bröer S, Bröer A, Hansen JT, Bubb WA, Balcar VJ, Nasrallah FA, Garner B, Rae C. | 01/21/2010 |
| LAB-deficient mice had increased levels of natural antibodies and slightly increased humoral response to a T-dependent antigen. | Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function.
Wang Y, Horvath O, Hamm-Baarke A, Richelme M, Grégoire C, Guinamard R, Horejsi V, Angelisova P, Spicka J, Schraven B, Malissen B, Malissen M., Free PMC Article | 01/21/2010 |
| LAB shares a redundant function with LAT to play a positive role in FcepsilonRI-mediated signaling. | Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL.
Zhu M, Liu Y, Koonpaew S, Granillo O, Zhang W., Free PMC Article | 01/21/2010 |
| LAB mediates immunoglobulin E-induced sustained Erk activation critical for mast cell survival. | LAT and NTAL mediate immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival.
Yamasaki S, Ishikawa E, Sakuma M, Kanagawa O, Cheng AM, Malissen B, Saito T., Free PMC Article | 01/21/2010 |