| Sphingosine kinase 2 and p62 regulation are determinants of sexual dimorphism in hepatocellular carcinoma. | Sphingosine kinase 2 and p62 regulation are determinants of sexual dimorphism in hepatocellular carcinoma.
Green CD, Brown RDR, Uranbileg B, Weigel C, Saha S, Kurano M, Yatomi Y, Spiegel S., Free PMC Article | 08/19/2024 |
| YTHDF1-mediated sphingosine kinase 2 upregulation alleviates bupivacaine-induced neurotoxicity via the PI3K/AKT axis. | YTHDF1-mediated sphingosine kinase 2 upregulation alleviates bupivacaine-induced neurotoxicity via the PI3K/AKT axis.
Yuan R, Wu C. | 03/19/2024 |
| The accumulation of sphingosine kinase 2 disrupts the DNA damage response and promotes resistance to genotoxic agents. | The accumulation of sphingosine kinase 2 disrupts the DNA damage response and promotes resistance to genotoxic agents.
da Silva G, Milan TM, Leopoldino AM. | 01/29/2024 |
| Accumulation of sphingosine kinase 2 protein induces malignant transformation in oral keratinocytes associated with stemness, autophagy, senescence, and proliferation. | Accumulation of sphingosine kinase 2 protein induces malignant transformation in oral keratinocytes associated with stemness, autophagy, senescence, and proliferation.
Fugio LB, Silva G, Ferraz CL, Trevisan GL, Coeli-Lacchini FB, Garcia CB, Sousa LO, Malta TM, Gil CD, Leopoldino AM. | 11/29/2023 |
| Inhibition of Sphingosine Kinase 2 Results in PARK2-Mediated Mitophagy and Induces Apoptosis in Multiple Myeloma. | Inhibition of Sphingosine Kinase 2 Results in PARK2-Mediated Mitophagy and Induces Apoptosis in Multiple Myeloma.
Wu J, Fan S, Feinberg D, Wang X, Jabbar S, Kang Y., Free PMC Article | 04/4/2023 |
| Sphingosine kinase 2 regulates insulin receptor trafficking in hepatocytes. | Sphingosine kinase 2 regulates insulin receptor trafficking in hepatocytes.
Aji G, Jiang S, Obulkasim H, Lu Z, Wang W, Xia P., Free PMC Article | 03/6/2023 |
| miR-153-3p Attenuates the Development of Gastric Cancer by Suppressing SphK2. | miR-153-3p Attenuates the Development of Gastric Cancer by Suppressing SphK2.
Jia Z, Tang X, Zhang X, Shen J, Sun Y, Qian L. | 09/24/2022 |
| Enzymatic independent role of sphingosine kinase 2 in regulating the expression of type I interferon during influenza A virus infection. | Enzymatic independent role of sphingosine kinase 2 in regulating the expression of type I interferon during influenza A virus infection.
Xu M, Xia S, Wang M, Liu X, Li X, Chen W, Wang Y, Li H, Xia C, Chen J, Wu J., Free PMC Article | 09/17/2022 |
| Loss of sphingosine kinase 2 protects against cisplatin-induced kidney injury. | Loss of sphingosine kinase 2 protects against cisplatin-induced kidney injury.
Xie D, Hu G, Chen C, Ahmadinejad F, Wang W, Li PL, Gewirtz DA, Li N., Free PMC Article | 08/27/2022 |
| Upregulated flotillins and sphingosine kinase 2 derail AXL vesicular traffic to promote epithelial-mesenchymal transition. | Upregulated flotillins and sphingosine kinase 2 derail AXL vesicular traffic to promote epithelial-mesenchymal transition.
Genest M, Comunale F, Planchon D, Govindin P, Noly D, Vacher S, Bièche I, Robert B, Malhotra H, Schoenit A, Tashireva LA, Casas J, Gauthier-Rouvière C, Bodin S. | 04/23/2022 |
| METTL3-mediated m(6)A methylation of SPHK2 promotes gastric cancer progression by targeting KLF2. | METTL3-mediated m(6)A methylation of SPHK2 promotes gastric cancer progression by targeting KLF2.
Huo FC, Zhu ZM, Zhu WT, Du QY, Liang J, Mou J. | 11/6/2021 |
| Inhibition of sphingosine kinase 2 attenuates hypertrophic scar formation via upregulation of Smad7 in human hypertrophic scar fibroblasts. | Inhibition of sphingosine kinase 2 attenuates hypertrophic scar formation via upregulation of Smad7 in human hypertrophic scar fibroblasts.
Zeng J, Jiang B, Xiao X, Zhang R., Free PMC Article | 05/1/2021 |
| Sphingosine kinase-2 is overexpressed in large granular lymphocyte leukaemia and promotes survival through Mcl-1. | Sphingosine kinase-2 is overexpressed in large granular lymphocyte leukaemia and promotes survival through Mcl-1.
LeBlanc FR, Pearson JM, Tan SF, Cheon H, Xing JC, Dunton W, Feith DJ, Loughran TP Jr., Free PMC Article | 03/6/2021 |
| Sphingosine kinase 1 and sphingosine kinase 2 have opposing roles in regulating p53-dependent function. siRNA knockdown of SK-2 reduces the expression of the pro-survival XBP-1s. | The regulation of p53, p38 MAPK, JNK and XBP-1s by sphingosine kinases in human embryonic kidney cells.
Alsanafi M, Kelly SL, McNaughton M, Merrill AH Jr, Pyne NJ, Pyne S. | 07/18/2020 |
| Serum S1P is decreased in PACI, which may be partly due to downregulation of pancreatic SPHK2 | Decreased S1P and SPHK2 are involved in pancreatic acinar cell injury.
Xiao J, Lin H, Liu B, Xia Z, Zhang J, Jin J. | 05/23/2020 |
| These findings suggested that LINC00460 could function as a competing endogenous RNA to regulate SphK2 expression by sponging miR-613 in papillary thyroid carcinoma. | Long noncoding RNA LINC00460 promotes carcinogenesis via sponging miR-613 in papillary thyroid carcinoma.
Feng L, Yang B, Tang XD. | 05/16/2020 |
| Increased SPHK2 levels in proliferating airway smooth muscle cells could be exploited to counteract airway smooth muscle thickening with synthetic substrates. | Metabolic Adaptation of Airway Smooth Muscle Cells to an SPHK2 Substrate Precedes Cytostasis.
Blais-Lecours P, Laouafa S, Arias-Reyes C, Santos WL, Joseph V, Burgess JK, Halayko AJ, Soliz J, Marsolais D., Free PMC Article | 05/16/2020 |
| The specific antagonism of beta3-AR by SR59230A inhibits Neuroblastoma growth and tumor progression, by switching from stemness to cell differentiation both in vivo and in vitro through the specific blockade of SK2/S1P2 signaling. | β3-adrenoreceptor blockade reduces tumor growth and increases neuronal differentiation in neuroblastoma via SK2/S1P(2) modulation.
Bruno G, Cencetti F, Pini A, Tondo A, Cuzzubbo D, Fontani F, Strinna V, Buccoliero AM, Casazza G, Donati C, Filippi L, Bruni P, Favre C, Calvani M., Free PMC Article | 04/18/2020 |
| SphK2 expression levels were down-regulated in the livers of human patients with alcoholic cirrhosis and hepatocellular carcinoma compared to healthy controls. | The role of sphingosine kinase 2 in alcoholic liver disease.
Kwong EK, Liu R, Zhao D, Li X, Zhu W, Wang X, Gurley EC, Lai G, Liu J, Hylemon PB, Zhou H., Free PMC Article | 04/18/2020 |
| We will also highlight the connections between SphK2 and the DNA damage response. Finally, we will provide our insight into the regulatory mechanisms of SphKs by two main categories, micro and long, noncoding RNAs as the novel players of cancer chemoresistance. | New insights into the roles and regulation of SphK2 as a therapeutic target in cancer chemoresistance.
Hasanifard L, Sheervalilou R, Majidinia M, Yousefi B. | 04/11/2020 |
| SPHK2 is degraded by autophagy at early time-points of macrophage activation. SPHK2 degradation is required for inflammatory cytokine production. | Sphingosine kinase 2 is a negative regulator of inflammatory macrophage activation.
Weigert A, von Knethen A, Thomas D, Faria I, Namgaladze D, Zezina E, Fuhrmann D, Petcherski A, Heringdorf DMZ, Radeke HH, Brüne B. | 03/7/2020 |
| Study demonstrated that increased SPHK1 expression and sphingosine-1-phosphate production, and conversely decreases in SPHK2 expression and dihydrosphingosine-1-phosphate production, are likely responsible for increased cathelicidin antimicrobial peptide levels in differentiated keratinocytes in parallel with endoplasmic reticulum stress. | Both Sphingosine Kinase 1 and 2 Coordinately Regulate Cathelicidin Antimicrobial Peptide Production during Keratinocyte Differentiation.
Shin KO, Kim KP, Cho Y, Kang MK, Kang YH, Lee YM, Ikushiro H, Yokota M, Yano T, Choe SJ, Choi EH, Lim CJ, Park K, Holleran WM, Park K, Uchida Y., Free PMC Article | 01/4/2020 |
| Normal CD8+ T-cell infiltration into the DENV-infected brain independent of SK2 or S1P. | In vitro and in vivo roles of sphingosine kinase 2 during dengue virus infection.
Al-Shujairi WH, Clarke JN, Davies LT, Pitman MR, Calvert JK, Aloia AL, Pitson SM, Carr JM. | 12/21/2019 |
| Sphingosine kinase 2 deficiency in mice significantly prevented the loss of beta-cell mass. | Sphingosine kinase 2 promotes lipotoxicity in pancreatic β-cells and the progression of diabetes.
Song Z, Wang W, Li N, Yan S, Rong K, Lan T, Xia P., Free PMC Article | 11/16/2019 |
| Kinases SphK1 and SphK2 regulate IL-17 expression in human T cells. | Sphingosine Kinases promote IL-17 expression in human T lymphocytes.
Barra G, Lepore A, Gagliardi M, Somma D, Matarazzo MR, Costabile F, Pasquale G, Mazzoni A, Gallo C, Nuzzo G, Annunziato F, Fontana A, Leonardi A, De Palma R., Free PMC Article | 11/9/2019 |