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    PSMB1 proteasome 20S subunit beta 1 [ Homo sapiens (human) ]

    Gene ID: 5689, updated on 5-May-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Uroplakin 1a Interacts with Regucalcin and Proteasome Subunit Beta 1.

    Uroplakin 1a Interacts with Regucalcin and Proteasome Subunit Beta 1.
    Munipalli SB, Yenugu S.

    12/5/2023
    Biallelic variants in PSMB1 encoding the proteasome subunit beta6 cause impairment of proteasome function, microcephaly, intellectual disability, developmental delay and short stature.

    Biallelic variants in PSMB1 encoding the proteasome subunit β6 cause impairment of proteasome function, microcephaly, intellectual disability, developmental delay and short stature.
    Ansar M, Ebstein F, Özkoç H, Paracha SA, Iwaszkiewicz J, Gesemann M, Zoete V, Ranza E, Santoni FA, Sarwar MT, Ahmed J, Krüger E, Bachmann-Gagescu R, Antonarakis SE.

    08/7/2021
    Collectively, our study demonstrates PSMB1 is an important regulator of innate immune signaling in viral infection

    PSMB1 Negatively Regulates the Innate Antiviral Immunity by Facilitating Degradation of IKK-ε.
    Wu F, Niu Z, Zhou B, Li P, Qian F., Free PMC Article

    06/22/2019
    In vitro analyses demonstrated significantly reduced protease activity in proteasomes of individuals with G/G genotype compared with that of C/C carriers, despite that PSMB1 expression and proteasome assembly remained unaltered.

    Proteasome Subunit Beta Type 1 P11A Polymorphism Is a New Prognostic Marker in Multiple Myeloma.
    Varga G, Mikala G, Kiss KP, Kosóczki É, Szabó E, Meggyesi N, Balassa K, Kövy P, Tegze B, Szombath G, Tordai A, Andrikovics H, Homolya L, Masszi T.

    07/7/2018
    The proteasome beta1 subunit plays a novel role in tumorigenesis by degrading p27Kip1.

    A novel role of proteasomal β1 subunit in tumorigenesis.
    Yuan F, Ma Y, You P, Lin W, Lu H, Yu Y, Wang X, Jiang J, Yang P, Ma Q, Tao T., Free PMC Article

    04/26/2014
    The mutated form of PSMB1 displayed increased nuclear translocation, resulting in activation of transcription in adipocytes.

    Role of nuclear localization of PSMB1 in transcriptional activation.
    Yamauchi J, Sekiguchi M, Shirai T, Yamada M, Ishimi Y.

    04/5/2014
    The proteasome was found to be activated in primary sjogren syndrome, with upregulation of gene expression of catalytic proteasome subunits.

    Gene expression of catalytic proteasome subunits and resistance toward proteasome inhibition of B lymphocytes from patients with primary sjogren syndrome.
    Martinez-Gamboa L, Lesemann K, Kuckelkorn U, Scheffler S, Ghannam K, Hahne M, Gaber-Elsner T, Egerer K, Naumann L, Buttgereit F, Dörner T, Kloetzel PM, Burmester GR, Faustman DL, Feist E.

    12/14/2013
    Follicular lymphoma patients with PSMB1 P11A (G allele) and low CD68 expression have significantly longer progression free survival with bortezomib-rituximab versus rituximab.

    Prespecified candidate biomarkers identify follicular lymphoma patients who achieved longer progression-free survival with bortezomib-rituximab versus rituximab.
    Coiffier B, Li W, Henitz ED, Karkera JD, Favis R, Gaffney D, Shapiro A, Theocharous P, Elsayed YA, van de Velde H, Schaffer ME, Osmanov EA, Hong X, Scheliga A, Mayer J, Offner F, Rule S, Teixeira A, Romejko-Jarosinska J, de Vos S, Crump M, Shpilberg O, Zinzani PL, Cakana A, Esseltine DL, Mulligan G, Ricci D.

    11/16/2013
    PSMB1 is part of the transcriptional machinery required for gastrin stimulated expression of PAI-2 and Reg1.

    The role of proteasome beta subunits in gastrin-mediated transcription of plasminogen activator inhibitor-2 and regenerating protein1.
    O'Hara A, Howarth A, Varro A, Dimaline R., Free PMC Article

    09/21/2013
    Expression of 26S proteasome beta(1)-subunit in NB4 cells increased after incubation with As(2)O(3).

    [Influence of As(2)O(3) on proteasome beta(1)-subunit in NB4 cells].
    Lü XH, Chen Y, Zhang M, He PC, Wang HY, Ni ZF, Lu R.

    08/27/2011
    data defined a unique motif of BCL-3 that is needed for its recruitment to the proteasome and identified PSMB1 as a key protein required for the proteasome-mediated degradation of a nuclear and oncogenic IkappaB protein.

    BCL-3 degradation involves its polyubiquitination through a FBW7-independent pathway and its binding to the proteasome subunit PSMB1.
    Keutgens A, Zhang X, Shostak K, Robert I, Olivier S, Vanderplasschen A, Chapelle JP, Viatour P, Merville MP, Bex F, Gothot A, Chariot A., Free PMC Article

    09/6/2010
    Observational study of gene-disease association. (HuGE Navigator)

    Evaluation of IDDM8 susceptibility locus in a Russian simplex family data set.
    Chistiakov DA, Seryogin YA, Turakulov RI, Savost'anov KV, Titovich EV, Zilberman LI, Kuraeva TL, Dedov II, Nosikov VV.

    03/13/2008
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