| Correlations of ultrasound and pathological features of thyroid carcinoma with TC-1 mRNA and protein expression. | Correlations of ultrasound and pathological features of thyroid carcinoma with TC-1 mRNA and protein expression.
Zhang CL, Geng CH, Jian JJ, He M, Zhao HW, Li HY. | 09/12/2020 |
| The lncRNA H19 serves as a competing endogenous RNA (ceRNA) for miR-30a to augment miR-30a downstream target C8orf4, therefore modulating adipogenic differentiation in adipose tissue-derived mesenchymal stem cells. | H19/miR-30a/C8orf4 axis modulates the adipogenic differentiation process in human adipose tissue-derived mesenchymal stem cells.
Li K, Wu Y, Yang H, Hong P, Fang X, Hu Y. | 06/6/2020 |
| The expressions of C8orf4 (TCIM) and beta-catenin increase synergystically in cervical squamous cell carcinoma (CSCC) and high-grade intraepithelial lesions compared with low-grade lesions and normal cervical tissues. The methylation level of C8orf4 is decreased in CSCCs and is responsible for the increased expression of C8orf4. | Association of C8orf4 expression with its methylation status, aberrant β-catenin expression, and the development of cervical squamous cell carcinoma.
Lan C, Huan DW, Nie XC, Niu JM, Sun JH, Huang WJ, Li ZH, Xu HT., Free PMC Article | 10/12/2019 |
| Identified a new circRNA, circZFR, that was significantly upregulated in papillary thyroid carcinoma (PTC). CircZFR could promote C8orf4 expression via serving as a competing endogenous RNA of miR-1261 in PTC cells. Rescue assays indicated that restoration of C8orf4 significantly attenuated the inhibitory effects of circZFR knockdown on PTC cell proliferation, migration and invasion. | Circular RNA circZFR contributes to papillary thyroid cancer cell proliferation and invasion by sponging miR-1261 and facilitating C8orf4 expression.
Wei H, Pan L, Tao D, Li R. | 12/1/2018 |
| Decreased capacity of fibrotic lung fibroblasts to up-regulate COX-2 expression and COX-2-derived PGE2 synthesis is due to an indirect epigenetic mechanism involving hypermethylation of the transcriptional regulator, c8orf4. | Epigenetic regulation of cyclooxygenase-2 by methylation of c8orf4 in pulmonary fibrosis.
Evans IC, Barnes JL, Garner IM, Pearce DR, Maher TM, Shiwen X, Renzoni EA, Wells AU, Denton CP, Laurent GJ, Abraham DJ, McAnulty RJ., Free PMC Article | 07/30/2016 |
| C8orf4 negatively regulates the self-renewal of liver CSCs via suppression of NOTCH2 signalling | C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling.
Zhu P, Wang Y, Du Y, He L, Huang G, Zhang G, Yan X, Fan Z., Free PMC Article | 03/26/2016 |
| the high expression of TC1 was common in oral tongue squamous cell carcinomas and correlated with the expression of b-catenin and cyclin D1 and the progression of oral tongue squamous cell carcinomas | The high expression of TC1 (C8orf4) was correlated with the expression of β-catenin and cyclin D1 and the progression of squamous cell carcinomas of the tongue.
Zhang P, Cao HY, Bai LL, Li WN, Wang Y, Chen SY, Zhang L, Yang LH, Xu HT, Wang EH. | 02/27/2016 |
| TC-1 overexpression promotes cell proliferation in human non-small cell lung cancer that can be inhibited by PD173074. | TC-1 overexpression promotes cell proliferation in human non-small cell lung cancer that can be inhibited by PD173074.
Lei J, Li W, Yang Y, Lu Q, Zhang N, Bai G, Zhong D, Su K, Liu B, Li X, Wang Y, Wang X., Free PMC Article | 10/10/2015 |
| TC-1 expression is associated with aggressive biologic behavior in lung cancer and might coordinate with the Wnt/beta-catenin pathway as a positive upstream regulator that induces these behaviors. | TC-1 (c8orf4) enhances aggressive biologic behavior in lung cancer through the Wnt/β-catenin pathway.
Su K, Huang L, Li W, Yan X, Li X, Zhang Z, Jin F, Lei J, Ba G, Liu B, Wang X, Wang Y. | 12/21/2013 |
| The higher expression of TC-1 in ovarian compared to colorectal adenocarcinomas suggests its potential use as a marker | TC-1 (C8orf4) expression is correlated with differentiation in ovarian carcinomas and might distinguish metastatic ovarian from metastatic colorectal carcinomas.
Xu HT, Liu Y, Liu SL, Miao Y, Li QC, Wang EH. | 04/20/2013 |
| The SNP rs10958605 in the C8orf4 gene had the smallest p value in analyses of the motor outcome. | Genomic determinants of motor and cognitive outcomes in Parkinson's disease.
Chung SJ, Armasu SM, Biernacka JM, Anderson KJ, Lesnick TG, Rider DN, Cunningham JM, Eric Ahlskog J, Frigerio R, Maraganore DM., Free PMC Article | 03/30/2013 |
| A significant association was found between the copy-number deletions of C8orf4 and the risk of hematological malignancies. | Investigation of copy-number variations of C8orf4 in hematological malignancies.
Zhang J, Gao Y, Zhao X, Guan M, Zhang W, Wan J, Yu B. | 08/25/2012 |
| TC1 was involved in the mitogen-activated ERK1/2 signaling pathway and positively regulated G(1)- to S-phase transition of the cell cycle. | TC1 (C8orf4) is involved in ERK1/2 pathway-regulated G(1)- to S-phase transition.
Wang YD, Bian GH, Lv XY, Zheng R, Sun H, Zhang Z, Chen Y, Li QW, Xiao Y, Yang QT, Ai JZ, Wei YQ, Zhou Q. | 01/21/2010 |
| intrinsically disordered TC-1 interacts with Cby via its transient helical structure | The intrinsically disordered TC-1 interacts with Chibby via regions with high helical propensity.
Gall C, Xu H, Brickenden A, Ai X, Choy WY., Free PMC Article | 01/21/2010 |
| TC-1 over expression is transforming and may link with the FGFR pathway in a subset of breast cancer. | Transforming properties of TC-1 in human breast cancer: interaction with FGFR2 and beta-catenin signaling pathways.
Yang ZQ, Moffa AB, Haddad R, Streicher KL, Ethier SP. | 01/21/2010 |
| The TC1 coordinates the up-regulation of Wnt/beta-catenin target genes that are implicated in the aggressive biological behavior of cancers. | TC1(C8orf4) correlates with Wnt/beta-catenin target genes and aggressive biological behavior in gastric cancer.
Kim B, Koo H, Yang S, Bang S, Jung Y, Kim Y, Kim J, Park J, Moon RT, Song K, Lee I. | 01/21/2010 |
| Our data suggest that TC1 is a novel heat shock response regulator. | TC1 (C8orf4) is upregulated by cellular stress and mediates heat shock response.
Park J, Jung Y, Kim J, Kim KY, Ahn SG, Song K, Lee I. | 01/21/2010 |
| Gene induces transformed phenotype when overexpressed in a cancer breast cell line. | Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer.
Yang ZQ, Streicher KL, Ray ME, Abrams J, Ethier SP. | 01/21/2010 |
| Overexpression of TC-1 may be important in thyroid carcinogenesis. | TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer.
Sunde M, McGrath KC, Young L, Matthews JM, Chua EL, Mackay JP, Death AK. | 01/21/2010 |
| data indicate that TC1 is a novel upstream regulator of the Wnt/beta-catenin pathway that enhances aggressive behavior of cancers | TC1 (C8orf4) enhances the Wnt/beta-catenin pathway by relieving antagonistic activity of Chibby.
Jung Y, Bang S, Choi K, Kim E, Kim Y, Kim J, Park J, Koo H, Moon RT, Song K, Lee I. | 01/21/2010 |