| UBQLN4 promotes the proliferation and invasion of non-small cell lung cancer cell by regulating PI3K/AKT pathway. | UBQLN4 promotes the proliferation and invasion of non-small cell lung cancer cell by regulating PI3K/AKT pathway.
He L, Chen H, Ruan B, He L, Luo M, Fu Y, Zou R., Free PMC Article | 07/31/2024 |
| Ubiquilin-4 induces immune escape in gastric cancer by activating the notch signaling pathway. | Ubiquilin-4 induces immune escape in gastric cancer by activating the notch signaling pathway.
Jiang Q, Chen H, Zhou S, Zhu T, Liu W, Wu H, Zhang Y, Liu F, Sun Y. | 03/1/2024 |
| Genomic Amplification of UBQLN4 Is a Prognostic and Treatment Resistance Factor. | Genomic Amplification of UBQLN4 Is a Prognostic and Treatment Resistance Factor.
Kobayashi Y, Bustos MA, Shoji Y, Jachimowicz RD, Shiloh Y, Hoon DSB., Free PMC Article | 11/5/2022 |
| Regulation of MRE11A by UBQLN4 leads to cisplatin resistance in patients with esophageal squamous cell carcinoma. | Regulation of MRE11A by UBQLN4 leads to cisplatin resistance in patients with esophageal squamous cell carcinoma.
Murakami T, Shoji Y, Nishi T, Chang SC, Jachimowicz RD, Hoshimoto S, Ono S, Shiloh Y, Takeuchi H, Kitagawa Y, Hoon DSB, Bustos MA., Free PMC Article | 01/15/2022 |
| Angiogenesis-Centered Molecular Cross-Talk in Amyotrophic Lateral Sclerosis Survival: Mechanistic Insights. | Angiogenesis-Centered Molecular Cross-Talk in Amyotrophic Lateral Sclerosis Survival: Mechanistic Insights.
Thakur K, Tiwari A, Sharma K, Modgil S, Khosla R, Anand A. | 07/10/2021 |
| Ubqln4 Facilitates Endoplasmic Reticulum-to-Cytosol Escape of a Nonenveloped Virus during Infection. | Ubqln4 Facilitates Endoplasmic Reticulum-to-Cytosol Escape of a Nonenveloped Virus during Infection.
Liu X, Tsai B., Free PMC Article | 10/24/2020 |
| Findings not only establish the anti-tumor potential of Ubqln4 in gastric cancer but also reveal a role for Ubqln4 in regulation of the cell cycle and cellular senescence via stabilizing p21. | The UbL-UBA Ubiquilin4 protein functions as a tumor suppressor in gastric cancer by p53-dependent and p53-independent regulation of p21.
Huang S, Li Y, Yuan X, Zhao M, Wang J, Li Y, Li Y, Lin H, Zhang Q, Wang W, Li D, Dong X, Li L, Liu M, Huang W, Huang C., Free PMC Article | 06/6/2020 |
| UBQLN4 therefore curtails HRR activity through removal of MRE11 from damaged chromatin. | UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors.
Jachimowicz RD, Beleggia F, Isensee J, Velpula BB, Goergens J, Bustos MA, Doll MA, Shenoy A, Checa-Rodriguez C, Wiederstein JL, Baranes-Bachar K, Bartenhagen C, Hertwig F, Teper N, Nishi T, Schmitt A, Distelmaier F, Lüdecke HJ, Albrecht B, Krüger M, Schumacher B, Geiger T, Hoon DSB, Huertas P, Fischer M, Hucho T, Peifer M, Ziv Y, Reinhardt HC, Wieczorek D, Shiloh Y. | 11/30/2019 |
| UBQLN4 may induce cell cycle arrest and apoptosis via activation of the ERK pathway and upregulation of cyclin D1 in GES-1 cells. | Overexpression of the Ubiquilin-4 (UBQLN4) is Associated with Cell Cycle Arrest and Apoptosis in Human Normal Gastric Epithelial Cell Lines GES-1 Cells by Activation of the ERK Signaling Pathway.
Huang S, Dong X, Wang J, Ding J, Li Y, Li D, Lin H, Wang W, Zhao M, Chang Q, Zhou N, Cui W, Huang C., Free PMC Article | 10/6/2018 |
| results suggest that ubiquitinated proteins are exported from the nucleus to the cytosol in the UBIN-POST complex-dependent manner for the maintenance of nuclear protein homeostasis. | Nuclear export of ubiquitinated proteins via the UBIN-POST system.
Hirayama S, Sugihara M, Morito D, Iemura SI, Natsume T, Murata S, Nagata K., Free PMC Article | 08/18/2018 |
| Here, the authors present a novel variant in UBQLN4 that is associated with ALS and show that its expression compromises motor axon morphogenesis in mouse motor neurons and in zebrafish. | A novel ALS-associated variant in UBQLN4 regulates motor axon morphogenesis.
Edens BM, Yan J, Miller N, Deng HX, Siddique T, Ma YC., Free PMC Article | 02/24/2018 |
| UBQLN4, APP, CTNNB1, SHBG, and COL1A1 might be involved in the development of nonalcoholic fatty liver disease, and are proposed as the potential markers for predicting the development of this condition | Candidate genes investigation for severe nonalcoholic fatty liver disease based on bioinformatics analysis.
Qi S, Wang C, Li C, Wang P, Liu M., Free PMC Article | 08/26/2017 |
| UBQLN4 recognizes not only the defective model substrate but also a pool of endogenous defective proteins that were induced by the depletion of the SRP54 subunit of the signal recognition particle. | UBQLN4 recognizes mislocalized transmembrane domain proteins and targets these to proteasomal degradation.
Suzuki R, Kawahara H., Free PMC Article | 08/19/2017 |
| results suggested that CIP75 is essential for the interaction of Cx43 and the proteasome, but that alternate compensatory mechanisms exist to supplement the degradation normally facilitated by CIP75 | CIP75 (connexin43-interacting protein of 75 kDa) mediates the endoplasmic reticulum dislocation of connexin43.
Su V, Hoang C, Geerts D, Lau AF. | 04/19/2014 |
| Targeting of Ubqln1 to autophagosomes requires the Ubqln4 UBL domain and the Ubqln1 UBA domain. | Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery.
Lee DY, Arnott D, Brown EJ., Free PMC Article | 09/21/2013 |
| although CIP75 can interact with ubiquitinated cellular proteins, its interaction with Cx43 and stimulation of Cx43 proteasomal degradation does not require the ubiquitination of Cx43. | Ubiquitin-independent proteasomal degradation of endoplasmic reticulum-localized connexin43 mediated by CIP75.
Su V, Nakagawa R, Koval M, Lau AF., Free PMC Article | 01/29/2011 |
| Co-immunoprecipitation confirmed the binding of small hydrophobic (SH) protein of mumps virus and ubiquilin 4 and demonstrates that a truncated protein fragment corresponding to amino acids 136-270 of ubiquilin 4 was sufficient for interaction. | Mumps virus small hydrophobic protein targets ataxin-1 ubiquitin-like interacting protein (ubiquilin 4).
Woznik M, Rödner C, Lemon K, Rima B, Mankertz A, Finsterbusch T. | 11/6/2010 |
| A novel connexin43-interacting protein, CIP75, which belongs to the UbL-UBA protein family, regulates the turnover of connexin43 | A novel connexin43-interacting protein, CIP75, which belongs to the UbL-UBA protein family, regulates the turnover of connexin43.
Li X, Su V, Kurata WE, Jin C, Lau AF., Free PMC Article | 01/21/2010 |