| WRNIP1 prevents transcription-associated genomic instability. | WRNIP1 prevents transcription-associated genomic instability.
Valenzisi P, Marabitti V, Pichierri P, Franchitto A., Free PMC Article | 03/19/2024 |
| AXL/WRNIP1 Mediates Replication Stress Response and Promotes Therapy Resistance and Metachronous Metastasis in HER2+ Breast Cancer. | AXL/WRNIP1 Mediates Replication Stress Response and Promotes Therapy Resistance and Metachronous Metastasis in HER2+ Breast Cancer.
Marquez-Palencia M, Reza Herrera L, Parida PK, Ghosh S, Kim K, Das NM, Gonzalez-Ericsson PI, Sanders ME, Mobley BC, Diegeler S, Aguilera TA, Peng Y, Lewis CM, Arteaga CL, Hanker AB, Whitehurst AW, Lorens JB, Brekken RA, Davis AJ, Malladi S. | 03/6/2024 |
| Discovering the nuclear localization signal of Werner Helicase Interacting Protein 1. | Discovering the nuclear localization signal of Werner Helicase Interacting Protein 1.
Jordan BR, Zhai Y, Li Z, Zhao H, Mackmull MT, Glavy JS. | 10/30/2023 |
| Functional Domain Mapping of Werner Interacting Protein 1 (WRNIP1). | Functional Domain Mapping of Werner Interacting Protein 1 (WRNIP1).
Yoshimura A, Sakakihara T, Enomoto T, Seki M. | 03/19/2022 |
| R-Loop-Associated Genomic Instability and Implication of WRN and WRNIP1. | R-Loop-Associated Genomic Instability and Implication of WRN and WRNIP1.
Marabitti V, Valenzisi P, Lillo G, Malacaria E, Palermo V, Pichierri P, Franchitto A., Free PMC Article | 03/19/2022 |
| WRNIP1 Is Recruited to DNA Interstrand Crosslinks and Promotes Repair. | WRNIP1 Is Recruited to DNA Interstrand Crosslinks and Promotes Repair.
Socha A, Yang D, Bulsiewicz A, Yaprianto K, Kupculak M, Liang CC, Hadjicharalambous A, Wu R, Gygi SP, Cohn MA., Free PMC Article | 05/1/2021 |
| miR-22 enhances the radiosensitivity of small-cell lung cancer by targeting the WRNIP1. | miR-22 enhances the radiosensitivity of small-cell lung cancer by targeting the WRNIP1.
Jiang W, Han X, Wang J, Wang L, Xu Z, Wei Q, Zhang W, Wang H., Free PMC Article | 09/12/2020 |
| The WRNIP1-mediated reduction in the amount of PrimPol was suppressed by treatment of the cells with proteasome inhibitors, suggesting that WRNIP1 is involved in the degradation of PrimPol via the proteasome. | WRNIP1 Controls the Amount of PrimPol.
Yoshimura A, Oikawa M, Jinbo H, Hasegawa Y, Enomoto T, Seki M. | 09/28/2019 |
| findings define the WHIP-TRIM14-PPP6C mitochondrial signalosome required for RIG-I-mediated innate antiviral immunity. | Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling.
Tan P, He L, Cui J, Qian C, Cao X, Lin M, Zhu Q, Li Y, Xing C, Yu X, Wang HY, Wang RF. | 10/28/2017 |
| WRNIP1 connects PCNA monoubiquitination with ATMIN/ATM to activate ATM signalling in response to replication stress and contribute to the maintenance of genomic stability. | RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress.
Kanu N, Zhang T, Burrell RA, Chakraborty A, Cronshaw J, DaCosta C, Grönroos E, Pemberton HN, Anderton E, Gonzalez L, Sabbioneda S, Ulrich HD, Swanton C, Behrens A., Free PMC Article | 09/2/2017 |
| The authors show that WRNIP1 is directly involved in preventing uncontrolled MRE11-mediated degradation of stalled replication forks by promoting RAD51 stabilization on ssDNA. | WRNIP1 protects stalled forks from degradation and promotes fork restart after replication stress.
Leuzzi G, Marabitti V, Pichierri P, Franchitto A., Free PMC Article | 07/1/2017 |
| We propose that UBZ domains can be divided into at least two different types in terms of the ubiquitin-binding surfaces: the pol type and the WRNIP1 type | A novel mode of ubiquitin recognition by the ubiquitin-binding zinc finger domain of WRNIP1.
Suzuki N, Rohaim A, Kato R, Dikic I, Wakatsuki S, Kawasaki M. | 06/24/2017 |
| results suggest that WRNIP1 functions upstream of Poleta in the response to UV irradiation | WRNIP1 functions upstream of DNA polymerase η in the UV-induced DNA damage response.
Yoshimura A, Kobayashi Y, Tada S, Seki M, Enomoto T. | 11/29/2014 |
| Mutated WRNIP1 with a deleted ATPase domain or with mutations in lysine residues accumulated in laser light irradiated sites, suggesting that the ATPase domain of WRNIP1 and ubiquitination of WRNIP1 are dispensable for the accumulation. | WRNIP1 accumulates at laser light irradiated sites rapidly via its ubiquitin-binding zinc finger domain and independently from its ATPase domain.
Nomura H, Yoshimura A, Edo T, Kanno S, Tada S, Seki M, Yasui A, Enomoto T. | 04/7/2012 |
| WHIP was identified as a partner/component of the nuclear envelope/nuclear pore complex (NPC) and set forth to investigate a role for the protein positioned at the NPC. | The discovery of a Werner Helicase Interacting Protein (WHIP) association with the nuclear pore complex.
Kaur S, White TE, DiGuilio AL, Glavy JS. | 12/4/2010 |
| Data show that that WRNIP1 interacts physically with RAD18 and interferes with the binding of RAD18 to forked DNA and to template/primer DNA. | Physical and functional interaction between WRNIP1 and RAD18.
Yoshimura A, Seki M, Kanamori M, Tateishi S, Tsurimoto T, Tada S, Enomoto T. | 01/21/2010 |
| analysis of the composite and regulated topography of Wrnip1 in the human nucleus highlights its potential role in replication and other nuclear transactions | Human Wrnip1 is localized in replication factories in a ubiquitin-binding zinc finger-dependent manner.
Crosetto N, Bienko M, Hibbert RG, Perica T, Ambrogio C, Kensche T, Hofmann K, Sixma TK, Dikic I., Free PMC Article | 01/21/2010 |
| Werner helicase-interacting protein 1 binds polyubiquitin via its zinc finger domain | Werner helicase-interacting protein 1 binds polyubiquitin via its zinc finger domain.
Bish RA, Myers MP. | 01/21/2010 |
| These results indicate that WRNIP1 functions as a modulator for initiation or restart events during pol delta-mediated DNA synthesis and that its ATPase activity is utilized to sense DNA ends and to regulate the extent of stimulation. | Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta.
Tsurimoto T, Shinozaki A, Yano M, Seki M, Enomoto T. | 01/21/2010 |