| Circ_0002715 promotes the development of osteoarthritis through regulating LXN by sponging miR-127-5p. | Circ_0002715 promotes the development of osteoarthritis through regulating LXN by sponging miR-127-5p.
Liu H, Zhao H, Huang Y, Lei M., Free PMC Article | 04/1/2023 |
| The putative tumour suppressor protein Latexin is secreted by prostate luminal cells and is downregulated in malignancy. | The putative tumour suppressor protein Latexin is secreted by prostate luminal cells and is downregulated in malignancy.
Seed RI, Taurozzi AJ, Wilcock DJ, Nappo G, Erb HHH, Read ML, Gurney M, Archer LK, Ito S, Rumsby MG, Petrie JL, Clayton A, Maitland NJ, Collins AT., Free PMC Article | 10/3/2020 |
| Deletion of latexin in vivo increases HSC repopulation capacity and survival, expands the entire hematopoietic system, and mitigates myelosuppression. Latexin inactivation downregulates thrombospondin 1 (Thbs1). It inhibits nuclear translocation of ribosomal protein subunit 3 (Rps3), a novel latexin-binding protein, and sensitizes hematopoietic cells to radiation-induced cell death. | Latexin and hematopoiesis.
Zhang C, Liang Y. | 03/9/2019 |
| Results identified that LXN expression inversely modulates taxane-chemoresistance in the PC-3 prostate cancer cell line. Inhibition of LXN expression in the bone microenvironment promotes chemoresistance, in part through a methylation-dependent mechanism. | Bone Microenvironment Changes in Latexin Expression Promote Chemoresistance.
Zhang M, Osisami M, Dai J, Keller JM, Escara-Wilke J, Mizokami A, Keller ET., Free PMC Article | 10/21/2017 |
| Results show that Lxn expression was clearly decreased in the pancreatic ductal adenocarcinoma tissues suggesting it that as a tumor suppressor that targets CD133-positive cancer cells. | Latexin exhibits tumor-suppressor potential in pancreatic ductal adenocarcinoma.
Xue Z, Zhou Y, Wang C, Zheng J, Zhang P, Zhou L, Wu L, Shan Y, Ye M, He Y, Cai Z., Free PMC Article | 10/22/2016 |
| Lxn protein and mRNA expression levels in CD133+ miapaca-2 cells were significantly lower than those in CD133- cells. | Latexin inhibits the proliferation of CD133+ miapaca-2 pancreatic cancer stem-like cells.
Xue ZX, Zheng JH, Zheng ZQ, Cai JL, Ye XH, Wang C, Sun WJ, Zhou X, Lu MD, Li PH, Cai ZZ., Free PMC Article | 01/16/2016 |
| latexin is markedly downregulated in hepatocellular carcinoma specimens, compared to adjacent non-cancerous tissues. | Latexin exhibits tumor suppressor potential in hepatocellular carcinoma.
Ni QF, Tian Y, Kong LL, Lu YT, Ding WZ, Kong LB. | 09/27/2014 |
| CD146 and Lxn increased tumor migration and invasion of thyroid cancer. | Clinical significance of CD146 and latexin during different stages of thyroid cancer.
Abd Elmageed ZY, Moroz K, Kandil E. | 02/15/2014 |
| The hematopoietic stem cell regulatory gene latexin has tumor-suppressive properties in malignant melanoma. | The hematopoietic stem cell regulatory gene latexin has tumor-suppressive properties in malignant melanoma.
Muthusamy V, Premi S, Soper C, Platt J, Bosenberg M., Free PMC Article | 09/7/2013 |
| These results are consistent with a tumor suppressor role for latexin. | Latexin is down-regulated in hematopoietic malignancies and restoration of expression inhibits lymphoma growth.
Liu Y, Howard D, Rector K, Swiderski C, Brandon J, Schook L, Mehta J, Bryson JS, Bondada S, Liang Y., Free PMC Article | 03/2/2013 |
| Latexin expression is lost or greatly reduced in approximately 50% of human leukemia/lymphoma cell lines. | Latexin regulates the abundance of multiple cellular proteins in hematopoietic stem cells.
Mitsunaga K, Kikuchi J, Wada T, Furukawa Y. | 04/28/2012 |
| downregulated expression in gastric carcinomas; tumor suppressor | Latexin expression is downregulated in human gastric carcinomas and exhibits tumor suppressor potential.
Li Y, Basang Z, Ding H, Lu Z, Ning T, Wei H, Cai H, Ke Y., Free PMC Article | 08/6/2011 |