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    CA10 carbonic anhydrase 10 [ Homo sapiens (human) ]

    Gene ID: 56934, updated on 14-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Carbonic anhydrase 10 functions as a tumor suppressor in renal cell carcinoma and its methylation is a risk factor for survival outcome.

    Carbonic anhydrase 10 functions as a tumor suppressor in renal cell carcinoma and its methylation is a risk factor for survival outcome.
    Li Q, Zhang L, Zhang Z, Fan Y, Zhang Q.

    04/23/2022
    Glycolysis, via NADH-dependent dimerisation of CtBPs, regulates hypoxia-induced expression of CAIX and stem-like breast cancer cell survival.

    Glycolysis, via NADH-dependent dimerisation of CtBPs, regulates hypoxia-induced expression of CAIX and stem-like breast cancer cell survival.
    Kreuzer M, Banerjee A, Birts CN, Darley M, Tavassoli A, Ivan M, Blaydes JP.

    05/15/2021
    Methylation of WT1, CA10 in peripheral blood leukocyte is associated with breast cancer risk: a case-control study.

    Methylation of WT1, CA10 in peripheral blood leukocyte is associated with breast cancer risk: a case-control study.
    Ge A, Gao S, Liu Y, Zhang H, Wang X, Zhang L, Pang D, Zhao Y., Free PMC Article

    02/13/2021
    results suggest that CA11 and CA10 negatively regulate neuronal activity-dependent glioma growth and inhibit glioma aggression. Thus, CA11/CA10 may represent a potential therapeutic target for the treatment of gliomas.

    CA10 and CA11 negatively regulate neuronal activity-dependent growth of gliomas.
    Tao B, Ling Y, Zhang Y, Li S, Zhou P, Wang X, Li B, Jun Z, Zhang W, Xu C, Shi J, Wang L, Zhang W, Li S., Free PMC Article

    04/25/2020
    CA10 directly binds in a cis configuration to a conserved membrane-proximal, extracellular sequence of alpha- and beta-neurexins.

    Carbonic anhydrase-related protein CA10 is an evolutionarily conserved pan-neurexin ligand.
    Sterky FH, Trotter JH, Lee SJ, Recktenwald CV, Du X, Zhou B, Zhou P, Schwenk J, Fakler B, Südhof TC., Free PMC Article

    04/13/2019
    Total heterogeneous methylation of CA10 conferred a significantly higher risk of Colorectal Cancer.The gene methylation status of blood leukocytes may be associated with CRC risk.

    Methylation Status of Transcriptional Modulatory Genes Associated with Colorectal Cancer in Northeast China.
    Gao HL, Wang X, Sun HR, Zhou JD, Lin SQ, Xing YH, Zhu L, Zhou HB, Zhao YS, Chi Q, Liu YP., Free PMC Article

    09/29/2018
    The changes in the ratios of mRNA levels and the respective proteins (HIF-1alpha, HIF-2, NF-kB, VEGF, VEGFR2, and carboanhydrase IX) may contribute to kidney-cancer metastasis.

    [Transcription factors NF-kB, HIF-1, HIF-2, growth factor VEGF, VEGFR2 and carboanhydrase IX mRNA and protein level in the development of kidney cancer metastasis].
    Spirina LV, Usynin YA, Yurmazov ZA, Slonimskaya EM, Kolegova ES, Kondakova IV.

    08/19/2017
    Two African-ancestry specific variants were found to be significantly associated with metabolic syndrome S: SNP rs73989312[A] near CA10 that conferred increased risk; and SNP rs77244975[C] in CTNNA3 that conferred protection against this disease.

    Genome-wide association study identifies African-ancestry specific variants for metabolic syndrome.
    Tekola-Ayele F, Doumatey AP, Shriner D, Bentley AR, Chen G, Zhou J, Fasanmade O, Johnson T, Oli J, Okafor G, Eghan BA Jr, Agyenim-Boateng K, Adebamowo C, Amoah A, Acheampong J, Adeyemo A, Rotimi CN., Free PMC Article

    10/1/2016
    Copy number deletion on CA10 was associated with a 1.69-fold decreased risk for osteoarthritis.

    A genome-wide association study of copy-number variation identifies putative loci associated with osteoarthritis in Koreans.
    Moon S, Keam B, Hwang MY, Lee Y, Park S, Oh JH, Kim YJ, Lee HS, Kim NH, Kim YJ, Kim DH, Han BG, Kim BJ, Lee J., Free PMC Article

    02/13/2016
    our results suggest that genes CA10 and also SGK493 may be an important risk factor for asthma development, especially for a nonatopic phenotype.

    Polymorphisms in recent GWA identified asthma genes CA10, SGK493, and CTNNA3 are associated with disease severity and treatment response in childhood asthma.
    Perin P, Potočnik U.

    04/12/2014
    Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

    Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article

    06/30/2010
    The results suggest that the variations of CA8 and CA10 loci may be important determinants of osteoporosis in Japanese women.

    Nucleotide variations in genes encoding carbonic anhydrase 8 and 10 associated with femoral bone mineral density in Japanese female with osteoporosis.
    Mori S, Kou I, Sato H, Emi M, Ito H, Hosoi T, Ikegawa S, Mori S, Kou I, Sato H, Emi M, Ito H, Hosoi T, Ikegawa S.

    01/21/2010
    Observational study of gene-disease association. (HuGE Navigator)See all PubMed (2) articles

    Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
    Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C.

    Nucleotide variations in genes encoding carbonic anhydrase 8 and 10 associated with femoral bone mineral density in Japanese female with osteoporosis.
    Mori S, Kou I, Sato H, Emi M, Ito H, Hosoi T, Ikegawa S, Mori S, Kou I, Sato H, Emi M, Ito H, Hosoi T, Ikegawa S.

    02/11/2009
    Identifies a string of seven CCG repeats in the 5' UTR of a carbonic anhydrase X cDNA from human brain.

    CCG repeats in cDNAs from human brain.
    Kleiderlein JJ, Nisson PE, Jessee J, Li WB, Becker KG, Derby ML, Ross CA, Margolis RL.

    03/7/2007
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