| Roles of VGLUT2 and Dopamine/Glutamate Co-Transmission in Selective Vulnerability to Dopamine Neurodegeneration. | Roles of VGLUT2 and Dopamine/Glutamate Co-Transmission in Selective Vulnerability to Dopamine Neurodegeneration.
Buck SA, Erickson-Oberg MQ, Bhatte SH, McKellar CD, Ramanathan VP, Rubin SA, Freyberg Z., Free PMC Article | 02/5/2022 |
| These findings indicate that VGluT2-expressing excitatory neurons play a crucial role in mediating nociceptive transmission in the spinal dorsal horn | Regulating nociceptive transmission by VGluT2-expressing spinal dorsal horn neurons.
Wang L, Chen SR, Ma H, Chen H, Hittelman WN, Pan HL., Free PMC Article | 10/12/2019 |
| This study demonstrated that Protein levels of vGLUT2 were significantly increased in schizophrenia subjects compared to controls. | Uncovering the role of the nucleus accumbens in schizophrenia: A postmortem analysis of tyrosine hydroxylase and vesicular glutamate transporters.
McCollum LA, Roberts RC., Free PMC Article | 10/1/2016 |
| Vglut2 and oligodendrocyte progenitor cells co-localize in multiple sclerosis lesions, supporting evidence that neuronal activity and release of glutamate instruct OPCs to differentiate into new myelinating oligodendrocytes that recover lost function. | Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyte progenitors.
Gautier HO, Evans KA, Volbracht K, James R, Sitnikov S, Lundgaard I, James F, Lao-Peregrin C, Reynolds R, Franklin RJ, Káradóttir RT., Free PMC Article | 05/7/2016 |
| Itch is regulated by VGLUT2-mediated transmission in neurons via Trpv1. | Multimodal use of calcitonin gene-related peptide and substance P in itch and acute pain uncovered by the elimination of vesicular glutamate transporter 2 from transient receptor potential cation channel subfamily V member 1 neurons.
Rogoz K, Andersen HH, Lagerström MC, Kullander K., Free PMC Article | 02/7/2015 |
| There is a glutamatergic signal from ventral tegmental area VGluT2-habenular neurons that plays a role in aversive conditioning. | Role of glutamatergic projections from ventral tegmental area to lateral habenula in aversive conditioning.
Root DH, Mejias-Aponte CA, Qi J, Morales M., Free PMC Article | 02/7/2015 |
| This study demonistrated that Distribution of vesicular glutamate transporter 2 (VGluT2) in the primary visual cortex(V1 area) | Distribution of vesicular glutamate transporter 2 (VGluT2) in the primary visual cortex of the macaque and human.
Garcia-Marin V, Ahmed TH, Afzal YC, Hawken MJ., Free PMC Article | 03/9/2013 |
| Data indicate that GABAergic axons were labeled with vesicular inhibitory aa transporter (VIAAT) antibodies, whereas glutamatergic axons were detected with antisera against the major vesicular glutamate transporter (VGLUT) isoforms, VGLUT1 and VGLUT2. | Glutamatergic and GABAergic innervation of human gonadotropin-releasing hormone-I neurons.
Hrabovszky E, Molnár CS, Nagy R, Vida B, Borsay BÁ, Rácz K, Herczeg L, Watanabe M, Kalló I, Liposits Z. | 08/18/2012 |
| This study may lend support to the multiple rare mutations hypothesis of schizophrenia, and may provide genetic clues to indicate the involvement of the glutamate transmission pathway in the pathogenesis of schizophrenia. | Resequencing of the vesicular glutamate transporter 2 gene (VGLUT2) reveals some rare genetic variants that may increase the genetic burden in schizophrenia.
Shen YC, Liao DL, Lu CL, Chen JY, Liou YJ, Chen TT, Chen CH, Shen YC, Liao DL, Lu CL, Chen JY, Liou YJ, Chen TT, Chen CH. | 11/13/2010 |
| This study decreased VGLUT2 mRNA expression in major depressive disorder in the middle temporal gyrus, and increased VGLUT2 mRNA expression in schizophrenia in the inferior temporal gyrus. | Vesicular glutamate transporter mRNA expression in the medial temporal lobe in major depressive disorder, bipolar disorder, and schizophrenia.
Uezato A, Meador-Woodruff JH, McCullumsmith RE. | 01/21/2010 |
| Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.
Need AC, Keefe RS, Ge D, Grossman I, Dickson S, McEvoy JP, Goldstein DB., Free PMC Article | 02/11/2009 |
| Our results suggest that VGLUT1 expression in the prefrontal cortex could be used as a valuable neurochemical marker of dementia in AD. | Loss of VGLUT1 and VGLUT2 in the prefrontal cortex is correlated with cognitive decline in Alzheimer disease.
Kashani A, Lepicard E, Poirel O, Videau C, David JP, Fallet-Bianco C, Simon A, Delacourte A, Giros B, Epelbaum J, Betancur C, El Mestikawy S. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesResequencing of the vesicular glutamate transporter 2 gene (VGLUT2) reveals some rare genetic variants that may increase the genetic burden in schizophrenia.
Shen YC, Liao DL, Lu CL, Chen JY, Liou YJ, Chen TT, Chen CH, Shen YC, Liao DL, Lu CL, Chen JY, Liou YJ, Chen TT, Chen CH. [A study of the single nucleotide polymorphism in seven genes (GHR, IGFBP3, IGFR1, IRS1, FMN1, ANXA2, TaGLN) in ethnic Russians and in patients with prostate cancer].
Lisitskaia KV, Krakhmaleva IN, Shishkin SS. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.
Gratacòs M, Costas J, de Cid R, Bayés M, González JR, Baca-García E, de Diego Y, Fernández-Aranda F, Fernández-Piqueras J, Guitart M, Martín-Santos R, Martorell L, Menchón JM, Roca M, Sáiz-Ruiz J, Sanjuán J, Torrens M, Urretavizcaya M, Valero J, Vilella E, Estivill X, Carracedo A, Psychiatric Genetics Network Group. | 01/11/2009 |
| VGluT2 is the only vesicular glutamate transporter expressed in transgenic ventral tegmental area/substantia nigra dopamine neurons in vivo. | Developmental and target-dependent regulation of vesicular glutamate transporter expression by dopamine neurons.
Mendez JA, Bourque MJ, Dal Bo G, Bourdeau ML, Danik M, Williams S, Lacaille JC, Trudeau LE., Free PMC Article | 01/21/2010 |
| higher in tendinosis tendons compared to normal tendons | VGluT2 expression in painful Achilles and patellar tendinosis: evidence of local glutamate release by tenocytes.
Scott A, Alfredson H, Forsgren S., Free PMC Article | 01/21/2010 |
| Vesicular glutamate transporter 2 was unchanged at both levels of gene expression. | Altered vesicular glutamate transporter expression in the anterior cingulate cortex in schizophrenia.
Oni-Orisan A, Kristiansen LV, Haroutunian V, Meador-Woodruff JH, McCullumsmith RE., Free PMC Article | 01/21/2010 |
| Docking and homology modeling explain the inhibition of VGLUT2. | Docking and homology modeling explain inhibition of the human vesicular glutamate transporters.
Almqvist J, Huang Y, Laaksonen A, Wang DN, Hovmöller S., Free PMC Article | 01/21/2010 |