| The IL-31/CysLT2R axis is associated with itching in patients with allergic rhinitis. | The IL-31/CysLT2R axis is associated with itching in patients with allergic rhinitis.
Du K, Zhang M, Yao S, Luo T, Yu H, Lou H. | 06/10/2024 |
| DNA Methylation and Gene Expression of the Cysteinyl Leukotriene Receptors as a Prognostic and Metastatic Factor for Colorectal Cancer Patients. | DNA Methylation and Gene Expression of the Cysteinyl Leukotriene Receptors as a Prognostic and Metastatic Factor for Colorectal Cancer Patients.
Ghatak S, Satapathy SR, Sjölander A., Free PMC Article | 03/2/2023 |
| Plasmalogen-Mediated Activation of GPCR21 Regulates Cytolytic Activity of NK Cells against the Target Cells. | Plasmalogen-Mediated Activation of GPCR21 Regulates Cytolytic Activity of NK Cells against the Target Cells.
Hossain MS, Mawatari S, Fujino T. | 07/23/2022 |
| The CysLT2R receptor mediates leukotriene C4-driven acute and chronic itch. | The CysLT(2)R receptor mediates leukotriene C(4)-driven acute and chronic itch.
Voisin T, Perner C, Messou MA, Shiers S, Ualiyeva S, Kanaoka Y, Price TJ, Sokol CL, Bankova LG, Austen KF, Chiu IM., Free PMC Article | 10/23/2021 |
| Involvement of mutant and wild-type CYSLTR2 in the development and progression of uveal nevi and melanoma. | Involvement of mutant and wild-type CYSLTR2 in the development and progression of uveal nevi and melanoma.
Nell RJ, Menger NV, Versluis M, Luyten GPM, Verdijk RM, Madigan MC, Jager MJ, van der Velden PA., Free PMC Article | 09/11/2021 |
| Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling. | Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling.
Ceraudo E, Horioka M, Mattheisen JM, Hitchman TD, Moore AR, Kazmi MA, Chi P, Chen Y, Sakmar TP, Huber T., Free PMC Article | 08/28/2021 |
| Mutations of GNAQ, GNA11, SF3B1, EIF1AX, PLCB4 and CYSLTR in Uveal Melanoma in Chinese Patients. | Mutations of GNAQ, GNA11, SF3B1, EIF1AX, PLCB4 and CYSLTR in Uveal Melanoma in Chinese Patients.
Hou C, Xiao L, Ren X, Tang F, Guo B, Zeng W, Liang C, Yan N. | 03/27/2021 |
| findings indicate that CysLT2R was involved in inflammation and neuronal damage by inducing the activation of microglia M1 polarization and NF-kappaB pathway, inhibiting microglia M1 polarization and promoting microglia polarization toward M2 phenotype which may exerts neuroprotective effects. | Cysteinyl Leukotriene Receptor 2 is Involved in Inflammation and Neuronal Damage by Mediating Microglia M1/M2 Polarization through NF-κB Pathway.
Zhao R, Ying M, Gu S, Yin W, Li Y, Yuan H, Fang S, Li M. | 08/1/2020 |
| Polymorphisms in the CYSLTR2 gene are associated with asthma, atopy markers and helminth infection in Brazilian individuals, which may lead to protection or risk for such conditions, however, more studies are needed to evaluate the functional of this variants here in described. | Variants in the CYSLTR2 are associated with asthma, atopy markers and helminths infections in the Brazilian population.
Dos S Jesus T, Dos S Costa R, Alcântara-Neves NM, Barreto ML, Figueiredo CA. | 05/2/2020 |
| CYSLTR2-mutant melanocytic blue neoplasms frequently exhibit a heavily pigmented exophytic tumor with a silhouette resembling "pigmented epithelioid melanocytoma" rather than usual cellular blue nevus. | CYSLTR2-mutant Cutaneous Melanocytic Neoplasms Frequently Simulate "Pigmented Epithelioid Melanocytoma," Expanding the Morphologic Spectrum of Blue Tumors: A Clinicopathologic Study of 7 Cases.
Goto K, Pissaloux D, Paindavoine S, Tirode F, de la Fouchardière A. | 04/11/2020 |
| Its mutation is found in patients with meningeal melanocytic tumour. | Whole-exome sequencing of a meningeal melanocytic tumour reveals activating CYSLTR2 and EIF1AX hotspot mutations and similarities to uveal melanoma.
Küsters-Vandevelde HVN, Germans MR, Rabbie R, Rashid M, Ten Broek R, Blokx WAM, Prinsen CFM, Adams DJ, Ter Laan M. | 12/1/2018 |
| our study identifies CYSLTR2 L129Q alterations as a previously unrecognized activating mutation in blue nevi, occuring in a mutually exclusive fashion with known GNAQ and GNA11 mutations. | Activating cysteinyl leukotriene receptor 2 (CYSLTR2) mutations in blue nevi.
Möller I, Murali R, Müller H, Wiesner T, Jackett LA, Scholz SL, Cosgarea I, van de Nes JA, Sucker A, Hillen U, Schilling B, Paschen A, Kutzner H, Rütten A, Böckers M, Scolyer RA, Schadendorf D, Griewank KG., Free PMC Article | 03/10/2018 |
| The expression of CysLTR1 and CysLTR2 is higher in the lymphocytes of hyperplasic tonsils in nonallergic children | Expression of cysteinyl leukotriene receptor 1 and 2 (CysLTR1 and CysLTR2) in the lymphocytes of hyperplastic tonsils: comparison between allergic and nonallergic snoring children.
Paulucci BP, Pereira J, Picciarelli P, Levy D, Di Francesco RC. | 11/18/2017 |
| findings implicate CYSLTR2 as a uveal melanoma oncogene and highlight the critical role of Galphaq signaling in uveal melanoma pathogenesis | Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma.
Moore AR, Ceraudo E, Sher JJ, Guan Y, Shoushtari AN, Chang MT, Zhang JQ, Walczak EG, Kazmi MA, Taylor BS, Huber T, Chi P, Sakmar TP, Chen Y., Free PMC Article | 07/1/2017 |
| CysLTRs -1 and -2 seem to be involved in lymphocyte maturation that occurs in tonsils, without influence of allergies. | Expression of CysLTR1 and 2 in Maturating Lymphocytes of Hyperplasic Tonsils Compared to Peripheral Cells in Children.
Paulucci BP, Pereira J, Picciarelli P, Levy D, di Francesco RC. | 03/11/2017 |
| CysLT2 receptors were expressed in lung specimens isolated from asthma subjects. Activation of CysLT2 receptors may contribute to antigen-induced bronchoconstriction in certain asthma population. | Expression of CysLT2 receptors in asthma lung, and their possible role in bronchoconstriction.
Sekioka T, Kadode M, Fujii M, Kawabata K, Abe T, Horiba M, Kohno S, Nabe T. | 07/16/2016 |
| Autocrine activity of cysteinyl leukotrienes in human vascular endothelial cells: Signaling through the CysLT receptor | Autocrine activity of cysteinyl leukotrienes in human vascular endothelial cells: Signaling through the CysLT₂ receptor.
Capra V, Carnini C, Accomazzo MR, Di Gennaro A, Fiumicelli M, Borroni E, Brivio I, Buccellati C, Mangano P, Carnevali S, Rovati G, Sala A. | 06/28/2016 |
| CysLTR-1 and CysLTR-2 are highly expressed in the adenoid tissues from children with AH, suggesting that leukotrienes are involved in the pathogenesis of AH. | [Expression of CysLTR-1 and CysLTR-2 in adenoid tissues from children with adenoid hypertrophy].
Zhu MH, Liang M, Wang ZJ, Shen Y, Wen HY, Zhai JM, Yang XB. | 08/8/2015 |
| Suggest that endothelial and nonendothelial CysLT2R niches have separate roles in mediating inflammatory responses in ischemic/perfusion injury. | Multiple-site activation of the cysteinyl leukotriene receptor 2 is required for exacerbation of ischemia/reperfusion injury.
Ni NC, Ballantyne LL, Mewburn JD, Funk CD. | 03/22/2014 |
| ATRA treatment induces CysLT(2)R mRNA and protein expression in colon cancer cell lines | The cysteinyl leukotriene 2 receptor contributes to all-trans retinoic acid-induced differentiation of colon cancer cells.
Bengtsson AM, Jönsson G, Magnusson C, Salim T, Axelsson C, Sjölander A., Free PMC Article | 11/30/2013 |
| CysLT2 receptor plays a primary role in the vascular responses in the upper respiratory tract. | Localization and up-regulation of cysteinyl leukotriene-2 receptor in human allergic nasal mucosa.
Shirasaki H, Kanaizumi E, Seki N, Fujita M, Kikuchi M, Himi T. | 10/19/2013 |
| increased expression in tonsillar tissues of Chinese children with sleep-disordered breathing | Increased cysteinyl leukotriene concentration and receptor expression in tonsillar tissues of Chinese children with sleep-disordered breathing.
Shen Y, Xu Z, Huang Z, Xu J, Qin Q, Shen K. | 11/17/2012 |
| There is a protective role against tumor progression for CysLT(2)R and that it highlights new possibilities to regulate the CysLT(2)R. | Regulation of cysteinyl leukotriene receptor 2 expression--a potential anti-tumor mechanism.
Magnusson C, Bengtsson AM, Liu M, Liu J, Ceder Y, Ehrnström R, Sjölander A., Free PMC Article | 09/1/2012 |
| The synthesis of cys-LTs from LTA(4) by endothelial cells is directly associated with the activation of the CysLT(2) receptor in a typical autocrine fashion. | Synthesis of cysteinyl leukotrienes in human endothelial cells: subcellular localization and autocrine signaling through the CysLT2 receptor.
Carnini C, Accomazzo MR, Borroni E, Vitellaro-Zuccarello L, Durand T, Folco G, Rovati GE, Capra V, Sala A. | 12/10/2011 |
| Cysteinyl leukotriene receptor 2 gene polymorphism -1220 A/C is not associated with atopic dermatitis or psoriasis vulgaris in Japanese patients. | Cysteinyl leukotriene receptor 2 gene polymorphism -1220 A/C is not associated with atopic dermatitis or psoriasis vulgaris in Japanese patients.
Kato T, Saeki H, Tsunemi Y, Shibata S, Sekiya T, Nakamura K, Kakinuma T, Kagami S, Fujita H, Tada Y, Sugaya M, Tamaki K. | 09/3/2011 |