| The ARFRP1-dependent Golgi scaffolding protein GOPC is required for insulin secretion from pancreatic beta-cells. | The ARFRP1-dependent Golgi scaffolding protein GOPC is required for insulin secretion from pancreatic β-cells.
Wilhelmi I, Grunwald S, Gimber N, Popp O, Dittmar G, Arumughan A, Wanker EE, Laeger T, Schmoranzer J, Daumke O, Schürmann A., Free PMC Article | 10/30/2021 |
| GOPC-ROS1 Fusion Due to Microdeletion at 6q22 Is an Oncogenic Driver in a Subset of Pediatric Gliomas and Glioneuronal Tumors. | GOPC-ROS1 Fusion Due to Microdeletion at 6q22 Is an Oncogenic Driver in a Subset of Pediatric Gliomas and Glioneuronal Tumors.
Richardson TE, Tang K, Vasudevaraja V, Serrano J, William CM, Mirchia K, Pierson CR, Leonard JR, AbdelBaki MS, Schieffer KM, Cottrell CE, Tovar-Spinoza Z, Comito MA, Boué DR, Jour G, Snuderl M. | 06/20/2020 |
| PIST, a Golgi-associated PDZ domain-containing protein, interacts with PCDH15 in the plasma membrane. | Plasma Membrane Targeting of Protocadherin 15 Is Regulated by the Golgi-Associated Chaperone Protein PIST.
Nie H, Liu Y, Yin X, Cao H, Wang Y, Xiong W, Lin Y, Xu Z., Free PMC Article | 09/23/2017 |
| CAL can regulate the anterograde trafficking, the internalization as well as the signaling of CRFR1 via modulating the post-translational modifications that the receptor undergoes at the Golgi apparatus. | Role of cystic fibrosis transmembrane conductance regulator-associated ligand (CAL) in regulating the trafficking and signaling of corticotropin-releasing factor receptor 1.
Hammad MM, Dunn HA, Walther C, Ferguson SS. | 06/4/2016 |
| CAL overexpression retards B2AR expression in Golgi apparatus and reduces the receptor expression in the plasma membrane. | Regulation of β2-adrenergic receptor cell surface expression by interaction with cystic fibrosis transmembrane conductance regulator-associated ligand (CAL).
Yang L, Zheng J, Xiong Y, Meng R, Ma Q, Liu H, Shen H, Zheng S, Wang S, He J. | 03/5/2016 |
| Six out of 65 (9%) BTC patients were positive for the FIG-ROS1 fusion, comprising two out of 14 (14%) gallbladder carcinoma (GBC) patients and four out of 25 (16%) extrahepatic cholangiocarcinoma (ECC) patients. | Screening for the FIG-ROS1 fusion in biliary tract carcinomas by nested PCR.
Peraldo Neia C, Cavalloni G, Balsamo A, Venesio T, Napoli F, Sassi F, Martin V, Frattini M, Aglietta M, Leone F. | 07/25/2015 |
| Our data suggest that PIST contributes to the fine-tuning of b1AR sorting both during biosynthetic and postendocytic trafficking | The golgi-associated PDZ domain protein PIST/GOPC stabilizes the β1-adrenergic receptor in intracellular compartments after internalization.
Koliwer J, Park M, Bauch C, von Zastrow M, Kreienkamp HJ., Free PMC Article | 05/23/2015 |
| None of 268 gliomas analysed showed the FIG-ROS1(L) rearrangement. | Lack of GOPC-ROS1 (FIG-ROS1) rearrangement in adult human gliomas.
Karayan-Tapon L, Cortes U, Rivet P, Jermidi C, Vassal G, Wager M, Taillandier L. | 11/29/2014 |
| Stereochemical preferences modulate affinity and selectivity among CAL PDZ domain protein variants that bind CFTR. | Stereochemical preferences modulate affinity and selectivity among five PDZ domains that bind CFTR: comparative structural and sequence analyses.
Amacher JF, Cushing PR, Brooks L 3rd, Boisguerin P, Madden DR., Free PMC Article | 08/30/2014 |
| FIG-ROS fusion protein, which is found in a subset of intrahepatic cholangiocarcinoma patients, accelerates cholangiocarcinogenesis. | Mouse model of intrahepatic cholangiocarcinoma validates FIG-ROS as a potent fusion oncogene and therapeutic target.
Saborowski A, Saborowski M, Davare MA, Druker BJ, Klimstra DS, Lowe SW., Free PMC Article | 02/1/2014 |
| Data indicate that E3 ubiquitin ligase MARCH2 co-immunoprecipitated and co-localized with CAL and syntaxin 6 (STX6), and show the ubiquitination of CFTR by MARCH2. | Ubiquitination and degradation of CFTR by the E3 ubiquitin ligase MARCH2 through its association with adaptor proteins CAL and STX6.
Cheng J, Guggino W., Free PMC Article | 02/1/2014 |
| The coiled-coil domain of PIST was then purified to homogeneity and crystallized at 293 K. Finally, X-ray diffraction data were collected to a resolution of 4.0 A from a crystal belonging to the hexagonal space group P6(2)22 or P6(4)22. | Crystallization and preliminary X-ray crystallographic studies of the coiled-coil domain of PIST.
Shin YC, Seo EK, Jeon JH, Park HH., Free PMC Article | 12/21/2013 |
| crystals of CAL PDZ domain diffracted to 1.4 A resolution | Crystallization and preliminary diffraction analysis of the CAL PDZ domain in complex with a selective peptide inhibitor.
Amacher JF, Cushing PR, Weiner JA, Madden DR., Free PMC Article | 09/3/2011 |
| establish CAL inhibitors as founding members of a class of CFTR "stabilizers" specifically designed to reduce DeltaF508-CFTR post-endocytic breakdown | A stabilizing influence: CAL PDZ inhibition extends the half-life of ΔF508-CFTR.
Cushing PR, Vouilleme L, Pellegrini M, Boisguerin P, Madden DR., Free PMC Article | 04/30/2011 |
| Syntaxin 6 and CAL mediate the degradation of the cystic fibrosis transmembrane conductance regulator | Syntaxin 6 and CAL mediate the degradation of the cystic fibrosis transmembrane conductance regulator.
Cheng J, Cebotaru V, Cebotaru L, Guggino WB., Free PMC Article | 08/9/2010 |
| The cystic fibrosis-associated ligand (CAL) PDZ domain of the C-terminus of cystic fibrosis-associated conductance regulator (CFTR) is competitively involved with PDZ proteins Na+/H+ exchanger-3 regulatory factors NHERF1 and NHERF2. | The relative binding affinities of PDZ partners for CFTR: a biochemical basis for efficient endocytic recycling.
Cushing PR, Fellows A, Villone D, Boisguérin P, Madden DR., Free PMC Article | 01/21/2010 |
| intracellular sorting of the somatostatin receptor subtype 5 is regulated by interactions with PDZ domain proteins PIST/GOPC and PDZK1 | Interactions with PDZ domain proteins PIST/GOPC and PDZK1 regulate intracellular sorting of the somatostatin receptor subtype 5.
Wente W, Stroh T, Beaudet A, Richter D, Kreienkamp HJ. | 01/21/2010 |
| modulates beta1AR intracellular trafficking | Interaction with cystic fibrosis transmembrane conductance regulator-associated ligand (CAL) inhibits beta1-adrenergic receptor surface expression.
He J, Bellini M, Xu J, Castleberry AM, Hall RA. | 01/21/2010 |
| The FIG-ROS locus encodes for an in-frame fusion protein with a constitutively active kinase activity, suggesting that FIG-ROS may act as an oncogene. | Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21).
Charest A, Lane K, McMahon K, Park J, Preisinger E, Conroy H, Housman D. | 01/21/2010 |
| golgin-160 assosiates in an isoform-specific manner with the Golgi-associated protein PIST | Isoform-specific interaction of golgin-160 with the Golgi-associated protein PIST.
Hicks SW, Machamer CE. | 01/21/2010 |
| Our discoveries provide insight into the specific interaction of the GOPC PDZ domain with the C-terminal peptide of Nlg and also provide a general insight about the possible binding mode of the interaction of Nlg with other PDZ domain-containing proteins. | Solution structure of GOPC PDZ domain and its interaction with the C-terminal motif of neuroligin.
Li X, Zhang J, Cao Z, Wu J, Shi Y., Free PMC Article | 01/21/2010 |
| CAL retains CFTR in the cell and targets CFTR for degradation. | Modulation of mature cystic fibrosis transmembrane regulator protein by the PDZ domain protein CAL.
Cheng J, Wang H, Guggino WB. | 01/21/2010 |
| CAL is a negative regulator of DeltaF508-CFTR cell-surface expression | Targeting CAL as a negative regulator of DeltaF508-CFTR cell-surface expression: an RNA interference and structure-based mutagenetic approach.
Wolde M, Fellows A, Cheng J, Kivenson A, Coutermarsh B, Talebian L, Karlson K, Piserchio A, Mierke DF, Stanton BA, Guggino WB, Madden DR. | 01/21/2010 |