| The E3 ligase SMURF1 stabilizes p27 via UbcH7 catalyzed K29-linked ubiquitin chains to promote cell migration SMURF1-UbcH7 K29 ubiquitination of p27 and cell migration. | The E3 ligase SMURF1 stabilizes p27 via UbcH7 catalyzed K29-linked ubiquitin chains to promote cell migration SMURF1-UbcH7 K29 ubiquitination of p27 and cell migration.
Weinberg J, Whitcomb E, Bohm A, Chekkilla UK, Taylor A., Free PMC Article | 04/10/2024 |
| SMURF1 activates the cGAS/STING/IFN-1 signal axis by mediating YY1 ubiquitination to accelerate the progression of lupus nephritis. | SMURF1 activates the cGAS/STING/IFN-1 signal axis by mediating YY1 ubiquitination to accelerate the progression of lupus nephritis.
Li X, Tao S, Xu Z, Ren Y, Xiang W, He X. | 03/13/2024 |
| Smurf1 polyubiquitinates on K285/K282 of the kinases Mst1/2 to attenuate their tumor-suppressor functions. | Smurf1 polyubiquitinates on K285/K282 of the kinases Mst1/2 to attenuate their tumor-suppressor functions.
Xu Y, Qu M, He Y, He Q, Shen T, Luo J, Tan D, Bao H, Xu C, Ji X, Hu X, Barkat MQ, Zeng LH, Wu X., Free PMC Article | 01/9/2024 |
| A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1 to suppress antiviral innate immunity. | A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1 to suppress antiviral innate immunity.
Zhao M, Zhang Y, Qiang L, Lu Z, Zhao Z, Fu Y, Wu B, Chai Q, Ge P, Lei Z, Zhang X, Li B, Wang J, Zhang L, Liu CH. | 10/13/2023 |
| SMURF1 attenuates endoplasmic reticulum stress by promoting the degradation of KEAP1 to activate NRF2 antioxidant pathway. | SMURF1 attenuates endoplasmic reticulum stress by promoting the degradation of KEAP1 to activate NRF2 antioxidant pathway.
Dong L, Xu M, Li Y, Xu W, Wu C, Zheng H, Xiao Z, Sun G, Ding L, Li X, Li W, Zhou L, Xia Q., Free PMC Article | 08/28/2023 |
| Smurf1 and Smurf2 mediated polyubiquitination and degradation of RNF220 suppresses Shh-group medulloblastoma. | Smurf1 and Smurf2 mediated polyubiquitination and degradation of RNF220 suppresses Shh-group medulloblastoma.
Li Y, Wang H, Sun B, Su G, Cang Y, Zhao L, Zhao S, Li Y, Mao B, Ma P., Free PMC Article | 08/7/2023 |
| Uncovering new insights into the role of the ubiquitin ligase Smurf1 on the regulation of innate immune signaling and resistance to infection. | Uncovering new insights into the role of the ubiquitin ligase Smurf1 on the regulation of innate immune signaling and resistance to infection.
Souza-Costa LP, Andrade-Chaves JT, Andrade JM, Costa VV, Franco LH., Free PMC Article | 06/12/2023 |
| SMURF1 inhibits the Th17 and Th17.1 polarization and improves the Treg/Th17 imbalance in systemic lupus erythematosus through the ubiquitination of RORgammat. | SMURF1 inhibits the Th17 and Th17.1 polarization and improves the Treg/Th17 imbalance in systemic lupus erythematosus through the ubiquitination of RORĪ³t.
Zhong W, Feng L, Tian W, Qu H, Xu H, Ning K, Liu L, Liu W, Gong X, Chen H. | 05/18/2023 |
| Smurf1 Facilitates Oxidative Stress and Fibrosis of Ligamentum Flavum by Promoting Nrf2 Ubiquitination and Degradation. | Smurf1 Facilitates Oxidative Stress and Fibrosis of Ligamentum Flavum by Promoting Nrf2 Ubiquitination and Degradation.
Gu Y, Hu J, Wang C, Qi M, Chen Y, Yu W, Wang Z, Wang X, Yuan W., Free PMC Article | 05/4/2023 |
| Smurf1 Suppression Enhances Temozolomide Chemosensitivity in Glioblastoma by Facilitating PTEN Nuclear Translocation. | Smurf1 Suppression Enhances Temozolomide Chemosensitivity in Glioblastoma by Facilitating PTEN Nuclear Translocation.
Dong L, Li Y, Liu L, Meng X, Li S, Han D, Xiao Z, Xia Q., Free PMC Article | 11/5/2022 |
| Effects of MiR-194-5p on the proliferation and invasion of laryngeal cancer cells by regulating the expression of smurf1 and activating the mTOR signaling pathway. | Effects of MiR-194-5p on the proliferation and invasion of laryngeal cancer cells by regulating the expression of smurf1 and activating the mTOR signaling pathway.
Yang Y, Zeng Q, Sun S, Zhang M, Liu W, Song D. | 10/22/2022 |
| E3 ligase Smurf1 protects against misfolded SOD1 in neuronal cells by promoting its K63 ubiquitylation and aggresome formation. | E3 ligase Smurf1 protects against misfolded SOD1 in neuronal cells by promoting its K63 ubiquitylation and aggresome formation.
Dong L, Liu L, Li Y, Li W, Zhou L, Xia Q. | 07/2/2022 |
| SMURF1 and SMURF2 in Progenitor Cells from Articular Cartilage and Meniscus during Late-Stage Osteoarthritis. | SMURF1 and SMURF2 in Progenitor Cells from Articular Cartilage and Meniscus during Late-Stage Osteoarthritis.
Schminke B, Kauffmann P, Schubert A, Altherr M, Gelis T, Miosge N., Free PMC Article | 04/9/2022 |
| Overexpressed Smurf1 is degraded in glioblastoma cells through autophagy in a p62-dependent manner. | Overexpressed Smurf1 is degraded in glioblastoma cells through autophagy in a p62-dependent manner.
Han D, Li S, Xia Q, Meng X, Dong L., Free PMC Article | 04/9/2022 |
| SMURF1, a promoter of tumor cell progression? | SMURF1, a promoter of tumor cell progression?
Xia Q, Li Y, Han D, Dong L. | 02/12/2022 |
| Neddylation modification of the U3 snoRNA-binding protein RRP9 by Smurf1 promotes tumorigenesis. | Neddylation modification of the U3 snoRNA-binding protein RRP9 by Smurf1 promotes tumorigenesis.
Du MG, Liu F, Chang Y, Tong S, Liu W, Chen YJ, Xie P., Free PMC Article | 12/18/2021 |
| The functions and regulation of Smurfs in cancers. | The functions and regulation of Smurfs in cancers.
Fu L, Cui CP, Zhang X, Zhang L. | 09/18/2021 |
| The impact of common Smurf1 gene variants on the risk, clinical characteristics and short-term prognosis of tuberculous meningitis. | The impact of common Smurf1 gene variants on the risk, clinical characteristics and short-term prognosis of tuberculous meningitis.
Zhang M, He JQ. | 06/5/2021 |
| Molecular Analysis of Membrane Targeting by the C2 Domain of the E3 Ubiquitin Ligase Smurf1. | Molecular Analysis of Membrane Targeting by the C2 Domain of the E3 Ubiquitin Ligase Smurf1.
Scott JL, Frick CT, Johnson KA, Liu H, Yong SS, Varney AG, Wiest O, Stahelin RV., Free PMC Article | 03/20/2021 |
| miR-4319 inhibited the development of thyroid cancer by modulating FUS-stabilized SMURF1. | miR-4319 inhibited the development of thyroid cancer by modulating FUS-stabilized SMURF1.
Bian S. | 02/27/2021 |
| SND1 facilitates the invasion and migration of cervical cancer cells by Smurf1-mediated degradation of FOXA2. | SND1 facilitates the invasion and migration of cervical cancer cells by Smurf1-mediated degradation of FOXA2.
Zhan F, Zhong Y, Qin Y, Li L, Wu W, Yao M. | 10/31/2020 |
| GDF11 contributes to hepatic hepcidin (HAMP) inhibition through SMURF1-mediated BMP-SMAD signalling suppression. | GDF11 contributes to hepatic hepcidin (HAMP) inhibition through SMURF1-mediated BMP-SMAD signalling suppression.
Fang Z, Zhu Z, Zhang H, Peng Y, Liu J, Lu H, Li J, Liang L, Xia S, Wang Q, Fu B, Wu K, Zhang L, Ginzburg Y, Liu J, Chen H., Free PMC Article | 08/13/2020 |
| SMURF1 expression is elevated in the ovarian cancer cells.SMURF1 plays role in the cell proliferation, invasive capability, and epithelial-to-mesenchymal transition in ovarian cancer through DAB2IP/AKT/Skp2 signaling loops. | Deletion of SMURF 1 represses ovarian cancer invasion and EMT by modulating the DAB2IP/AKT/Skp2 feedback loop.
Fan X, Wang Y, Fan J, Chen R. | 08/12/2020 |
| UVRAG is ubiquitinated by SMURF1 at lysine residues 517 and 559, which decreases the association of UVRAG with RUBCN and promotes autophagosome maturation. | Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth.
Feng X, Jia Y, Zhang Y, Ma F, Zhu Y, Hong X, Zhou Q, He R, Zhang H, Jin J, Piao D, Huang H, Li Q, Qiu X, Zhang Z., Free PMC Article | 06/20/2020 |
| ARHGAP26 upregulation in SKOV3 cells significantly inhibited SMURF1 upregulation-induced cell migration and invasion. Overall, SMURF1-mediated ubiquitination of ARHGAP26 may promote invasion and migration of ovarian cancer cells via the beta-catenin pathway. | SMURF1-mediated ubiquitination of ARHGAP26 promotes ovarian cancer cell invasion and migration.
Chen X, Chen S, Li Y, Gao Y, Huang S, Li H, Zhu Y., Free PMC Article | 06/13/2020 |