| TRPML1 triggers ferroptosis defense and is a potential therapeutic target in AKT-hyperactivated cancer. | TRPML1 triggers ferroptosis defense and is a potential therapeutic target in AKT-hyperactivated cancer.
Zhang HL, Hu BX, Ye ZP, Li ZL, Liu S, Zhong WQ, Du T, Yang D, Mai J, Li LC, Chen YH, Zhu XY, Li X, Feng GK, Zhu XF, Deng R. | 07/4/2024 |
| Transient receptor potential mucolipin 1 circumvents oxidative stress in primary human melanocytes. | Transient receptor potential mucolipin 1 circumvents oxidative stress in primary human melanocytes.
Chen Y, Xie B, Hu Y, Sun J, Xu J, Shen Y, Zhu Y, Song X., Free PMC Article | 07/2/2024 |
| UBA6 Inhibition Accelerates Lysosomal TRPML1 Depletion and Exosomal Secretion in Lung Cancer Cells. | UBA6 Inhibition Accelerates Lysosomal TRPML1 Depletion and Exosomal Secretion in Lung Cancer Cells.
Lee D, Lee PC, Hong JH., Free PMC Article | 03/20/2024 |
| Lisch Epithelial Corneal Dystrophy Is Caused by Heterozygous Loss-of-Function Variants in MCOLN1. | Lisch Epithelial Corneal Dystrophy Is Caused by Heterozygous Loss-of-Function Variants in MCOLN1.
Patterson K, Chong JX, Chung DD, Lisch W, Karp CL, Dreisler E, Lockington D, Rohrbach JM, Garczarczyk-Asim D, Müller T, Tuft SJ, Skalicka P, Wilnai Y, Samra NN, Ibrahim A, Mandel H, Davidson AE, Liskova P, Aldave AJ, Bamshad MJ, Janecke AR. | 02/14/2024 |
| Endolysosomal TRPML1 channel regulates cancer cell migration by altering intracellular trafficking of E-cadherin and beta1-integrin. | Endolysosomal TRPML1 channel regulates cancer cell migration by altering intracellular trafficking of E-cadherin and β(1)-integrin.
Frey N, Ouologuem L, Blenninger J, Siow WX, Thorn-Seshold J, Stöckl J, Abrahamian C, Fröhlich T, Vollmar AM, Grimm C, Bartel K., Free PMC Article | 02/13/2024 |
| Modulation of Cisplatin Sensitivity through TRPML1-Mediated Lysosomal Exocytosis in Ovarian Cancer Cells: A Comprehensive Metabolomic Approach. | Modulation of Cisplatin Sensitivity through TRPML1-Mediated Lysosomal Exocytosis in Ovarian Cancer Cells: A Comprehensive Metabolomic Approach.
Kim B, Kim G, Kim H, Song YS, Jung J., Free PMC Article | 02/9/2024 |
| Ezrin inhibition alleviates oxidative stress and pyroptosis via regulating TRPML1-calcineurin axis mediated enhancement of autophagy in spinal cord injury. | Ezrin inhibition alleviates oxidative stress and pyroptosis via regulating TRPML1-calcineurin axis mediated enhancement of autophagy in spinal cord injury.
Lou J, Jin M, Zhou C, Fan Y, Ni L, Mao Y, Shen H, Li J, Zhang H, Fu C, Mao X, Chen Y, Zhong J, Zhou K, Wang L, Wu J. | 01/29/2024 |
| The Lysosomal Calcium Channel TRPML1 Maintains Mitochondrial Fitness in NK Cells through Interorganelle Cross-Talk. | The Lysosomal Calcium Channel TRPML1 Maintains Mitochondrial Fitness in NK Cells through Interorganelle Cross-Talk.
Clement D, Szabo EK, Krokeide SZ, Wiiger MT, Vincenti M, Palacios D, Chang YT, Grimm C, Patel S, Stenmark H, Brech A, Majhi RK, Malmberg KJ., Free PMC Article | 11/3/2023 |
| Increased expression or activation of TRPML1 reduces hepatic storage of toxic Z alpha-1 antitrypsin. | Increased expression or activation of TRPML1 reduces hepatic storage of toxic Z alpha-1 antitrypsin.
Pastore N, Annunziata F, Colonna R, Maffia V, Giuliano T, Custode BM, Lombardi B, Polishchuk E, Cacace V, De Stefano L, Nusco E, Sorrentino NC, Piccolo P, Brunetti-Pierri N., | 11/1/2023 |
| Modulation of Lysosomal Cl[-] Mediates Migration and Apoptosis through the TRPML1 as a Lysosomal Cl[-] Sensor. | Modulation of Lysosomal Cl(-) Mediates Migration and Apoptosis through the TRPML1 as a Lysosomal Cl(-) Sensor.
Lee D, Hong JH., Free PMC Article | 08/2/2023 |
| TRPML1 and TFEB, an Intimate Affair. | TRPML1 and TFEB, an Intimate Affair.
Medina DL. | 05/3/2023 |
| A Structural Overview of TRPML1 and the TRPML Family. | A Structural Overview of TRPML1 and the TRPML Family.
Fine M, Li X. | 05/3/2023 |
| Autophagy inhibition mediated by MCOLN1/TRPML1 suppresses cancer metastasis via regulating a ROS-driven TP53/p53 pathway. | Autophagy inhibition mediated by MCOLN1/TRPML1 suppresses cancer metastasis via regulating a ROS-driven TP53/p53 pathway.
Xing Y, Wei X, Liu Y, Wang MM, Sui Z, Wang X, Zhu W, Wu M, Lu C, Fei YH, Jiang Y, Zhang Y, Wang Y, Guo F, Cao JL, Qi J, Wang W., Free PMC Article | 08/6/2022 |
| TRPML1-induced autophagy inhibition triggers mitochondrial mediated apoptosis. | TRPML1-induced autophagy inhibition triggers mitochondrial mediated apoptosis.
Liu Y, Wang X, Zhu W, Sui Z, Wei X, Zhang Y, Qi J, Xing Y, Wang W. | 06/11/2022 |
| Mucolipidosis Type IV in Omani Families with a Novel MCOLN1 Mutation: Search for Evidence of Founder Effect. | Mucolipidosis Type IV in Omani Families with a Novel MCOLN1 Mutation: Search for Evidence of Founder Effect.
Al-Alawi B, Harikrishna B, Al-Thihli K, Al Zuhabi S, Ganesh A, Al Hashami Z, Al Dhamhmani Z, Zadjali R, Al Riyami NB, Zadjali F., Free PMC Article | 04/30/2022 |
| Interaction between TRPML1 and p62 in Regulating Autophagosome-Lysosome Fusion and Impeding Neuroaxonal Dystrophy in Alzheimer's Disease. | Interaction between TRPML1 and p62 in Regulating Autophagosome-Lysosome Fusion and Impeding Neuroaxonal Dystrophy in Alzheimer's Disease.
Zhang L, Fang Y, Cheng X, Lian Y, Xu H., Free PMC Article | 03/12/2022 |
| MCOLN1 gene therapy corrects neurologic dysfunction in the mouse model of mucolipidosis IV. | MCOLN1 gene therapy corrects neurologic dysfunction in the mouse model of mucolipidosis IV.
DeRosa S, Salani M, Smith S, Sangster M, Miller-Browne V, Wassmer S, Xiao R, Vandenberghe L, Slaugenhaupt S, Misko A, Grishchuk Y. | 03/5/2022 |
| Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors. | Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors.
Rühl P, Rosato AS, Urban N, Gerndt S, Tang R, Abrahamian C, Leser C, Sheng J, Jha A, Vollmer G, Schaefer M, Bracher F, Grimm C., Free PMC Article | 11/22/2021 |
| Genome-wide scan identifies opioid overdose risk locus close to MCOLN1. | Genome-wide scan identifies opioid overdose risk locus close to MCOLN1.
Cheng Z, Yang BZ, Zhou H, Nunez Y, Kranzler HR, Gelernter J., Free PMC Article | 02/20/2021 |
| Long-term observation of a Japanese mucolipidosis IV patient with a novel homozygous p.F313del variant of MCOLN1. | Long-term observation of a Japanese mucolipidosis IV patient with a novel homozygous p.F313del variant of MCOLN1.
Hayashi T, Hosono K, Kubo A, Kurata K, Katagiri S, Mizobuchi K, Kurai M, Mamiya N, Kondo M, Tachibana T, Saitsu H, Ogata T, Nakano T, Hotta Y. | 02/2/2021 |
| Mitochondria-lysosome contacts regulate mitochondrial Ca(2+) dynamics via lysosomal TRPML1. | Mitochondria-lysosome contacts regulate mitochondrial Ca(2+) dynamics via lysosomal TRPML1.
Peng W, Wong YC, Krainc D., Free PMC Article | 10/24/2020 |
| TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling. | TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling.
Kasitinon SY, Eskiocak U, Martin M, Bezwada D, Khivansara V, Tasdogan A, Zhao Z, Mathews T, Aurora AB, Morrison SJ., Free PMC Article | 08/29/2020 |
| the lysosomal TRPML1 channel regulates triple negative breast cancer development by promoting mTORC1 and purinergic signaling pathways | The lysosomal TRPML1 channel regulates triple negative breast cancer development by promoting mTORC1 and purinergic signaling pathways.
Xu M, Almasi S, Yang Y, Yan C, Sterea AM, Rizvi Syeda AK, Shen B, Richard Derek C, Huang P, Gujar S, Wang J, Zong WX, Trebak M, El Hiani Y, Dong XP., Free PMC Article | 07/25/2020 |
| Increased TRPML1 activity in HRAS-driven cancer cells is needed for the restoration of plasma membrane cholesterol that gets collaterally internalized during endocytosis.[review] | TRPML1 and RAS-driven cancers - exploring a link with great therapeutic potential.
Jung J, Venkatachalam K., Free PMC Article | 07/18/2020 |
| These findings reveal a selective vulnerability of HRAS-driven cancers to TRPML1 inhibition, which may be leveraged as an actionable therapeutic strategy. | HRAS-driven cancer cells are vulnerable to TRPML1 inhibition.
Jung J, Cho KJ, Naji AK, Clemons KN, Wong CO, Villanueva M, Gregory S, Karagas NE, Tan L, Liang H, Rousseau MA, Tomasevich KM, Sikora AG, Levental I, van der Hoeven D, Zhou Y, Hancock JF, Venkatachalam K., Free PMC Article | 05/2/2020 |