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    PTBP1 polypyrimidine tract binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 5725, updated on 3-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    M6A-modified lncRNA FAM83H-AS1 promotes colorectal cancer progression through PTBP1.

    M6A-modified lncRNA FAM83H-AS1 promotes colorectal cancer progression through PTBP1.
    Luo XJ, Lu YX, Wang Y, Huang R, Liu J, Jin Y, Liu ZK, Liu ZX, Huang QT, Pu HY, Zeng ZL, Xu R, Zhao Q, Wu QN.

    09/25/2024
    PTBP1-mediated repression of neuron-specific CDC42 splicing constitutes a genomic alteration-independent, developmentally conserved vulnerability in IDH-wildtype glioblastoma.

    PTBP1-mediated repression of neuron-specific CDC42 splicing constitutes a genomic alteration-independent, developmentally conserved vulnerability in IDH-wildtype glioblastoma.
    Yang J, Feng J, Lv J, Chu X, Wei Y, Zhang Y, Li J, Sun Y, Li G, Jiang T, Huang J, Fan X.

    09/18/2024
    Upregulated LncRNA-LINC00659 expression by H. pylori infection promoted the progression of gastritis to cancer by regulating PTBP1 expression.

    Upregulated LncRNA-LINC00659 expression by H. pylori infection promoted the progression of gastritis to cancer by regulating PTBP1 expression.
    Zhang J, Zhang Z, Shen D.

    09/9/2024
    Splicing Factor PTBP1 Silencing Induces Apoptosis of Human Cervical Cancer Cells via PI3K/AKT Pathway and Autophagy.

    Splicing Factor PTBP1 Silencing Induces Apoptosis of Human Cervical Cancer Cells via PI3K/AKT Pathway and Autophagy.
    Liu T, Zhou Y, Chen L, Liu Q, Hu D, Huang R, Ji H, Lin Y, Sun Y.

    09/3/2024
    Hsa_circ_0007590/PTBP1 complex reprograms glucose metabolism by reducing the stability of m[6]A-modified PTEN mRNA in pancreatic ductal adenocarcinoma.

    Hsa_circ_0007590/PTBP1 complex reprograms glucose metabolism by reducing the stability of m(6)A-modified PTEN mRNA in pancreatic ductal adenocarcinoma.
    Zheng D, Chen W, Peng J, Huang X, Zhang S, Zhuang Y.

    08/19/2024
    CircTOP1 targeted regulation of PTBP1 expression promotes the progression of coronary artery calcification.

    CircTOP1 targeted regulation of PTBP1 expression promotes the progression of coronary artery calcification.
    Hu H, Shen S, Wu J, Ma L.

    08/12/2024
    LncRNA HCP5 Facilitates the Progression of Ovarian Cancer by Interacting with the PTBP1 Protein.

    LncRNA HCP5 Facilitates the Progression of Ovarian Cancer by Interacting with the PTBP1 Protein.
    Shou J, Zhang C, Zheng X, Li Y, Wu P, Chen L, Wei X., Free PMC Article

    07/31/2024
    A novel link between melatonin and circ_0005753/PTBP1/TXNIP regulatory network in the modulation of osteogenic potential in mesenchymal stem cells.

    A novel link between melatonin and circ_0005753/PTBP1/TXNIP regulatory network in the modulation of osteogenic potential in mesenchymal stem cells.
    Tu W, Zhu S, Li F, Xu C, Tu W, Chen Y.

    07/2/2024
    Inhibition of IGF2BP1 attenuates the progression of endometriosis through PTBP1.

    Inhibition of IGF2BP1 attenuates the progression of endometriosis through PTBP1.
    Su Y, Tian W, Cheng L, Yin L, He X, Wei X.

    04/25/2024
    The leader RNA of SARS-CoV-2 sequesters polypyrimidine tract binding protein (PTBP1) and influences pre-mRNA splicing in infected cells.

    The leader RNA of SARS-CoV-2 sequesters polypyrimidine tract binding protein (PTBP1) and influences pre-mRNA splicing in infected cells.
    Altina NH, Maranon DG, Anderson JR, Donaldson MK, Elmegerhi S, St Clair LA, Perera R, Geiss BJ, Wilusz J.,

    02/23/2024
    RNA Binding Protein PTBP1 Promotes the Metastasis of Gastric Cancer by Stabilizing PGK1 mRNA.

    RNA Binding Protein PTBP1 Promotes the Metastasis of Gastric Cancer by Stabilizing PGK1 mRNA.
    Wang X, Liang C, Wang S, Ma Q, Pan X, Ran A, Qin C, Huang B, Yang F, Liu Y, Zhang Y, Ren J, Ning H, Li H, Jiang Y, Xiao B., Free PMC Article

    02/9/2024
    PTBP1 promotes the progression of hepatocellular carcinoma by enhancing the oncogenic splicing switch of FGFR2.

    PTBP1 promotes the progression of hepatocellular carcinoma by enhancing the oncogenic splicing switch of FGFR2.
    Chen YY, Zhang Q, Gui MH, Feng L, Cao PB, Zhou GQ.

    02/6/2024
    LncRNA MIAT Modulates LPS-Induced Acute Kidney Injury via BECN1-Dependent Autophagy by Interacting with PTBP1.

    LncRNA MIAT Modulates LPS-Induced Acute Kidney Injury via BECN1-Dependent Autophagy by Interacting with PTBP1.
    Xu M, Zhou Y.

    12/18/2023
    N4-acetylcytidine modification of lncRNA CTC-490G23.2 promotes cancer metastasis through interacting with PTBP1 to increase CD44 alternative splicing.

    N4-acetylcytidine modification of lncRNA CTC-490G23.2 promotes cancer metastasis through interacting with PTBP1 to increase CD44 alternative splicing.
    Yu XM, Li SJ, Yao ZT, Xu JJ, Zheng CC, Liu ZC, Ding PB, Jiang ZL, Wei X, Zhao LP, Shi XY, Li ZG, Xu WW, Li B.

    10/23/2023
    The lncRNA MIR99AHG directs alternative splicing of SMARCA1 by PTBP1 to enable invadopodia formation in colorectal cancer cells.

    The lncRNA MIR99AHG directs alternative splicing of SMARCA1 by PTBP1 to enable invadopodia formation in colorectal cancer cells.
    Li D, Wang X, Miao H, Liu H, Pang M, Guo H, Ge M, Glass SE, Emmrich S, Ji S, Zhou Y, Ye X, Mao H, Wang J, Liu Q, Kim T, Klusmann JH, Li C, Liu Z, Jin H, Nie Y, Wu K, Fan D, Song X, Wang X, Li L, Lu Y, Zhao X.

    09/22/2023
    The role of RNA splicing factor PTBP1 in neuronal development.

    The role of RNA splicing factor PTBP1 in neuronal development.
    Liu HL, Lu XM, Wang HY, Hu KB, Wu QY, Liao P, Li S, Long ZY, Wang YT.

    08/20/2023
    PTBP1 regulates injury responses and sensory pathways in adult peripheral neurons.

    PTBP1 regulates injury responses and sensory pathways in adult peripheral neurons.
    Alber S, Di Matteo P, Zdradzinski MD, Dalla Costa I, Medzihradszky KF, Kawaguchi R, Di Pizio A, Freund P, Panayotis N, Marvaldi L, Doron-Mandel E, Okladnikov N, Rishal I, Nevo R, Coppola G, Lee SJ, Sahoo PK, Burlingame AL, Twiss JL, Fainzilber M., Free PMC Article

    08/14/2023
    The Splicing Factor PTBP1 Represses TP63 gamma Isoform Production in Squamous Cell Carcinoma.

    The Splicing Factor PTBP1 Represses TP63 γ Isoform Production in Squamous Cell Carcinoma.
    Taylor W, Deschamps S, Reboutier D, Paillard L, Méreau A, Audic Y., Free PMC Article

    08/1/2023
    Polypyrimidine tract binding protein 1 (PTBP1) contains a novel regulatory sequence, the rBH3, that binds the prosurvival protein MCL1.

    Polypyrimidine tract binding protein 1 (PTBP1) contains a novel regulatory sequence, the rBH3, that binds the prosurvival protein MCL1.
    Carico C, Cui J, Acton A, Placzek WJ., Free PMC Article

    07/12/2023
    MiR-506 targets polypyrimidine tract-binding protein 1 to inhibit airway inflammatory response and remodeling via mediating Wnt/beta-catenin signaling pathway.

    MiR-506 targets polypyrimidine tract-binding protein 1 to inhibit airway inflammatory response and remodeling via mediating Wnt/β-catenin signaling pathway.
    Cai Y, Tian J, Su Y, Shi X.

    06/2/2023
    A feedback loop between NONHSAT024276 and PTBP1 inhibits tumor progression and glycolysis in HCC by increasing the PKM1/PKM2 ratio.

    A feedback loop between NONHSAT024276 and PTBP1 inhibits tumor progression and glycolysis in HCC by increasing the PKM1/PKM2 ratio.
    Li Y, Chen X, Huang H, Liao L, Chong H, Li G, Yuan T, Lu W, Deng S, Huang Q., Free PMC Article

    04/6/2023
    PTBP1 drives c-Myc-dependent gastric cancer progression and stemness.

    PTBP1 drives c-Myc-dependent gastric cancer progression and stemness.
    Ni T, Chu Z, Tao L, Zhao Y, Zhu M, Luo Y, Sunagawa M, Wang H, Liu Y., Free PMC Article

    03/15/2023
    Analysis of RBP expression and binding sites identifies PTBP1 as a regulator of CD19 expression in B-ALL.

    Analysis of RBP expression and binding sites identifies PTBP1 as a regulator of CD19 expression in B-ALL.
    Ziegler N, Cortés-López M, Alt F, Sprang M, Ustjanzew A, Lehmann N, El Malki K, Wingerter A, Russo A, Beck O, Attig S, Roth L, König J, Paret C, Faber J., Free PMC Article

    03/8/2023
    Long noncoding RNA ENST00000436340 promotes podocyte injury in diabetic kidney disease by facilitating the association of PTBP1 with RAB3B.

    Long noncoding RNA ENST00000436340 promotes podocyte injury in diabetic kidney disease by facilitating the association of PTBP1 with RAB3B.
    Hu J, Wang Q, Fan X, Zhen J, Wang C, Chen H, Liu Y, Zhou P, Zhang T, Huang T, Wang R, Lv Z., Free PMC Article

    02/23/2023
    Polypyrimidine-Tract-Binding Protein Isoforms Differentially Regulate the Hepatitis C Virus Internal Ribosome Entry Site.

    Polypyrimidine-Tract-Binding Protein Isoforms Differentially Regulate the Hepatitis C Virus Internal Ribosome Entry Site.
    Angulo J, Cáceres CJ, Contreras N, Fernández-García L, Chamond N, Ameur M, Sargueil B, López-Lastra M., Free PMC Article

    01/28/2023
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