| Leukotriene B4 receptor 2 governs macrophage migration during tissue inflammation. | Leukotriene B4 receptor 2 governs macrophage migration during tissue inflammation.
Ermis E, Nargis T, Webster K, Tersey SA, Anderson RM, Mirmira RG., Free PMC Article | 02/13/2024 |
| Leukotriene B4 receptor-2 contributes to KRAS-driven lung tumor formation by promoting interleukin-6-mediated inflammation. | Leukotriene B4 receptor-2 contributes to KRAS-driven lung tumor formation by promoting interleukin-6-mediated inflammation.
Jang JH, Park D, Park GS, Kwak DW, Park J, Yu DY, You HJ, Kim JH., Free PMC Article | 04/9/2022 |
| Contributory Role of BLT2 in the Production of Proinflammatory Cytokines in Cecal Ligation and Puncture-Induced Sepsis. | Contributory Role of BLT2 in the Production of Proinflammatory Cytokines in Cecal Ligation and Puncture-Induced Sepsis.
Park D, Ro M, Lee AJ, Kwak DW, Chung Y, Kim JH., Free PMC Article | 04/2/2022 |
| Leukotriene B4 receptors contribute to house dust mite-induced eosinophilic airway inflammation via TH2 cytokine production. | Leukotriene B4 receptors contribute to house dust mite-induced eosinophilic airway inflammation via TH2 cytokine production.
Park D, Kwak DW, Kim JH., Free PMC Article | 10/16/2021 |
| Leukotriene B4 receptors play critical roles in house dust mites-induced neutrophilic airway inflammation and IL-17 production. | Leukotriene B(4) receptors play critical roles in house dust mites-induced neutrophilic airway inflammation and IL-17 production.
Kwak DW, Park D, Kim JH. | 04/24/2021 |
| Leukotriene B4 Receptor Type 2 Accelerates the Healing of Intestinal Lesions by Promoting Epithelial Cell Proliferation. | Leukotriene B(4) Receptor Type 2 Accelerates the Healing of Intestinal Lesions by Promoting Epithelial Cell Proliferation.
Matsumoto Y, Matsuya Y, Nagai K, Amagase K, Saeki K, Matsumoto K, Yokomizo T, Kato S. | 09/12/2020 |
| FABP4 regulates the expression of BLT1R and its downstream signaling via control of oxidative stress in macrophages | Fatty acid binding protein 4/aP2-dependent BLT1R expression and signaling.
Hertzel AV, Xu H, Downey M, Kvalheim N, Bernlohr DA., Free PMC Article | 03/10/2018 |
| findings suggest that a leukotriene B4 receptor-2-linked cascade plays a pivotal role in LPS/TLR4 signaling for IL-13 synthesis in mast cells, thereby potentially exacerbating allergic response. | Lipopolysaccharide/TLR4 Stimulates IL-13 Production through a MyD88-BLT2-Linked Cascade in Mast Cells, Potentially Contributing to the Allergic Response.
Lee AJ, Ro M, Cho KJ, Kim JH. | 09/30/2017 |
| This study demonstrates that LTB4 promotes macrophage phagocytosis of bacteria via BLT1, and that BLT2 can fulfill this role in the absence of BL | Macrophage LTB(4) drives efficient phagocytosis of Borrelia burgdorferi via BLT1 or BLT2.
Zhang Y, Olson RM, Brown CR., Free PMC Article | 09/2/2017 |
| BLT2 expression in mast cells is essential for the production of VEGF in OVA-induced allergic asthma. | Leukotriene B4 Receptor 2 Is Critical for the Synthesis of Vascular Endothelial Growth Factor in Allergen-Stimulated Mast Cells.
Lee AJ, Ro M, Kim JH. | 08/12/2017 |
| the data show that the two leukotriene B4 receptors have opposing roles in the sensitization of peripheral sensory neurons forming a self-restricting system. | The leukotriene B4 receptors BLT1 and BLT2 form an antagonistic sensitizing system in peripheral sensory neurons.
Zinn S, Sisignano M, Kern K, Pierre S, Tunaru S, Jordan H, Suo J, Treutlein EM, Angioni C, Ferreiros N, Leffler A, DeBruin N, Offermanns S, Geisslinger G, Scholich K., Free PMC Article | 04/29/2017 |
| These results show that 12-HHT/BLT2 enhances epithelial barrier function by increasing CLDN4 expression via the Galphai protein-p38 MAPK pathway. | Leukotriene B4 receptor type 2 (BLT2) enhances skin barrier function by regulating tight junction proteins.
Ishii Y, Saeki K, Liu M, Sasaki F, Koga T, Kitajima K, Meno C, Okuno T, Yokomizo T. | 06/28/2016 |
| Data indicate that leukotriene B4 receptor 2 protein BLT2-deficient mice exhibited impaired re-epithelialization and delayed wound closure after skin punching. | 12-Hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor.
Liu M, Saeki K, Matsunobu T, Okuno T, Koga T, Sugimoto Y, Yokoyama C, Nakamizo S, Kabashima K, Narumiya S, Shimizu T, Yokomizo T., Free PMC Article | 08/23/2014 |
| Findings indicate that BLT2 has a protective role in allergic airway inflammation and that diminished BLT2 expression in CD4(+) T cells may contribute to the pathophysiology of asthma. | Leukotriene B4 receptor BLT2 negatively regulates allergic airway eosinophilia.
Matsunaga Y, Fukuyama S, Okuno T, Sasaki F, Matsunobu T, Asai Y, Matsumoto K, Saeki K, Oike M, Sadamura Y, Machida K, Nakanishi Y, Kubo M, Yokomizo T, Inoue H. | 12/21/2013 |
| Leukotriene B4 receptor-2 promotes invasiveness and metastasis of ovarian cancer cells through signal transducer and activator of transcription 3 (STAT3)-dependent up-regulation of matrix metalloproteinase 2 | Leukotriene B4 receptor-2 promotes invasiveness and metastasis of ovarian cancer cells through signal transducer and activator of transcription 3 (STAT3)-dependent up-regulation of matrix metalloproteinase 2.
Seo JM, Park S, Kim JH., Free PMC Article | 07/21/2012 |
| Selective inhibition of the BLT2 receptor in mice reduces the release of vascular reactive oxygen species and improves endothelial function in mice | Selective inhibition of leukotriene receptor BLT-2 reduces vascular oxidative stress and improves endothelial function in ApoE-/- mice.
Hoyer FF, Albrecht L, Nickenig G, Müller C. | 06/16/2012 |
| Results suggest a direct anti-inflammatory role of BLT2 that is distinct from the proinflammatory roles of BLT1. | Protective role of the leukotriene B4 receptor BLT2 in murine inflammatory colitis.
Iizuka Y, Okuno T, Saeki K, Uozaki H, Okada S, Misaka T, Sato T, Toh H, Fukayama M, Takeda N, Kita Y, Shimizu T, Nakamura M, Yokomizo T. | 01/8/2011 |
| our results suggest that the BLT2-Nox1-reactive oxygen species cascade is a previously unsuspected mediatory signaling mechanism to Th2 cytokine production in Ag-stimulated BMMCs | BLT2 Is upregulated in allergen-stimulated mast cells and mediates the synthesis of Th2 cytokines.
Cho KJ, Seo JM, Lee MG, Kim JH. | 12/4/2010 |
| BLT2-deficient mice develop normally; analysis of immune cells shows that disruption of BLT2 does not alter BLT1 expression or function. | Nonredundant roles for leukotriene B4 receptors BLT1 and BLT2 in inflammatory arthritis.
Mathis SP, Jala VR, Lee DM, Haribabu B. | 10/30/2010 |
| BLT2 plays a pivotal, mediatory role in the pathogenesis of asthma, acting through a "reactive oxygen species-NF-kappaB"-linked inflammatory signaling pathway. | Blockade of airway inflammation and hyperresponsiveness by inhibition of BLT2, a low-affinity leukotriene B4 receptor.
Cho KJ, Seo JM, Shin Y, Yoo MH, Park CS, Lee SH, Chang YS, Cho SH, Kim JH. | 03/15/2010 |
| The BLT2 receptor is involved in 12(S)-lipoxygenase-product-induced scratching in ICR mice. | Involvement of the BLT2 receptor in the itch-associated scratching induced by 12-(S)-lipoxygenase products in ICR mice.
Kim HJ, Kim DK, Kim H, Koh JY, Kim KM, Noh MS, Lee S, Kim S, Park SH, Kim JJ, Kim SY, Lee CH., Free PMC Article | 01/21/2010 |
| 12-HHT is a natural lipid agonist of BLT2 in vivo and induces chemotaxis of mast cells | 12(S)-Hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for leukotriene B4 receptor 2.
Okuno T, Iizuka Y, Okazaki H, Yokomizo T, Taguchi R, Shimizu T., Free PMC Article | 01/21/2010 |
| demonstrates expression of functional Leukotriene B4 receptors, both BLT1 and BLT2, in murine and human mast cells and a regulatory role for stem cell factor in their expression | Leukotriene B4 receptors BLT1 and BLT2: expression and function in human and murine mast cells.
Lundeen KA, Sun B, Karlsson L, Fourie AM. | 01/21/2010 |
| BLT2 is a leukotriene B4 receptor with a role in ERK activation and cell migration of primary mouse keratinocytes | Characterization of a mouse second leukotriene B4 receptor, mBLT2: BLT2-dependent ERK activation and cell migration of primary mouse keratinocytes.
Iizuka Y, Yokomizo T, Terawaki K, Komine M, Tamaki K, Shimizu T. | 01/21/2010 |
| 360 amino acid sequence determined and aligned with human sequence | BLT1 and BLT2: the leukotriene B(4) receptors.
Tager AM, Luster AD. | 01/21/2010 |